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基于婴儿运动表现测试的脑瘫患儿早期运动表现特点分析

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陆军军医大学学报 2024年第6期46卷 515-521页

作者：申亚丽屈福祥王成举吴至凤程旺杨秋霞胡楠张雨平陆军军医大学(第三军医大学)第二附属医院儿科重庆400037 盘州市第二人民医院儿科贵州六盘水553537

目的通过分析脑瘫患儿在2~4月龄时的婴儿运动表现测试(test of infant motor performance, TIMP)结果,探讨脑瘫患儿的早期运动表现特点。方法采用横断面研究设计方案,纳入2018年12月至2022年12月期间在陆军军医大学第二附属医院早产... 详细信息

目的通过分析脑瘫患儿在2~4月龄时的婴儿运动表现测试(test of infant motor performance, TIMP)结果,探讨脑瘫患儿的早期运动表现特点。方法采用横断面研究设计方案,纳入2018年12月至2022年12月期间在陆军军医大学第二附属医院早产高危儿随访门诊就诊、1岁后确诊为脑瘫的患儿17例,收集其2~4月龄的TIMP评估结果;以相同月龄的TIMP中国常模样本作为对照,计算Z值;比较两组之间TIMP总分、7个体位分组得分以及42个项目得分的差异。结果脑瘫患儿2~4月龄的TIMP总分Z值为(-0.95±1.11),显著低于常模对照组得分(P<0.01)。体位分组中坐位、侧方位、翻身、立位项目得分Z值分别为(-0.89±0.88)、(-1.17±0.66)、(-0.43±0.79)及(-0.63±0.77),均显著低于常模对照组得分(P<0.05),尤其以坐位、侧方位、立位项得分差异最为显著(P<0.01),而观察项目、仰卧位、俯卧位与正常同龄婴儿无显著差异。42个项目得分中,脑瘫患儿有17项评分显著低于中国常模,以第15项(坐位头控)、第16项(颈后肌群活动)、第26项(上肢防御)、第32项(拉坐)、第33项(侧卧位牵拉上肢转为侧坐)、第34项(侧卧位髋关节外展)、第40项(站立)的得分差异最为显著。结论脑瘫高危儿随访中尤其需要关注坐位、侧方位以及立位项的运动表现,这可能对脑瘫的早期识别具有提示意义。

关键词：婴儿运动表现测试脑瘫运动评估

Bilinear approach to N=2 supersymmetric KdV equations

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Science China Mathematics 2009年第9期52卷 1973-1981页

作者： ZHANG MengXia LIU QingPing shen yali WU Ke Department of Mathematics China University of Mining and TechnologyBeijing 100083China School of Mathematical Sciences Capital Normal UniversityBeijing 100037China Department of Applied Mathematics Yuncheng UniversityYuncheng 044000China

The N=2 supersymmetric KdV equations are studied within the framework of Hirota bilinear method. For two such equations, namely N=2, a=4 and N=2, a=1 supersymmetric KdV equations, we obtain the corresponding bilinear formulations. Using them, we construct particular solutions for both cases. In particular, a bilinear Bcklund transformation is given for the N=2, a=1 supersymmetric KdV equation.

关键词： supersymmetric KdV equation Hirota bilinear form solitons Backlund transformation Lax representation

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基于归一化磁源强度的磁目标实时定位方法

测试技术学报 2024年第5期38卷 535-542页

作者：张樱子刘改改申雅丽王晨刘文怡中北大学省部共建动态测试技术国家重点实验室山西太原030051

标量三角剖分与测距(STAR)方法利用磁梯度收缩特性实现运动状态下对单个磁偶极子目标的实时定位,且对运动平台的姿态不敏感。然而,磁梯度收缩量(C_(T))引入的非球面误差会限制其定位精度。针对该问题,提出了一种新的磁偶极子目标线性定... 详细信息

标量三角剖分与测距(STAR)方法利用磁梯度收缩特性实现运动状态下对单个磁偶极子目标的实时定位,且对运动平台的姿态不敏感。然而,磁梯度收缩量(C_(T))引入的非球面误差会限制其定位精度。针对该问题,提出了一种新的磁偶极子目标线性定位方法,利用归一化磁源强度(NSS)代替C_(T),消除了非球面误差的影响。为了分析该方法对不同方位磁目标的定位性能,建立了全向仿真分析模型。仿真结果表明,该方法的实时性与STAR方法相当,在标准差为10 nT的高斯白噪声影响下与STAR方法的最大定位误差分别为0.18 m与1.5 m。现场实验结果表明,当探测距离为1.284 m时,该方法在纬线轨迹上的平均定位误差仅为0.094 m,比传统STAR方法低56.7%;在经线轨迹上的平均定位误差为0.097 m,比传统STAR方法低30.7%。

关键词：磁梯度张量磁目标定位磁偶极子归一化磁源强度

Phase Ⅰ/Ⅱ study of gemcitabine and oxaliplatin chemotherapy in combination with concurrent 3-D conformal radiotherapy for locally advanced non-small cell lung cancer

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中国肺癌杂志 2006年第4期9卷 362-368页

作者： XU Feng WANG Jin shen yali ZHANG Hong ZHOU Qinghua Department of Radiation Oncology Cancer Center West China Hospital Sichuan University ChengduSichuan 610041 P. R. China

Background and objective Recent studies have showed that combination of chemotherapy and radiotherapy might result in better outcome for locally advanced non-small cell lung cancer (NSCLC). The aim of this study is to determine the maximal tolerance dose (MTD) and efficacy of full-dose gemcitabine and oxaliplatin when given concurrently with 3-dimentional radiation therapy (3D-RT) for locally advanced NSCLC. Methods Oxaliplatin was administered at a fixed dose of 130mg/m^2, and gemcitabine was administered at a starting dose of 800mg/m^2 with an incremental dose gradient of 200mg/m^2 for 3 dose levels. MTD was defined as the immediate dose level lower than the dose at which dose-limiting toxicity (DLT) occurred in more than one-third of the patients. The chemotherapy was administered at 3-week cycle. The RT was given as 3-D conformal manner at a single daily dose of 2Gy for 5 days per week. Results Twenty-two patients were evaluable and distributed to three different dose levels: 6 at level 1, 8 at level 2 and 8 at level 3. Pulmonary toxicity, esophageal and hematologic toxicity were the main DLT. Grade Ⅲ acute pulmonary toxicity occurred in one patient each at level 2 and level 3, both with V20>20%, and grade Ⅲ esophagitis in two patients at level 3. The MTD of gemcitabine in this study was 1000mg/m^2. The overall response rate was 75.0% (9/12). The 1- and 2-year survival rate was 70.0% and 30.5% respectively. The median time to progression was 8.7 months (range 5--11.8 months). Conclusion With reduced radiation volume, gemcitabine of 1000mg/m^2 in combination with oxaliplatin of 130mg/m^2 was effective and could be safely administered for NSCLC.

关键词： Lung neoplasms Gemcitabine Oxaliplatin Concurrent radiotherapy Toxicity

基于心率监测的高温户外电力基建作业工人热安全评估

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职业与健康 2024年第5期40卷 581-586页

作者：沈雅利杨帆李华亮毛焱王琪如杜晨秋广东电网有限责任公司中山供电局广东中山528400 广东电网有限责任公司电力科学研究院广东广州510080 重庆大学土木工程学院重庆400045

目的准确评估高温作业工人个体热应激风险。方法以广州220 kV电力综自改造户外基建现场为例,于2019年7-8月开展热环境和工人生理参数监测调研,分析高温暴露与工人工作时长、心率等变化关系。结果调研期间平均湿球黑球温度(wet bulb glob... 详细信息

目的准确评估高温作业工人个体热应激风险。方法以广州220 kV电力综自改造户外基建现场为例,于2019年7-8月开展热环境和工人生理参数监测调研,分析高温暴露与工人工作时长、心率等变化关系。结果调研期间平均湿球黑球温度(wet bulb globe temperature,WBGT)指数值在28.4~40.2℃,工人工作时长随WBGT增加显著降低。基于心率得到了工人6种作业类型的平均代谢率,破碎作业代谢率最高[(300±62)W],不同作业类型工人代谢率比较,差异有统计学意义(P<0.05)。以标准推荐的WBGT与代谢率的安全限值为参考,多数作业工人代谢率处于Ⅱ级轻度和Ⅲ级中等范围,且平均代谢率均处于推荐限值之上,表明高温环境中多数工人户外作业劳动代谢率超出了限值。结论基于心率监测的实时评估户外高温作业人群热安全方法可为我国高温保护和风险人群识别提供参考。

关键词：高温暴露作业工人实时心率劳动代谢率热安全评估

FORMATION OF QUASICRYSTALLINE PHASE IN RAPIDLY SOLIDIFIED Al-Fe-V-Si ALLOY

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Acta Metallurgica Sinica(English Letters) 1994年第3期7卷 167-170页

作者： GUAN Shaokang, TANG yali, shen Ningfu, ZHAO DongshanZhengzhou Institute of Technology. Zhengzhou. ChinaHU HanqiUniversity of Science and Technology Beijing. Beijing, China Zhengzhou Inst of Technology Zhengzhou China

The icosahedral quasicrvstalline phase (i-phase) with the chemical composition of 82.4at%Al. 8.8at%Fe. 3.6at%V and 5.2at%Si in melt spun Al-Fe-V-Si ribbons was found. It is suggested that the temperature and holding t... 详细信息

关键词： quasicrvstalline phase Al-Fe-V-Si alloy rapid solidification

基于激光消融与系统治疗的保肾治疗新模式在局限性高风险UTUC中的应用

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中华泌尿外科杂志 2024年第7期45卷 502-507页

作者：唐钵陈泽昱涂祥廖鑫扬林天海张朋刘继彦沈亚丽曾浩李响魏强鲍一歌四川大学华西医院泌尿外科、四川大学华西医院泌尿外科研究所成都610041 四川大学华西医院生物治疗科成都610041 四川大学华西医院腹部肿瘤科成都610041

目的探讨基于输尿管镜激光消融与系统治疗的保肾治疗新模式在局限性高风险上尿路尿路上皮癌(UTUC)中的疗效和安全性。方法云回顾性分析四川大学华西医院2020年1月至2021年12月接受激光消融与系统治疗的10例局限性高风险UTUC患者的资料。... 详细信息

目的探讨基于输尿管镜激光消融与系统治疗的保肾治疗新模式在局限性高风险上尿路尿路上皮癌(UTUC)中的疗效和安全性。方法云回顾性分析四川大学华西医院2020年1月至2021年12月接受激光消融与系统治疗的10例局限性高风险UTUC患者的资料。男5例,女5例;中位年龄76岁(52~87岁)。肾孟肿瘤3例;输尿管肿瘤7例,其中输尿管下段肿瘤5例,中上段肿瘤2例。5例尿脱落细胞学阳性;6例合并肾积水。临床分期:1例输尿管镜活检确认存在肌层浸润(cT2+期),7例为高级别浸润性尿路上皮癌(cT1+期),2例为高级别乳头状尿路上皮癌(cT期)。5例拒绝接受根治性肾输尿管全切除术(RUN),3例为一般状况较差无法耐受RNU;1例为独肾,1例为双侧肿瘤。患者接受输尿管镜下激光肿瘤消融联合系统治疗的综合治疗模式。术前系统治疗方案包括铂类化疗±免疫治疗、维迪西妥单抗+免疫治疗、单纯免疫治疗等,术后系统治疗方案为免疫治疗维持±局部放疗。治疗完成后严格随访。分析患者的治疗情况,并发症及预后。结果9例消融术前接受系统治疗:3例围术期使用4个周期铂类化疗方案(2例顺铂,1例卡铂),3例使用铂类化疗+免疫治疗方案(1例予6个周期顺铂+特瑞普利单抗,1例予4个周期顺铂+特瑞普利单抗,1例予4个周期卡铂+替雷丽珠单抗),2例使用4个周期维迪西妥单抗+免疫治疗方案(替雷利珠单抗、特瑞普利单抗各1例),1例单纯免疫治疗(特瑞普利单抗)4个周期。1例术前未用系统治疗。10例手术均顺利完成,激光工作时间(42.4±15.2)min。10例中有4例在初次消融时即完全消融;6例初次消融不完全,其中2例行1~2个周期系统治疗后达到临床完全缓解,4例再次使用激光消融达到完全消融。10例术后均以单纯免疫治疗维持1年,其中2例额外予以辅助放疗。中位随访时间为40个月(26~53个月)。5例复发,其中3例后续行挽救性RNU,2例再次行输尿管镜下激光消融;5例无肿瘤复发。10例均未出现肿瘤远处转移。至末次随访,1例因合并症死亡,6例保持患侧肾脏生存。围手术期并发症包括肉眼血尿(8例)、发热(3例)等,远期并发症为输尿管狭窄(4例)。结论对于局限性高风险UTUC,局部激光消融结合全身系统治疗对部分经选择的患者在保留患侧肾脏的同时具有良好的肿瘤控制效果,可进一步评估其潜在应用价值。

关键词：泌尿系肿瘤上尿路尿路上皮癌激光消融系统治疗疗效安全性

Molecular compositions and sources of organic aerosols at a rural site on the Guanzhong Plain,Northwest China:The importance of biomass burning

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Particuology 2024年第6期89卷 44-56页

作者： yali Liu Minxia shen Haijiao Liu Wenting Dai Weining Qi Yifan Zhang Lu Li Yue Cao Xin Wang Xiao Guo Yingkun Jiang Jianjun Li State Key Laboratory of Loess and Quaternary Geology Key Lab of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Xi'an Institute for Innovative Earth Environment Research Xi'an 710061China National Observation and Research Station of Regional Ecological Environment Change and Comprehensive Management in the Guanzhong Plain ShaanxiChina

The concentration of PM_(2.5)has considerably reduced in recent years,but remains relatively high in *** particular,the increasing contribution of organic compounds to PM_(2.5)generates popular pressure for further reductions,resulting in an urgent need to study organic aerosol(OA).To investigate the molecular composition and source contribution of OA in the rural area of the Guanzhong Plain,Northwest China,PM_(2.5)samples were collected during 3–23 August 2016 and 5–20 January 2017 and studied for more than 100 organic tracer *** mean concentration of total measured organic compounds is 662±296 ng/m^(3)in summer and 3258±1925 ng/m^(3)in *** is the most abundant single compound found throughout the sampling period,which is a crucial tracer for biomass burning emissions,preliminary suggesting that biomass burning is an essential source of *** summer,organic compounds such as lipid compounds,sugar compounds,and polycyclic aromatic hydrocarbons(PAHs),more come from higher plants,wood burning,vehicle exhausts,plastic waste,and other direct emission *** PAHs(OPAHs),nitrophenols,and phthalic acids more come from the atmosphere through the oxidation reaction of aromatic precursors,especially photochemical ***,in winter,most of the increases in concentrations of organic compounds are attributed to biomass *** analysis of a haze event(14–19 January 2017)during the winter sampling period shows that the increases in the concentration of organic compounds are unaccompanied by strong secondary formation under lower relative humidity(49.1%±13.5%).The main reason for the growth of OA in this haze event is the accumulation of primary OA(POA).The source apportionment by the positive matrix factorization(PMF)model shows that biomass burning(37.1%)is the primary source of OA in the rural regions of the Guanzhong Plain,especially in winter(40.6%).The contribution of secondary formation decreases from 26.0%in summer t

关键词： Organic aerosol Molecular composition Seasonal variation Source apportionment Guanzhong Plain

Solvothermal syntheses,and crystal structures of Chromiu（Ⅲ） complexes of AsS33- ligand

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Solvothermal syntheses,and crystal structures of Chromiu（Ⅲ...