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标准孔板流量计内部流场的CFD数值模拟

实验流体力学 2008年第2期22卷 51-55页

作者：陈家庆王波吴波初庆东北京石油化工学院机械工程学院北京102617

通过在标准孔板流量计中引入CFD数值模拟,为流出系数的获取提供了新途径。对不可压缩流体在不同流量、不同直径比、不同孔板轴向厚度和不同流动介质下的内部流场进行了数值模拟计算,并将计算出的流出系数与根据ISO公式计算出的流出系数... 详细信息

通过在标准孔板流量计中引入CFD数值模拟,为流出系数的获取提供了新途径。对不可压缩流体在不同流量、不同直径比、不同孔板轴向厚度和不同流动介质下的内部流场进行了数值模拟计算,并将计算出的流出系数与根据ISO公式计算出的流出系数进行了分析对比。结果表明,随着结构参数和工作条件的改变,流出系数都会随之发生变化,但ISO公式对孔板厚度的变化不太敏感。CFD数值模拟可以作为标准孔板流量计的辅助设计与标定手段,以进一步提高孔板流量计计量的准确性。

关键词：标准孔板流量计流场计算数值模拟 CFD

负载型纳米Pd-M(Ag,Cu)催化剂的制备与催化性能

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材料工程 2013年第5期41卷 53-56页

作者：隋静胡娜段芳施冬健陈明清江南大学化学与材料工程学院江苏无锡214122

以自制的聚N,N-二乙基丙烯酰胺接枝聚丙烯腈/聚苯乙烯(PDEAm-g-PAN/PSt)微球作为载体,采用原位还原方法,将与酰胺基团配位的金属离子还原成纳米金属颗粒,制得负载型纳米Pd-M(Ag,Cu)催化剂。采用扫描电子显微镜(SEM)对聚合物微球进行表征... 详细信息

以自制的聚N,N-二乙基丙烯酰胺接枝聚丙烯腈/聚苯乙烯(PDEAm-g-PAN/PSt)微球作为载体,采用原位还原方法,将与酰胺基团配位的金属离子还原成纳米金属颗粒,制得负载型纳米Pd-M(Ag,Cu)催化剂。采用扫描电子显微镜(SEM)对聚合物微球进行表征,采用透射电子显微镜(TEM)、X射线衍射(XRD)、能谱分析(EDS)和热重分析(TGA)对负载型催化剂进行表征,结果表明:该聚合物微球表面呈现规整的花状形态,Pd-M颗粒均匀分散于PDEAm-g-PAN/PSt微球表面,其粒径约为10nm。将制备的Pd-M(Ag,Cu)催化剂应用于1-辛烯的催化加氢反应,并与商业化催化剂Pd/C相比,催化1-辛烯加氢的效率为Pd-Cu>Pd-Ag>Pd/C。

关键词：聚合物微球聚N,N-二乙基丙烯酰胺双金属催化剂加氢反应

IP10, KC and M-CSF Are Remarkably Increased in the Brains from the Various Strains of Experimental Mice Infected with Different Scrapie Agents

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Virologica Sinica 2020年第5期35卷 614-625页

作者： Jia Chen Cao Chen Chao Hu Lian Liu Ying Xia Lin Wang Wei Yang Hai-Yan Wu Wei Zhou Kang Xiao Qi shi Yuezhang Wu Zhi-Bao Chen Xiao-Ping dong College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural UniversityDaqing 163000China State Key Laboratory of Infectious Disease Prevention and Control NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 100000China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang UniversityHangzhou 310000China Center for Global Public Health Chinese Center for Disease Control and PreventionBeijing 100000China Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan 430000China China Academy of Chinese Medical Sciences Beijing 100000China College of Life Science and Technology Heilongjiang Bayi Agricultural UniversityDaqing 163000China

Activation of inflammatory cells and upregulations of a number of cytokines in the central nervous system(CNS)of patients with prion diseases are frequently *** evaluate the potential changes of some brain cytokines that were rarely addressed during prion infection,the levels of 17 different cytokines in the brain homogenates of mice infected with different scrapie mouse-adapted agents were firstly screened with Luminex *** upregulations of interferon gamma-induced protein 10(IP10),keratinocyte chemoattractant(KC)and macrophage colony stimulating factor(M-CSF)were frequently detected in the brain lysates of many strains of scrapie infected *** upregulations of those three cytokines in the brains of scrapie infected mice were further validated by the individual specific ELISA and immunohistochemical *** specific mRNAs of IP10,M-CSF and KC in the brains of scrapie infected mice were also detected by the individual specific qRT-PCRs and IP10-specific digital *** analyses of the brain samples collected at different time points post infection revealed the time-dependent increases of those three cytokines,particularly IP10 during the incubation period of scrapie *** addition,we also found that the levels of IP10 in cerebral spinalfluid(CSF)of 45 sporadic Creutzfeldt–Jakob disease(sCJD)patients were slightly but significantly higher than those of the cases who were excluded the diagnosis of prion *** data give us a better understanding of inflammatory reaction during prion infection and progression of prion disease.

关键词： Prion Cytokines Interferon gamma-induced protein 10(IP10) Keratinocyte chemoattractant(KC) Macrophage colony stimulating factor(M-CSF)

Stoichiometric effect on electrical and near-infrared photodetection properties of full-composition-range GaAs1−xSbx nanowires

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Nano Research 2021年第11期14卷 3961-3968页

作者： Jiamin Sun Mingming Han Meng Peng Lei Zhang dong Liu Chengcheng Miao Jiafu Ye Zhiyong Pang Longbing He Hailu Wang qing Li Peng Wang Lin Wang Xiaoshuang Chen Chongxin Shan Litao Sun Weida Hu Zai-xing Yang School of Physics and School of Microelectronics Shandong UniversityJinan250100China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai200083China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China SEU-FEI Nano-Pico Center Key Lab of MEMS of Ministry of EducationCollaborative Innovation Center for Micro/Nano FabricationDevice and SystemSoutheast UniversityNanjing210096China School of Physics and Photoelectric Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310024China Henan Key Laboratory of Diamond Optoelectronic Materials and Devices School of Physics and EngineeringZhengzhou UniversityZhengzhou450001China

As one of the most important narrow bandgap ternary semiconductors, GaAs1−xSbx nanowires (NWs) have attracted extensive attention recently, due to the superior hole mobility and the tunable bandgap, which covers the whole near-infrared (NIR) region, for technological applications in next-generation high-performance electronics and NIR photodetection. However, it is still a challenge to the synthesis of high-quality GaAs1−xSbx NWs across the entire range of composition, resulting in the lack of correlation investigation among stoichiometry, microstructure, electronics, and NIR photodetection. Here, we demonstrate the success growth of high-quality GaAs1−xSbx NWs with full composition range by adopting a simple and low-cost surfactant-assisted solid source chemical vapor deposition method. All of the as-prepared NWs are uniform, smooth, and straight, without any phase segregation in all stoichiometric compositions. The lattice constants of each NW composition have been well correlated with the chemical stoichiometry and confirmed by high-resolution transmission electron microscopy, X-ray diffraction, and Raman spectrum. Moreover, with the increase of Sb concentration, the hole mobility of the as-fabricated field-effect-transistors and the responsivity and detectivity of the as-fabricated NIR photodetectors increase accordingly. All the results suggest a careful stoichiometric design is required for achieving optimal NW device performances.

关键词： GaAs1−xSbx nanowire stoichiometry effect full-composition-range field-effect hole mobility near-infrared photodetection

Design, synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antitumor agents

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Chinese Chemical Letters 2014年第7期25卷 978-982页

作者： Kun Fang Guo-Qiang dong Hai Gong Na Liu Zhen-Gang Li shi-Ping Zhu Zhen-Yuan Miao Jian-Zhong Yao Wan-Nian Zhang Chun-Quan Sheng School of Pharmacy Second Military Medical University Department of Radiation Oncology Ji’nan Military General Hospital

A series of novel E-ring modified evodiamine derivatives were designed and synthesized as antitumor agents. Their capacity to interfere with the catalytic activity of topoisomerase Ⅰ and Ⅱ was evaluated by the relaxation assay. In vitro antitumor activity results revealed that compound 12 showed good antitumor activity with a broad spectrum. Its binding modes with topoisomerase Ⅰ and Ⅱ were clarified by molecular docking.

关键词： Evodiamine derivatives Topoisomerase Ⅰ Topoisomerase Ⅱ Antitumor activity

带有径向电极的小尺度电容层析成像传感器设计

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中国电机工程学报 2007年第23期27卷 66-70页

作者：董向元郭淑青于海龙李惊涛刘石中原工学院能环学院河南省郑州市450007 中国科学院工程热物理研究所北京市海淀区100080

电容层析成像应用于小尺度管道内成像的关键问题是传感器的设计,而常规传感器往往无法满足测量需要。该文在分析小管道测量特点后,提出3种不同径向电极布置的小型电容成像传感器结构,并通过有限元仿真比较了不同径向电极布置对测量电容... 详细信息

电容层析成像应用于小尺度管道内成像的关键问题是传感器的设计,而常规传感器往往无法满足测量需要。该文在分析小管道测量特点后,提出3种不同径向电极布置的小型电容成像传感器结构,并通过有限元仿真比较了不同径向电极布置对测量电容的影响。同时,对电极间绝缘介质介电常数及屏蔽罩与电极外表面距离对电极对间电容的影响进行了详细地探讨。结果表明,对于具有较厚厚度的电极,电极对间的本体电容主要来自电极对侧表面间的电容,且相邻电极间绝缘介质介电常数对电极对间电容的影响不显著,但电极对间电容随着屏蔽罩与电极外表面距离增加而增加。依据仿真结果,设计出一种新型径向电极布置的小尺度传感器,并将其用于实测,获得了较好的结果。

关键词：热能动力工程电容层析成像小尺度传感器径向电极有限元仿真

Armarium facilitating angina management post myocardial infarction concomitant with coronavirus disease 2019

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Journal of Geriatric Cardiology 2020年第4期17卷 217-220页

作者： Xiao-qing CAI Pi-Qi JIAO Tao WU Fu-Ming CHEN Bao-shi HAN Jiu-Cong ZHANG Yong-Jiu XIAO Zhi-Feng CHEN Jun LI Yu-Ying ZHAO Ling MA Yan LIU Ya-Jun shi Pei-Jun DAI Yun-Dai CHEN Department of Cardiology the 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouChina Department of Cardiology the First Medical Center of Chinese PLA General HospitalBeijingChina Department of Cardiology the 980th Hospital of Joint Logistics Support Force of Chinese PLAShijiazhuangChina Department of Infectious Diseases Huoshenshan HospitalWuhanChina

The outbreak and spread of coronavirus disease 2019(COVID-19)are not only a disaster of people’s life and health over the world,[1–3]but also the challenge for medical practitioner in clinical *** to many diagnostic instruments are not suitable or convenient to use any more in contagious ward considering the risk of cross infections,such as traditional stethoscope or electrocardiogram(ECG).In this scenarios,wireless and digital equipment are optimal choices for epidemic management in order to exert rapid diagnosis and disease ***,we reported a case of the patient suffering both COVID-19 and myocardial infarction,for which the tele-ECG and wireless stethoscope facilitated the accurate diagnosis and instant management.

关键词： Acute myocardial infarction Angina Coronavirus disease 2019 Electrocardiogram Stethoscope

基于位移测量的非线性涡激力模型参数识别方法

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中国公路学报 2019年第10期32卷 49-56页

作者：朱乐东孙颢朱青杜林清同济大学土木工程防灾国家重点实验室上海200092 同济大学土木工程学院上海200092 同济大学桥梁结构抗风技术交通行业重点实验室上海200092 同济建筑设计研究院(集团)有限公司上海200092

利用半经验数学模型来近似表示涡激力是目前研究涡激共振所采用的主要方法,但关于非线性涡激力模型参数的试验识别研究还较少,现有识别方法也有待改进。为了更方便可靠地识别非线性涡激力模型中的参数,根据能量等效原理推导出一种基于... 详细信息

利用半经验数学模型来近似表示涡激力是目前研究涡激共振所采用的主要方法,但关于非线性涡激力模型参数的试验识别研究还较少,现有识别方法也有待改进。为了更方便可靠地识别非线性涡激力模型中的参数,根据能量等效原理推导出一种基于节段模型位移响应的气动参数识别新方法。通过节段模型风洞试验测得中央开槽箱梁断面的扭转涡激共振位移响应,应用新方法识别简化非线性涡激扭矩模型中的气动参数,并对参数识别精度做出评价。将新方法与Ehsan等所建议的位移法以及基于实测力时程的三步最小二乘拟合法进行了对比。结果表明:利用新方法识别得到的气动参数可以较好地预测系统的扭转涡激共振位移响应;基于一致的系统线性机械参数,新方法识别得到的气动参数与Ehsan等所建议位移法的识别结果基本相同,而新方法能进一步考虑对识别结果影响较为显著的机械参数非线性特性;当新方法考虑非线性机械参数时,其识别结果和基于实测力时程的三步最小二乘拟合法相比也十分吻合,并且新方法更为简便。

关键词：桥梁工程位移法参数识别风洞试验涡振非线性涡激力模型能量等效原理

高效毛细管电泳法/液质联用分离与测控硫酸卷曲霉素各组分

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中国抗生素杂志 2009年第7期34卷 416-418页

作者：祝仕清牛长群华北制药集团新药研究开发中心石家庄050015

目的建立分离硫酸卷曲霉素组份的高效毛细管电泳法(HPCE)和液质联用(LC-MS),定性定量分析各组分。方法通过环糊精的种类及浓度、缓冲液的pH及浓度、温度及电压的优化,选择最佳的HPCE分离条件,并建立适合于LC-MS的分析条件。结果最佳的H... 详细信息

目的建立分离硫酸卷曲霉素组份的高效毛细管电泳法(HPCE)和液质联用(LC-MS),定性定量分析各组分。方法通过环糊精的种类及浓度、缓冲液的pH及浓度、温度及电压的优化,选择最佳的HPCE分离条件,并建立适合于LC-MS的分析条件。结果最佳的HPCE缓冲液为30mmol/L磷酸盐缓冲液(pH 2.5,内含8 mmol/L羧甲基-β-环糊精);检测波长为214nm;电压为30kV;温度为30℃,基线分离了卷曲霉素4个组分;采用XBP-C18色谱柱,电喷雾ESI为电离源,分析检测了卷曲霉素的各组分。结论建立的HPCE法和LC-MS法可用于为该产品的质量控制提供了可靠的分析方法。

关键词：硫酸卷曲霉素组分分析高效毛细管电泳法液质联用