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Computing Optimal Interfacial Structure of Modulated Phases

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Communications in Computational Physics 2017年第1期21卷 1-15页

作者： Jie Xu Chu Wang An-Chang shi Pingwen Zhang LMAM and School of Mathematical Sciences Peking UniversityBeijing 100871China Program in Applied and Computational Mathematics Princeton UniversityPrincetonNew Jersey 08544USA Department of Physics and Astronomy McMaster UniversityHamiltonOntario L8S4M1Canada

We propose a general framework of computing interfacial structures between two modulated *** we propose to use a computational box consisting of two half spaces,each occupied by a modulated phase with given position and *** boundary conditions and basis functions are chosen to be commensurate with the bulk *** observe that the ordered nature of modulated structures stabilizes the interface,which enables us to obtain optimal interfacial structures by searching local minima of the free energy *** framework is applied to the Landau-Brazovskii model to investigate interfaces between modulated phases with different relative positions and *** types of novel complex interfacial structures emerge from the calculations.

关键词： Interface modulated phase metastable state compatibility Landau-Brazovskiimodel

Regulation of human chorionic gonadotropin secretion and messenger ribonucleic acid levels by follistatin in the NUCC-3 choriocarcinoma cell line

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Chinese Science Bulletin 1998年第19期43卷 1635-1642页

作者： Lingyun shi Zilong Fang Hongbo Li Zhiwen Zhang Beijing Med Univ Inst Physiol Beijing 100083 Peoples R China Natl Res Inst Sports Med Beijing 100029 Peoples R China

NUCC-3 choriocarcinoma cell line was used as an in vitro placental cell model to investigate the effects of follistatin on GnRH-stimulated hCG secretion and its subunit mRNA level and stability. Follistatin alone did not affect basal hCG secretion and its subunit mRNA level. GnRH increased hCG secretion and hCG β-mRNA level in a dose-dependent manner. Follistatin significantly suppressed GnRH-stimulated hCG secretion and hCG α- and β-mRNA level. It inhibited hCG secretion in response to PMA, and did not affect the stability of hCG α- and β-mRNA. The authors suggest that follistatin inhibits GnRH-stimulated hCG secretion as well as hCG α- and β-RNA level by decreasing the rate of transcription through the second messenger transduction system--protein kinase-C.

关键词： follistatin NUCC-3 choriocarcinoma cell line GnRH hCG Northern hybridization second messenger transduction system.

A reinforcement learning approach to vehicle coordination for structured advanced air mobility

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Green Energy and Intelligent Transportation 2024年第2期3卷 20-37页

作者： Sabrullah Deniz Yufei Wu Yang shi Zhenbo Wang Department of Mechanical Aerospaceand Biomedical EngineeringThe University of TennesseeKnoxvilleTN37996USA

Advanced Air Mobility(AAM)has emerged as a pioneering concept designed to optimize the efficacy and ecological sustainability of air *** core objective is to provide highly automated air transportation services for passengers or cargo,operating at low altitudes within urban,suburban,and rural *** seeks to enhance the efficiency and environmental viability of the aviation sector by revolutionizing the way air travel is *** a complex aviation environment,traffic management and control are essential technologies for safe and effective AAM *** of the most difficult obstacles in the envisioned AAM systems is vehicle coordination at merging points and *** escalating demand for air mobility services,particularly within urban areas,poses significant complexities to the execution of such *** this study,we propose a novel multi-agent reinforcement learning(MARL)approach to efficiently manage high-density AAM operations in structured *** approach provides effective guidance to AAM vehicles,ensuring conflict avoidance,mitigating traffic congestion,reducing travel time,and maintaining safe ***,intelligent learning-based algorithms are developed to provide speed guidance for each AAM vehicle,ensuring secure merging into air corridors and safe passage through *** validate the effectiveness of our proposed model,we conduct training and evaluation using BlueSky,an open-source air traffic control simulation *** the simulation of thousands of aircraft and the integration of real-world data,our study demonstrates the promising potential of MARL in enabling safe and efficient AAM *** simulation results validate the efficacy of our approach and its ability to achieve the desired outcomes.

关键词： Advanced Air Mobility(AAM) Urban Air Mobility(UAM) Air Traffic Control(ATC) Multi-Agent Reinforcement Learning(MARL)

Reducing feather pecking and cloacal cannibalism by providing layer breeders with nest boxes in colony cages for natural mating

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International Journal of Agricultural and Biological Engineering 2018年第6期11卷 27-32页

作者： Haipeng shi Weichao Zheng Jiang Tu Baoming Li College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China Key Laboratory of Agricultural Engineering in Structure and Environment Ministry of Agriculture and Rural AffairsBeijing 100083China Beijing Engineering Research Center for Livestock and Poultry Healthy Environment Beijing 100083China

Colony cages for natural mating have been applied on many layer breeder ***,feather pecking and cloacal cannibalism are considered as prominent problems for these *** study aimed to investigate the effects on feather pecking and vent pecking behaviors by providing layer breeders with nest boxes(0.90 m L×0.40 m W×0.60 m H)in colony cages for natural mating(4.80 m L×1.20 m W×0.71 m H).Video recording and artificial observation were *** results showed that the usage of nest boxes gradually increased from the beginning of nest boxes providing at the age of 37 weeks to the end of the experiment at the age of 55 *** utilization rates of nest boxes were 36.75%,44.75%and 50.38%at the ages of 41 weeks,47 weeks and 53 weeks,*** hens in the cages without nest boxes showed significantly more frequent gentle feather pecks(both given and received)than hens in the cages with nest boxes at the ages of 41 weeks,47 weeks and 53 weeks.A decreasing trend of gentle feather pecking frequency(both given and received)was found with the increasing age for both the two *** significant difference was found in the number of given or received severe feather pecks at the age of 41 *** hens in the cages without nest boxes showed a significantly higher frequency of given and received severe feather pecks than hens in the cages with nest boxes at the ages of 47 weeks and 53 weeks(p<0.05).Both cannibalistic injury occurrence and mortality rate in the cages with nest boxes were significantly lower than those in the cages without nest *** conclusion,providing nest boxes in colony cages for natural mating could decrease abnormal pecking behaviors and improve animal welfare conditions of layer breeders.

关键词： feather pecking vent pecking nest box colony cage cloacal cannibalism layer breeder animal welfare

Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease

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World Journal of Stem Cells 2022年第9期14卷 684-699页

作者： Meng-Yue shi Lian Liu Fu-Yuan Yang School of Medicine Yangtze UniversityJingzhou 434023Hubei ProvinceChina Department of Pharmacology Medical School of Yangtze UniversityYangtze UniversityJingzhou 434023Hubei ProvinceChina Health Science Center Yangtze UniversityJingzhou 434020Hubei ProvinceChina

Inflammatory bowel disease(IBD)includes Crohn’s disease and ulcerative colitis and is an idiopathic,chronic inflammatory disease of the colonic *** occurrence of IBD,causes irreversible damage to the colon and increases the risk of *** routine clinical treatment of IBD includes drug treatment,endoscopic treatment and *** vast majority of patients are treated with drugs and biological agents,but the complete cure of IBD is *** stem cells(MSCs)have become a new type of cell therapy for the treatment of IBD due to their immunomodulatory and nutritional functions,which have been confirmed in many clinical *** review discusses some potential mechanisms of MSCs in the treatment of IBD,summarizes the experimental results,and provides new insights to enhance the therapeutic effects of MSCs in future applications.

关键词： Mesenchymal stem cells Inflammatory bowel diseases Inflammation Pretreatment Gene editing

Health benefits of traditional Chinese sports and physical activity for older adults: A systematic review of evidence

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Journal of Sport and Health Science 2016年第3期5卷 270-280,382页

作者： Yucheng Guo Haiyang shi Dinghai Yu Pixiang Qiu School of Martial Arts Shanghai University of Sport

Background: Traditional Chinese sports and physical activities(PAs) have a long history and are practiced by millions of Chinese. However,relatively few systematic reviews of the scientific evidence for their health benefits, especially for older Chinese adults, have been *** acquisition: Between January and March 2016, a systematic search was conducted using the CNKI and Pub Med databases to identify studies published between 2000 and 2015. Studies were selected for review if they were designed specifically to evaluate the health benefits of traditional Chinese sports and PAs in adults aged 50 years and older in the Mainland of China. The studies included observational, uncontrolled,and randomized and controlled designs. Papers published without an English title or abstract were *** synthesis: The initial search identified a total of 229 studies. After removing duplicates and studies that did not meet the inclusion/exclusion criteria, 95 studies were selected for review. Special attention was given to studies of the most commonly practiced activities: Tai Ji Quan,Qigong, and Yangko exercises. A positive association between these types of exercise and health benefits was noted for healthy older adults and those with chronic diseases. Evidence on other types of activities was less clear due to the limited number of studies ***: There is promising evidence that traditional Chinese sports and PAs provide many health benefits for older Chinese adults. While additional scientifically rigorous research is warranted, promoting these traditional and culturally-based sports and PAs as forms of behavioral medicine in primary and secondary prevention of diseases among the aging Chinese population will help fulfill an urgent public health need.

关键词： Chinese culture Chinese martial arts Elderly Health Physical activity Sports

Synchronous parathyroid adenoma, papillary thyroid carcinoma and thyroid adenoma in pregnancy: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5426-5431页

作者： Qiang Li Xiao-Zhang Xu Jian-Hua shi Department of Breast and Thyroid Surgery The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai'an 223300Jiangsu ProvinceChina

BACKGROUND There is a common pathologic relationship between parathyroid adenoma and thyroid cancer,but this relationship is infrequent in pregnant patients with primary hyperparathyroidism(PHPT).CASE SUMMARY A 27-year-old gravida 1 woman was transferred to our hospital at 16 wk of *** was diagnosed with parathyroidoma,papillary carcinoma of the thyroid and thyroid adenoma and was managed *** the mother and the newborn were stable after a right inferior parathyroidectomy and total *** healthy infant was delivered at the 40th week of *** mother had no evidence of recurrence over three years of *** Awareness of concomitant PHPT and thyroid diseases may help in managing patients with a history of hypercalcemia.

关键词： Primary hyperparathyroidism Pregnancy Papillary thyroid carcinoma Parathyroid adenoma Thyroid adenoma Case report

Modified surgical method of supra-and infratentorial epidural hematoma and the related anatomical study of the squamous part of the occipital bone

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World Journal of Clinical Cases 2022年第2期10卷 477-484页

作者： Rui-Chun Li shi-Wen Guo Chen Liang Department of Neurosurgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Supra-and infratentorial acute epidural hematoma(SIEDH)is a common posterior cranial fossa epidural hematoma located at the inner surface of the squamous part of the occipital bone(SOB).Traditionally,surgical treatment of the SIEDH requires a combined supra-infratentorial *** To analyze the morphological characteristics of the SOB and introduce a single supratentorial craniotomy for *** Skull computed tomography(CT)scan data from 32 adult patients were collected from January 1,2019 to January 31,*** the median sagittal plane of the CT scan,the angle of the SOB(ASOB)was defined by two lines:Line A was defined from the lambdoid suture(LambS)to the external occipital protuberance(EOP),while line B was defined from the EOP to the posterior edge of the foramen magnum(poFM).The operative angle for the SIEDH(OAS)from the supra-to infratentorial epidural space was determined by two lines:The first line passes from the midpoint between the EOP and the LambS to the poFM,while the second line passes from the EOP to the *** ASOB and OAS were measured and *** Based on the anatomical study,a single supratentorial craniotomy was performed in 8 patients with *** procedure and the results of the modified surgical method were demonstrated in *** males,the ASOB was 118.4±4.7 and the OAS was 15.1±1.8;for females,the ASOB was 130.4±5.1 and the OAS was 12.8±*** were significant differences between males and females both in ASOB and *** smaller the ASOB was,the larger the OAS *** bone flaps in 8 patients were designed above the transverse sinus intraoperatively,and the SIEDH was completely removed without suboccipital *** SOB does not present as a single straight plane but bends at an angle around the EOP and the superior nuchal *** OAS was negatively correlated with the *** The single supratentorial craniotomy for SIEDH is reliable and effective.

关键词： Epidural hematoma External occipital protuberance Occipital bone Transverse sinus Supra-and infratentorial acute epidural hematoma Modified surgical method

Genetic diversity and differentiation of masu salmon(Oncorhynchus masou masou)between and within cultured populations inferred from microsatellite DNA analysis

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Zoological Research 2012年第4期33卷 33-39页

作者： Zhiying JIA Yuyong ZHANG Shuqiang CHEN Lianyu shi Heilongjiang River Fisheries Research Institute Chinese Academy of Fishery SciencesHarbin 150070China College of Fisheries and Life Science Shanghai Ocean UniversityShanghai 201306China

Masu salmon,Oncorhynchus masou masou,is one of the most valuable fishery species that has been introduced to China,though to date no studies on the genetic diversity and genetic relationship among hatchery populations has been performed with molecular *** undertook such a study and sampled 120 individuals from three hatchery stocks and analyzed 20 microsatellite *** loci were polymorphic and a total of 91 alleles were detected.A relatively low level of genetic diversity was revealed with effective number of allele of 3.1094,3.3299 and 3.1894 and expected heterozygosity of 0.6600,0.6648 and 0.6638 in the three stocks,*** from Hardy-Weinberg equilibrium were found due to heterozygote ***,evidence of genetic bottlenecks were found in the three *** individual assignment test demonstrated that 85%of individuals were correctly assigned into their original *** Fst revealed that significant differentiation occurred between these three *** results of the study indicated that disequilibrium of genetic structure and differentiation has occurred in all three *** information collectively provides a basis for measures to avoid of loss of genetic diversity and introgression in Chinese aquaculture.

关键词： Oncorhynchus masou masou Microsatellite Genetic diversity Genetic differentiation