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围绝经期妇女血清抑制素B水平测定及临床意义

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中国妇幼保健 2008年第28期23卷 3970-3972页

作者：时青云全海英首都医科大学附属北京友谊医院妇产科北京100050 首都医科大学生物医学工程学院

目的：探讨围绝经期妇女血清抑制素B（InhibinsB）水平的变化、并分析其与围绝经期症状、月经状态的关系。方法：289例围绝经期妇女按照月经周期情况分为4组，研究组1共有106例，月经周期规律；研究组2共有84例，月经周期不规律，但最... 详细信息

目的：探讨围绝经期妇女血清抑制素B（InhibinsB）水平的变化、并分析其与围绝经期症状、月经状态的关系。方法：289例围绝经期妇女按照月经周期情况分为4组，研究组1共有106例，月经周期规律；研究组2共有84例，月经周期不规律，但最长周期不超过3个月；研究组3共有63例，月经周期不规律，月经周期在3～11个月之间；研究组4，绝经1年，共有36例。每位妇女均测定血清抑制素B、卵泡刺激素（follicle stimulating hormone，FSH）、雌激素（您）水平，及临床症状分析。结果：（1）InhibinsB水平研究组2与研究组1相比明显下降（P〈0．001），但与研究组3、研究组4相比没有变化（P〉0．05）；FSH水平研究组2与研究组1相比无变化（P〉0．05）；E2水平研究组2与研究组1相比无意义（P〉0．05）。②FSH、E2水平在正常范围内时，InhibimB〈50ng／L组临床症状发生率明显高于InhibinsB〉50ng／L组（P〈0．05）。结论：早期围绝经期妇女内分泌变化是抑制素B水平下降、雌激素水平可无变化。

关键词：围绝经期月经周期血清抑制素B 卵泡刺激素

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一种基于边缘生长的灰度和彩色图象分割方法

中国图象图形学报（A辑） 2000年第11期5卷 911-915页

作者：林通石青云北京大学视觉与听觉信息处理国家重点实验室北京100871

边缘检测可以快速准确地提供区域分割的边缘点 ,是图象处理的一个重要领域 .但由于边缘点不连续和难以把存在大量碎边缘点的高细节区提取出来这两个原因 ,而不能直接实现完整意义上的图象分割 .为此提出用边缘生长的方法来解决不连续的... 详细信息

边缘检测可以快速准确地提供区域分割的边缘点 ,是图象处理的一个重要领域 .但由于边缘点不连续和难以把存在大量碎边缘点的高细节区提取出来这两个原因 ,而不能直接实现完整意义上的图象分割 .为此提出用边缘生长的方法来解决不连续的边缘点链接问题和通过找出高细节区周围的区域 ,以便间接地将高细节区围成一个区域 .该算法是边缘检测的后续处理 ,适合于多种应用目的 ,同时还可以嵌入到其它利用边缘信息的分割算法中 .

关键词：图象分割边缘检测边缘生长图象处理梯度计算

A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan shi yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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RiceDB:基于Web界面的水稻基因芯片注释整合数据库

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中国水稻科学 2007年第3期21卷 235-241页

作者：何飞施清芸陈铭吴平浙江大学生命科学学院植物生理与生物化学国家重点实验室浙江杭州310058

开发了1个基于Web界面在生物学背景下注释水稻基因芯片的整合数据库RiceDB,它的注释信息比同类针对水稻Affymetrix 57K全基因组表达谱芯片的注释数据库更全面、更快捷且可以自动更新。它由8个功能模块组成,RiceMap建立水稻Affymetrix 57... 详细信息

开发了1个基于Web界面在生物学背景下注释水稻基因芯片的整合数据库RiceDB,它的注释信息比同类针对水稻Affymetrix 57K全基因组表达谱芯片的注释数据库更全面、更快捷且可以自动更新。它由8个功能模块组成,RiceMap建立水稻Affymetrix 57K探针组与基因的对应关系,从而提供来自各个水稻生物信息学数据库功能描述信息;RiceGO整合Gene Ontology数据库从生物学途径/分子功能和细胞构建对Affymetrix 57K探针组进行注释;RiceKO确定Affymetrix 57K探针组代表的基因可能参与的代谢与调控路径;RiceUP、RiceDO、RiceMR、RiceCD、RiceGF分别确定Affymetrix 57K探针组代表的基因上游小于1 kb启动子序列、结构功能域组成、受哪些水稻MicroRNA调控、染色体定位、基因家族分类。

关键词：芯片注释水稻分子数据库

CT whole lung radiomic nomogram:a potential biomarker for lung function evaluation and identification of COPD

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Military Medical Research 2025年第1期12卷 36-47页

作者： Tao-Hu Zhou Xiu-Xiu Zhou Jiong Ni Yan-qing Ma Fang-Yi Xu Bing Fan Yu Guan Xin-Ang Jiang Xiao-qing Lin Jie Li Yi Xia Xiang Wang yun Wang Wen-Jun Huang Wen-Ting Tu Peng Dong Zhao-Bin Li shi-Yuan Liu Li Fan Department of Radiology the Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China School of Medical Imaging Shandong Second Medical UniversityWeifang 261053ShandongChina Department of Radiology School of MedicineTongji HospitalTongji UniversityShanghai 200065China Department of Radiology Zhejiang Province People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China Department of Radiology Sir Run Run Shaw HospitalZhejiang 310018China Jiangxi Provincial People’s Hospital the First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China College of Health Sciences and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Radiology the Second People’s Hospital of DeyangDeyang 618000SichuanChina Department of Radiation Oncology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Background:Computed tomography(CT)plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease(COPD).This study aimed to explore the performance of CT-based whole lung radiomic in discriminating COPD patients and non-COPD ***:This retrospective study was performed on 2785 patients who underwent pulmonary function examination in 5 hospitals and were divided into non-COPD group and COPD *** radiomic features of the whole lung volume were *** absolute shrinkage and selection operator(LASSO)logistic regression was applied for feature selection and radiomic signature construction.A radiomic nomogram was established by combining the radiomic score and clinical *** operating characteristic(ROC)curve analysis and decision curve analysis(DCA)were used to evaluate the predictive performance of the radiomic nomogram in the training,internal validation,and independent external validation ***:Eighteen radiomic features were collected from the whole lung volume to construct a radiomic *** area under the curve(AUC)of the radiomic model in the training,internal,and independent external validation cohorts were 0.888[95%confidence interval(CI)0.869–0.906],0.874(95%CI 0.844–0.904),and 0.846(95%CI 0.822–0.870),*** were higher than the clinical model(AUC were 0.732,0.714,and 0.777,respectively,P<0.001).DCA demonstrated that the nomogram constructed by combining radiomic score,age,sex,height,and smoking status was superior to the clinical factor ***:The intuitive nomogram constructed by CT-based whole-lung radiomic has shown good performance and high accuracy in identifying COPD in this multicenter study.

关键词： Chronic obstructive pulmonary disease(COPD) Computed tomography(CT) Radiomic

Different Acupuncture Therapies for Postherpetic Neuralgia:An Overview of Systematic Reviews and Meta-analysis

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Chinese Journal of Integrative Medicine 2025年第1期31卷 55-67页

作者： XIA yun-fan SUN Ruo-han LI shi-min WANG Yi-yi LI Rong-rong FANG Jian-qiao The Third Clinical Medical College of Zhejiang Chinese Medical University Hangzhou310000China Department of Rehabilitation Medicine Hangzhou Third People’s Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou310000China Department of Acupuncture the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310000China

Background: Postherpetic neuralgia(PHN) is the most common complication of herpes zoster infection and affects patients' quality of life. Acupuncture therapy is regarded as a competitive method of treatment for analgesia. Objective: To summarize evidence from systematic reviews(SRs) and evaluate the effectiveness and safety of different acupuncture therapies for treating PHN. Methods: Eight electronic databases were searched from their inception to August 5, 2022, including 4 international electronic databases(PubMed, EMBASE, the Cochrane Library, and Web of Science) and 4 Chinese databases(Chinese Biomedical Database, China National Knowledge Infrastructure, VIP Database and Wanfang Database).Methodological quality was assessed by A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2).The Risk of Bias in Systematic Review(ROBIS) tool was used to assess the risk of bias in SRs. Evidence level was assessed by the Grading of Recommendations Assessment, Development, and Evaluation(GRADE)approach. Results: Totally, 7 SRs were included, including 128 studies and 9,792 patients. In AMSTAR 2, most of the SRs were of low or critically low levels since they had more than 1 critical deficiency. In ROBIS, 1 SR(14.29%)was rated as high risk, and the other 6(85.71%) were rated as low risk. In the GRADE system, 9 outcomes(28.13%)were valued as high level, 5(15.63%) as moderate level, 1(3.13%) as low, and 17(53.13%) as very low. In the effectiveness of acupuncture therapy, the group "moxibustion vs. original medical treatment" [mean difference(MD)=–1.44, 95% confidence interval(CI): –1.80 to –1.08, I2=99%, P<0.00001] was of the highest heterogeneity and the group "bloodletting vs. original medical treatment"(MD=–2.80, 95% CI: –3.14 to –2.46, I2=0, P<0.00001)was of the lowest heterogeneity. Six SRs have reported the safety of their studies and no serious events were shown in the treatment and control groups. Conclusions: Acupuncture therapy seems to be effective in treating PH

关键词： acupuncture postherpetic neuralgia systematic review Chinese medicine

一个基于各向异性的热传导方程导出的图像锐化算子

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计算机研究与发展 2000年第6期37卷 692-696页

作者：何金国石青云黄克勤北京大学视觉与听觉信息处理国家重点实验室北京100871 北京皇城股骨头坏死专科医院北京102200

Witkin等人的尺度空间滤波办法是对原图像一个逐渐平滑的过程，这个过程可以用传统的热传导方程来描述．假设“热量”由低温向高温处流动，导出一个各向异性的反向热传导方程．将它用于图像处理，通过选择合适的各向异性函数，使得在感... 详细信息

Witkin等人的尺度空间滤波办法是对原图像一个逐渐平滑的过程，这个过程可以用传统的热传导方程来描述．假设“热量”由低温向高温处流动，导出一个各向异性的反向热传导方程．将它用于图像处理，通过选择合适的各向异性函数，使得在感兴趣的边缘处“热量”由低温向高温处流动，即“灰度”从“低灰度”向“高灰度”流动，以此得到一个适合一类图像的图像锐化算子．实验证明，这种锐化算子的导出方法能够有效利用已有的尺度空间研究成果，基于目的设计合适的图像锐化算子，得到理想的结果．

关键词：各向异性热传导方程图像锐化算子图像处理

CYP17和CYP3A4基因多态性与成都地区妊娠期肝内胆汁淤积症关系的研究

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四川大学学报（医学版） 2006年第4期37卷 551-553,582页

作者：张力刘淑芸陈强时青云邹海吴琳四川大学华西第二医院妇产科成都610041 四川省脐带血造血干细胞库首都医科大学附属北京友谊医院妇产科

目的探讨参与雌激素合成和代谢的细胞色素P 450酶系的CYP 17和CYP 3A 4基因多态性与成都地区妊娠期肝内胆汁淤积症(in trahepatic cho lestas is of pregnancy,ICP)的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,... 详细信息

目的探讨参与雌激素合成和代谢的细胞色素P 450酶系的CYP 17和CYP 3A 4基因多态性与成都地区妊娠期肝内胆汁淤积症(in trahepatic cho lestas is of pregnancy,ICP)的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对成都地区100例ICP患者(ICP组)和100例正常孕妇(对照组)的CYP 17基因启动子区-1931T/C多态和CYP 3A 4基因转录启动子区-290A/G多态进行分析。结果ICP组和对照组均存在CYP 17基因T/C多态,但两组CYP 17基因型TT、TC、CC频率和等位基因T、C频率的比较差异均无统计学意义(P>0.05)。两组孕妇均未检测到CYP 3A 4-V(即CYP 3A 4*1B)等位基因,所有孕妇的CYP 3A 4基因型均为w t/w t型。结论CYP 17基因启动子区T/C多态与成都地区ICP发病风险无相关性;成都地区妊娠妇女不存在CYP 3A 4基因-290A/G多态。

关键词：妊娠期肝内胆汁淤积症 CYP17,CYP3A4基因遗传多态性

低成本远程诊断和维护系统在铝熔化保温炉上的应用

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有色金属加工 2007年第3期36卷 57-58,62页

作者：石云卿洛阳有色金属加工设计研究院河南洛阳471039

本文结合贵州铝厂铸轧生产线项目介绍一种基于西门子远程服务适配器 TSAdapter 构成的远程诊断和维护系统,该系统具有结构简单、使用方便、成本低等特点。

关键词： TSAdapter 远程诊断远程维护