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Machine learning-based discovery of vibrationally stable materials

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npj Computational Materials 2023年第1期9卷 2304-2309页

作者： sherif Abdulkader Tawfik Mahad Rashid Sunil Gupta Salvy P.Russo Tiffany R.Walsh Svetha Venkatesh Institute for Frontier Materials Deakin UniversityGeelongVIC 3216Australia ARC Centre of Excellence in Exciton Science RMIT UniversityMelbourneVIC 3001Australia Applied Artificial Intelligence Institute(A2I2) Deakin UniversityGeelongVIC 3216Australia Chemical and Quantum Physics School of ScienceRMIT UniversityMelbourneVIC 3001Australia

The identification of the ground state phases of a chemical space in the convex hull analysis is a key determinant of the synthesizability of *** material databases have been instrumental in exploring one aspect of the synthesizability of many materials,namely thermodynamic ***,the vibrational stability,which is another aspect of synthesizability,of new materials is not *** first principles approaches to calculate the vibrational spectra of materials in online material databases is computationally ***,a dataset of vibrational stability for~3100 materials is used to train a machine learning classifier that can accurately distinguish between vibrationally stable and unstable *** classifier has the potential to be further developed as an essential filtering tool for online material databases that can inform the material science community of the vibrational stability or instability of the materials queried in convex hulls.

关键词： materials stability vibrational

Novel approach to quantify the chemical stability and shelf life of modified double-base propellants

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Defence Technology（防务技术） 2018年第6期14卷 720-724页

作者： Ashraf M.A.Elghafour Mostafa Radwan Ahmed Fahd Hosam E.Mostafa sherif Elbasuney School of Chemical Engineering Military Technical CollegeKobry El-KobbaCairoEgypt British University in Egypt Elshrouk CityCairoEgypt

Double-base(DB) propellant is vulnerable to auto-catalytic decomposition reactions during storing with the evolution of nitrogen oxides. Modified DB propellant based on energetic nitramines(RDX) can offer enhanced thrust and action time. This study is devoted to evaluate the impact of RDX on chemical stability and shelf life of DB propellant. Extruded modified DB propellant based on RDX was manufactured by solventless extrusion process. Shelf life assessment was performed using an artificial aging at70 ℃ up to 120 days and employing Van't Hoffs formula. Quantification of evolved NOx gases and stabilizer depletion with aging time was conducted using Bergmann-Junk test and HPLC *** DB formulation based on RDX 20 wt % demonstrated enhanced chemical stability and extended service life up to 46 years compared with reference formulation. This finding was ascribed to the high chemical and thermal stability of RDX as well as its compatibility with DB constituents; no side chemical reactions could take place during storing. This manuscript shaded the light on RDX as effective energetic constituent that offered DB propellants with enhanced performance, good chemical stability, and extended service life.

关键词： Double-base propellant Chemical stability Artificial aging Shelf life assessment

Optical mesoscopic membrane sensor layouts for waterfree and blood-free toxicants

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Nano Research 2015年第10期8卷 3150-3163页

作者： sherif A. El-Safty Mohamed Khairy Mohamed A. Shenashen Emad Elshehy Wojciech Warkocki Masaru Sakai NationalInstituteforMaterialsScience(NIMS) 1-2-1SengenTsukuba-shiIbaraki305-0047Japan GraduateSchoolforScienceandEngineering WasedaUniversity3-4-1OkuboShinjuku-kuTokyo169-8555Japan CenterforResearchinIsotopesandEnvironmentalDynamics TsukubaUniversity1-1-1TennodaiTsukubaIbaraki305-8572Japan

Advances in fabrication of mesoscopic membrane sensors with unique structures and morphologies inside anodic alumina membrane （AAM） nanochannels have led to the development of various methods for detecting, visualizing, adsorbing, filtering, and recovering ultra-trace concentrations of toxic metal ions, such as Hg^2＋ and Pb^2＋, in water and blood. These often ＂one-pot＂ screening methods offer advantages over conventional methods in that they do not require sophisticated instruments or laborious sample preparation. In the present study, we fabricated two mesoscopic membrane sensors for naked-eye detection, recognition, filtration, and recovery of Hg^2＋ and Pb^2＋ in biological and environmental samples. These sensors were characterized by the dense immobilization of organic colorants on the mesopore surfaces of silica nanotubes that were constructed using the nanochannels of an AAM as a scaffold. We confirmed that the nanotubes were oriented along the long axis of the AAM nanochannels, open at both ends, and completely and uniformly filled with organic colorants; also, the dense immobilization of the organic colorants did not affect the speed of ion-to-ligand binding events. We used simple, desk-top, flow-through assays to assess the suitability of the developed membrane sensors for detection, removal, and filtration of Hg^2＋ and Pb^2＋ with respect to recyclability and continuous monitoring. Removal of the target ions from biological fluids was assessed by means of flow cytometric analysis. Our results demonstrate the potential of our membrane sensors to be used for preventing the health risks associated with exposure to toxic metal ions in the environment and blood.

关键词： health risks optical sensor mesoscopic nanotubes toxins blood

The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL MAGDY MYOUSSEF AHMED EL-SEBAIE sherif REFAAT AFAF EL-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,p<0.001)and dominant(GT+TT ***,OR=5.4,p<0.001)*** cyclophosphamide chemotherapy,we found that the patients with variant genotypes(GT+TT)were less likely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

New Technique for Medial Patellar Desmotomy in Cattle and Donkeys

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Open Journal of Veterinary Medicine 2017年第10期7卷 144-150页

作者： Mohamed Wefky El sherif sherif Department of Animal Surgery Faculty of Veterinary Medicine Assiut University New Valley Egypt

The present technique is designed to transect the medial patellar ligament indicated for treatment of upward fixation of patella in cattle and donkeys. A medial patellar desmotomy was performed first on cadavers and then on 21 live cattle or donkeys. In live animals under local anesthesia, a sterile silk strand (USP 1) mounted on a curved needle is inserted through skin at the medial aspect of the medial patellar ligament to the subcutaneous fascia and directed beneath the ligament to emerge at opposite side. The silk is then sawed to cut the ligament. In contrast to other procedures, the desmotomy is less invasive as skin at the surgical site is not incised, pericapsular fat and joint capsules not invaded, and the ligament is fully transected in a one-step procedure. Minimal tissue invasiveness limited infection of surgical site, minimized bleeding, and decreased related postoperative consequences.

关键词： Patella Desmotomy Donkey Cattle Upward Fixation

Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin

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World Journal of Gastroenterology 2011年第33期17卷 3836-3841页

作者： Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi sherif M Karam Department of Physiology Faculty of Medicine and Health SciencesUAE UniversityAl AinPO Box 17666United Arab Emirates Department of Biology Faculty of ScienceUAE UniversityAl AinPO Box 17666United Arab Emirates Department of Anatomy Faculty of Medicine and Health SciencesUAE UniversityAl AinPO Box 17666United Arab Emirates Department of Microbiology and Immunology Faculty of Medicine and Health SciencesUAE UniversityAl AinPO Box 17666United Arab Emirates

AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)***:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic *** label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before *** stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU ***:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day *** ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined *** analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by *** mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin ***:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation.

关键词： Gastrointestinal cell proliferation Gastrointestinal mucosal damage Ghrelin

Development of Social Media Analytics System for Emergency Event Detection and Crisis Management

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Computers, Materials & Continua 2021年第9期68卷 3079-3100页

作者： Shaheen Khatoon Majed AAlshamari Amna Asif Md Maruf Hasan sherif Abdou Khaled Mostafa Elsayed Mohsen Rashwan Department of Information System College of Computer Science and Information TechnologyKing Faisal UniversityAl-Ahsa31982Saudi Arabia Faculty of Computers and Artificial Intelligence Cairo UniversityEgypt Faculty of Computing&Information Cairo UniversityEgypt Faculty of Engineering Cairo UniversityEgypt

Social media platforms have proven to be effective for information gathering during emergency events caused by natural or human-made *** response authorities,law enforcement agencies,and the public can use this information to gain situational awareness and improve disaster *** case of emergencies,rapid responses are needed to address victims’requests for *** research community has developed many social media platforms and used them effectively for emergency response and coordination in the ***,most of the present deployments of platforms in crisis management are not automated,and their operational success largely depends on experts who analyze the information manually and coordinate with relevant humanitarian agencies or law enforcement authorities to initiate emergency response *** seamless integration of automatically identifying types of urgent needs from millions of posts and delivery of relevant information to the appropriate agency for timely response has become *** research project aims to develop a generalized Information Technology(IT)solution for emergency response and disaster management by integrating social media data as its core *** this paper,we focused on text analysis techniques which can help the emergency response authorities to filter through the sheer amount of information gathered automatically for supporting their relief *** specifically,we applied state-of-the-art Natural Language Processing(NLP),Machine Learning(ML),and Deep Learning(DL)techniques ranging from unsupervised to supervised learning for an in-depth analysis of social media data for the purpose of extracting real-time information on a critical event to facilitate emergency response in a *** a proof of concept,a case study on the COVID-19 pandemic on the data collected from Twitter is presented,providing evidence that the scientific and operational goals have been achieved.

关键词： Crisis management social media analytics machine learning natural language processing deep learning

Efficient Data Compression of ECG Signal Based on Modified Discrete Cosine Transform

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Computers, Materials & Continua 2022年第6期71卷 4391-4408页

作者： Ashraf Mohamed Ali Hassan Mohammed S.Alzaidi sherif S.M.Ghoneim Waleed El Nahal Electronics and Communications Engineering Department Faculty of EngineeringSinai UniversityArishCO 45511Egypt Department of Electrical Engineering College of EngineeringTaif UniversityTaif21944Saudi Arabia Faculty of Technology and Education Suez UniversitySuez43527Egypt Electronics and Communications Engineering Department Faculty of EngineeringMSA UniversityCO 12585Egypt

This paper introduced an efficient compression technique that uses the compressive sensing(CS)method to obtain and recover sparse electrocardiography(ECG)*** recovery of the signal can be achieved by using sampling rates lower than the Nyquist frequency.A novel analysis was proposed in this *** apply CS on ECG signal,the first step is to generate a sparse signal,which can be obtained using Modified Discrete Cosine Transform(MDCT)on the given *** transformation is a promising key for other transformations used in this search domain and can be considered as the main contribution of this paper.A small number of wavelet components can describe the ECG signal as related work to obtain a sparse *** technique for ECGsignal compression,which is a novel area of research,is *** signals are introduced randomly between any successive beats of the ***-BIH database can be represented as the experimental database in this domain of ***-BIH database consists of various ECG signals involving a patient and standard ECG *** can be considered as the simulation tool used in this *** proposed method’s uniqueness was inspired by the compression ratio(CR)and achieved by *** performance measurement of the recovered signal was done by calculating the percentage root mean difference(PRD),mean square error(MSE),and peak signal to noise ratio(PSNR)besides the calculation of ***,the simulation results indicated that this work is one of the most important works in ECG signal compression.

关键词： Compressive sensing sparse beats of hearts compression ratio percentage root mean difference

Engineered Cleistogamy in Camelina sativa for bioconfinement

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Horticulture Research 2023年第2期10卷 275-285页

作者： Debao Huang Liwei Gao Jeremy McAdams Fangzhou Zhao Hongyan Lu Yonghui Wu Jeremy Martin sherif Msherif Jayasankar Subramanian Hui Duan Wusheng Liu Department of Horticultural Science North Carolina State UniversityRaleighNC 27607USA College of Life Sciences Ganzhou Normal UniversityGanzhouJiangxi 341000China National Center for Soybean Improvement State Key Laboratory of Crop Genetics and Germplasm EnhancementNanjing Agricultural UniversityNanjingJiangsu 210095China College of Food Science and Engineering Wuhan Polytechnic UniversityWuhanHubei 430048China Sandhills Research Station North Carolina State UniversityJackson SpringsNC 27281USA Vineland Research Station Department of Plant AgricultureUniversity of GuelphVinland StationON LOR 2E0Canada Alson H.Smith Jr.Agricultural Research and Extension Center School of Plant and Environmental SciencesVirginia TechWinchesterVA 22602USA USDA-ARS U.S.National ArboretumFloral and Nursery Plants Research UnitBeltsville Agricultural Research Center(BARC)-WestBeltsvilleMD 20705USA

Camelina sativa is a self-pollinating and facultative outcrossing oilseed *** engineering has been used to improve camelina yield potential for altered fatty acid composition,modified protein profiles,improved seed and oil yield,and enhanced drought *** deployment of transgenic camelina in the field posits high risks related to the introgression of transgenes into nontransgenic camelina and wild ***,effective bioconfinement strategies need to be developed to prevent pollen-mediated gene f low(PMGF)from transgenic *** the present study,we overexpressed the cleistogamy(i.e.f loral petal non-openness)-inducing PpJAZ1 gene from peach in transgenic *** camelina overexpressing PpJAZ1 showed three levels of cleistogamy,affected pollen germination rates after anthesis but not during anthesis,and caused a minor silicle abortion only on the main *** also conducted field trials to examine the effects of the overexpressed PpJAZ1 on PMGF in the field,and found that the overexpressed PpJAZ1 dramatically inhibited PMGF from transgenic camelina to non-transgenic camelina under the field ***,the engineered cleistogamy using the overexpressed PpJAZ1 is a highly effective bioconfinement strategy to limit PMGF from transgenic camelina,and could be used for bioconfinement in other dicot species.

关键词： drought expressing limit