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Changes in genioglossus and their association with serum adiponectin levels in rats subjected to chronic intermittent hypoxia

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Chinese Medical Journal 2010年第16期123卷 2249-2253页

作者： ZHANG Xiao-feng WANG Ya-hui LI Qin ZHANG Xi-long shen jiu-cheng LI Chong LIU Hao Department of Respiratory Medicine First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China Department of Respiratory Medicine Third Affiliated Hospital of Suzhou Unversity Changzhou Jiangsu 213003 China

Background The genioglossus （GG） is involved in the maintenance of an open airway for effective *** the pathogenesis of obstructive sleep apnea hypopnea syndrome （OSAHS） was closely associated with GG dysfunction,its causes and possible treatment have not been *** aim of the study was to investigate the effects of chronic intermittent hypoxia （CIH） on serum adiponectin levels, electromyograph （EMG） activity and ultrastructure of GG, as well as the effect of an adiponectin supplement in anesthetized *** Forty-two healthy male Wistar rats were randomly divided into normal control （A）, CIH （B） and adiponectin treatment （C） groups, 14 rats in each *** was performed eight hours per day for five weeks in both groups B and *** C received transvenous injection of adiponectin at the dosage of 10 μg per injection, twice a week for five *** the end of the 5th week the GG EMG voltage was measured and compared among the three *** electron microscope was used to observe the ultrastructure of the *** CIH caused significant hypoadiponectinemia, weakened activity of GG EMG at both baseline and hypoxia stimulation, and induced ultrastructural pathological changes, such as, myofibril discontinuities, lysis of myofilament,edema of mitochondria and disruption of cristae, vacuolus and lysis of some *** supplement of adiponectin improved the above pathological changes resulting from *** CIH resulted in pathological changes in GG＇s EMG and ultrastructure, which could be improved by supplement of adiponectin and be associated with hypoadiponectinemia caused by ClH.

关键词： intermittent hypoxia genioglossus adiponectin obstructive sleep apnea syndrome

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Correlation of Epworth Sleepiness Scale with multiple sleep latency test and its diagnostic accuracy in assessing excessive daytime sleepiness in patients with obstructive sleep apnea hypopnea syndrome

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Chinese Medical Journal 2013年第17期126卷 3245-3250页

作者： CAI Si-jie CHEN Rui ZHANG Yan-lin XIONG Kang-ping LIAN Yi-xin LI Jie shen jiu-cheng LIU Chun-feng Department of Respiratory Medicine Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China Department of Neurology Medicine Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China Department of Respiratory Medicine First People's Hospital of Kunshan Kunshan Jiangsu 215300 China Laboratory of Aging and Nervous Diseases Institute of Neuroscience Soochow University Suzhou Jiangsu 215004 China

Background Excessive daytime sleepiness （EDS） is often associated with obstructive sleep apnea hypopnea syndrome （OSAHS） and contributes to a number of comorbidities in these patients. Therefore, early detection of EDS is critical in disease management. We examined the association between Epworth Sleepiness Scale （ESS） and multiple sleep latency test （MSLT） and diagnostic accuracy of ESS in assessing EDS in OSAHS patients. Methods The ESS, MSLT and overnight polysomnography were administered to 107 Chinese patients to assess EDS and its correlations with polysomnographic parameters. The diagnostic accuracy of ESS in classifying EDS （mean sleep latency （MSL）〈10 minutes） was evaluated by calculating the area under ROC curve. Results As the severity of OSAHS increased, MSL decreased with increase in ESS score. Conversely, patients with worsening EDS （shorter MSL） were characterized by advanced nocturnal hypoxaemia and sleep disruption compared to those with normal MSL, suggesting EDS is associated with more severe OSAHS. There was a negative correlation between ESS score and MSL and both moderately correlated with some polysomnographic nocturnal hypoxaemic parameters. The area under ROC curve of ESS for identifying EDS was 0.80 （95% CI： 0.71 to 0.88） and ESS score 〉12 provided the best predictive value with a sensitivity of 80% and specificity of 69%. Conclusion The ESS score moderately correlates with MSL and our ROC study supports ESS as a screening strategy for assessing EDS in OSAHS.

关键词： obstructive sleep apnea hypopnea syndrome excessive daytime sleepiness multiple sleep latency test Epworth Sleepiness Scale polysomnography

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慢性间歇低氧对大鼠颏舌肌细胞线粒体功能的影响及脂联素的干预作用

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中华结核和呼吸杂志 2011年第1期34卷 21-25页

作者：李勤李翀沈久成刘皓黄茂张希龙南京医科大学第一附属医院呼吸科 210029 常州市第一人民医院呼吸科

目的探讨慢性间歇低氧（CIH）对大鼠颏舌肌细胞线粒体功能的影响及脂联素干预作用.方法健康雄性Wistar大鼠39只,采用随机数字表法分成健康对照（NC）组、CIH组、CIH脂联素干预组（CIH＋Ad组）,每组13只.NC组大鼠呼吸正常空气,CIH组与... 详细信息

目的探讨慢性间歇低氧（CIH）对大鼠颏舌肌细胞线粒体功能的影响及脂联素干预作用.方法健康雄性Wistar大鼠39只,采用随机数字表法分成健康对照（NC）组、CIH组、CIH脂联素干预组（CIH＋Ad组）,每组13只.NC组大鼠呼吸正常空气,CIH组与CIH＋Ad组均接受CIH环境（CIH 8 h/d,共5周）,CIH＋Ad组加用经静脉脂联素注射10 μg/次,2次/周,共5周.于实验终止（第35天）时测定并比较各组大鼠血清脂联素浓度、颏舌肌线粒体膜电位、线粒体复合物Ⅰ活性、线粒体复合物Ⅳ活性.结果 CIH组血清脂联素浓度明显低于NC组[（1108±112）ng/ml,（2241±121）ng/ml,P＜0.01];CIH＋Ad组高于CIH组[（1889±119）ng/ml]但低于NC组[（2241±121）ng/ml,均P＜0.01].CIH组颏舌肌线粒体膜电位相对值（1.82±0.11）明显低于NC组（2.09±0.14,P＜0.01）,CIH＋Ad组（1.98±0.09）较CIH组略高但低于NC组,差异均有统计学差异（均P＜0.05）.CIH组线粒体复合物Ⅰ、Ⅳ浓度[（35.68±1.73）μmol·min-1·mg-1,（2.37±0.11）nmol·min-1·mg-1]最低,CIH＋Ad组[（37.18±1.95）μmol·min-1·mg-1,（2.49±0.09）nmol·min-1·mg-1]及NC组[（39.02±1.38）μmol·min-1·mg-1,（2.81±0.12）nmol·min-1·mg-1]依次增高.NC组与CIH组比较差异有统计学意义（P＜0.01）,CIH＋Ad组与CIH组和NC组比较差异有统计学意义（均P＜0.05）.结论 CIH可致大鼠血清脂联素水平降低,并能显著损伤颏舌肌细胞线粒体功能,补充外源性脂联素能部分改善CIH对大鼠颏舌肌细胞线粒体功能的损伤,提示低脂联素血症可能参与CIH导致的颏舌肌能量代谢障碍.

关键词：慢性间歇低氧脂联素基因,线粒体颏舌肌

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阻塞性睡眠呼吸暂停综合征与冠心病相关性的研究进展

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国际呼吸杂志 2008年第24期28卷 1534-1536页

作者：沈久成张希龙南京医科大学第一附属医院呼吸科 210029

阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea syndrome，OSAS）一种发病率高、具有潜在危险性的疾病。近年研究显示OSAS与冠心病（coronary heart disease、CHD）关系密切，是CHD的独立危险因素，充分认识OSAS引起和促进CHD的... 详细信息

阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea syndrome，OSAS）一种发病率高、具有潜在危险性的疾病。近年研究显示OSAS与冠心病（coronary heart disease、CHD）关系密切，是CHD的独立危险因素，充分认识OSAS引起和促进CHD的发病机制，可以为OSAS相关CHD的防治提供重要的理论依据和新思路。

关键词：睡眠呼吸暂停阻塞性冠心病发病机制

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Localizing base stations with measured data:a concatenated image-based deep learning approach

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Science China(Information Sciences) 2025年

作者： Yang CHEN Ziyuan LIU Feng JIANG Hong shen Wei XU Mengyu LI Ritao cheng National Mobile Communications Research Laboratory Southeast University China Mobile Group Design Institute Co. Ltd.

Localization has become an indispensable function of modern cellular communication systems[1]. In a cloud radio access network （C-RAN）, the remote radio head （RRH） is the actual signal transmitter, whose location ...

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抗病毒治疗艾滋病患者HIV相关性痴呆量表测试分析

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昆明医科大学学报 2017年第12期38卷 125-129页

作者：杨永锐冯煜沈九成沈凌昆明市第三人民医院云南昆明650041 云南省药物依赖防治研究所云南昆明650034 昆明医科大学公共卫生学院云南昆明650500

目的探讨影响HIV/AIDS抗病毒治疗患者国际HIV相关性痴呆量表(IHDS)评分的相关因素,为HIV/AIDS干预提供基础数据.方法选取2015年11月至2016年11月昆明市第三人民医院收治入院,且年龄小于60周岁的HIV血清阳性的抗病毒治疗患者,随机抽取20... 详细信息

目的探讨影响HIV/AIDS抗病毒治疗患者国际HIV相关性痴呆量表(IHDS)评分的相关因素,为HIV/AIDS干预提供基础数据.方法选取2015年11月至2016年11月昆明市第三人民医院收治入院,且年龄小于60周岁的HIV血清阳性的抗病毒治疗患者,随机抽取200例进行IHDS的量表调查研究活动.结果数据经过统计处理和分析后,全体调查对象的IHDS得分为(8.12±1.93)分;按照调查对象的不同特征比较,年纪小的调查对象(≤50岁)得分为(8.81±1.82),高于年长(51~60岁)的得分(8.10±2.09),(t=2.470,P=0.010);民族中,汉族得分为(9.43±1.64),高于其他民族的(8.89±1.77),(t=-9.310,0.038);文化程度,小学未毕业得分为(7.21±1.25),其他文化程度的得分为(9.55±1.47),(t=-7.841,P=0.001);饮酒情况,饮酒者得分为(8.36±1.48),低于非饮酒者的(9.35±1.67),(t=3.125,P=0.027).数据通过多元线性回归分析方法处理后,结果显示,患者的年龄和饮酒与IHDS得分成负相关,而文化程度则呈现正相关,抗病毒治疗时间对该量表的得分无相关关系.结论艾滋病抗病毒治疗患者的年龄、文化程度和饮酒状况等因素对IHDSHIV相关性痴呆量表得分影响较大,但是,调查对象的抗病毒治疗时间对该评分影响不大.

关键词： HIV相关性痴呆量表抗病毒治疗艾滋病患者测试分析相关因素

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脂肪型脂肪酸结合蛋白与阻塞性睡眠呼吸暂停综合征患者血脂异常的关系

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中华医学杂志 2012年第2期92卷 94-97页

作者：王永滨陈锐张艳林李洁沈久成熊康平刘春风苏州大学附属第二医院呼吸睡眠中心江苏省苏州市215004

目的探讨阻塞性睡眠呼吸暂停综合征（OSAS）患者血清中脂肪型脂肪酸结合蛋白（A-FABP）水平与血脂异常的关系.方法收集2010年11月至2011年5月因打鼾在苏州大学附属第二医院呼吸睡眠中心行多导睡眠监测的患者80例,其中男63例,女17例；... 详细信息

目的探讨阻塞性睡眠呼吸暂停综合征（OSAS）患者血清中脂肪型脂肪酸结合蛋白（A-FABP）水平与血脂异常的关系.方法收集2010年11月至2011年5月因打鼾在苏州大学附属第二医院呼吸睡眠中心行多导睡眠监测的患者80例,其中男63例,女17例；年龄22～77岁,平均（48±14）岁.按呼吸暂停低通气指数（AHI）将患者分为3组：单纯鼾症组（AHI＜5次/h）19例,轻中度OSAS组（5次/h≤AHI≤40次/h）22例,重度OSAS组（AHI＞ 40次/h）39例.测定空腹血中A-FABP及血总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）水平,分析A-FABP与血脂水平和睡眠呼吸参数的相关性.结果重度OSAS组血清A-FABP水平为（20.4±4.6）μg/L,明显高于单纯鼾症组的（15.7±3.3）μg/L和轻中度OSAS组的（17.3±4.3）μg/L（P =0.001和P=0.026）.经校正年龄、体质指数之后,血清A-FABP与血TC、TG、LDL-C水平呈正相关（r=0.469、0.239、0.366,P=0.000、0.035、0.001）;血清A-FABP水平与睡眠呼吸暂停低通气指数和夜间动脉血氧饱和度（ SaO2）＜90％时间呈正相关（r=0.231,P=0.042和r=0.226,P=0.047）,与最低SaO2和平均SaO2呈负相关（r=-0.234,P=0.039和r=- 0.270,P=0.017）.结论 OSAS患者存在血脂异常及血清A-FABP水平的增高,血清A-FABP水平与OSAS患者的严重程度及低氧参数相关,提示血清A-FABP可能参与OSAS血脂异常的发生.

关键词：睡眠呼吸暂停综合征脂肪酸结合蛋白质类血脂异常

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Remaining Life Prediction Method for Photovoltaic Modules Based on Two-Stage Wiener Process

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Energy Engineering 2025年第1期122卷 331-347页

作者： Jie Lin Hongchi shen Tingting Pei Yan Wu School of Electrical Engineering and Information Engineering Lanzhou University of TechnologyLanzhou730050China

Photovoltaic (PV) modules, as essential components of solar power generation systems, significantly influence unitpower generation *** service life of these modules directly affects these costs. Over time, the performanceof PV modules gradually declines due to internal degradation and external environmental *** cumulativedegradation impacts the overall reliability of photovoltaic power generation. This study addresses the complexdegradation process of PV modules by developing a two-stage Wiener process model. This approach accountsfor the distinct phases of degradation resulting from module aging and environmental influences. A powerdegradation model based on the two-stage Wiener process is constructed to describe individual differences inmodule degradation processes. To estimate the model parameters, a combination of the Expectation-Maximization(EM) algorithm and the Bayesian method is employed. Furthermore, the Schwarz Information Criterion (SIC) isutilized to identify critical change points in PV module degradation trajectories. To validate the universality andeffectiveness of the proposed method, a comparative analysis is conducted against other established life predictiontechniques for PV modules.

关键词： Photovoltaic modules degradation stochastic processes lifetime prediction

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Optimizing Fine-Tuning in Quantized Language Models:An In-Depth Analysis of Key Variables

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Computers, Materials & Continua 2025年第1期82卷 307-325页

作者： Ao shen Zhiquan Lai Dongsheng Li Xiaoyu Hu National Key Laboratory of Parallel and Distributed Computing National University of Defense TechnologyChangsha410073China Strategic Assessments and Consultation Institute Academy of Military ScienceBeijing100091China

Large-scale Language Models(LLMs)have achieved significant breakthroughs in Natural Language Processing(NLP),driven by the pre-training and fine-tuning *** this approach allows models to specialize in specific tasks with reduced training costs,the substantial memory requirements during fine-tuning present a barrier to broader ***-Efficient Fine-Tuning(PEFT)techniques,such as Low-Rank Adaptation(LoRA),and parameter quantization methods have emerged as solutions to address these challenges by optimizing memory usage and computational *** these,QLoRA,which combines PEFT and quantization,has demonstrated notable success in reducing memory footprints during fine-tuning,prompting the development of various QLoRA *** these advancements,the quantitative impact of key variables on the fine-tuning performance of quantized LLMs remains *** study presents a comprehensive analysis of these key variables,focusing on their influence across different layer types and depths within LLM *** investigation uncovers several critical findings:(1)Larger layers,such as MLP layers,can maintain performance despite reductions in adapter rank,while smaller layers,like self-attention layers,aremore sensitive to such changes;(2)The effectiveness of balancing factors depends more on specific values rather than layer type or depth;(3)In quantization-aware fine-tuning,larger layers can effectively utilize smaller adapters,whereas smaller layers struggle to do *** insights suggest that layer type is a more significant determinant of fine-tuning success than layer depth when optimizing quantized ***,for the same discount of trainable parameters,reducing the trainable parameters in a larger layer is more effective in preserving fine-tuning accuracy than in a smaller *** study provides valuable guidance for more efficient fine-tuning strategies and opens avenues for further research into optimizing LLM

关键词： Large-scale Language Model Parameter-Efficient Fine-Tuning parameter quantization key variable trainable parameters experimental analysis

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa shen Chang cheng Yu-Han Wang Wen-Chao cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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