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Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing shen qiu-Wan Wei Yi-Ren Tian Yun-zhi Ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

小肝癌CT增强不同时相组合模式增强效果的研究

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影像技术 2017年第5期29卷 17-18页

作者：沈志秋杨慧王昂江苏省盐城市亭湖区人民医院江苏224001

目的:探究小肝癌CT增强不同时相组合模式增强效果,寻找一种最佳组合方式。方法:选择50例小肝癌患者进行研究,分为动脉期和门静脉期组合,动脉期和延迟期组合,动脉期、门静脉期和延迟期三期组合,分析每种组合模式对小肝癌的诊断率。结果:5... 详细信息

目的:探究小肝癌CT增强不同时相组合模式增强效果,寻找一种最佳组合方式。方法:选择50例小肝癌患者进行研究,分为动脉期和门静脉期组合,动脉期和延迟期组合,动脉期、门静脉期和延迟期三期组合,分析每种组合模式对小肝癌的诊断率。结果:50例患者共55个病灶,有5例患者存在两个病灶,平扫病变显示率76%,动脉期病变显示率84%,门静脉期病变显示率88%(P<0.05),通过动脉期和门静脉期组合进行小肝癌的诊断,能诊断出33例,诊断率66%;动脉期和延迟期组合能诊断出48例,诊断率96%;三个时期联合诊断,可以诊断出小肝癌48例,诊断率96%。结论:CT增强多期检查在进行小肝癌的诊断时诊断率较高,值得推广应用。

关键词：小肝癌组合模式不同时相增强效果

肩关节疾患MR诊断与关节镜下手术所见的研究对比

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影像技术 2017年第6期29卷 27-28页

作者：刘伟刘国华沈志秋王昂江苏省盐城市亭湖区人民医院江苏224000

目的:探讨常规MR诊断与关节镜下结果,对比MR诊断在肩关节疾患中的应用价值。方法:选取我院2016年3月至2017年3月收治的30例肩关节疾患患者为研究对象,将本组患者MRI表现与关节镜下手术所见进行对比分析。结果:MR判断肩袖损伤准确率为81.... 详细信息

目的:探讨常规MR诊断与关节镜下结果,对比MR诊断在肩关节疾患中的应用价值。方法:选取我院2016年3月至2017年3月收治的30例肩关节疾患患者为研究对象,将本组患者MRI表现与关节镜下手术所见进行对比分析。结果:MR判断肩袖损伤准确率为81.40%、敏感度86%、特异度72.09%;判断关节盂唇损伤准确率为88.37%、敏感度51%、特异性99.98%;判断肱二头肌长头肌腱撕裂准确率90.70%、敏感度67.44%、特异度81.40%。结论:MR诊断可清晰显示肩关节周围软组织结构,能多方位成像且对软组织分辨率较高,有效提高肩关节疾患诊断率,具有临床应用价值。

关键词：肩关节 MR诊断关节镜对比

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa shen Chang Cheng Yu-Han Wang Wen-Chao Cheng De-zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

Synthesis and characterization of biodegradable amphiphilic PEG-grafted poly(DTC-co-CL)

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Chinese Chemical Letters 2010年第10期21卷 1255-1258页

作者： qiu Jin Zhang Wei Pu Zhu zhi Quan shen MOE Key Laboratory of Macromolecule Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

A novel biodegradable copolymer, poly（5,5-dibromomethyltrimethylene carbonate-co-ε-caprolactone）（poly（DBTC-co-CL）） with pendant bromine groups, was synthesized via ring-opening polymerization （ROP） of ε-caprolactone （CL） and 5,5- dibromomethyltrimethylene carbonate （DBTC） using stannous octoate （Sn（Oct）2） as catalyst. Then the pendant bromine groups were completely converted into azide form, which permitted ＂click＂ reaction with alkyne-terminated polyethylene （A-PEG） by Huisgen 1,3-dipolar cycloadditions preparing biodegradable amphiphilic poly（DTC-co-CL）-g-PEG graft copolymer. The graft copolymer was characterized by nuclear magnetic resonance （NMR） and size-exclusion chromatography （SEC）.

关键词： Polycarbonate "Click" reaction Graft copolymer Ring-opening polymerization

CATALYTIC ACTIVITIES OF RARE-EARTH CALIXARENE COMPLEXES IN POLYMER SYNTHESES

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Chinese Journal of Polymer Science 2005年第6期23卷 593-602页

作者： zhi-quan shen Institute of Polymer Science Zhejiang University Hangzhou 310027 China

The studies of our group on the catalytic activities of rare earth calixarene complexes in polymer syntheses are reviewed. Rare earth calixarene complexes are effect catalysts for the polymerizations of butadiene, isoprene, ethylene, styrene, propylene oxide, styrene oxide, trimethylene carbonate and 2,2-dimethyl-trimethylene carbonate.

关键词： Rare earth complex Calixarene Polymer synthesis.

The Lapinized Chinese Strain Vaccine Against Classical Swine Fever Virus:A Retrospective Review Spanning Half A Century

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Agricultural Sciences in China 2006年第1期5卷 1-14页

作者： qiu Hua-ji shen Rong-xian TONG Guang-zhi National Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001 P.R.China

Classical swine fever （CSF）, a list A disease of Office International des Epizooties, is caused by classical swine fever virus （CSFV） belonging to the Flaviviridae family. The well-known lapinized Chinese strain of CSFV, also known as C-strain, was developed in China in the mid-1950s. In the past half a century, the vaccine has been proved to be safe and immunogenic in pigs of essentially any age. It is of high efficacy, providing immunized animals with broad-spectrum, sometimes lifelong, protection, which is contributed by both cell-mediated immunity and humoral immunity, against essentially all genotypes or subgenotypes of the virus. The maternal antibodies derived from immunized sows can confer solid protection of their offspring from disease; however, they have been proved to inhibit the successful active immunization of C-strain vaccine. The complete genomes of C-strain and dozens of established or field strains have been sequenced and annotated. Recently, the reverse genetics system of C-strain has been developed, resulting in several C- strain-derived candidate marker vaccines. Many countries manage to control or even eradicate CSF with the aid of mass vaccination with C-strain. in spite of these efforts, the eradication of the disease worldwide remains a big challenge and needs to go a long way, and provably still resorts to genetically modified C-strain vaccine. The authors present an overview of the characteristics of the vaccine, which has stood the test of half a century.

关键词： classical swine fever classical swine fever virus C-strain vaccine

Differential expression of salt tolerance related genes in Brassica campestris L. ssp. chinensis (L.) Makino var. communis Tsen et Lee

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 847-851页

作者： Yang qiu Xi-xiang LI Hai-ying zhi Di shen Peng LU Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences Beijing 100081 China

We examined salt tolerance responsive genes in Pak-choi under salt stress and analyze their potential function. The LRNA differential display was used to screen the transcript derived fragments （TDFs） related to salinity tolerance in tolerant and Loderately tolerant Pak-choi germplasm. Seventy-eight primer combinations generated 101 differential eDNA fragments, which ere divided into 10 expression types. Seven cDNA sequences （GenBank accession Nos. DQ006915-DQ006921） obtained and ,~quenced were highly homologous to some known expression genes or the genes related to the signaling pathways in plants under ifferent abiotic stress.

关键词： Brassica campestris L. ssp. chinensis (L.) Makino var. communis Tsen et Lee Salinity tolerance Gene differential expression cDNA fragments Basic local alignment search tool (BLAST) analysis

Fuzzy finite difference method for heat conduction analysis with uncertain parameters

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Acta Mechanica Sinica 2014年第3期30卷 383-390页

作者： Chong Wang zhi-Ping qiu Institute of Solid Mechanics Beihang University

A new numerical technique named as fuzzy finite difference method is proposed to solve the heat conduction problems with fuzzy uncertainties in both the phys- ical parameters and initial/boundary conditions. In virtue of the level-cut method, the difference discrete equations with fuzzy parameters are equivalently transformed into groups of interval equations. New stability analysis theory suited to fuzzy difference schemes is developed. Based on the parameter perturbation method, the interval ranges of the uncertain temperature field can be approximately predicted. Subsequently, fuzzy solutions to the original difference equations are obtained by the fuzzy resolution theorem. Two numerical examples are given to demonstrate the feasibility and efficiency of the presented method for solving both steady-state and transient heat conduction problems.

关键词： Heat conduction Fuzzy uncertainties Finitedifference method Parameter perturbation Stability analysis