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Chinese Journal of Natural Medicines 2016年第7期14卷 549-560页

作者： shen zhuo-wei LUO Meng-Yue HU Hai-Hong ZHOU Hui JIANG Hui-Di YU Lu-Shan ZENG Su Institute of Drug Metabolism and Pharmaceutical Analysis Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical Sciences Zhejiang University

NTCP is specifically expressed on the basolateral membrane of hepatocytes, participating in the enterohepatic circulation of bile salts, especially conjugated bile salts, to maintain bile salts homeostasis. In addition, recent studies have found that NTCP is a functional receptor of HBV and HDV. Therefore, it is important to study the interaction between drugs and NTCP and identify the inhibitors/substrates of NTCP. In the present study, a LLC-PK1 cell model stably expressing human NTCP was established, which was simple and suitable for high throughput screening, and utilized to screen and verify the potential inhibitors of NTCP from 102 herbal medicinal ingredients. The results showed that ginkgolic acid(GA)(13 : 0), GA(15 : 1), GA(17 : 1), erythrosine B, silibinin, and emodin have inhibitory effects on NTCP uptake of TCNa in a concentration-dependent manner. Among them, GA(13 : 0) and GA(15 : 1) exhibited the stronger inhibitory effects, with IC_(50) values being less than 8.3 and 13.5 mmol·L^(-1), respectively, than the classical inhibitor, cyclosporin A(CsA)(IC_(50) = 20.33 mmol·L^(-1)). Further research demonstrated that GA(13 : 0), GA(15 : 1), GA(17 : 1), silibinin, and emodin were not substrates of NTCP. These findings might contribute to a better understanding of the disposition of the herbal ingredients in vivo, especially in biliary excretion.

关键词： Herbal medicinal ingredients Human NTCP Inhibitor Transport Biliary excretion

FGF21-mediated autophagy:Remodeling the homeostasis in response to stress in liver diseases

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Genes & Diseases 2024年第3期11卷 264-274页

作者： wei shen Modan Yang Hao Chen Chiy He Huigang Li Xinyu Yang Jianyong zhuo Zuyuan Lin Zhihang Hu Di Lu Xiao Xu Zhejiang University School of Medicine HangzhouZhejiang 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China The Institute for Organ Repair and Regenerative Medicine of Hangzhou HangzhouZhejiang 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhouZhejiang 310003China National Center for Healthcare Quality Management in Liver Transplant HangzhouZhejiang 310003China

Liver diseases are worldwide problems closely associated with various stresses,such as endoplasmic reticulum stress.The exact interplay between stress and liver diseases remains unclear.Autophagy plays an essential role in maintaining homeostasis,and recent studies indicate tight crosstalk between stress and autophagy in liver diseases.Once the bal-ance between damage and autophagy is broken,autophagy can no longer resist injury or main-tain homeostasis.In recent years,FGF21(fibroblast growth factor 21)-induced autophagy has attracted much attention.FGF21 is regarded as a stress hormone and can be up-regulated by an abundance of signaling pathways in response to stress.Also,increased FGF21 activates autophagy by a complicated signaling network in which mTOR plays a pivotal role.This review summarizes the mechanism of FGF21-mediated autophagy and its derived application in the defense of stress in liver diseases and offers a glimpse into its promising prospect in future clinical practice.

关键词： Autophagy Fibroblast growth factor 21 Liver diseases mTOR Stress

Intravitreal conbercept injection with panretinal photocoagulation for high-risk proliferative diabetic retinopathy with vitreous hemorrhage

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1066-1072页

作者： Yao Xu Qing Ye wei shen Department of Ophthalmology the Fourth Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedcineSuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

AIM:To assess the clinical efficacy and safety of combining panretinal photocoagulation(PRP)with intravitreal conbercept(IVC)injections for patients with high-risk proliferative diabetic retinopathy(HR-PDR)complicated by mild or moderate vitreous hemorrhage(VH),with or without diabetic macular edema(DME).METHODS:Patients diagnosed with VH with/without DME secondary to HR-PDR and received PRP combined with IVC injections were recruited in this retrospective study.Upon establishing the patient’s diagnosis,an initial IVC was performed,followed by prompt administration of PRP.In cases who significant bleeding persisted and impeded the laser operation,IVC was sustained before supplementing with PRP.Following the completion of PRP,patients were meticulously monitored for a minimum of six months.Laser therapy and IVC injections were judiciously adjusted based on fundus fluorescein angiography(FFA)results.Therapeutic effect and the incidence of adverse events were observed.RESULTS:Out of 42 patients(74 eyes),29 were male and 13 were female,with a mean age of 59.17±12.74y(33-84y).The diabetic history was between 1wk and 26y,and the interval between the onset of visual symptoms and diagnosis of HR-PDR was 1wk-1y.The affected eye received 2.59±1.87(1-10)IVC injections and underwent 5.5±1.02(4-8)sessions of PRP.Of these,68 eyes received PRP following 1 IVC injection,5 eyes after 2 IVC injections,and 1 eye after 3 IVC injections.Complete absorption of VH was observed in all 74 eyes 5-50wk after initial treatment,with resolution of DME in 51 eyes 3-48wk after initial treatment.A newly developed epiretinal membrane was noted in one eye.Visual acuity significantly improved in 25 eyes.No complications such as glaucoma,retinal detachment,or endophthalmitis were reported.CONCLUSION:The study suggests that the combination of PRP with IVC injections is an effective and safe modality for treating diabetic VH in patients with HR-PDR.

关键词： conbercept panretinal photocoagulation high-risk proliferative diabetic retinopathy vitreous hemorrhage

Wireless multisite sensing systems for continuous physiological monitoring

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Science China Materials 2024年第6期67卷 2045-2047页

作者： Ruilai wei Qilin Hua Guozhen shen School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China Institute of Flexible Electronics Beijing Institute of TechnologyBeijing 102488China

Respiratory diseases rank as the third leading cause of adult mortality[1],while cardiopulmonary and gastrointestinal issues are the primary cause of death within the first five years of a child’s life[2].The monitoring of cardiac,respiratory,and gastrointestinal sounds plays a vital role in routine care,as alterations or absence of these body sounds can serve as indicators of underlying diseases.

关键词： routine continuous monitoring

Auto-parametric resonance of a continuous-beam-bridge model under two-point periodic excitation:an experimental investigation and stability analysis

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 445-454页

作者： Li Yuchun shen Chao Liu wei Li Dong Department of Hydraulic Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this study.An auto-parametric resonance experiment of the test model is conducted to observe and measure the auto-parametric resonance of a continuous beam under a two-point excitation on columns.The parametric vibration equation is established for the test model using the finite-element method.The auto-parametric resonance stability of the structure is analyzed by using Newmark's method and the energy-growth exponent method.The effects of the phase difference of the two-point excitation on the stability boundaries of auto-parametric resonance are studied for the test model.Compared with the experiment,the numerical instability predictions of auto-parametric resonance are consistent with the test phenomena,and the numerical stability boundaries of auto-parametric resonance agree with the experimental ones.For a continuous beam bridge,when the ratio of multipoint excitation frequency(applied to the columns)to natural frequency of the continuous girder is approximately equal to 2,the continuous beam may undergo a strong auto-parametric resonance.Combined with the present experiment and analysis,a hypothesis of Volgograd Bridge's serpentine vibration is discussed.

关键词： auto-parametric resonance continuous beam bridge model two-point excitation experimental investigation stability analysis vibration of Volgograd Bridge

Transient Stability Analysis and Design of VSGs with Different DC-Link Voltage Controllers

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 593-604页

作者： Chao shen wei Gu Wanxing sheng Keyan Liu School of Electrical Engineering Southeast UniversityNanjingChina Power Distribution Research Department China Electric Power Research InstituteBeijing 100192China

Virtual synchronous control has been widely studied for the advantages of emulating inertia for voltage source converters (VSCs). A constant dc-link voltage is usually assumed in existing literature to estimate transient stability of virtual synchronous generators (VSGs). However, actual power supply in the dc-side of VSGs is limited and different dc-link voltage controllers are needed to achieve power balance between DC side and AC side. Addition of dc-link voltage controller has great influence on transient behavior of VSGs, which has not been investigated by previous research. To fill this gap, this paper gives insights into the effect of dc-link voltage dynamics on transient stability of VSGs. First, two typical kinds of VSGs with dc-link voltage controllers are introduced. Then, mathematical models considering dc-link dynamics are established and the effect of dc-link voltage controllers on transient synchronization stability of VSGs is revealed through equal area criterion (EAC). It is found that dc-link voltage controller would reduce stability margin of VSGs and design-oriented transient stability analysis is carried out quantitively using critical clearing time (CCT). Finally, simulation results are given to validate correctness of theoretical analysis.

关键词： DC-link voltage dynamics equal area criterion(eac) transient synchronization stability virtual synchronous generator(VSG)

Coupled simulation of fluid-particle interaction for large complex granules:A resolved CFD-DEM method for modelling the airflow in a vertical fixed bed of irregular sinter particles

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Particuology 2024年第7期90卷 292-306页

作者： Chengzhi Li Yu Zhang Jiahe shen wei Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China School of Transportation and Logistics Engineering Wuhan University of TechnologyWuhan 430063China Centre for Bulk Solids and Particulate Technologies The University of NewcastleCallaghan NSW 2308Australia

A resolved CFD-DEM method is proposed to simulate the fluid-particle interaction for large complex granules.The airflow in a vertical sinter fixed bed is numerically studied using this method.The multi-sphere clumped method is used to create irregular sinter particles in DEM.The immersed boundary method and dynamic cell refinement are applied to describe the fluid flow around particles with higher resolution,by which the fluid-particle interaction can be simulated more accurately.The simulation results presented the packing voidage distributions and the airflow fields in the sinter beds of different single and mixed particle size ranges.The bed pressure drops were simulated and the results were compared with the corresponding experimental ones.The good agreement indicated that the proposed resolved CFD-DEM method is an effective tool to model the fluid-particle interaction for irregular large granules in the gas-solid multi-phase systems.

关键词： Resolved CFD-DEM method Irregular sinter particles Multi-sphere clumped method Immersed boundary method Dynamic cell refinement

Fabrication and integration of photonic devices for phase-change memory and neuromorphic computing

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International Journal of Extreme Manufacturing 2024年第2期6卷 2-27页

作者： Wen Zhou Xueyang shen Xiaolong Yang Jiangjing Wang wei Zhang Center for Alloy Innovation and Design(CAID) State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049People’s Republic of China

In the past decade,there has been tremendous progress in integrating chalcogenide phase-change materials(PCMs)on the silicon photonic platform for non-volatile memory to neuromorphic in-memory computing applications.In particular,these non von Neumann computational elements and systems benefit from mass manufacturing of silicon photonic integrated circuits(PICs)on 8-inch wafers using a 130 nm complementary metal-oxide semiconductor line.Chip manufacturing based on deep-ultraviolet lithography and electron-beam lithography enables rapid prototyping of PICs,which can be integrated with high-quality PCMs based on the wafer-scale sputtering technique as a back-end-of-line process.In this article,we present an overview of recent advances in waveguide integrated PCM memory cells,functional devices,and neuromorphic systems,with an emphasis on fabrication and integration processes to attain state-of-the-art device performance.After a short overview of PCM based photonic devices,we discuss the materials properties of the functional layer as well as the progress on the light guiding layer,namely,the silicon and germanium waveguide platforms.Next,we discuss the cleanroom fabrication flow of waveguide devices integrated with thin films and nanowires,silicon waveguides and plasmonic microheaters for the electrothermal switching of PCMs and mixed-mode operation.Finally,the fabrication of photonic and photonic–electronic neuromorphic computing systems is reviewed.These systems consist of arrays of PCM memory elements for associative learning,matrix-vector multiplication,and pattern recognition.With large-scale integration,the neuromorphic photonic computing paradigm holds the promise to outperform digital electronic accelerators by taking the advantages of ultra-high bandwidth,high speed,and energy-efficient operation in running machine learning algorithms.

关键词： nanofabrication silicon photonics phase-change materials non-volatile photonic memory neuromorphic photonic computing

A Low Cost, Green Sustainable and Biodegradable Biomass-based Fluorine-free Water and Oil Repellent

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Chinese Journal of Polymer Science 2024年第4期42卷 480-491页

作者： Zhi-wei shen Shu-Feng Hu Chen Zeng wei-Qing Kong Mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers&Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510630China

With the global ban on plastics intensifying, the substitution of plastic with paper has garnered increasing attention. However, the inadequate water and oil repellency of pulp molding hinders its practical applications. Currently, the common method to enhance the oil and water repellency of pulp molding is by adding fluorinated water and oil repellents. Nevertheless, fluorinated compounds are environmentally and physiologically harmful. Therefore, the development of fluorine-free, water and oil repellent alternatives is crucial. In this study, chitosan and stearic acid were utilized as the first and second layers of the oil and water repellent coatings, respectively. The coated samples exhibited favorable water repellency, with a water contact angle of 116.4°, and excellent oil repellency, achieving a 12/12 rating on the kit scale. Importantly, the samples did not exhibit any leakage after being soaked in hot water and hot oil at 95±5℃ for 30 min, demonstrating remarkable performance as a barrier against hot water and oil. Moreover, the coated samples displayed outstanding mechanical properties, thermal stability, biodegradability, and recyclability. The approach presented in this study is simple, cost-effective, environmentally friendly, and represents a promising technique for producing fluoride-free, oil-and water-resistant pulp molding products.

关键词： Biomass Fluoride-free Oil-andwater-resistant Plasticfree

ZnSb/Ti_(3)C_(2)T_(x)MXene van der Waals heterojunction for flexible near-infrared photodetector arrays

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Journal of Semiconductors 2024年第5期45卷 99-105页

作者： Chuqiao Hu Ruiqing Chai Zhongming wei La Li Guozhen shen State Key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronic Engineering University of Chinese Academy of SciencesBeijing 100049China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China

Two-dimension(2D)van der Waals heterojunction holds essential promise in achieving high-performance flexible near-infrared(NIR)photodetector.Here,we report the successful fabrication of ZnSb/Ti_(3)C_(2)T_(x)MXene based flexible NIR photodetector array via a facile photolithography technology.The single ZnSb/Ti_(3)C_(2)T_(x)photodetector exhibited a high light-to-dark current ratio of 4.98,fast response/recovery time(2.5/1.3 s)and excellent stability due to the tight connection between 2D ZnSb nanoplates and 2D Ti_(3)C_(2)T_(x)MXene nanoflakes,and the formed 2D van der Waals heterojunction.Thin polyethylene terephthalate(PET)substrate enables the ZnSb/Ti_(3)C_(2)T_(x)photodetector withstand bending such that stable photoelectrical properties with non-obvious change were maintained over 5000 bending cycles.Moreover,the ZnSb/Ti_(3)C_(2)T_(x)photodetectors were integrated into a 26×5 device array,realizing a NIR image sensing application.

关键词： ZnSb nanoplates Ti_(3)C_(2)T_(x)MXene van der Waals heterojunction flexible photodetector image sensing