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Biodegradation,hemocompatibility and covalent bonding mechanism of electrografting polyethylacrylate coating on Mg alloy for cardiovascular stent

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Journal of Materials Science & Technology 2020年第11期42卷 114-126页

作者： Yong-xin Yang Zhe Fang Yi-Hao Liu Ya-Chen Hou Li-guo Wang Yi-Fan Zhou shi-Jie zhu Rong-Chang Zeng Yu-Feng Zheng Shao-Kang Guan School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China Henan Key Laboratory of Advanced Magnesium Alloys Zhengzhou450002China Key Laboratory of Advanced Materials Processing&Mold Ministry of Education Zhengzhou450002China Corrosion Laboratory of Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao266590China State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China

Organic coatings are the most widely employed approach for the promotion of corrosion resistance of magnesium(Mg)***,traditional organic coatings are weakly bonded to Mg substrates due to physical ***,a polyethylacrylate(PEA)coating was fabricated on Mg-Zn-YNd alloy via *** surface structure and chemical composition were characterized by means of scanning electron microscope(SEM),energy dispersive X-ray spectroscopy(EDS),atomic force microscope(AFM)and Fourier transform infrared(FTIR)as well as time of flight-secondary ion mass spectrometer(To F-SIMS).The results showed that the surface roughness of PEA coating was dominated by scan rate;while the coverage and integrity of PEA coating were mainly affected by the monomer concentration and sweep *** F-SIMS results indicated that PEA coating was wholly covered on Mg alloy,and the presence of C2H3Mg-fragment confirmed the covalent bond between PEA coating and Mg *** addition,DFT calculation results of the adsorption of EA molecules with Mg substrate agree well with the experimental phenomena and observation,suggesting that the electrons in 3s orbit of Mg atoms and 2pz orbit of C1 atom participated in the formation of covalent bond between PEA coating and Mg *** polarization curves and immersion test demonstrated that the PEA coatings could effectively enhance the corrosion resistance of Mg *** platelet adhesion results designated that platelets were barely visible on PEA coating,which implied that PEA coating could effectively prevent the thrombosis and coagulation of *** coating might be a promising candidate coating of Mg alloy for cardiovascular stent.

关键词： Magnesium alloy Organic coating Electro-grafting Covalent bond Density functional theory Biomaterial

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2022年西藏自治区察雅县幼儿园藏族儿童营养状况分析

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预防医学论坛 2024年第5期30卷 372-377页

作者：郭蕾施欣唐本玉尼玛张晓乾次仁吉宗朱顺叶中山大学附属第三医院儿科广东广州510630 察雅县人民医院

目的分析2022年西藏自治区察雅县幼儿园藏族儿童的营养状况,为当地卫生决策提供参考依据。方法采用横断面调查方法,对2022年西藏自治区察雅县13个乡镇的1 263名3~7岁幼儿园藏族儿童进行身高、体质量测量及血红蛋白检测。采用标准统计... 详细信息

目的分析2022年西藏自治区察雅县幼儿园藏族儿童的营养状况,为当地卫生决策提供参考依据。方法采用横断面调查方法,对2022年西藏自治区察雅县13个乡镇的1 263名3~7岁幼儿园藏族儿童进行身高、体质量测量及血红蛋白检测。采用标准统计量检定法(Z值法),用WHO儿童成长测评软件计算每个儿童的年龄别身高Z值(HAZ)、年龄别体质量Z值(WAZ)、年龄别体质量指数Z值(BAZ)及3~4岁儿童的身高别体质量Z值(WHZ)。依据WHO营养不良及贫血诊断标准,评价儿童营养状况。结果西藏自治区察雅县幼儿园藏族儿童各年龄组HAZ中位数均为负数,3、5、6岁组儿童WAZ中位数为负数,5、6岁组儿童BAZ中位数为负数。农村儿童各项营养评价指标Z值中位数均为负数;城市儿童除HAZ外,其余营养评价指标Z值中位数均为正数。全体幼儿园儿童除WHZ外,其余营养评价指标Z值中位数均为负数。营养不良总体检出率为23.2%,生长迟缓、低体质量、消瘦、超重、肥胖及贫血的检出率分别为10.7%、10.2%、9.3%、3.6%、1.5%及24.5%。男童消瘦率和贫血率低于女童,生长迟缓、低体质量、超重、肥胖及营养不良总检出率均高于女童,差异均无统计学意义(χ^(2)值分别为0.019、1.162、0.037、0.422、3.787、3.789、2.182,P值分别为0.848、0.516、0.891、0.052、0.052、0.140、0.281)。农村儿童营养不良、生长迟缓、低体质量、消瘦及贫血检出率均高于城市儿童,超重率及肥胖率低于城市儿童,除肥胖率及贫血率外,差异均有统计学意义(χ^(2)值分别8.419、21.597、12.623、5.994、2.028、3.910、1.280,P值分别为0.004、<0.001、<0.001、0.014、0.154、0.048、0.258)。不同年龄组间超重率、肥胖率及贫血率的差异有统计学意义(χ^(2)值分别12.664、16.776、16.813,P值分别为0.011、0.001、0.002)。结论察雅县幼儿园藏族儿童的营养不良率及贫血率较高,以农村儿童的营养低下较为突出,城市儿童超重和肥胖问题显现。

关键词：儿童营养不良贫血藏族

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Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C

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World Journal of Gastroenterology 2010年第35期16卷 4460-4466页

作者： bing-Shui Xiu Xiao-Yan Feng Jing He guo-Hua Wang He-Qiu Zhang Xiao-guo Song Kun Chen shi-Gan Ling Cui-Xia zhu Xiang-Ying Zhang Lai Wei Hui-Ying Rao Institute of Basic Medical Sciences Academy of Military Medical Sciences Beijing 100850 China National Institute for Control of Pharma-ceutical and Biological Products Beijing 100050 China Hepatology Institute People Hospital Peking University Beijing 100044China

AIM:To evaluate the presence and cross-reactive anti-bodies against hypervariable region 1(HVR1) in hepatitis C virus(HCV) infected patients and its relationship with the progression of the ***:Sixteen representative HVR1 proteins selected from a unique set of 1600 natural sequences were used to semiquantitate the cross-reactivity of HVR1 antibodies in the sera of HCV ***-five chronic HCV patients including 23 with asymptomatic mild hepatitis,18 with chronic hepatitis and 16 with liver cirrhosis patients were ***:The degree of the cross-reactivity of anti-HVR1 antibodies in 23 patients with mild asymptomatic hepatitis was 3.09 ± 2.68,which was signif icantly lower than in those with chronic hepatitis(5.44 ± 3.93,P < 0.05) and liver cirrhosis(7.44 ± 3.90,P < 0.01).No correlation was observed between the broadness of the cross-reactivity anti-HVR1 antibodies and patient's age,infection time,serum alanine aminotransferase activity,or serum HCV-RNA *** was the breath of cross-reactivity rather than the presence of anti-HVR1 antibody in HCV sera that was associated with the progression of liver ***:The broadly cross-reactive HVR1 antibodies generated in natural HCV patients can not neutralize the virus,which results in persistent infection in patients with chronic hepatitis.

关键词： Hepatitis C virus Hypervariable region 1 Cross-reactivity

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Protective efficacy of an H5/H7 trivalent inactivated vaccine(H5-Re13,H5-Re14, and H7-Re4 strains) in chickens, ducks, and geese against newly detected H5N1, H5N6, H5N8, and H7N9 viruses

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Journal of Integrative Agriculture 2022年第7期21卷 2086-2094页

作者： ZENG Xian-ying HE xin-wen MENG Fei MA Qi WANG Yan BAO Hong-mei LIU Yan-jing DENG guo-hua shi Jian-zhong LI Yan-bing TIAN guo-bin CHEN Hua-lan State Key Laboratory of Veterinary Biotechnology National Poultry Laboratory Animal Resource CenterHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China

Some H5 viruses isolated in poultry or wild birds between 2020 and 2021 were found to be antigenically different from the vaccine strains(H5-Re11 and H5-Re12) used in China. In this study, we generated three new recombinant vaccine seed viruses by using reverse genetics and used them for vaccine production. The vaccine strain H5-Re13 contains the hemagglutinin(HA) and neuraminidase(NA) genes of an H5 N6 virus that bears the clade 2.***.4.4 h HA gene, H5-Re14 contains the HA and NA genes of an H5 N8 virus that bears the clade 2.***.4.4 b HA gene, and H7-Re4 contains the HA and NA genes of H7 N9 virus detected in 2021. We evaluated the protective efficacy of the novel H5/H7 trivalent inactivated vaccine in chickens, ducks, and geese. The inactivated vaccine was immunogenic and induced substantial antibody responses in the birds tested. Three weeks after vaccination, chickens were challenged with five different viruses detected in 2020 and 2021: three viruses(an H5 N1 virus, an H5 N6 virus, and an H5 N8 virus) bearing the clade 2.***.4.4 b HA gene, an H5 N6 virus bearing the clade 2.***.4.4 h HA gene, and an H7 N9 virus. All of the control birds shed high titers of virus and died within 4 days post-challenge, whereas the vaccinated chickens were completely protected from these viruses. Similar protective efficacy against H5 viruses bearing the clade 2.***.4.4 h or 2.***.4.4 b HA gene was observed in ducks and geese. Our study indicates that the newly updated H5/H7 vaccine can provide solid protection against the H5 and H7 N9 viruses that are currently circulating in nature.

关键词： avian influenza H5/H7 trivalent vaccine H5-Re13 H5-Re14 H7-Re4 strains protective efficacy chickens ducks and geese

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Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy

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Neural Regeneration Research 2023年第6期18卷 1277-1285页

作者： Xiao-Xue Xu Rui-Xue shi Yu Fu Jia-Lu Wang xin Tong shi-Qi Zhang Na Wang Mei-Xuan Li Yu Tong Wei Wang Miao He bing-Yang Liu Gui-Lan Chen Feng guo Department of Pharmaceutical Toxicology School of Pharmaceutical ScienceChina Medical UniversityShenyangLiaoning ProvinceChina Department of Neurology the First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Key Laboratory of Medical Electrophysiology Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan ProvinceInstitute of Cardiovascular ResearchSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Endocrinology and Metabolism the Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Endocrinology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Dysfunction of neuronal nitric oxide synthase contributes to neurotoxicity,which triggers cell death in various neuropathological diseases,including *** have shown that inhibition of neuronal nitric oxide synthase activity increases the epilepsy threshold,that is,has an anticonvulsant ***,the exact role and potential mechanism of neuronal nitric oxide synthase in seizures are still *** this study,we performed RNA sequencing,functional enrichment analysis,and weighted gene coexpression network analysis of the hippocampus of tremor rats,a rat model of genetic *** found damaged hippocampal mitochondria and abnormal succinate dehydrogenase level and Na+-K+-ATPase *** addition,we used a pilocarpine-induced N2a cell model to mimic epileptic *** application of neuronal nitric oxide synthase inhibitor 7-nitroindazole,changes in malondialdehyde,lactate dehydrogenase and superoxide dismutase,which are associated with oxidative stress,were reversed,and the increase in reactive oxygen species level was reversed by 7-nitroindazole or reactive oxygen species inhibitor *** of 7-nitroindazole or N-acetylcysteine downregulated the expression of caspase-3 and cytochrome c and reversed the apoptosis of epileptic ***,7-nitroindazole or N-acetylcysteine downregulated the abnormally high expression of NLRP3,gasdermin-D,interleukin-1βand *** indicated that 7-nitroindazole and N-acetylcysteine each reversed epileptic cell *** together,our findings suggest that the neuronal nitric oxide synthase/reactive oxygen species pathway is involved in pyroptosis of epileptic cells,and inhibiting neuronal nitric oxide synthase activity or its induced oxidative stress may play a neuroprotective role in epilepsy.

关键词： apoptosis bioinformatics analysis cell death epilepsy nitric oxide synthase oxidative stress pyroptosis RNA sequencing Tremor rat weighted gene co-expression network analysis

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Clinical study of NFNC in the treatment of acute exacerbation chronic obstructive pulmonary disease patients with respiratory failure

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World Journal of Clinical Cases 2023年第32期11卷 7770-7777页

作者： Xiang Chen Ling Dai Jin-zhu Ma xin-Xu Chu Liang Dai Jian-Ming Liu Si-Wei guo xin-Wei Ru Xue-shi zhuang Pulmonary and Critical Care Medicine The Sixth Hospital of WuhanAffiliated Hospital of Jianghan UniversityWuhan 430000Hubei ProvinceChina Department of Intensive Care Second Unit Wuhan No.1 HospitalWuhan 430000Hubei ProvinceChina Department of Intensive Care Medicine Lixin County People's HospitalBozhou 236700Anhui ProvinceChina

BACKGROUND Most patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD)have respiratory failure that necessitates active correction and the improvement of oxygenation is particularly important during *** flow nasal cannula(HFNC)oxygen therapy is a non-invasive respiratory aid that is widely used in the clinic that improves oxygenation state,reduces dead space ventilation and breathing effort,protects the loss of cilia in the airways,and improves patient *** To compare HFNC and non-invasive positive pressure ventilation in the treatment of patients with *** Eighty AECOPD patients were included in the *** patients were in the intensive care department of our hospital from October 2019 to October *** patients were divided into the control and treatment groups according to the different treatment methods with 40 patients in each *** in patient comfort,blood gas analysis and infection indices were analyzed between the two *** After treatment,symptoms including nasal,throat and chest discomfort were significantly lower in the treatment group compared to the control group on the 3rd and 5th days(P0.05).After treatment,the same indicators were significantly improved in both patient groups but had improved more in the treatment group compared to the control group(P<0.05).After treatment,the white blood cell count,and the levels of C-reactive protein and calcitonin in patients in the treatment group were significantly higher compared to patients in the control group(P<0.05).CONCLUSION HFNC treatment can improve the ventilation of AECOPD patients whilst also improving patient comfort,and reducing *** is a clinically valuable technique for the treatment of AECOPD.

关键词： Acute exacerbation chronic obstructive pulmonary disease HFNC Noninvasive positive pressure ventilation Application value

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不同乳酸菌发酵黄浆水对酸浆豆腐凝胶特性及其品质的影响

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食品安全质量检测学报 2024年第4期15卷 274-282页

作者：郑欣茹刘琳琳吕铭守杨春华黄雨洋朱颖曲敏朱秀清石彦国孙冰玉哈尔滨商业大学食品工程学院黑龙江省谷物食品与谷物资源综合加工重点实验室哈尔滨150028

目的研究不同乳酸菌发酵黄浆水对酸浆豆腐凝胶特性及其品质的影响,探究酸浆豆腐的凝固机制,提高酸浆豆腐的品质稳定性,量化生产工艺参数。方法以大豆为原料,分别以鼠李糖乳杆菌、耐高温鼠李糖乳杆菌、混合菌(乳酸链球菌乳亚种、嗜热链... 详细信息

目的研究不同乳酸菌发酵黄浆水对酸浆豆腐凝胶特性及其品质的影响,探究酸浆豆腐的凝固机制,提高酸浆豆腐的品质稳定性,量化生产工艺参数。方法以大豆为原料,分别以鼠李糖乳杆菌、耐高温鼠李糖乳杆菌、混合菌(乳酸链球菌乳亚种、嗜热链球菌和耐高温鼠李糖乳杆菌)发酵黄浆水制成的酸浆作为凝固剂制作豆腐,测定豆腐的凝胶强度、持水性、出品率、色差、质构特性、感官评价、流变特性、水分分布、二级结构、三级结构、表面疏水性和微观结构等指标。结果混合菌酸浆诱导的豆腐质构特性最好,具有较高的凝胶强度、持水性和储能模量,分别为579.63g、69.93%和8166.4Pa,感官评分最高。而耐高温鼠李糖乳杆菌酸浆诱导的豆腐凝胶强度和持水性比鼠李糖乳杆菌酸浆诱导的豆腐高。鼠李糖乳杆菌酸浆诱导的豆腐则硬度较低,为1481.38 gf,水分流动性较大。表面疏水性结果显示,混合菌酸浆诱导的豆腐表面疏水性较低,为268.75%,三级构象最为紧密,鼠李糖乳杆菌酸浆豆腐表面疏水性较大,为469.29%,三级构象较为松散。扫描电镜结果显示,混合菌酸浆豆腐呈致密均匀的三维网状结构,耐高温鼠李糖乳杆菌酸浆豆腐凝胶较为连续,孔隙较大,鼠李糖乳杆菌酸浆豆腐凝胶网络结构较松散。结论混合菌酸浆可使豆腐具有较好的凝胶特性和品质,为酸浆豆腐的品质提高提供了理论和技术支持。

关键词：酸浆豆腐凝胶特性流变特性品质

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Neural differentiation of human Wharton＇s jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats

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Neural Regeneration Research 2017年第7期12卷 1103-1110页

作者： Lei Zhang Lin-mei Wang Wei-wei Chen Zhi Ma Xiao Han Cheng-ming Liu Xiang Cheng Wei shi Jing-jing guo Jian-bing Qin Xiao-qing Yang guo-hua Jin xin-hua Zhang Department of Anatomy Nantong University Nantong Jiangsu Province China Department of Radiation Oncology Third People's Hospital of Yancheng Yancheng Jiangsu Province China Department of Neurosurgery the-Affiliated Hosptial of Nantong University Nantong Jiangsu Province China Department of Obstetricsand Gynecology the Affiliated Hosptial of Nantong University Nantong Jiangsu Province China Co-innovation Center of Neuroregeneration Nantong University Nantong Jiangsu Province China

Human Wharton＇s jelly-derived mesenchymal stem cells（h WJ-MSCs）have excellent proliferative ability,differentiation ability,low immunogenicity,and can be easily ***,there are few studies on their application in the treatment of ischemic stroke,therefore their therapeutic effect requires further *** this study,h WJ-MSCs were transplanted into an ischemic stroke rat model via the tail vein 48 hours after transient middle cerebral artery *** 4 weeks,neurological functions of the rats implanted with h WJ-MSCs were significantly ***,many h WJ-MSCs homed to the ischemic frontal cortex whereby they differentiated into neuron-like cells at this *** results confirm that h WJ-MSCs transplanted into the ischemic stroke rat can differentiate into neuron-like cells to improve rat neurological function and behavior.

关键词： nerve regeneration human Wharton's jelly-derived mesenchymal stem cells ischemic stroke cell transplantation middle cerebral arteryocclusion neural differentiation neurological function neural regeneration

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Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension

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Neuroscience Bulletin 2020年第4期36卷 385-395页

作者： Qing Yang Xiao-Jing Yu Qing Su Qiu-Yue Yi xin-Ai Song Xiao-Lian shi Hong-Bao Li Jie Qi guo-Qing zhu Yu-Ming Kang Department of Physiology and Pathophysiology Xi'an Jiaotong University School of Basic Medical SciencesKey Laboratory of Environment and Genes Related to Diseases of the Ministry of EducationXi'an Jiaotong UniversityXi’an 710061China Department of Cardiovascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Department of Pharmacology School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’an 710061China Key Laboratory of Cardiovascular Disease and Molecular Intervention Department of PhysiologyNanjing Medical UniversityNanjing 210029China

Toll-like receptor 4 (TLR4) and cellular Src (cSrc) are closely associated with inflammatory cytokines and oxidative stress in hypertension, so we designed this study to explore the exact role of c-Src in the mechanism of action of the TLR4 signaling pathway in salt-induced hypertension. Salt-sensitive rats were given a high salt diet for 10 weeks to induce hypertension. This resulted in higher levels of TLR4, activated c-Src, pro-inflammatory cytokines, oxidative stress, and arterial pressure. Infusion of a TLR4 blocker into the hypothalamic paraventricular nucleus (PVN) decreased the activated c-Src, while microinjection of a c-Src inhibitor attenuated the PVN levels of nuclear factor-kappa B, pro-inflammatory cytokines, and oxidative stress. Our findings suggest that a longterm high-salt diet increases TLR4 expression in the PVN and this promotes the activation of c-Src, which upregulates the expression of pro-inflammatory cytokines and results in the overproduction of reactive oxygen ***, inhibiting central c-Src activity may be a new target for treating hypertension.

关键词： Toll-like receptor 4 Cellular Src Inflammatory cytokines Oxidative stress Hypothalamic paraventricular nucleus Salt-induced hypertension

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New strategies for prevention and treatment of splenic artery steal syndrome after liver transplantation

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World Journal of Gastroenterology 2014年第41期20卷 15367-15373页

作者： Ji-Yong Song bing-Yi shi Zhi-Dong zhu De-Hua Zheng Gang Li Li-Kui Feng Lin Zhou Tian-Tian Wu guo-Sheng Du Organ Transplant Institute the 309th Hospital of Chinese People’s Liberation Army

AIM: To explore a prophylactic procedure to prevent splenic artery steal syndrome (SASS), as well as a therapeutic intervention to correct it.

关键词： Organ transplantation Liver transplantation Splenic artery steal syndrome Vascular complication Angiography

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