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叙事地图的要素及组织:基于电子游戏“要素-结构-场景”架构的视角

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测绘学报 2024年第5期53卷 967-980页

作者：应申徐雅洁李玉武汉大学资源与环境科学学院湖北武汉430079 地理信息系统教育部重点实验室湖北武汉430079 自然资源部数字制图与国土信息应用重点实验室湖北武汉430079

信息通信技术背景下,地图的对象空间从二元空间拓展到三元空间,信息空间的出现给地图学带来的一系列挑战,由地图投影、制图综合、符号系统构成的传统制图学经典理论框架已难以满足元宇宙、虚实融合和人机物融合等带来的空间刻画需求。... 详细信息

信息通信技术背景下,地图的对象空间从二元空间拓展到三元空间,信息空间的出现给地图学带来的一系列挑战,由地图投影、制图综合、符号系统构成的传统制图学经典理论框架已难以满足元宇宙、虚实融合和人机物融合等带来的空间刻画需求。针对目前叙事地图的理论框架大多面向传统的地图媒介和形式,本文以“要素-结构-场景”为架构探讨了叙事地图在新时代背景和数字载体下的组织形式。明确叙事要素是叙事地图构建的基础,叙事结构为叙事要素提供组织形式,叙事场景为叙事地图的叙事要素和叙事结构的呈现提供载体。鉴于地理环境类电子游戏具有天然的叙事性,本文通过该类游戏对“要素-结构-场景”这一框架进行了例证,旨在为信息通信时代下叙事地图的应用和实践提供理论基础。

关键词：叙事地图电子游戏地图学要素结构场景时空性

Two different mutational types of familial gastrointestinal stromal tumors:Two case reports

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4028-4036页

作者： Xiao-Ke Wang Lu-Fan shen Xin Yang He Su Tao Wu Peng-Xian Tao Hong-ying Lv Tong-Han Yao Lin Yi Yuan-Hui Gu The First School of Clinical Medical Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina School of Traditional Chinese and Western Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases/million each *** rarer familial GISTs,which often represent a population,differ in screening,diagnosis,and *** GISTs include primary familial GISTs with predominantly KIT/PDGFRA mutations and wild-type ***,whether the same genetic family has different phenotypes has not been *** SUMMARY We report two cases of rare GISTs in the same family:A male patient with the V561D mutation in exon 12 of the PDGFRA gene,who has been taking the targeted drug imatinib since undergoing surgery,and a female patient diagnosed with wild-type GIST,who has been taking imatinib for 3 years since undergoing *** favorable prognosis of these patients during the 7-year follow-up period validates the accuracy of our treatment strategy,and we have refined the entire process of diagnosis and treatment of familial GISTs in order to better manage this rare familial *** Different mutation types of familial GISTs in the same family are very rare,thus it is very important to make the correct diagnosis and treatment strategies according to the results of molecular detection for the management of familial GISTs.

关键词： Gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA Imatinib Treatment Case report

Prognostic and immunological roles of heat shock protein A4 in lung adenocarcinoma

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World Journal of Clinical Oncology 2024年第1期15卷 45-61页

作者： Xuan Wu shen-ying Yang Yi-Hua Zhang Jin-Zhou Fang Shuai Wang Zhi-wei Xu Xiao-Ju Zhang Department of Respiratory and Critical Care Medicine Zhengzhou University People’s HospitalZhengzhou 450008Henan ProvinceChina Graduate School Xinxiang Medical UniversityXinxiang 453003Henan ProvinceChina Department of Pulmonary and Critical Care Medicine Zhengzhou University People’s HospitalZhengzhou 450008Henan ProvinceChina

BACKGROUND Heat shock protein A4(HSPA4)belongs to molecular chaperone protein family which plays important roles within variable cellular activities,including cancer initiation and ***,the prognostic and immunological significance of HSPA4 in lung adenocarcinoma(LUAD)has not been revealed *** To explore the prognostic and immunological roles of HSPA4 to identify a novel prognostic biomarker and therapeutic target for *** We assessed the prognostic and immunological significance of HSPA4 in LUAD using data from The Cancer Genome Atlas *** association between HSPA4 expression and clinical-pathological features was assessed through Kruskal-Wallis and Wilcoxon signed-rank ***/multivariate Cox regression analyses and Kaplan-Meier curves were employed to evaluate prognostic factors,including HSPA4,in *** set enrichment analysis(GSEA)was conducted to identify the key signaling pathways associated with *** correlation between HSPA4 expression and cancer immune infiltration was evaluated using single-sample gene set enrichment analysis(ssGSEA).RESULTS Overexpressing HSPA4 was significantly related to advanced pathologic TNM stage,advanced pathologic stage,progression disease status of primary therapy outcome and female subgroups with *** addition,increased HSPA4 expression was found to be related to worse disease-specific survival and overall *** analysis indicated a significant correlation between HSPA4 and cell cycle regulation and immune response,particularly through diminishing the function of cytotoxicity cells and CD8 T *** ssGSEA algorithm showed a positive correlation between HSPA4 expression and infiltrating levels of Th2 cells,while a negative correlation was observed with cytotoxic cell infiltration *** Our findings indicate HSPA4 is related to prognosis and immune cell infiltrates and may act as a novel prognostic biomarker and therapeutic target for LUAD.

关键词： Heat shock protein A4 Lung adenocarcinoma Tumor-infiltration Prognosis T helper cells

Hybrid argon plasma coagulation for the treatment of Barrett’s esophagus:A prospective,multicenter study

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World Journal of Clinical Cases 2024年第19期12卷 3866-3872页

作者： Dong Wang Yan Chen feng Ji Jian-wei Hu Ping-Hong Zhou Shu-Chang Xu ying Chen Li-Ping Ye Guo-Liang Ye Rui Li Zhao-shen Li Department of Gastroenterology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200011China Department of Gastroenterology Changhai HospitalShanghai 200438China Department of Gastroenterology The First Affiliated Hospital Zhejiang University School of MedicineHangzhou 311399Zhejiang ProvinceChina Endoscopy Center Zhongshan HospitalFudan UniversityShanghai 200032China Endoscopy Center Tongji Hospital of Tongji UniversityShanghai 200092China Department of Gastroenterology Taizhou Hospital of Zhejiang ProvinceTaizhou 318001Zhejiang ProvinceChina Department of Gastroenterology The Affiliated Hospital of Medicine SchoolNingbo UniversityNingbo 315021Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND The incidence of Barrett’s esophagus(BE)in China is lower compared to the Western ***,studies conducted in the Chinese population has been *** current treatment options available for BE treatment includes argon plasma coagulation(APC),radiofrequency ablation and cryoablation,all with varying degrees of *** To determine the efficacy and safety of HybridAPC in the treatment of *** The study cohort consisted of patients with BE who underwent HybridAPC ablation *** procedures were performed by seven endoscopists from different tertiary *** duration of the procedure,curative rate,complications and recurrent rate by 1-year follow-up were *** Eighty individuals were enrolled for treatment from July 2017 to June 2020,comprising of 39 males and 41 females with a median age of 54 years(range,30 to 83 years).The technical success rate of HybridAPC was 100%and the overall curative rate was 98.15%.No severe complications occurred during the *** cases were classified as short-segment BE and long-segment *** with short-segment BE were all considered cured without ***-six patients completed the one-year follow-up without ***-four percent had mild dysplasia which were all resolved with one post-procedural *** mean duration of the procedure was 10.94±6.52 *** Treatment of BE with HybridAPC was found to be a simple and quick procedure that is safe and effective during the short-term follow-up,especially in cases of short-segment *** technique could be considered as a feasible alternative ablation therapy for BE.

关键词： Barrett’s esophagus Hybrid argon plasma coagulation Ablation treatment Prospective study Multicenter study

碳纳米管自交织薄膜载网的构建及用于电池中的沉积分析

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分析化学 2024年第7期52卷 1012-1019页

作者：陈芳张魏栋沈泽宇陆盈盈浙江大学化学系浙江大学化学工程与生物工程学院

透射电子显微镜（TEM）能提供材料在纳米尺度的化学信息与空间信息，是研究电池材料结构和反应机理必不可少的表征工具。由于TEM要求测试样品的厚度<0.1μm，通常的电极表面材料需要采用聚焦离子束刻蚀、超薄切片或超声分散等方法处理... 详细信息

透射电子显微镜（TEM）能提供材料在纳米尺度的化学信息与空间信息，是研究电池材料结构和反应机理必不可少的表征工具。由于TEM要求测试样品的厚度<0.1μm，通常的电极表面材料需要采用聚焦离子束刻蚀、超薄切片或超声分散等方法处理后才能用于TEM观测，而这些前处理过程极有可能丢失最真实的电极表面结构。本研究在常规TEM的铜载网上利用刮涂法制备碳纳米管自交织薄膜层，通过研究不同浓度下碳纳米管的交织状况，优化了交织膜的厚度和覆盖区域，制得新型TEM载网。将此载网作为电池正极，用于电池中电极沉积物的获取和TEM分析，得到电极表面高清晰显微结构图像。本研究为研究高能量密度金属负极中的沉积/剥离机制提供了制样新思路。

关键词：碳纳米管载网电沉积扫描电子显微镜透射电子显微镜

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The role of gut microbiota associated metabolites in digestive disorders

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Engineered Regeneration 2024年第2期5卷 228-246页

作者： Na Li Cheng Zhao Pingnan Zhang Songting Wu Xiaotan Dou Saifei Xu Xiaoqi Zhang Chunyan Peng ying Xie Shuling Huang Lin Zhou Yonghua shen Lei Wang Jinglin Wang Chenggong Yu Department of Gastroenterology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China Division of Hepatobiliary and Transplantation Surgery Department of Gernal SurgeryNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China

The gut has been a focal point in the research of digestive system *** internal microbiota generates metabolites that function as signaling molecules and substrates,interacting with the intestinal wall and influ-encing host physiology and ***,the gut microbiota and metabolites owe highly diverse types and quantities,posing challenges for quantitative analysis,and monitoring frequent interactions between diges-tive tract metabolites and the intestinal wall remains a ***,research targeting gut microbiota metabolites has elucidated their relevance to digestive *** modulating metabolites such as short-chain fatty acids,bile acids,and lipopolysaccharides,it is possible to intervene in the progression of diseases such as inflammatory bowel disease and non-alcoholic fatty liver ***,research on gut microbiota is advancing,and more work is required to explore the interactions between host,microbes and underlying *** this review,we have revisited the generation of gut microbiota-related metabolites,their impact on diseases,and modes of interaction,emphasizing the significant role of metabolites in digestive system *** is believed that the linkage between gut microbiota and diseases in current research can be established through metabolites,providing a framework and foundation for research in the field of metabolomics and fundamental mechanisms.

关键词： Gut microbial metabolites Digestive disorders Inflammatory bowel disease(IBD) Non-alcoholic fatty liver disease(NAFLD)

叙事医学视角下《得心集医案》的多重叙事呈现方式

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中国医学伦理学 2024年第3期37卷 302-308页

作者：申颖曾俊敏广州中医药大学外国语学院广东广州510006

《得心集医案》以夹叙夹议的方式展现了医者对生命时间的关注、对个性的塑造、情节的推进以及对治疗主体间性和伦理性的思考,体现了丰富的故事性特质。《得心集医案》作者谢星焕基于医者视域从医患和社会之关系、患者依从性、自我医疗... 详细信息

《得心集医案》以夹叙夹议的方式展现了医者对生命时间的关注、对个性的塑造、情节的推进以及对治疗主体间性和伦理性的思考,体现了丰富的故事性特质。《得心集医案》作者谢星焕基于医者视域从医患和社会之关系、患者依从性、自我医疗行为等角度进行多维叙事反思,展现了医者的内省和对人性的深层次理解。通过描写人物间的互动细节,展示了医生与患者、医者与他医以及医者与门人之间的关系,不仅蕴有叙事医学的核心内涵,同时也彰显了中医诊疗的独特文化属性。

关键词：叙事医学医患关系得心集医案叙事反思人物互动

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财政货币政策、盯住目标偏好与结构性调控

数理统计与管理 2024年第1期43卷 162-176页

作者：张龙申瑛琦吉林大学商学与管理学院吉林长春130012

本文首先定量测度中国财政货币政策调控指数,并结合经济现实总结中国财政货币政策的盯住目标偏好,进一步基于TVTP-MS-FAVAR模型“量化”检验财政货币政策的“总量调控”与“结构调控”效应。研究发现:第一,财政货币政策调控指数具有较... 详细信息

本文首先定量测度中国财政货币政策调控指数,并结合经济现实总结中国财政货币政策的盯住目标偏好,进一步基于TVTP-MS-FAVAR模型“量化”检验财政货币政策的“总量调控”与“结构调控”效应。研究发现:第一,财政货币政策调控指数具有较好拟合效果与指引功效,宏观调控“逆周期”特征明显,财政政策主要关注经济增长,货币政策侧重盯住物价水平。第二,财政政策的增长效应存在“收支”差异与“结构”异同,政府投资性支出与消费税的“区制”调控功效明显。第三,货币政策的价格效应存在“量价”分化与“区制”偏好,数量工具在物价上涨“区制”调控效应显著,价格工具在物价下跌“区制”调控效果更优。本文结论对政策当局准确把握财政货币政策调控取向时变动态特征、盯住目标偏好、结构调控及协同配合范式,具有重要参考价值。

关键词：财政政策货币政策目标偏好结构调控

Tislelizumab in previously treated,locally advanced unresectable/metastatic microsatellite instability-high/mismatch repair-deficient solid tumors

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Chinese Journal of Cancer Research 2024年第3期36卷 257-269页

作者： Jian Li Ye Xu Aimin Zang Yunong Gao Quanli Gao Yanqiao Zhang Dong Wang Jianming Xu ying Yuan Haiping Jiang Jieer ying Chunmei Shi Yanhong Deng Jing Wang Tianshu Liu Yi Huang Xiaoping Qian Yueyin Pan ying Cheng sheng Hu Jin Wang Mengyue Shi Ke Wang Han Hu Lin shen State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Medical Oncology Affiliated Hospital of Hebei UniversityBaoding 071000China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of GynecologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450001China Department of Gastrointestinal Oncology Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150086China Department of Gastrointestinal Oncology Chongqing University Cancer HospitalChongqing 400030China Department of Gastrointestinal Oncology the Fifth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Medical Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Medical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Medical Oncology Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Department of Medical Oncology Fujian Medical University Union HospitalFuzhou 350001China Department of Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Medical Oncology Hunan Cancer HospitalChangsha 410013China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Immunotherapy Hubei Cancer HospitalWuhan 430079China Department of Medical Oncology the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Medical Oncology Anhui Provincial HospitalHefei 230001China Department of Medical Oncology Jilin Cancer Hospital

Objective:The open-label,phase II RATIONALE-209 study evaluated tislelizumab(anti-programmed cell death protein 1 antibody)as a tissue-agnostic monotherapy for microsatellite instability-high(MSI-H)/mismatch repair-deficient(dMMR)***:Adults with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR solid tumors were *** received tislelizumab 200 mg intravenously every 3 *** response rate(ORR;primary endpoint),duration of response(DoR),and progression-free survival(PFS)were assessed by independent review committee(Response Evaluation Criteria in Solid Tumors v1.1).Results:Eighty patients were enrolled and treated;75(93.8%)patients had measurable disease at *** had metastatic disease and received at least one prior therapy for advanced/metastatic disease(n=79;98.8%).At primary analysis(data cutoff July 8,2021;median follow-up 15.2 months),overall ORR[46.7%;95%confidence interval(95%CI),35.1−58.6;one-sided P<0.0001]and ORR across tumor-specific subgroups[colorectal(n=46):39.1%(95%CI,25.1–54.6);gastric/gastroesophageal junction(n=9):55.6%(95%CI,21.2−86.3);others(n=20):60.0%(95%CI,36.1−80.9)]were significantly greater with tislelizumab vs.a prespecified historical control ORR of 10%;five(6.7%)patients had complete *** DoR,PFS,and overall survival were not reached with long-term follow-up(data cutoff December 5,2022;median follow-up 28.9 months).Tislelizumab was well tolerated with no unexpected safety ***-related adverse events(TRAEs)of grade≥3 occurred in 53.8%of patients;7.5%of patients discontinued treatment due to ***:Tislelizumab demonstrated a significant ORR improvement in patients with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR tumors and was generally well tolerated.

关键词： Biomarkers DNA mismatch repair immune checkpoint inhibitors microsatellite instability phase II clinical trials programmed cell death 1 receptor