检索结果-南通市图书馆

Bioinspired anti-freezing 3D-printable conductive hydrogel microfibers for highly-sensitive and wide-range detection of ultralow and high strains

在线全文

学校读者我要写书评

暂无评论

Green Chemical Engineering 2024年第1期5卷 132-143页

作者： Yi-Min Yang Ting-Yuan Hu Haidong Fan lu shi shi-Yuan Zhang Zhuang Liu Xiao-Jie Ju Rui Xie Wei Wang Liang-Yin Chu School of Chemical Engineering Sichuan UniversityChengdu610065China Department of Mechanics Sichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China

Soft strain sensors that can transduce stretch stimuli into electrical readouts are promising as sustainable wearable ***,most strain sensors cannot achieve highly-sensitive and wide-range detection of ultralow and high *** by bamboo structures,anti-freezing microfibers made of conductive poly(vinyl alcohol)hydrogel with poly(3,4-ethylenedioxythiphene)-poly(styrenesulfonate)are developed via continuous microfluidic *** microfibers provide unique bamboo-like structures with enhanced local stress to improve both their length change and resistance change upon stretching for efficient signal *** microfibers allow highlysensitive(detection limit:0.05%strain)and wide-range(0%-400%strain)detection of ultralow and high strains,as well as features of good stretchability(485%strain)and anti-freezing property(freezing temperature:-41.1°C),fast response(200 ms),and good *** experimental results,together with theoretical foundation analysis and finite element analysis,prove their enhanced length and resistance changes upon stretching for efficient signal *** integrating microfluidic spinning with 3D-printing technique,the textiles of the microfibers can be flexibly *** microfibers and their 3D-printed textiles enable highperformance monitoring of human motions including finger bending and throat vibrating during *** work provides an efficient and general strategy for developing advanced conductive hydrogel microfibers as highperformance wearable strain sensors.

关键词： Conductive hydrogel microfibers Microfluidics Sensitive detection Wide detection range Anti-freezing

C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第1期16卷 61-78页

作者： Bai-Bei Li Lei-Jie Chen shi-Liu lu Biao Lei Gui-Lin Yu Shui-Ping Yu Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021Guangxi Zhuang Autonomous RegionChina Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The Second Xiangya Hospital of Central South UniversityNanning 410011Guangxi Zhuang Autonomous RegionChina Department of Emergency The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over the years,programmed cell death-1(PD-1)inhibitors have been routinely used for hepatocellular carcinoma(HCC)treatment and yielded improved survival ***,significant heterogeneity surrounds the outcomes of most ***,it is critical to search for biomarkers that predict the efficacy of PD-1 inhibitors in patients with *** To investigate the role of the C-reactive protein to albumin ratio(CAR)in evaluating the efficacy of PD-1 inhibitors for *** The clinical data of 160 patients with HCC treated with PD-1 inhibitors from January 2018 to November 2022 at the First Affiliated Hospital of Guangxi Medical University were retrospectively *** The optimal cut-off value for CAR based on progression-free survival(PFS)was determined to be 1.20 using x-tile *** proportional risk model was used to determine the factors affecting *** Cooperative Oncology Group performance status[hazard ratio(HR)=1.754,95%confidence interval(95%CI)=1.045-2.944,P=0.033],CAR(HR=2.118,95%CI=1.057-4.243,P=0.034)and tumor number(HR=2.932,95%CI=1.246-6.897,P=0.014)were independent prognostic factors for overall ***(HR=2.730,95%CI=1.502-4.961,P=0.001),tumor number(HR=1.584,95%CI=1.003-2.500,P=0.048)and neutrophil to lymphocyte ratio(HR=1.120,95%CI=1.022-1.228,P=0.015)were independent prognostic factors for *** nomograms were constructed based on independent prognostic *** C-index index and calibration plots confirmed that the nomogram is a reliable risk prediction *** ROC curve and decision curve analysis confirmed that the nomogram has a good predictive effect as well as a net clinical *** Overall,we reveal that the CAR is a potential predictor of short-and long-term prognosis in patients with HCC treated with PD-1 *** further verified,CAR-based nomogram may increase the number of markers that predict individualized prognosis.

关键词： C-reactive protein to albumin ratio Hepatocellular carcinoma Programmed cell death-1 inhibitors Prognosis Nomogram

High mechanical strength Si anode synthesis with interlayer bonded expanded graphite structure for lithium-ion batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第6期93卷 253-263,I0007页

作者： Wenhui Lai Jong Hak Lee lu shi Yuqing Liu Yanhui Pu Yong Kang Ong Carlos Limpo Ting Xiong Yifan Rao Chorng Haur Sow Barbaros Ozyilmaz Department of Material Science&Engineering National University of SingaporeSingapore 117575Singapore Center for Advanced 2D Materials National University of SingaporeSingapore 117546Singapore Department of Physics National University of SingaporeSingapore 117551Singapore Institute forFunctional Intelligent Materials National University of SingaporeSingapore 117544Singapore

Despite advancements in silicon-based anodes for high-capacity lithium-ion batteries,their widespread commercial adoption is still hindered by significant volume expansion during cycling,especially at high active mass loadings crucial for practical *** root of these challenges lies in the mechanical instability of the material,which subsequently leads to the structural failure of the ***,we present a novel synthesis of a composite combining expanded graphite and silicon *** composite features a unique interlayer-bonded graphite structure,achieved through the application of a modified spark plasma sintering ***,this innovative structure not only facilitates efficient ion and electron transport but also provides exceptional mechanical strength(Vickers hardness:up to658 MPa,Young's modulus:11.6 GPa).This strength effectively accommodates silicon expansion,resulting in an impressive areal capacity of 2.9 mA h cm^(-2)(736 mA h g^(-1)) and a steady cycle life(93% after 100cycles).Such outsta nding performance is paired with features appropriate for large-scale industrial production of silicon batteries,such as active mass loading of at least 3.9 mg cm^(-2),a high-tap density electrode material of 1.68 g cm^(-3)(secondary clusters:1.12 g cm^(-3)),and a production yield of up to 1 kg per day.

关键词： Lithium-ion battery Silicon anode Spark plasma sintering Interlayer bonding Mechanical strength Tap density

FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第6期14卷 1605-1623页

作者： Zhifeng Huang Tongtong Pan Liang Xu lu shi Xiong Ma Liya Zhou luyao Wang Jiaojiao Wang Guoqing Zhu Dazhi Chen Lingtao Song Xiaomin Pan Xiaodong Wang Xiaokun Li Yongde luo Yongping Chen Hepatology Diagnosis and Treatment Center Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseasesthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)&School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China School of Laboratory Medicine and Life Sciences Wenzhou Medical University&Key Laboratory of Laboratory MedicineMinistry of EducationWenzhou Medical UniversityWenzhou 325035China Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and HepatologyMinistry of HealthState Key Laboratory for Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Hangzhou Medical College Hangzhou 311300China

Immune-mediated liver injury (ILI) is a condition where an aberrant immune response due to various triggers causes the destruction of hepatocytes. Fibroblast growth factor 4 (FGF4) was recently identified as a hepatoprotective cytokine;however, its role in ILI remains unclear. In patients with autoimmune hepatitis (type of ILI) and mouse models of concanavalin A (ConA)- or S-100-induced ILI, we observed a biphasic pattern in hepatic FGF4 expression, characterized by an initial increase followed by a return to basal levels. Hepatic FGF4 deficiency activated the mitochondria-associated intrinsic apoptotic pathway, aggravating hepatocellular apoptosis. This led to intrahepatic immune hyper-reactivity, inflammation accentuation, and subsequent liver injury in both ILI models. Conversely, administration of recombinant FGF4 reduced hepatocellular apoptosis and rectified immune imbalance, thereby mitigating liver damage. The beneficial effects of FGF4 were mediated by hepatocellular FGF receptor 4, which activated the Ca^(2+)/calmodulin-dependent protein kinasekinase 2 (CaMKKβ) and its downstream phosphatase and tensin homologue-induced putative kinase 1 (PINK1)-dependent B-cell lymphoma 2-like protein 1-isoform L (Bcl-XL) signalling axis in the mitochondria. Hence, FGF4 serves as an early response factor and plays a protective role against ILI, suggesting a therapeutic potential of FGF4 and its analogue for treating clinical immune disorder-related liver injuries.

关键词： Fibroblast growthfactor 4 Fibroblast growth factor receptor 4 Immune liver injury Ca^(2+)/Calmodulin dependent protein

环境分权与企业生产率--来自“国控源环境数据直报”政策的经验证据

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

当代经济科学 2024年第1期46卷 117-130页

作者：李卫兵史璐华中科技大学经济学院湖北武汉430074

环境分权是中央政府和地方政府对于环境事权的分配,而“国控源环境数据直报”政策本质上是一次调整环境分权化水平的改革。将该政策视为一个准自然实验,构建双重差分模型,考察其对企业生产率的影响。研究发现,该政策在短期内会显著抑制... 详细信息

环境分权是中央政府和地方政府对于环境事权的分配,而“国控源环境数据直报”政策本质上是一次调整环境分权化水平的改革。将该政策视为一个准自然实验,构建双重差分模型,考察其对企业生产率的影响。研究发现,该政策在短期内会显著抑制国家重点监控企业的生产率提升,但随着时间的推移,这种抑制作用会逐渐消失。结合环境分权理论进一步阐释和验证该政策对企业生产率的潜在影响机制,发现该政策主要通过挤出企业研发投入、抑制企业寻租行为和激励企业自愿规制环境行为等机制抑制企业生产率。进一步分析表明,企业所有制、行业污染密集程度和地区市场化水平等特征会对环境分权与企业生产率之间的关系产生异质性影响。环境分权与微观企业行为之间因果关系的揭示,可以为政府健全“国控源环境数据直报”政策的长效机制提供决策参考。

关键词：环境分权环境政策企业生产率环境治理环境数据

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

基于前景理论的行为安全博弈

中国科学：信息科学 2024年第1期54卷 210-226页

作者：路石杨浩姜斌南京航空航天大学自动化学院南京211106

本文基于前景理论在博弈的框架下研究了行为感知概率对网络化系统中攻防资源配置的影响.首先,在理性决策情形下,通过融合物理系统、执行器攻击和资源分配模型,构建了一个新的安全博弈框架.其次,针对决策者依靠感知概率而非真实概率进行... 详细信息

本文基于前景理论在博弈的框架下研究了行为感知概率对网络化系统中攻防资源配置的影响.首先,在理性决策情形下,通过融合物理系统、执行器攻击和资源分配模型,构建了一个新的安全博弈框架.其次,针对决策者依靠感知概率而非真实概率进行主观决策的情形,基于前景理论构造了行为安全博弈模型.然后,建立了安全博弈和行为安全博弈下期望收益函数关于攻防资源凹凸性的充要条件,并深入分析和比较了安全博弈和行为安全博弈下攻防资源最优配置的存在性和唯一性以及行为概率对安全博弈的影响.最后以无人机群为例进行了仿真,验证了所提方法的有效性.

关键词：执行器攻击前景理论资源分配安全博弈行为安全博弈

Xylooligosaccharides Alleviate Inflammatory Dermatoses and Related Depression-Like Behaviors in Atopic Dermatitis Mice Induced by 2,4-Dinitrofluorobenzene

在线全文

学校读者我要写书评

暂无评论

食品科学 2024年第17期45卷 113-126页

作者： FANG Mingyu TANG Liu LI Zimo NIE Tingting CHEN Shaoze FANG Zhenfeng shi lu HU Song CAO Xiaoqin School of Medicine Jianghan UniversityWuhan 430100China Department of Pharmacy Renmin Hospital of Wuhan UniversityWuhan 430100China

Objective:To investigate the influence of xylooligosaccharides on skin inflammation,behavioral characteristics,neurotransmitters,and gut flora in a mouse model of atopic dermatitis(AD)induced by 2,4-dinitrofluorobenzene(DNFB).Methods:The AD mouse model was created by administration of DNFB for 14 consecutive *** scoring atopic dermatitis index,enzyme-linked immunosorbent assay(ELISA),histopathology,and immunohistochemical analyses were used to assess inflammation and depression-like ***,high-throughput 16S rRNA gene sequencing was used to determine the composition of fecal ***:Xylooligosaccharides treatment reduced the number of scratches and skin thickness,mast cell infiltration and the levels of immunoglobulin(Ig)E and T-helper cytokines compared with the AD model ***,xylooligosaccharides treatment reduced the immobility time of mice in the forced swimming test and increased the total movement distance and movement distance in the center area in the open-field ***,5-hydroxytryptamine and dopamine expression in the brain was increased following xylooligosaccharides *** network pharmacology,Gene Ontology analysis showed that the targets were mainly enriched in phosphatase binding and the regulation of leukocyte differentiation,which ameliorated AD mainly through the hypoxia inducible factor-1 and phosphatidylinositide 3-kinase-protein kinase B pathways.16S rRNA gene sequencing,diversity indices,and gut microbial taxonomic composition analysis showed DNFB-induced changes in intestinal microbiota diversity in AD *** analysis indicated that xylooligosaccharides intake improved the gut microbiome by dramatically enhancing the concentration of Lactobacillus while decreasing the concentration of Bacteroides in ***:Xylooligosaccharides reduce inflammatory dermatosis and related depression-like behaviors via regulating intestinal homeostasis,having medicinal value as a nutrit

关键词： atopic dermatitis intestinal flora xylooligosaccharides depression-like behaviors

基于FK-FE混合方法的位错点源作用下全过程结构地震反应模拟

在线全文

学校读者我要写书评

暂无评论

工程力学 2024年第4期41卷 184-198页

作者：巴振宁鲁世斌付继赛梁建文芦燕中国地震局地震工程综合模拟与城乡抗震韧性重点实验室天津300354 天津大学土木工程系天津300354

基于区域缩减思想,集整基于精确动力刚度矩阵的频率波数域(FK)半解析方法和有限元(FE)数值方法各自优势(FK精确高效模拟一维波速结构地震波传播;FEM具有丰富单元和本构类型,可精细模拟工程结构地震反应),提出了一种从震源到工程结构全... 详细信息

基于区域缩减思想,集整基于精确动力刚度矩阵的频率波数域(FK)半解析方法和有限元(FE)数值方法各自优势(FK精确高效模拟一维波速结构地震波传播;FEM具有丰富单元和本构类型,可精细模拟工程结构地震反应),提出了一种从震源到工程结构全过程地震反应模拟的FK-FE混合方法。并将FK代码作为插件二次开发到大型商业有限元软件ABAQUS中,实现了ABAQUS平台下从震源到工程结构的全过程宽频地震反应物理模拟。验证了FK-FE混合方法正确性,进而将其应用于位错点源作用下美国SAC机构设计的9层Benchmark抗弯钢框架结构全过程0 Hz~15 Hz宽频地震反应模拟,重点探讨了地壳层波速结构和近地表场地条件对框架结构地震反应的影响。研究表明:地壳层速度结构和场地类别对该结构的地震反应均有显著影响,地壳层速度结构3(较硬)相比速度结构1(较软),结构最大位移和层间位移角分别减小了22.7%和62.0%;Ⅱ类场地相较于Ⅳ类场地,结构最大位移和层间位移角分别减小了22.3%和44.7%。

关键词：地震反应位错点源 FK-FE混合方法区域缩减全过程模拟

在线全文

学校读者我要写书评

暂无评论

数字经济时代商品包装设计新理念

山西财经大学学报 2024年第S01期46卷 154-156页

作者：鲁仕贵四川文理学院四川达州635000

在数字经济蓬勃发展的今天,消费者群体的消费需求和消费行为都发生了深刻的变化,并且对商品包装设计提出了更高的要求。当前商品包装设计不仅要保护商品、传递信息、吸引消费者注意,还要适应数字经济时代下的数字化销售模式、满足消费... 详细信息

在数字经济蓬勃发展的今天,消费者群体的消费需求和消费行为都发生了深刻的变化,并且对商品包装设计提出了更高的要求。当前商品包装设计不仅要保护商品、传递信息、吸引消费者注意,还要适应数字经济时代下的数字化销售模式、满足消费者心理需求、体现品牌价值且达到美观低碳的要求。本文主要分析了数字经济时代消费者群体对商品包装设计的主要需求,并指出商品包装设计未来发展的新理念、新形态、新趋势,总结了商品包装设计模式的未来变革路径。

关键词：数字经济时代商品包装设计新理念