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Seasonal and inter-annual variation of surface roughness length and bulk transfer coefficients in a semiarid area

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Science China Earth Sciences 2012年第2期55卷 254-261页

作者： FENG JianWu LIU HuiZhi WANG Lei DU Qun shi liqing State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Graduate University of Chinese Academy of Sciences Beijing 100049China

Here we report a multiyear study on the surface roughness length and bulk transfer coefficients over the degraded grassland and cropland surfaces in a semiarid area of China. Eddy covariance measurement and the meteorological profile observation data were used to analyze characteristics of these parameters on the diurnal, seasonal, and annual scales. Significant seasonal and annual variations of the aerodynamic roughness length are observed over the two surfaces. A large variation of kB-1 is measured during the day. Both kB-1 and the bulk transfer coefficients exhibit significant seasonal and annual variations. During the growing season (May to October), average Cd and Ch are 3.1×10-3 and 2.5×10-3 over the degrade grassland surface, and 4.7×10-3 and 3.1×10-3 over the cropland surface respectively. During the non-growing season, average Cd and Ch are 2.3×10-3 and 2.0×10-3 over the degrade grassland surface, and 2.9×10-3 and 2.2×10-3 over the cropland surface respectively.

关键词：表面传热系数粗糙度长度半干旱地区年际变化季节性体积传热系数相关测量 KB-1

Effects of Feiwei granules in the treatment of idiopathic pulmonary fibrosis:a randomized and placebo-controlled trial

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Journal of Traditional Chinese Medicine 2016年第4期36卷 427-433页

作者： Yu Yang Sun Zengtao shi liqing Zhang Yanping Zhou Zhaoshan Zhang Shunan Chao Enxiang Graduate School Beijing University of Chinese Medicine Department of Respiratory Medicine the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Respiratory Pyrexia Department Dongfang Hospital Affiliated to Beijing University of Chinese Medicine Department of Respiratory Medicine Xiyuan Hospital of China Academy of Traditional Chinese Medicine Department of Respiratory Medicine Qingdao Hiser Medical Group Department of Respiratory Disease of Traditional Chinese Medicine China-Japan Friendship Hospital

OBJECTIVE:To document the therapeutic effect of Feiwei granules(FGs) for idiopathic pulmonary fi brosis(IPF).METHODS:One hundred cases with IPF were randomized into the treatment group(80) and control group(20).Both groups were given basic treatment with prednisone.The treatment group was given FGs,and the control group was given Jinshuibao capsules(JCs).Treatment lasted for 6 months.The Medical Research Council Dyspnea Scale(MRCDS),the Saint George's Hospital Respiratory Questionnaire(SGHRQ),pulmonary function,the Traditional Chinese Medicine Syndrome Score(TCMSS),6-min walking test(6MWT) and blood gas analyses were recorded before the study as well as3 months and 6 months after treatment.RESULTS:FGs showed greater efficacy than the control in certain parameters between before the study and 6 months,and between 3 months and 6months,in the MRCDS,some indicators in the SGHRQ,and the TCMSS.There were no significant differences between the treatment group and control group in the remainder of the indices evaluated.In the treatment group,there were significant differences in before and after treatment in the MRCDS,SGHRQ,TCMSS and 6MWT.CONCLUSION:FGs were similar to JCs for IPF treatment.

关键词： Idiopathic pulmonary fibrosis Dys pnea Surveys and questionnaires 6-min walking test Feiwei granules Jinshuibao capsules Random ized controlled trial

基于本体和语义网的中医专家问诊信息模型构建与呼吸科应用示范研究

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中华中医药学刊 2024年第2期42卷 17-22,I0011,I0012页

作者：白逸晨史利卿孙美玲李海燕中国中医科学院中医药信息研究所北京100700 北京中医药大学东方医院北京100078

目的通过梳理中医专家问诊思维导图,采用本体和语义网技术探索构建中医专家问诊信息模型的方法。方法中医专家问诊信息模型是由中医专家问诊数据采集信息模型和中医专家问诊知识库本体两部分组成,基于对中医专家问诊思维导图的梳理,结... 详细信息

目的通过梳理中医专家问诊思维导图,采用本体和语义网技术探索构建中医专家问诊信息模型的方法。方法中医专家问诊信息模型是由中医专家问诊数据采集信息模型和中医专家问诊知识库本体两部分组成,基于对中医专家问诊思维导图的梳理,结合已发表的论文和专著中所载各类中医病-证-症量表、已发布的各专病标准数据集、中医和中西医指南/专家共识、高校教材、中医问诊相关国家标准和行业标准等,对研究素材中的中医专家问诊数据采集相关信息框架提炼,完成中医专家问诊数据采集信息模型的构建;参考复用中医药语言系统(Traditional Chinese Medicine language systems,TCMLS)、中医临床术语系统(Traditional Chinese Medicine clinical terminological systems,TCMCTS)、国标、行标中的术语进行筛选、合并、分类,确立领域概念,结合中医临床问诊实际情况和呼吸科专病中医问诊思维导图,采用人工知识抽取方法,构建中医专家问诊知识库相关语义关系,采用七步法及protégé本体工具构建中医专家问诊知识库本体,实现中医专家问诊信息的知识推理表示。结果成功绘制了中医专家问诊思维导图,初步完成了中医专家问诊信息模型的构建,实现了中医专家问诊知识库的结构化表达。结论整合了中医专家问诊相关知识,构建了中医专家问诊信息模型,规范了中医专家问诊知识库信息化表达,为中医临床专科问诊信息化研究的创新发展提供了借鉴和参考。

关键词：中医问诊信息模型本体语义网专家思维

四君子汤合三子养亲汤对慢性阻塞性肺疾病小鼠肺功能及肺组织损伤的影响

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辽宁中医杂志 2024年第5期51卷 193-196,I0005页

作者：李雅兰李渊马建岭史利卿郝素英季坤王丽云北京中医药大学北京100029 北京中医药大学东方医院北京100078

目的探讨四君子汤合三子养亲汤对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)小鼠肺功能、肺组织的保护作用。方法将40只小鼠按照随机数字表法平均分为空白组、模型组、西药组(盐酸氨溴索)、中药组(四君子汤合三子... 详细信息

目的探讨四君子汤合三子养亲汤对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)小鼠肺功能、肺组织的保护作用。方法将40只小鼠按照随机数字表法平均分为空白组、模型组、西药组(盐酸氨溴索)、中药组(四君子汤合三子养亲汤),每组10只,采用烟熏联合脂多糖的方法建立慢阻肺小鼠模型。观察小鼠一般情况,动物肺功能仪检测肺功能,ELISA检测肺泡灌洗液(BALF)中IL-4、IL-8、IL-13的表达,HE染色观察肺组织病理。结果与空白组比较,模型组0.15 s用力呼气容积与用力肺活量的比值(FEV_(0.15)/FVC)、每分钟最大通气量(MVV)明显下降;与模型组比较,中药组和西药组FEV0.15/FVC、MVV显著升高。与空白组比较,模型组最大呼气峰流速(PEF)显著下降;与模型组比较,中药组PEF显著升高,西药组PEF升高不明显,差异有统计学意义(P<0.05)。与空白组比较,模型组BALF中IL-4、IL-8、IL-13的表达增加,肺组织出现病理学损伤;与模型组比较,中药组和西药组BALF中IL-4、IL-8、IL-13的表达减少,肺组织损伤程度减轻。结论四君子汤合三子养亲汤可下调小鼠肺部炎症因子水平,减轻肺组织结构的破坏,提高慢阻肺小鼠的肺功能。

关键词：四君子汤三子养亲汤慢性阻塞性肺疾病肺功能肺组织

基于两样本孟德尔随机化分析哮喘与胃食管反流病因果关系的研究

同方期刊数据库博看期刊评论

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华西医学 2024年第4期39卷 546-552页

作者：刘松马建岭史利卿罗景舒郭兆迪北京中医药大学第二临床医学院北京100029 北京中医药大学东方医院呼吸热病科北京100078

目的采用两样本孟德尔随机化(Mendelian randomization,MR)研究方法评估哮喘与胃食管反流病(gastroesophageal reflux disease,GERD)发生风险之间的潜在因果关系。方法利用大样本全基因关联研究汇总数据,选择与哮喘密切相关的遗传位点[... 详细信息

目的采用两样本孟德尔随机化(Mendelian randomization,MR)研究方法评估哮喘与胃食管反流病(gastroesophageal reflux disease,GERD)发生风险之间的潜在因果关系。方法利用大样本全基因关联研究汇总数据,选择与哮喘密切相关的遗传位点[单核苷酸多态性(single nucleotide polymorphism,SNP)]作为工具变量,分别采用逆方差加权法、加权中位数法和MR-Egger法进行MR分析。同时采用MR-Egger检测水平多效性,留一法进行敏感性分析保证结果稳健性。结果共纳入77个SNP作为评估哮喘与GERD因果关联的工具变量。逆方差加权法分析结果显示哮喘与GERD呈正相关[比值比(odds ratio,OR)=1.044,95%置信区间(confidence interval,CI)(1.006,1.083),P=0.024],加权中位数结果显示了相似的因果关系[OR=1.075,95%CI(1.021,1.133),P=0.006]。MR-Egger回归结果显示,哮喘与GERD呈正相关,但无统计学意义[OR=1.080,95%CI(0.983,1.187),P=0.115]。异质性检验结果显示,哮喘与GERD的因果关系不存在异质性(P>0.05)。水平多效性检验结果显示SNP不存在水平多效性(P>0.05)。留一法检验结果显示,未检测到对结果影响大的SNP。结论哮喘与GERD存在正向因果关系。

关键词：哮喘胃食管反流病孟德尔随机化研究因果关系

基于“风邪伏肺”理论探讨慢性咳嗽脏腑相关病机

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现代中医临床 2024年第2期31卷 78-82页

作者：刘智霖史利卿马建岭王丽云季坤温绍惠王颖郭淑娟范钰晗北京中医药大学第二临床医学院北京100078 北京中医药大学东方医院呼吸热病科浙江省中医院

慢性咳嗽是呼吸科常见病症,具有反复发作、迁延难愈的特点。结合团队近二十年来对慢性咳嗽的研究成果,我们认为“风邪伏肺,脏腑相关”是其重要病机。关于风邪伏肺的认识可以分为内外两端,在“外”主要责之外感风邪,在“内”归因于脏腑相... 详细信息

慢性咳嗽是呼吸科常见病症,具有反复发作、迁延难愈的特点。结合团队近二十年来对慢性咳嗽的研究成果,我们认为“风邪伏肺,脏腑相关”是其重要病机。关于风邪伏肺的认识可以分为内外两端,在“外”主要责之外感风邪,在“内”归因于脏腑相关,内外合邪,可涉及肺、脾、肝、肾多脏,从而咳嗽迁延难愈,时作时止。因此,在治疗方面更应该多方面兼顾。文章基于“风邪伏肺”理论对慢性咳嗽脏腑相关病机进行探讨,以期获得更多的思路和方法,丰富中医治疗慢性咳嗽的学术内涵。

关键词：慢性咳嗽风邪伏肺脏腑相关内外合邪病因病机

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新时代全民水道德教育的意义及途径

华北水利水电大学学报（社会科学版） 2022年第5期38卷 95-100页

作者：史丽晴华北水利水电大学人文艺术教育中心河南郑州450046

新时代全民水道德教育对落实习近平生态文明思想,促进水文化研究与建设,提高国民素质,都有积极的作用。加强全民水德教育的途径主要体现在认知教育和情感教育相结合,广大民众节水意识的培养,水利职业道德教育等方面。

关键词：水道德教育意义途径

Corrosion Behavior and Protection Efficiency of 2024Al and SiC_p/2024Al Metal Matrix Composite

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Journal of Materials Science & Technology 2002年第4期18卷 351-353页

作者： Chunlin HE, Changsheng LIU, Fengqin LI and Qingkui CAISchool of Materials and Metallurgy, Northeastern University, Shenyang 110004, ChinaZhiming shi, liqing CHEN and Jing BIInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Sch. of Mat. and Metall. Northeastern Univ. Shenyang 110004 China Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

The corrosion resistance of 2024 Al and SiC particle reinforced 2024 Al metal matrix composite (SiCp?024AI MMC) in 3.5% NaCl solution was investigated with electrochemical method and immersion test, and the corrosion protection of sulfuric acid anodized coatings on both materials was evaluated by electrochemical impedance spectroscopy. The results showed that the SiCp?024AI MMC is more susceptible to corrosion than its matrix alloy in 3.5% NaCI. For 2024AI, the anodized coating provides excellent corrosion resistance to 3.5% NaCI. The anodized coating on the SiCp?024AI provides satisfactory corrosion protection, but it is not as effective as that for 2024AI because the structure of the anodized layer is affected by the SiC particulates.

关键词： 2024 Al Metal matrix composite Anodizing Electrochemical impedance spcctroscopy Potentiodynamic polarization Corrosion resistance

Hypoglycemic Effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi Green Tea and Their Compatibility on Mice

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Medicinal Plant 2024年第3期15卷 53-55,70页

作者： Chen YANG Zhaohui HUANG liqing TANG Wenjing HUANG Danyu CHEN Rujun shi Suoyi HUANG Lixiang LU shiyou ZHOU School of Clinical Medicine Youjiang Medical University for NationalitiesBaise 533000China School of Pharmacy Youjiang Medical University for NationalitiesBaise 533000China Key Laboratory of Research on Characteristic Ethnic Medicine in the Youjiang River Basin of Guangxi Colleges and Universities Baise 533000China

[Objectives]To explore the hypoglycemic effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi green tea and their compatibility on mice,so as to provide more options for the adjuvant treatment of diabetes and improve the comprehensive utilization value of Guixi green tea.[Methods]After being fed adaptively for 7 d,60 SPF-grade male mice were intraperitoneally injected with alloxouracil(180 mg/kg)to induce hyperglycemia model,from which 35 mice with a successful model were selected.They were randomly divided into 5 groups(Danshen group,green tea group,compatible group,positive control group and blank control group),with 7 animals in each group.The mice in all groups were administered according to the dose of 200 mg/kg once a day for 15 d.After the last administration,their body weight was measured on the 15 th day after fasting for 12 h,and their fasting blood glucose was measured by tail clipping.[Results]After modeling,the mice in each group showed typical hyperglycemia symptoms,namely obvious polydipsia,polyphagia,polyuria and weight loss.Compared with the blank control group,Danshen group and green tea group had obvious hypoglycemic effect(P<0.05),and compatible group had significant hypoglycemic effect(P<0.01).Compared with the blank control group,the weight loss of diabetic mice could also be inhibited in green tea group and compatible group(P<0.05).[Conclusions]Danshen,Guixi green tea and their compatibility had the effect of lowering blood sugar,among which the compatible group had the most obvious effect.

关键词： Salvia miltiorrhiza Guixi green tea Compatibility Blood sugar