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Yiguanjian decoction enhances fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state

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World Journal of Gastroenterology 2018年第42期24卷 4759-4772页

作者： Ying Xu Wei-Wei Fan Wen Xu shi-Li Jiang Gao-Feng Chen cheng Liu Jia-Mei Chen Hua Zhang Ping Liu Yong-Ping Mu Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai 201203China Clinical Key Laboratory of TCM of Shanghai Shanghai 201203China

AIM To investigate whether Yiguanjian decoction(YGJ) has an anti-liver cirrhotic effect and whether it regulates hepatic stem cell *** A rat model of liver cirrhosis was established via subcutaneous injection of carbon tetrachloride(CCl4) for8 wk. From the beginning of the ninth week, the rats received 2-acetylaminofluorene(2-AAF) by oral gavage and a DLK-1+ fetal liver stem/progenitor cell(FLSPC)transplant or an FLSPC transplant in combination with YGJ treatment for 4 wk. In vitro, lipopolysaccharide(LPS)-activated macrophages were co-cultured with WB-F344 cells, and the differentiation of WB-F344 cells was observed in the presence and absence of YGJ *** FLSPC transplantation improved liver function and histopathology, and inhibited the activation of the noncanonical Wnt signaling pathway, while activating the canonical Wnt signaling pathway. YGJ enhanced the therapeutic effects of FLSPCs and also promoted the liver regeneration differentiation of FLSPCs into *** vitro, LPS-activated macrophages promoted the differentiation of WB-F344 cells into myofibroblasts, and the canonical Wnt signaling was inhibited while the noncanonical Wnt signaling was activated in WB-F344 *** suppressed the activation of macrophages and then inhibited non-canonical Wnt signaling and promoted canonical Wnt *** YGJ enhances FLSPC-mediated repair of liver cirrhosis through regulation of macrophage activation state, and YGJ in combination with stem cell transplantation may be a suitable treatment for end-stage liver cirrhosis.

关键词： Cirrhosis Hepatic progenitor cells Wnt signaling pathway Macrophage 2-acetylaminofluorene Carbon tetrachloride Yiguanjian decoction

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Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway

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World Journal of Stem Cells 2021年第12期13卷 1928-1946页

作者： Peng-Zhi shi Jun-Wu Wang Ping-Chuan Wang Bo Han Xu-Hua Lu Yong-Xin Ren Xin-Min Feng Xiao-Fei cheng Liang Zhang Department of Orthopedic Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of Orthopedics Clinical Medical College of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina Department of Orthopedic Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Orthopedics Changzheng Hospital of The Second Military Medical UniversityShanghai 200003China Department of Orthopedics First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Orthopedic Surgery Shanghai Key Laboratory of Orthopedics ImplantsShanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China

BACKGROUND In degenerative intervertebral disc(IVD),an unfavorable IVD environment leads to increased senescence of nucleus pulposus(NP)-derived mesenchymal stem cells(NPMSCs)and the inability to complete the differentiation from NPMSCs to NP cells,leading to further aggravation of IVD degeneration(IDD).Urolithin A(UA)has been proven to have obvious effects in delaying cell senescence and resisting oxidative *** To explore whether UA can alleviate NPMSCs senescence and to elucidate the underlying *** In vitro,we harvested NPMSCs from rat tails,and divided NPMSCs into four groups:the control group,H2O2 group,H2O2+UA group,and H2O2+UA+SR-18292 ***-associatedβ-Galactosidase(SA-β-Gal)activity,cell cycle,cell proliferation ability,and the expression of senescence-related and silent information regulator of transcription 1/PPAR gamma coactivator-1α(SIRT1/PGC-1α)pathway-related proteins and mRNA were used to evaluate the protective effects of *** vivo,an animal model of IDD was constructed,and Xrays,magnetic resonance imaging,and histological analysis were used to assess whether UA could alleviate IDD in *** We found that H2O2 can cause NPMSCs senescence changes,such as cell cycle arrest,reduced cell proliferation ability,increased SA-β-Gal activity,and increased expression of senescence-related proteins and *** UA pretreatment,the abovementioned senescence indicators were significantly *** further demonstrate the mechanism of UA,we evaluated the mitochondrial membrane potential and the SIRT1/PGC-1αpathway that regulates mitochondrial *** protected mitochondrial function and delayed NPMSCs senescence by activating the SIRT1/PGC-1α*** vivo,we found that UA treatment alleviated an animal model of IDD by assessing the disc height index,Pfirrmann grade and the histological *** In summary,UA could activate the SIRT1/PGC-1αsignaling pathway to protect mitochondrial function and alleviate ce

关键词： Urolithin A Mitochondrial function Oxidative stress Senescence Nucleus pulposus-derived Mesenchymal stem cells The silent information regulator of transcription 1/PPAR gamma coactivator-1αpathway

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Proteomic analysis of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention

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Journal of Traditional Chinese Medical Sciences 2021年第3期8卷 224-237页

作者： Jiayi Ma Shuxian Sun cheng Ni Lingru Li jing Xia Houqin Li Huirong Song Xujun Heng Dandan Hu Yuanyuan Li Center for Studies in Constitution Research of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China The GULOU Hospital of Traditional Chinese Medicine of BEIjing Beijing100009China Putuo Hospital Shanghai University of Traditional Chinese Medicine Shanghai200333China

Objective:To investigate the proteomic characteristics of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention to identify related ***:Seventy-one subjects were enrolled in the *** assessed blood glucose,blood lipids,body mass index(BMI),and phlegm-dampness pattern,which was confirmed by a traditional Chinese medicine *** the participants,we included healthy participants with normal weight(NW,n=23),overweight/obese participants with normal metabolism(ONM,n=19),overweight/obese participants with pre-diabetes(OPD,n=12),and overweight/obese participants with marginally-elevated blood lipids(OML,n=17).Among them,the ONM,OPD,and OML groups were diagnosed with phlegmdampness *** data-independent acquisition(DIA)method was first used to analyze the plasma protein expression of each group,and the relevant differential proteins of each group were *** co-expressed proteins were evaluated by Venn *** pathway analyses of the differential proteins were analyzed using Ingenuity Pathway Analysis(IPA)*** reaction monitoring(PRM)was used to verify the differential and common proteins in each ***:After comparing ONM,OPD,and OML groups with NW group,we identified the differentially expressed proteins(DEPs).Next,we determined the DEPs among OPD,OML,and ONM *** Venn analysis of the DEPs in each group,24 co-expressed proteins were *** co-expressed proteins were verified by *** analysis showed that pathways including LXR/RXR activation,acute phase response signaling,and FXR/RXR activation were common to all three groups of phlegmdamp overweight/obesity ***,the activation or inhibition of these pathways was different among the three ***:Participants with overweight/obesity have similar proteomic characteristics,though each type shows specific proteomic *** co-expressed proteins,VTN and ORM1,ar

关键词： Phlegm-dampness retention Overweight Obesity Abnormal glucose and lipid metabolism Biomarkers

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Designing high k dielectric films with LiPON-Al_(2)O_(3)hybrid structure by atomic layer deposition

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Chinese Physics B 2022年第5期31卷 647-651页

作者： Ze Feng Yitong Wang Jilong Hao Meiyi jing Feng Lu Weihua Wang Yahui cheng Shengkai Wang Hui Liu Hong Dong Engineering Research Center of Thin Film Optoelectronics Technology Ministry of EducationNankai UniversityTianjin 300350China High-Frequency High-Voltage Device and Integrated Circus R&D Center Institute of Microelectronics of the Chinese Academy of SciencesBeijing 100029China

A large amount of ultra-low-power consumption electronic devices are urgently needed in the new era of the internet of things,which demand relatively low frequency ***,atomic layer deposition has been utilized to fabricate the ion polarization dielectric of the Li PON-Al_(2)O_(3) hybrid *** Li PON thin film is periodically stacked in the Al_(2)O_(3) *** hybrid structure presents a frequency-dependent dielectric constant,of which k is significantly higher than the aluminum oxide matrix from 1 k Hz to 200 k Hz in *** increased dielectric constant is attributed to the lithium ions shifting locally upon the applied electrical field,which shows an additional polarization to the Al_(2)O_(3) *** work provides a new strategy with promising potential to engineers for the dielectric constant of the gate oxide and sheds light on the application of electrolyte/dielectric hybrid structure in a variety of devices from capacitors to transistors.

关键词： high k dielectric atomic layer deposition polarization

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精准宏观超分子组装

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高分子学报 2020年第6期51卷 598-608页

作者：成梦娇石峰有机无机复合材料国家重点实验室软物质科学与工程高精尖创新中心生物医用材料北京实验室北京化工大学

宏观超分子组装是近年来超分子科学的新兴研究方向,其本质是表面修饰有大量超分子官能团的宏观构筑基元的界面组装.由于组装过程中存在较多热力学亚稳态,导致最终产生大量非精准组装体,整体结构有序度低,制约了其在高性能超分子材料方... 详细信息

宏观超分子组装是近年来超分子科学的新兴研究方向,其本质是表面修饰有大量超分子官能团的宏观构筑基元的界面组装.由于组装过程中存在较多热力学亚稳态,导致最终产生大量非精准组装体,整体结构有序度低,制约了其在高性能超分子材料方面的应用,因此,如何实现精准宏观超分子组装,构建有序超分子结构,成为了制约宏观超分子组装发展的瓶颈问题之一.本专论从宏观超分子组装的概念与组装机制出发,根据宏观超分子组装过程的特点,分析阐述了组装体中存在不同界面匹配度的热力学亚稳态的问题;继而,从能量面的角度展开分析,总结和归纳了提高组装结构有序度的精准组装策略,包括:(1)利用组装体热力学稳定性差异,设计各向异性构筑基元诱导目标组装结构的形成,发展自纠错策略提高组装界面匹配度;(2)引入宏观构筑基元的组装动力学设计,使构筑基元发生自驱动运动并通过界面长程力取向,使组装界面达到高度匹配,实现近热力学平衡态的精准组装,直接获得精准结构.进而,结合精准宏观超分子组装制备的有序结构,我们展望了其在构建组织工程支架方面的应用前景.

关键词：精准宏观超分子组装动态组装/解组装自纠错各向异性构筑基元界面自由能最小化原理

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Malignant extra-gastrointestinal stromal tumor of the pancreas:Report of two cases and review of the literature

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World Journal of Gastroenterology 2014年第3期20卷 863-868页

作者： Yan-Tao Tian Hao Liu Su-Sheng shi Yi-Bin Xie Quan Xu Jian-Wei Zhang Dong-Bing Zhao cheng-Feng Wang Ying-Tai Chen Department of Abdominal Surgery Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College Department of Pathology Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College

Gastrointestinal stromal tumors(GISTs)are mesenchymal tumors that arise from the gastrointestinal *** rare cases,these tumors are found in intra-abdominal sites unrelated to the gastrointestinal tract,such as the mesentery,omentum and ***,pancreatic extra-gastrointestinal stromal tumors are extremely rare,with only 14 previous cases reported.A 61-year-old man with no clinical symptoms had a routine check-up,during which an abdominal mass located in the pancreas tail was *** surgery was performed with resection of the pancreas tail and the spleen,and he was diagnosed with lowrisk *** 60-year-old man with no clinical symptoms underwent Computed tomography which revealed a well-demarcated tumor,6 cm in diameter,in the head of the *** was diagnosed with pancreatic ***,we describe two rare cases of pancreatic GISTs and review the cases previously reported in the literature.

关键词： Gastrointestinal Stromal tumors Extra-gastrointestinal Stromal Tumors Pancreatic gastrointestinal stromal tumors

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Preparation,Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study

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Chemical Research in Chinese Universities 2012年第1期28卷 166-170页

作者： JI Jin-gou, ZHANG jing-fen, HAO shi-lei, WU Dan-jun, LIU Li and XU Yi College of Chemistry and Chemical Engineering, University of Chongqing, Chongqing 400030, P. R. China College of Chemistry and Chemical Engineering University of Chongqing Chongqing 400030

Chitosan/cyclodextrin/trisodium citrate（CS/CD/TSC） nanoparticles with ibuprofen（IBU） loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-loading capacity, particle size, zeta potential and surface morphology of the obtained nanoparticles were inves tigated. The results show a good drug-loading capacity. The prepared nanoparticles were spherical in shape with an average size of 293.7 nm and a zeta potential of ＋30.72 mV. The in vitro release studies show that the controlled re lease of IBU from the nanoparticles was followed. The drug release from CS/β-CD/TSC nanoparticles followed non-Fickian or anomalous diffusion.

关键词： Chitosan Cyclodextrin Nanoparticle Ibuprofen(IBU)

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Computational Prediction of Graphdiyne-Supported Three-Atom Single-Cluster Catalysts

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CCS Chemistry 2023年第1期5卷 152-163页

作者： Jin-cheng Liu Hai Xiao Xiao-Kun Zhao Nan-Nan Zhang Yuan Liu Deng-Hui Xing Xiaohu Yu Han-shi Hu Jun Li Department of Chemistry Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of EducationTsinghua UniversityBeijing Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdong Shaanxi Key Laboratory of Catalysis School of Chemical and Environment SciencesShaanxi University of TechnologyHanzhongShaanxi

While heterogeneous single-atom catalysts(SACs)have achieved great success in the past decade,their application is potentially limited by their simplistic single-atom active centers,which make single-cluster catalysts(SCCs)a natural extension in the domain of heterogeneous *** with precise numbers of atoms and structural configurations possess SAC merits,yet have greater potential for catalyzing complex reactions and/or bulky *** systematic quantum-chemical studies and computational screening,we report here the rational design of transition metal three-atom clusters anchored on graphdiyne(GDY)as a novel kind of stable SCC with great promise for efficient and atomically precise heterogenous *** investigating their structure and catalytic performance for the oxygen reduction reaction,the hydrogen evolution reaction,and the CO_(2)reduction reaction,we have provided theoretical guidelines for their potential applications as heterogeneous *** GDY-supported three-atom SCCs provide an ideal benchmark scaffold for rational design of atomically precise heterogeneous catalysts for industrially important chemical reactions.

关键词： single-cluster catalyst single-atom catalyst graphdiyne atomically precise heterogenous catalysis

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A Heuristic for Resource Reconfiguration of Agile Manufacturing Supply Chain

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厦门大学学报（自然科学版） 2002年第S1期41卷 237-238页

作者： WANG Jie-fa, LI shi-jing, FENG Zu-ren (System Engineering Institute, Xi’an Jiaotong University, Xi’an 710049 , China)

The agile manufacturing is a new conception for rap id reaction to the consumers. One of its implements is establishing a virtual ente rprise (VE) around the task, where each manufacturing unit, or sub-task, probab ly have at least one resource, or referred to as suppliers. Because each manufac turing unit might be carried out in different geographical places that implies t his probably gives rise to transportation cost, the selection of resources for e ach manufacturing unit must considers not only the manufacturing price of each r esource but also the transfer cost between any two potential resources. This pap er discusses the resource reconfiguration problem with two hypotheses: 1. Permit s one or more resources to attend the same manufacturing unit as long as the tot al cost can reach its least; 2. The freight contains the initial part, that is t he freight concave. Indeed, these hypotheses are much meaningful in the real wor ld. Furthermore, to simplify the solution for this problem, we propose two conce pts: assembly tree (AT) and combinatorial mode base (CMB). Formally an AT is a c omplete production line, which can ensure the parts equilibrium, and its capacit y is subjected to the least capacity of every resources and every path in it. In the end, we propose an implicit enumeration algorithm (IEA) by the use of CMB, including it is a heuristic algorithm for integer programming (HAIP) by the use of AT. The IEA can be outlined that for a determined combinatorial mode, if it h as not enumerated, we use the HAIP to get an near optima and corresponding CMB, marking every combinatorial mode extended from the CMB as enumerated, other cont inue a new iteration. The HAIP can be outlined that for a determined combinatori al mode, there are some determined number of AT, we select an AT with the le ast slope, and select the volume of this AT to its ultimate within its capacity, iterates this doing until the needed volume reached. In the end, we conclude th is paper and

关键词： supply chain agile manufacturing resource recon figuration integer programming

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矿山生产过程时变计算实验及精准执行方法

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控制与决策 2022年第5期37卷 1241-1250页

作者：冯治东井石滚榆林学院信息工程学院陕西榆林719000 洛阳栾川钼业集团股份有限公司博士后工作站河南栾川471500 西安建筑科技大学资源工程学院西安710055

在复杂多变的矿山开采环境下,计划难以执行等问题较为突出,如计划方案不可行、工序流程欠合理,且突发事件频繁,该问题已成为长期以来矿山企业面临的关键困难之一.为此,提出“先时变计算实验再精准过程执行”的智能开采新范式.首先,根据... 详细信息

在复杂多变的矿山开采环境下,计划难以执行等问题较为突出,如计划方案不可行、工序流程欠合理,且突发事件频繁,该问题已成为长期以来矿山企业面临的关键困难之一.为此,提出“先时变计算实验再精准过程执行”的智能开采新范式.首先,根据基本需求初始化生产计划方案;其次,对计划方案进行时变计算实验,即借助多代理方法构建基于计算机的人工系统,利用各简单代理自主推演和互动涌现进行计算实验或试验,评估方案的合理性和可靠性,预测生产现场人员、设备、环境的属性状态和整体系统的经济、空间及安全状态,根据实验结果调整方案后再次实验,直到具有稳定的实验结果为止;最后,以优化后的最优方案和工序流程进行现场执行,同时对执行过程进行实时感知、分析及纠正,实现按计划控制.在物联网数据驱动下,这种低成本、高效率、零风险和快速的事前预演手段及精准过程控制方法,对于辅助计划制定及安全高效生产意义重大.

关键词：矿山生产智能开采生产计划时变计算实验过程控制精准执行

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