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Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study

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Chinese Journal of Integrative Medicine 2024年第5期30卷 443-448页

作者： WU shi-hao shi wei-qi LI Yu-hang LIU Ru-hui HU Da-yi ZHENG Li-qiang MA Wen-lin Department of Geriatric Medicine Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Peking University People's HospitalBeijing 100044China School of Public Health Shanghai Jiao Tong UniversityShanghai 200030China

Objective: To evaluate the efficacy of Guanxin Danshen Dripping Pill(GXDSDP) in treating anxiety and depression in patients with coronary heart disease(CHD). Methods: A total of 1,428 patients diagnosed with CHD screened for anxiety, depression, and quality of life(QOL) at baseline received 0.4 g of GXDSDP treatment 3 times per day and returned for monthly reassessment. Patients were recruited after stable treatment for CHD and received assessment of General Anxiety Disorder-7(GAD-7), Patient Health Questionnaire-9(PHQ-9), and Seattle Angina Questionnaire(SAQ) for evaluating anxiety, depression, and *** were followed up 3 times, once every 4 weeks, during outpatient visits for 12 weeks. Results: At the third follow-up(F3), the anxiety symptom of 63.79%(673/1,055) of the patients improved to sub-clinical level, and the GAD-7 score improved significantly(8.11 vs. 3.87, P<0.01);57.52%(585/1,017) patients' depressive symptoms improved to sub-clinical level, with a significant improvement in PHQ-9 score(8.69 vs. 4.41, P<0.01) at F3. All aspects of QOL significantly improved at the end of treatment compared to those at baseline(all P<0.01) as assessed by SAQ: physical limitation(31.17 vs. 34.14), anginal stability(2.74 vs. 4.14), anginal frequency(8.16vs. 9.10), treatment satisfaction(13.43 vs. 16.29), and disease perception(8.69 vs. 11.02). Conclusions: A fixed dosage of GXDSDP may be a potential treatment option for CHD patients comorbid with anxiety or depression.(Registration No. ChiCTR2100051523)

关键词： Guanxin Danshen Dripping Pill coronary heart disease depression anxiety quality of life Chinese medicine

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I_κB kinase-beta inhibitor attenuates hepatic fibrosis in mice

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World Journal of Gastroenterology 2011年第47期17卷 5203-5213页

作者： Jue wei Min shi wei-qi Wu Hui Xu Ting Wang Na Wang Jia-Li Ma Yu-Gang Wang Department of Gastro-enterology Shanghai Changning Central Hospital Shanghai200336 China

AIM: To investigate the anti-fibrosis effect of IκB kinase-beta inhibitor (IKK2 inhibitor IMD0354) in liver fibrosis. METHODS: Twenty male C57BL6 mice were divided into four groups. Five high-fat fed mice were injected with lipopolysaccharide (LPS, 10 mg/kg) intraperitoneally and five high-fat fed mice were without LPS injection to build models of liver injury, and the intervention group (five mice) was injected intraperitoneally with IKK2 inhibitor (IMD 30 mg/kg for 14 d), while the remaining five mice received a normal diet as controls. Hepatic function, pathological evaluation and liver interleukin-6 (IL-6) expression were examined. Western blotting and real-time polymerase chain reaction were used to detect the expressions of nuclear factor-κB (NF-κB), alpha-smooth muscle actin (α-SMA), tumor growth factor-beta1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), typeⅠand type Ⅲ collagen proteins and mRNA. RESULTS: A mouse model of liver injury was successfully established, and IMD decreased nuclear transloca-tion of NF-κB p65 in liver cells. In the IMD-treated group, the levels of alanine aminotransferase (103 ± 9.77 μ/L vs 62.4 ± 7.90 μ/L, P < 0.05) and aminotransferase (295.8 ± 38.56 μ/L vs 212 ± 25.10 μ/L, P < 0.05) were significantly decreased when compared with the model groups. The histological changes were significantly ameliorated. After treatment, the expressions of IL-6 (681 ± 45.96 vs 77 ± 7.79, P < 0.05), TGF-β1 (Western blotting 5.65% ± 0.017% vs 2.73% ± 0.005%, P < 0.05), TNF-α (11.58% ± 0.0063% vs 8.86% ± 0.0050%, P < 0.05), typeⅠcollagen (4.49% ± 0.014% vs 1.90% ± 0.0006%, P < 0.05) and type Ⅲ collagen (3.46% ± 0.008% vs 2.29% ± 0.0035%, P < 0.05) as well as α-SMA (6.19 ± 0.0036 μ/L vs 2.16 ± 0.0023 μ/L, P < 0.05) protein and mRNA were downregulated in the IMD group compared to the fibrosis control groups (P < 0.05). CONCLUSION: IKK2 inhibitor IMD markedly improved non-alcoholic fatty liver disease in mice by lowering NF-κB activation, which could be

关键词： Liver fibrosis IKK2 inhibitor Nuclear factor-kappa B Tumor growth factor-beta1 Interleukin-6 Alpha-smooth muscle actin C57BL mouse

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Effects of a new nitrification inhibitor 3,4-dimethylpyrazole phosphate(DMPP) on nitrate and potassium leaching in two soils

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Journal of Environmental Sciences 2007年第7期19卷 841-847页

作者： WU Shao-fu WU Liang-huan shi qi-wei WANG Zhong-qiang CHEN Xian-you LI Yong-shan Ministry of Education Key Lab of Environmental Remediation and Ecosystem Health College of Environmental and Resource Sciences Zhefiang University Hangzhou 310029 China. Agricultural Extension Station of Shaoxing City Shaoxing 312000 China Agricultural Extension Station of Shaoxing Country Shaoxing 312000 China

In this study, soil column was used to study the new nitrification inhibitor 3,4-dimethylpyrazole phosphate （DMPP） on nitrate （NO3^-- N） and potassium （K） leaching in the sandy loam soil and clay loam soil. The results showed that DMPP with ammonium sulphate nitrate （ASN）（（NH4）2SO4 and NHaNO3） or urea could reduce NO3^--N leaching significantly, whereas ammonium （NH4^＋-N） leaching increased slightly. In case of total N （NO3^--N＋NH4^＋-N）, losses by leaching during the experimental period （40 d） were 37.93 mg （urea）, 31.61 mg （urea＋DMPP）, 108.10 mg （ASN）, 60.70 mg （ASN＋DMPP） in the sandy loam soil, and 30.54 mg （urea）, 21.05 mg （urea＋DMPP）, 37.86 mg （ASN）, 31.09 mg （ASN＋DMPP） in the clay loam soil, respectively. DMPP-amended soil led to the maintenance of relatively high levels of NH4^＋ -N and low levels of NO3^--N in soil, and nitrification was slower. DMPP supplementation also resulted in less potassium leached, but the difference was not significant except the treatment of ASN and ASN＋DMPP in the sandy loam soil. Above results indicate that DMPP is a good nitrification inhibitor, the efficiency of DMPP seems better in the sandy loam soil than in the clay loam soil and lasts longer.

关键词： 3,4-dimethylpyrazole phosphate (DMPP) nitrate potassium leaching sandy loam soil clay loam soil

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Spatial variability of soil properties in red soil and its implications for site-specific fertilizer management

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Journal of Integrative Agriculture 2020年第9期19卷 2313-2325页

作者： SONG Fang-fang XU Ming-gang DUAN Ying-hua CAI Ze-jiang WEN shi-lin CHEN Xian-ni shi wei-qi Gilles COLINET National Engineering Laboratory for Improving Quality of Arable Land Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081P.R.China Gembloux Agro-Bio Tech University of LiegeGembloux 5030Belgium South Subtropical Crop Research Institute Chinese Academy of Tropical Agricultural SciencesZhanjiang 524091P.R.China College of Agriculture Henan University of Science&TechnologyLuoyang 471003P.R.China

Assessing spatial variability and mapping of soil properties constitute important prerequisites for soil and crop management in agricultural areas. To explore the relationship between soil spatial variability and land management, 256 samples were randomly collected at two depths (surface layer 0–20 cm and subsurface layer 20–40 cm) under different land use types and soil parent materials in Yujiang County, Jiangxi Province, a red soil region of China. The pH, soil organic matter (SOM), total nitrogen (TN), cation exchange capacity (CEC), and base saturation (BS) of the soil samples were examined and mapped. The results indicated that soils in Yujiang were acidified, with an average pH of 4.87 (4.03–6.46) in the surface layer and 4.99 (4.03–6.24) in the subsurface layer. SOM and TN were significantly higher in the surface layer (27.6 and 1.50 g kg–1, respectively) than in the subsurface layer (12.1 and 0.70 g kg–1, respectively), while both CEC and BS were low (9.0 and 8.0 cmol kg–1, 29 and 38% for surface and subsurface layers, respectively). Paddy soil had higher pH (mean 4.99) than upland and forest soils, while soil derived from river alluvial deposits (RAD) had higher pH (mean 5.05) than the other three parent materials in both layers. Geostatistical analysis revealed that the best fit models were exponential for pH and TN, and spherical for BS in both layers, while spherical and Gaussian were the best fitted for SOM and CEC in the surface and subsurface layers. Spatial dependency varied from weak to strong for the different soil properties in both soil layers. The maps produced by selecting the best predictive variables showed that SOM, TN, and CEC had moderate levels in most parts of the study area. This study highlights the importance of site-specific agricultural management and suggests guidelines for appropriate land management decisions.

关键词： spatial variability soil pH CEC BS site-specific fertilizer management

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电子货币——影响未来金融竞争的新型货币

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特区经济 2007年第7期 65-66页

作者：魏诗琪华中科技大学经济学院湖北武汉430074

作为信息技术和网络银行业务相结合的一种新型货币形式,电子货币影响并改变着我们的生活。相对于国际市场,我国的电子货币存在着品种少,使用范围窄等一系列的问题。只有加快制定和实施我国电子货币发展的各项方案,才能有机会掌握未来金... 详细信息

作为信息技术和网络银行业务相结合的一种新型货币形式,电子货币影响并改变着我们的生活。相对于国际市场,我国的电子货币存在着品种少,使用范围窄等一系列的问题。只有加快制定和实施我国电子货币发展的各项方案,才能有机会掌握未来金融竞争的主动权。

关键词：金融服务电子货币信用卡

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脚本程序安全漏洞的动态防御方法

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计算机工程与设计 2007年第17期28卷 4126-4128,4174页

作者：史伟奇湖南公安高等专科学校计算机系湖南长沙410138

脚本程序漏洞经常引起安全问题,导致出现网络攻击。对常见脚本程序漏洞进行了分类研究,分析了漏洞产生机理,总结出参数引用(参数未过滤、数据未判断、数据未过滤)和逻辑考虑不足(逻辑推理缺陷、逻辑运算符滥用)两类主要的脚本安全问题... 详细信息

脚本程序漏洞经常引起安全问题,导致出现网络攻击。对常见脚本程序漏洞进行了分类研究,分析了漏洞产生机理,总结出参数引用(参数未过滤、数据未判断、数据未过滤)和逻辑考虑不足(逻辑推理缺陷、逻辑运算符滥用)两类主要的脚本安全问题。在此基础上,提出一种针对脚本源代码漏洞的动态防御方法,阐明了防御原理及方法,设计了攻击字符库。实验表明,该方法可以有效地防范脚本漏洞攻击,提高了Web系统的安全性。

关键词：脚本程序 Web安全脚本漏洞漏洞分析网络攻击动态防御

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载荷水平对HCF寿命分散性影响的有限元模拟

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航空动力学报 2016年第12期31卷 2928-2932页

作者：杨晓光苗国磊韩世伟石多奇北京航空航天大学能源与动力工程学院北京100191 先进航空发动机协同创新中心北京100191

给出了基于晶体塑性理论的高循环疲劳(HFC)寿命分散性有限元模拟方法.针对典型钛合金TC4的微结构特征,采用Voronoi方法建立其晶粒模型,建立钛合金晶体塑性本构方程,计算模拟了应力水平对疲劳寿命分散性的影响,给出表征疲劳寿命分散性的... 详细信息

给出了基于晶体塑性理论的高循环疲劳(HFC)寿命分散性有限元模拟方法.针对典型钛合金TC4的微结构特征,采用Voronoi方法建立其晶粒模型,建立钛合金晶体塑性本构方程,计算模拟了应力水平对疲劳寿命分散性的影响,给出表征疲劳寿命分散性的参数.结果表明:应力水平越低,疲劳寿命越长,疲劳寿命的分散性越大,与实验规律一致.

关键词：钛合金高周疲劳微结构寿命分散性晶体塑性理论

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丛枝菌根真菌对羊草生物量和氮磷吸收及土壤碳的影响

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西北植物学报 2011年第2期31卷 357-362页

作者：石伟琦丁效东张士荣中国热带农业科学院南亚热带作物研究所广东湛江524091

采用大田试验的方法在内蒙古锡林格勒草原进行牧草接种试验,通过灭菌和未灭菌两种土壤研究接种丛枝菌根真菌Glomus mosseae和Glomus claroidium对内蒙古典型草原优势种羊草生长的影响.结果显示,接种丛枝菌根真菌对羊草的地上部干重未产... 详细信息

采用大田试验的方法在内蒙古锡林格勒草原进行牧草接种试验,通过灭菌和未灭菌两种土壤研究接种丛枝菌根真菌Glomus mosseae和Glomus claroidium对内蒙古典型草原优势种羊草生长的影响.结果显示,接种丛枝菌根真菌对羊草的地上部干重未产生显著影响,但向未灭菌土壤中接种能显著增加羊草根系量,同时接种***显著增加了地上部的N、P含量及吸收量,有效地改善了植株N、P营养,提高了牧草品质;2种菌对根系的营养吸收影响不同,接种***在灭菌土壤和未灭菌土壤中均能显著增加根系的N、P吸收量,而接种***仅在土壤未灭菌状态下增加根系N、P吸收量;接种对土壤中的菌丝密度未产生显著影响,但接种后土壤中微生物量碳有增加的趋势,短期内难以观察到接种对土壤有机碳的影响.研究表明,丛枝菌根真菌能够提高牧草对N、P吸收,促进牧草的生长,改善牧草品质,增强牧草根际微生物量碳.

关键词：丛枝菌根真菌羊草接种效应

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不饱和脂质氮杂环丙烷化反应中间体的原位质谱分析

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质谱学报 2024年第1期45卷 149-156,I0005页

作者：陈凯祥魏是奇陈素明武汉大学高等研究院湖北武汉430072

脂质结构决定生物功能,对不饱和脂质C C双键异构体的鉴定面临着挑战。直接的氮-甲基(N-Me)氮杂环丙烷化反应可以对不饱和脂质双键进行衍生,通过与串联质谱结合可实现不饱和脂质双键位置的解析。然而,目前N-Me氮杂环丙烷化反应机理研究... 详细信息

脂质结构决定生物功能,对不饱和脂质C C双键异构体的鉴定面临着挑战。直接的氮-甲基(N-Me)氮杂环丙烷化反应可以对不饱和脂质双键进行衍生,通过与串联质谱结合可实现不饱和脂质双键位置的解析。然而,目前N-Me氮杂环丙烷化反应机理研究尚缺乏中间过程的直接证据。本工作采用一种基于θ毛细管的纳升静电喷雾离子化质谱(nESTASI-MS)分析装置,研究不饱和磷脂酰胆碱的氮杂环丙烷化反应过程,捕获并鉴定了反应过程中的关键中间体,为阐明氮杂环丙烷化反应机理提供了直接证据。

关键词：质谱(MS) 化学反应中间体氮杂环丙烷化反应双键位置鉴定

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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan qi Biao shi Ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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