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World Journal of Gastroenterology 2024年第6期30卷 527-541页

作者： Xin Li Li-Jiang Ji Kai-Di Feng Hua Huang Mei-Rou Liang shi-jin cheng Xiu-Dong Meng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina Department of Anorectal Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu 215500Jiangsu ProvinceChina College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel *** ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strategies for patients with *** are nanoscale membrane particles that mediate intercellular communication by carrying various bioactive molecules,such as proteins,RNAs,DNA,and *** NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome is a cytosolic tripartite protein complex whose activation induces the maturation and secretion of proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,triggering the inflammatory response to a pathogenic agent or *** evidence suggests that exosomes are new modulators of the NLRP3 inflammasome,with vital roles in the pathological process of ***,recent evidence is reviewed on the role of exosomes and NLRP3 inflammasome in ***,the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are ***,an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are high-lighted.

关键词： Ulcerative colitis Exosomes Inflammasome Evidence Therapeutics

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会聚视角下关键核心技术研发特征与突破路径

科学学研究 2024年第3期42卷 571-582,672页

作者：施锦诚朱凌王迎春上海人工智能实验室治理研究中心上海200232 浙江大学中国科教战略研究院浙江杭州310058

会聚科学引发新一波科技创新浪潮,对关键核心技术实现从“落后追赶”到“领先超越”的突破具有重要作用,然而对关键核心技术的研发特征及其突破路径的研究仍存在缺口。本文面向传统制造业和新兴产业领域,选取工业机器人轴承和脑机接口... 详细信息

会聚科学引发新一波科技创新浪潮,对关键核心技术实现从“落后追赶”到“领先超越”的突破具有重要作用,然而对关键核心技术的研发特征及其突破路径的研究仍存在缺口。本文面向传统制造业和新兴产业领域,选取工业机器人轴承和脑机接口两个典型技术,运用德温特专利网络分析方法,探索关键核心技术研发特征及突破路径。研究发现:技术会聚视角下关键核心技术研发特征存在显著差异,工业机器人轴承为代表的基础性技术,以相近学科交叉、技术内部类别交叉为主,强调技术网络融通;脑机接口为代表的前沿性技术,以大范围学科交叉、跨技术部类交叉为主,强调技术集群多样性;在关键核心技术研发特征分析基础上,研究得出“场景需求牵引+技术内部类别融合+领军企业带动产业链”“技术创新驱动+跨技术部类间融合+产学研创新联合体”两条突破路径。本文进一步完善与发展了关键核心技术突破的理论研究,对实现我国高水平科技自立自强具有一定的借鉴意义。

关键词：关键核心技术技术网络技术会聚研发特征突破路径

Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice

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Food Science and Human Wellness 2024年第4期13卷 2346-2352页

作者： Jialu shi Yan Xu cheng Liu shizhi Wang jin Wang Vijaya Raghavan Key Laboratory of Environmental Medicine and Engineering Ministry of Educationand Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Bioresource Engineering Faculty of Agricultural and Environmental SciencesMcGill UniversitySainte-Anne-de-BellevueQC H9X3V9Canada

Food allergy is a significant public health concern *** probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and ***,the effects of Bifidobacterium lactis Probio-M8 on food allergy have not been thoroughly *** present study examined the anti-allergic properties of Probio-M8,particularly in relation to immune response and gut microbiota *** demonstrate that oral administration of Probio-M8 effectively mitigated the allergy symptoms triggered by ovalbumin(OVA)by ameliorating the morphological damage in the jejunum,reducing OVA-specific IgE and histamine levels in the serum,and suppressing Th2 cytokines(interleukin(IL)4 and IL-13)while increasing Th1 cytokines(interferon(IFN)γ)and regulatory T(Treg)cytokines(IL-10 and transforming growth factor(TGF)β1)in the culture supernatants of splenic ***,Probio-M8 effectively altered the diversity and composition of gut microbiota,particularly the relative abundances of Akkermansia_muciniphila in OVA-induced *** to the OVA group,the Probio-M8 group showed a decrease in the relative abundance of Akkermansia_*** conclusion,Probio-M8 demonstrates the potential to alleviate food allergy by regulating the Th1/Th2 response and modulating gut microbiota,thereby offering a novel therapeutic strategy for patients with food allergy.

关键词： Food allergy Bifidobacterium lactis Probio-M8 T cell immune response Gut microbiota

Static recrystallization behaviors and mechanisms of 7Mo super-austenitic stainless steel with undissolved sigma precipitates during double-stage hot deformation

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Journal of Iron and Steel Research(International) 2024年第2期31卷 475-487页

作者： shi-guang Xu jin-shan He Run-ze Zhang Fu-cheng Zhang Xi-tao Wang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina Shandong Provincial Key Laboratory for High Strength Lightweight Metallic Materials Advanced Materials InstituteQilu University of Technology(Shandong Academy of Science)Jinan250353ShandongChina

Static recrystallization(SRX)behaviors and corresponding recrystallization mechanisms of 7Mo super-austenitic stainless steel were studied under different deformation *** order of influence of deformation parameters on static recrystallization behaviors,from high to low,is followed by temperature,first-stage strain and strain ***,the effect of holding time on static recrystallization behaviors is significantly controlled by *** addition,with the increase in temperature from 1000 to 1200°C,the static recrystallization mechanism evolves from discontinuous static recrystallization and continuous static recrystallization(cSRX)to metadynamic recrystallization and cSRX,and finally to *** cSRX exists at all *** is because high stacking fault energy(56 mJ m−2)promotes the movement of dislocations,making the deformation mechanism of this steel is dominated by planar slip of *** undissolved sigma precipitates promote static recrystallization through particle-stimulated ***,small strain-induced precipitates at grain boundaries hinder the nucleation of conventional SRX and the growth of recrystallized grains,while the hindering effect decreases with the increase in temperature.

关键词： 7Mo super-austenitic stainless steel Double-stage hot deformation Conventional static recrystallization Metadynamic recrystallization Strain-induced precipitation

Suitable region of dynamic optimal interpolation for efficiently altimetry sea surface height mapping

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Geodesy and Geodynamics 2024年第2期15卷 142-149页

作者： Jiasheng shi Taoyong jin School of Geodesy and Geomatics Hubei Luojia LaboratoryWuhan UniversityWuhan 430079China MOE Key Laboratory of Geospace Environment and Geodesy Wuhan UniversityWuhan 430079China

The dynamic optimal interpolation(DOI)method is a technique based on quasi-geostrophic dynamics for merging multi-satellite altimeter along-track observations to generate gridded absolute dynamic topography(ADT).Compared with the linear optimal interpolation(LOI)method,the DOI method can improve the accuracy of gridded ADT locally but with low computational ***,considering both computational efficiency and accuracy,the DOI method is more suitable to be used only for regional *** this study,we propose to evaluate the suitable region for applying the DOI method based on the correlation between the absolute value of the Jacobian operator of the geostrophic stream function and the improvement achieved by the DOI *** verifying the LOI and DOI methods,the suitable region was investigated in three typical areas:the Gulf Stream(25°N-50°N,55°W-80°W),the Japanese Kuroshio(25°N-45°N,135°E-155°E),and the South China Sea(5°N-25°N,100°E-125°E).We propose to use the DOI method only in regions outside the equatorial region and where the absolute value of the Jacobian operator of the geostrophic stream function is higher than1×10^(-11).

关键词： Dynamic optimal interpolation Linearoptimal interpolation Satellite altimetry Sea surface height Suitable region

Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis

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Biomedical and Environmental Sciences 2024年第2期37卷 170-177页

作者： GU Wen Fei shi Xia MA Xin YU Jun Lei XU jin Chuan QIAN cheng cheng HU Zhi Dong ZHANG Hui Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China School of Laboratory Medicine and Life Science Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Laboratory Medicine Zhejiang Putuo HospitalZhoushan 316100ZhejiangChina Zhongshan Hospital Fudan UniversityShanghai 200032China

Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the Shanghai Public Health Clinical Center.A total of 115patients underwent ultrasound-guided puncture biopsy,followed by MGIT 960 culture(culture),smear,Gene Xpert MTB/RIF(Xpert),and histopathological *** assays were performed to evaluate their effectiveness in diagnosing EPTB in comparison to two different diagnostic criteria:liquid culture and composite reference standard(CRS).Results When CRS was used as the reference standard,the sensitivity and specificity of culture,smear,Xpert,and histopathological examination were(44.83%,89.29%),(51.72%,89.29%),(70.11%,96.43%),and(85.06%,82.14%),*** on liquid culture tests,the sensitivity and specificity of smear,Xpert,and pathological examination were(66.67%,72.60%),(83.33%,63.01%),and(92.86%,45.21%),*** examination showed the highest sensitivity but lowest ***,we found that the combination of Xpert and histopathological examination showed a sensitivity of 90.80%and a specificity of 89.29%.Conclusion Ultrasound-guided puncture sampling is safe and effective for the diagnosis of *** with culture,smear,and Xpert,histopathological examination showed higher sensitivity but lower *** combination of histopathology with Xpert showed the best performance characteristics.

关键词： Extrapulmonary tuberculosis Diagnosis Biopsy Histopathological examination Puncture samples

Assessment of climate damage in China based on integrated assessment framework

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Advances in Climate Change Research 2024年第1期15卷 124-133页

作者： Jie LIU Xiang-Zhen shi Li YANG Chang-Yi LIU jin-cheng WANG Rui-Min ZHU Xue-Li shi Qiu-Feng LIU International Business School Shanxi Normal UniversityXi'an 710062China University of Chinese Academy of Social Sciences Bejing 102488China School of Economics and Management Xinjiang UniversityUrumqi 830046China Global Energy Interconnection Development and Cooperation Organization(GEIDCO) Bejing 100031China Hubei Enshi College Enshi 445099China CMA Earth System Modeling and Prediction Centre China Meteorological AdministrationBeijing 100081China National Climate Centre China Meteorological AdministrationBeijing 100081China

Developing a localized and consistent model framework for climate loss and damage assessment is crucial for the policy-making of climate change mitigation and *** study introduces a comprehensive,multidisciplinary Integrated Assessment Model(IAM)framework for evaluating climate damage in China,utilizing BCC-SESM climate model and FUND sectoral climate damage model under the SSP2-RCPs *** a bottom-up approach,the research estimates climate damage across eight major sectors,recalibrates sectoral climate damage functions and parameters for China,and elucidates distinctions among direct climate loss,market climate loss,and aggregate climate *** findings reveal that the total climate damage function for China follows a quadratic pattern in response to temperature *** 2050,the estimated climate damage is projected to be 5.4%,5.7%,and 8.2%of GDP under RCP2.6,RCP4.5,and RCP8.5,***,both direct and market climate losses are projected to remain below 2%of GDP by 2050,while the aggregate climate loss could reach as high as 8.2%,which is predominantly attributed to non-market *** a sectoral perspective,under the RCP8.5 scenario,human health damage constitutes the largest share(61.9%)of the total climate loss by 2050,followed by sea-level rise damage(18.6%).This study sheds lights on the adaptation policy that should attach importance to the non-market sectors,particularly focusing on human health and sea-level rise.

关键词： Climate loss and damage Integrated assessment model(IAM) FUND model Representative concentration pathways(RCPs)scenario BCC-SESM

Effect of Al_(2)O_(3)/SiO_(2) mass ratio and CaO content on viscosity and structure of slag for pyrometallurgical processing of spent automotive catalysts

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Journal of Iron and Steel Research(International) 2024年第3期31卷 608-621页

作者： Zhe Wang Qi-long Wei cheng-bin shi Zhan-cheng Guo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The effect of Al_(2)O_(3)/SiO_(2) mass ratio and CaO content on the viscosity and structure of the CaO-Al_(2)O_(3)-SiO_(2)-6MgO-1.5ZrO_(2)-1.5CeO_(2) slag was *** results show that with the increase in Al_(2)O_(3)/SiO_(2) mass ratio,the viscous flow units within the slag gradually change from Si-O-Si to Al-O-Al and ***,the substitution of Al_(2)O_(3) for SiO_(2) leads to the transformation of Si-O bonds towards weaker Al-O bonds,which weaken the bond strength of the aluminosilicate networks,thus leading to a decrease in the viscosity of *** increase in CaO content effectively promotes the depolymerization of the aluminosilicate networks,resulting in a significant decrease in the viscosity of the *** slag with Al_(2)O_(3)/SiO_(2) of 0.7-1.5 and CaO of 30 wt.%shows promise as the reference slag system for the Fe-collection smelting of spent automotive catalysts due to its good comprehensive performance.

关键词： Aluminosilicate slag Al_(2)O_(3)/SiO_(2)mass ratio CaO content Viscosity Slag structure

Fate of organophosphate esters from the Northwestern Pacific to the Southern Ocean:Occurrence,distribution,and fugacity model simulation

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Journal of Environmental Sciences 2024年第3期137卷 347-357页

作者： Tengda shi Ruijing Li Jie Fu Chao Hou Hui Gao Guanjie cheng Haibo Zhang Shuaichen jin Liang Kong Guangshui Na College of Marine Technology and Environment Dalian Ocean UniversityDalian 116023China Laboratory for coastal marine eco-environment process and carbon sink of Hainan province/Yazhou Bay Innovation Institute Hainan Tropical Ocean UniversitySanya 572022China National Marine Environmental Monitoring Center Dalian 116023China College of Marine Ecology and Environment Shanghai Ocean UniversityShanghai 201306China NCS Testing Technology Co. Ltd.Beijing 10081China

Eleven organophosphate esters(OPEs)in the air and seawater were investigated from the northwestern Pacific Ocean to the Southern Ocean during the 2018 Chinese 34th Antarctic Scientific *** concentration of total OPEs ranged from 164.82 to 3501.79 pg/m~3in air and from 4.54 to 70.09 ng/L in *** halogenated OPEs,tri(chloropropyl)phosphate(TCPP)and tri(2-chloroethyl)phosphate(TCEP),were generally more abundant than the non-halogenated OPEs.A levelⅢfugacity model was developed to simulate the transfer and fate of seven OPEs in the air and seawater regions of the central Ross *** model results indicate that OPEs are transferred from the air to the seawater in the central Ross Sea in summer,during which the Ross Sea acts as a final OPE *** and wet deposition dominated the processes involving OPE transfer to *** OPE degradation process was also found to be more pervasive in the atmosphere than in the seawater *** findings highlights the importance of long-range transport of OPEs and their air–seawater interface behavior in the Antarctic.

关键词： Organophosphate esters(OPEs) Long-range transport Fugacity model Antarctic Fate

Decreased Nrf2 protein level and low sperm quality in intractable spermatocystitis

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Asian Journal of Andrology 2024年第2期26卷 189-194页

作者： shi-Ze Wang Jian-Nan Liu Fen-Fang Zhou Ye-jin-Peng Wang Peng Zhang Song-Tao cheng Department of Urology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health Management and Clinical Medicine School of Medicine and HealthWuhan PolytechnicUniversityWuhan 430071China

To investigate the molecular etiology of low sperm quality in patients with intractable spermatocystitis,spermatozoa samples from patients with persistent hematospermia undergoing transurethral seminal vesiculoscopy and healthy volunteers were *** samples were collected from the seminal vesicles through transurethral seminal vesiculoscopy or by masturbation *** quality was analyzed by a WLJY-9000 color semen analysis *** of tumor necrosis factor alpha(TNFa)and interleukin-6(IL-6)in the seminal plasma was performed using enzyme-linked immunosorbent assay(ELISA).Measurement of H_(2)O_(2)in the seminal plasma was performed with a hydrogen peroxide *** protein levels of nuclear factor erythroid 2-related factor 2(Nrf2)and phosphorylated-Nrf2(p-Nrf2)were measured by western blot analysis and immunofluorescence *** sperm quality parameters and increased levels of inflammatory cytokines(TNFa,IL-6,and H_(2)O_(2))in the seminal plasma were detected among the semen samples from the patients with persistent ***2 and p-Nrf2 were strongly expressed in the nucleus and periphery of human sperm cells,according to the results of the immunofluorescence *** protein levels of Nrf2 and p-Nrf2 were significantly lower in the spermatozoa samples from patients with persistent hematospermia than in those from healthy volunteers with normal sperm *** results suggested that Nrf2 signaling might play a role in the low sperm quality of patients with intractable spermatocystitis.

关键词： H_(2)O_(2) Nrf2 sperm quality spermatocystitis