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Multimodal cardiac imaging assisted tumor characterization and surgical planning of a patient with rare primary cardiac paraganglioma

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Journal of Geriatric Cardiology 2024年第2期21卷 246-250页

作者： Shu-Yu MENG Li-Qun WANG Hao-Dan DANG Lin ZHANG sheng-Li jiang Bo-Han LIU Department of Ultrasound Diagnosis the First Medical CenterChinese PLA General HospitalBeijingChina Department of Nuclear Medicine the First Medical CenterChinese PLA General HospitalBeijingChina Department of Pathology the First Medical CenterChinese PLA General HospitalBeijingChina Department of Cardiovascular Surgery the First Medical CenterChinese PLA General HospitalBeijingChina

Paragangliomas,also known as pheochromocytomas(1–9 cases per million),arise in the paraganglia.[1]Pheochromocytomas occur in the adrenal glands,while paragangliomas occur elsewhere.[2]Paragangliomas originate from paraganglion cells,which are derived from the neural ectoderm of the nerves and migrate along both sides of the median axis from the base of the skull to the pelvis during embryonic development.

关键词： glioma cardiac nerves

Gut microbiota induced abnormal amino acids and their correlation with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 883-895页

作者： sheng-Qun jiang Su-Na Ye Yin-Hua Huang Yi-Wen Ou Ke-Yang Chen Jian-Su Chen Shi-Bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affiliated Hospital of Bengbu Medical University Bengbu 233000Anhui ProvinceChina School of Public Health Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore the correlation of gut microbiota and the metabolites with the progression of diabetic retinopathy(DR)and provide a novel strategy to elucidate the pathological mechanism of ***:The fecal samples from 32 type 2 diabetes patients with proliferative retinopathy(PDR),23 with nonproliferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched healthy controls(29 HC)were analyzed by 16S rDNA gene *** fecal samples from PDR,DM,and HC groups were assayed by untargeted *** metabolites were measured using liquid chromatographymass spectrometry(LC-MS)*** between gut microbiota and fecal metabolites were ***:A cluster of 2 microbiome and 12 metabolites accompanied with the severity of DR,and the close correlation of the disease progression with PDR-related microbiome and metabolites were *** be specific,the structure of gut microbiota differed in four *** and richness of gut microbiota were significantly lower in PDR and NPDR groups,than those in DM and HC groups.A cluster of microbiome enriched in PDR group,including Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenellaceae-R-7,was *** analysis showed that the glucose and nicotinate degradations were significantly higher in PDR group than those in HC ***,serine,ornithine,and arachidonic acid were significantly enriched in PDR group,while proline was enriched in HC *** analysis illustrated that arginine biosynthesis,lysine degradation,histidine catabolism,central carbon catabolism in cancer,D-arginine and D-ornithine catabolism were elevated in PDR *** analysis revealed that Ruminococcaceae-UCG-002 and Christensenellaceae-R-7 were positively associated with L-arginine,ornithine levels in fecal ***:This study elaborates the different microbiota structure in the gut from four *** relative abundance of

关键词： proliferative retinopathy gut microbiota Ruminococcaceae amino acid metabolism arginine

The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 712-728页

作者： Xiaoxuan Zhong Xiang Wei Yan Xu Xuehai Zhu Bo Huo Xian Guo Gaoke Feng Zihao Zhang Xin Feng Zemin Fang Yuxuan Luo Xin Yi Ding-sheng jiang Division of Cardiovascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationNHC Key Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430030China School of Life Science and Technology Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China

Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart ***,we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum-and PDGF-BB-induced vascular smooth muscle cells(VSMCs),and in tissues of carotid artery injury-induced neointimal ***2 overexpression in VSMCs(Smyd2-vTg)facilitates,but treatment with its specific inhibitor LLY-507 or SMYD2 knockdown significantly inhibits VSMC phenotypic switching and carotid artery injury-induced neointima formation in *** sequencing revealed that SMYD2 knockdown represses the expression of serum response factor(SRF)target genes and that SRF overexpression largely reverses the inhibitory effect of SMYD2 knockdown on VSMC ***3 directly interacts with and deacetylates SRF,which enhances SRF transcriptional activity in ***,SMYD2 promotes HDAC3 expression via tri-methylation of H3K36 at its ***966,a specific inhibitor of HDAC3,not only counteracts the pro-proliferation effect of SMYD2 overexpression on VSMCs,but also inhibits carotid artery injury-induced neointima formation in ***3 partially abolishes the inhibitory effect of SMYD2 knockdown on VSMC proliferation in a deacetylase activity-dependent *** results reveal that the SMYD2-HDAC3-SRF axis constitutes a novel and critical epigenetic mechanism that regulates VSMC phenotypic switching and neointimal hyperplasia.

关键词： Neointimaformation Histonemethylation Histoneacetylation SRFacetylation SMYD2 HDAC3 LLY-507 RGFP966

Application of STEEP and Interpretive Structural Modeling in the Design Imagery of Taiwan Public Ceramic Relief Murals

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Journal of Contemporary Educational Research 2024年第5期8卷 117-127页

作者： Chuan-Chin Chen Jiann-sheng jiang Shaolei Zhou Graduate Institute of Cultural and Creative Design Tung-Fang Design UniversityKaohsiung 83044Taiwan ProvinceChina Department of Art and Design Shaoguan UniversityShaoguan 512000Guangdong ProvinceChina

Ceramic relief mural is a contemporary landscape art that is carefully designed based on human nature,culture,and architectural wall space,combined with social customs,visual sensibility,and *** may also become the main axis of ceramic art in the *** public ceramic relief murals(PCRM)are most distinctive with the PCRM pioneered by Pan-Hsiung Chu of Meinong Kiln in *** addition to breaking through the limitations of traditional public ceramic murals,Chu leveraged local culture and *** theme of art gives PCRM its unique style and innovative value throughout the Taiwan *** study mainly analyzes and understands the design image of public ceramic murals,taking Taiwan PCRM’s design and creation as the scope,and applies STEEP analysis,that is,the social,technological,economic,ecological,and political-legal environments are analyzed as core factors;eight main important factors in the artistic design image of ceramic murals are ***,interpretive structural modeling(ISM)is used to establish five levels,analyze the four main problems in the main core factor area and the four main target results in the affected factor area;and analyze the problem points and target points as well as their causal *** is expected to sort out the relationship between these factors,obtain the hierarchical relationship of each factor,and provide a reference basis and research methods.

关键词： Interpretive structural modeling(ISM) STEEP analysis Public ceramic relief murals(PCRM)

Application of Choquet Integral-Importance-Performance Analysis and TOPSIS Methods in Approaching the Preference Factors of Calligraphy and Seal Engraving Imagery

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Journal of Contemporary Educational Research 2024年第5期8卷 276-288页

作者： Yu Hsuan Chang Jiann sheng jiang Min Min Lin Graduate Institute of Cultural and Creative Design Tung-Fang Design UniversityKaohsiung 83044Taiwan ProvinceChina Department of Art and Design Shaoguan UniversityShaoguan 512000Guangdong ProvinceChina

Classical Chinese characters,presented through calligraphy,seal engraving,or painting,can exhibit different aesthetics and essences of Chinese characters,making them the most important asset of the Chinese *** and seal engraving,as two closely related systems in traditional Chinese art,have developed through the *** to changes in lifestyle and advancements in modern technology,their original functions of daily writing and verification have gradually ***,they have increasingly played a significant role in commercial *** study utilizes the Evaluation Grid Method(EGM)and the Analytic Hierarchy Process(AHP)to research the key preference factors in the application of calligraphy and seal engraving *** from the traditional 5-point equal interval semantic questionnaire,this study employs a non-equal interval semantic questionnaire with a golden ratio scale,distinguishing the importance ratio of adjacent semantic meanings and highlighting the weighted emphasis on visual ***,the study uses Importance-Performance Analysis(IPA)and Technique for Order Preference by Similarity to Ideal Solution(TOPSIS)to obtain the key preference sequence of calligraphy and seal engraving ***,the Choquet integral comprehensive evaluation is used as a reference for IPA *** is hoped that this study can provide cultural imagery references and research methods,injecting further creativity into industrial design.

关键词： Evaluation Grid Method Analytic Hierarchy Process Calligraphy Seal engraving Importance-Performance Analysis Choquet integral TOPSIS

Light-activated tautomeric transition enhanced buried heterointerface for highly efficient and ultraviolet robust perovskite solar cells

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Science China Chemistry 2024年

作者： sheng jiang Shaobing Xiong Shuaifei Mao Yefan Zhang Dongyang Zhao Xiaomeng You Vladimir Gaishun Dmitry Kovalenk Qinye Bao School of Physics and Electronic Science East China Normal University Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of OptoelectronicsFudan University Institute of Functional Nano & Soft Materials (FUNSOM) Soochow University Shanghai Key Laboratory of Magnetic Resonance East China Normal University Department of Physics and Information Technologies Francisk Skorina Gomel State University Collaborative Innovation Center of Extreme Optics Shanxi University

The buried heterointerface of perovskite solar cells（PSCs） suffers from serious nonradiative recombination and ultraviolet（UV）light stress, relentlessly limiting further increase in their power conversion efficiency and operational stability. Herein, we develop an emerging strategy of incorporating a thin UV-activated tautomeric transition layer onto underlying charge transport layer and then depositing perovskite layer to construct an efficient hole-selective buried heterojunction. It is revealed that the UV-activated tautomeric transition interlayer not only improves upper perovskite crystallinity, diminishes thermionic loss for collecting hole and passivates defect site at such buried contact that significantly promote charge transport and suppress nonradiative recombination, but also effectively protects adjacent perovskite from UV degradation through “UV sunscreen”effect. As a result, we report a remarkably enhanced efficiency of 24.76% compared to 22.02% of the control device. More importantly, the achieved high-efficiency PSC features excellent resistance against UV radiation at 365 nm of 100 and 850 mW cm-2, which are approximately 21 and 184 times of UV flux(4.6 mW cm-2) under AM 1.5G solar illumination. This work provides a promising approach of strengthening buried heterointerface for simultaneous realization of highly efficient and UV robust PSCs.

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Serum inflammatory markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for mycoplasma severity

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World Journal of Clinical Cases 2024年第22期12卷 4940-4946页

作者： Li-Ping Wang Zhong-Hua Hu Jun-sheng jiang Jie Jin Department of Pediatrics The First People's Hospital of Linping DistrictHangzhou 310000Zhejiang ProvinceChina Department of Pediatrics Changzhou Children HospitalChangzhou 213100Jiangsu ProvinceChina

BACKGROUND Mycoplasma pneumoniae pneumonia(MPP)significantly impacts pediatric health,necessitating markers for early severe disease *** To investigate the correlation between serum inflammatory marker and the severity of MPP in *** A prospective study was carried out from January 2023 to November 2023.A total of 160 children with MPP who underwent treatment were selected:80 had severe MPP and 80 had mild *** and laboratory data were collected at the time of hospital admission and during *** operating characteristic curves were utilized to assess the diagnostic and prognostic for severe *** Fever duration and length of hospitalization in pediatric patients with severe MPP exceeded those with mild *** incidence of pleural effusion,lung consolidation,and bronchopneumonia on imaging was markedly elevated in the severe MPP cohort compared to the mild MPP *** contrast to the mild cohort,there was a notable increase in C-reactive protein(CRP),procalcitonin(PCT),erythrocyte sedimentation rate,lactic dehydrogenase,D-dimer,and inflammatory cytokines[interleukin(IL)-6,IL-8,IL-10 and tumor necrosis factor(TNF)-α]in the severe MPP group were significantly *** Serum inflammatory markers(CRP,PCT,IL-6,D-dimer,IL-10 and TNF-α)were considered as predictors in children with severe MPP.

关键词： Cytokine Mycoplasma pneumoniae pneumonia Children,Community-acquired pneumonia levels Interleukin-6 D-dimer

Evolution of helium bubbles in FeCoNiCr-based high-entropy alloys containing γ′ nanoprecipitates

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Chinese Physics B 2024年第7期33卷 491-500页

作者：冯婷蒋胜明胡潇天张子骏黄子敬董士刚张建 College of Energy Xiamen UniversityXiamen 361005China16

A series of high-entropy alloys(HEAs) containing nanoprecipitates of varying sizes is successfully prepared by a non-consuming vacuum arc melting *** order to study the irradiation evolution of helium bubbles in the FeCoNiCrbased HE As with γ' precipitates,these samples are irradiated by 100-keV helium ions with a fluence of 5 × 10^(20) ions/m^(2) at 293 K and 673 K,*** the samples irradiated at room temperature are annealed at different temperatures to examine the diffusion behavior of helium *** electron microscope(TEM) is employed to characterize the structural morphology of precipitated nanoparticles and the evolution of helium *** results reveal that nanosized,spherical,dispersed,coherent,and ordered L1_(2)-type Ni_(3)Ti γ' precipitations are introduced into FeCoNiCr(Ni_(3)Ti)_(0.1) HEAs by means of ageing treatments at temperatures between 1073 K and 1123 *** the ageing treatment conditions adopted in this work,γ' nanoparticles are precipitated in FeCoNiCr(Ni_(3)Ti)_(0.1) HE As,with average diameters of 15.80 nm,37.09 nm,and 62.50 nm,*** average sizes of helium bubbles observed in samples after 673-K irradiation are 1.46 nm,1.65 nm,and 1.58 nm,*** improvement in the irradiation resistance of FeCoNiCr(Ni_(3)Ti)_(0.1) HEAs is evidenced by the diminution in bubbles ***,the FeCoNiCr(Ni_(3)Ti)_(0.1) HEAs containing γ' precipitates of 15.8 nm exhibits the minimum size and density of helium bubbles,which can be ascribed to the considerable helium trapping effects of heterogeneous coherent phase ***,annealing experiments conducted after 293-K irradiation indicate that HEAs containing precipitated phases exhibits smaller apparent activation energy(E_(a)) for helium bubbles,resulting in larger helium bubble *** study provides guidance for improving the irradiation resistance of L1_(2)-strengthened high-entropy alloy.

关键词： high-entropy alloys irradiation resistance coherent precipitates helium bubbles

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生物导向型牙体预备技术对修复体边缘牙周菌斑定植水平和龈沟液炎症因子水平的影响

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实用口腔医学杂志 2024年第1期40卷 91-96页

作者：徐启蒙蒋升南京医科大学附属苏州医院口腔科 215026

目的:探讨运用生物导向型预备技术制备的修复体边缘牙周菌斑定植和龈沟液(GCF)炎症因子水平及临床意义。方法:纳入102例慢性牙周炎患者,随机分为2组(n=51),对照组行传统牙体预备,观察组行生物导向性预备技术。比较两组患者术前和术后6... 详细信息

目的:探讨运用生物导向型预备技术制备的修复体边缘牙周菌斑定植和龈沟液(GCF)炎症因子水平及临床意义。方法:纳入102例慢性牙周炎患者,随机分为2组(n=51),对照组行传统牙体预备,观察组行生物导向性预备技术。比较两组患者术前和术后6月修复体边缘骨吸收量、探诊方面的具体深度、牙龈乳头以及改良菌斑方面的具体指数、改良龈沟出血指数,在修复体位置采集龈沟液,测定TNF-α、 IL-6和MMP8水平。结果:术后6月观察组和对照组患者近中、远中及平均骨吸收量差异无统计学意义(P>0.05)。两组患者修复体牙周指数明显降低(P0.05)。结论:生物导向性预备技术应用于慢性牙周炎患者,可有效改善修复体定植水平,消除龈沟液炎症反应,提高患者满意度。

关键词：生物导向性预备技术固定义齿修复慢性牙周炎炎症因子