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Chinese Journal of Cancer Research 2021年第3期33卷 289-301页

作者： Jun Zhu Jun Ma Union for china Lymphoma Investigators of Chinese Society of Clinical Oncology Zhixiang shen Zifen Gao Huiqiang Huang Xiaoqiu Li Yexiong Li Lugui Qiu Weili zhao Qingyuan Zhang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China department of Hematology&Oncology Harbin Institute of Hematology&OncologyHarbin 150010China 不详 Peking university Health Science Center Sun Yat-sen university Cancer Center Fudan university shanghai Cancer Center Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Science and Peking Union Medical College Ruijin Hospital affiliated to shanghai jiao tong university School of Medicine Harbin Medical university Cancer Hospital

1. General guidelines2. Diagnosis3. Staging4. Treatment4.1 Diffuse large B-cell lymphoma(DLBCL)4.2 Follicular lymphoma(FL)4.3 Mantle cell lymphoma(MCL)4.4 Marginal zone lymphoma(MZL)4.5 Burkitt lymphoma(BL)4.6 CLL/Small lymphocytic lymphoma(SLL)4.7 Extra-nodal natural killer/T-cell lymphoma(ENKTCL), nasal type4.8 Peripheral T-cell lymphoma(PTCL)4.9 HL4.10 Primary central nervous system lymphoma5. Prognosis Lymphomas are a group of heterogeneous diseases.

关键词： lymphoma diagnosis lymphocytic

Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor

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World Journal of Gastroenterology 2010年第37期16卷 4716-4724页

作者： Yun Zhang Hui Cao Ming Wang Wen-Yi zhao Zhi-Yong shen Dan-Ping shen Xing-Zhi Ni Zhi-Yong Wu Yan-Ying shen Yan-Yan Song department of General Surgery Ren Ji Hospital shanghai jiao tong university School of Medicine shanghai 200127 china department of Pathology china Section of Statistics Teaching and Research Shanghai Jiao Tong University School of MedicineShanghai 200025China

AIM: To investigate loss of heterozygosity (LOH) of chromosome 9p21 and the prognostic relevance of p16 expression in gastrointestinal stromal tumor (GIST). METHODS: Fifty-one GIST patients (30 men and 21 women; median age 59 years; range 29-80 years) treated surgically within a 10-year period were grouped by aggressive behavior risk (17 with very low and low, 14 intermediate, and 20 high risk). GISTs were characterized immunohistochemically and evaluated for LOH of 9p21 by microsatellite analysis at D9S1751, D9S1846, D9S942, and D9S1748. LOH of 9p21 and immunohistochemicalexpression of p16 protein encoded at 9p21 were correlated with clinicopathological parameters, and the prognostic significance of p16 alterations was evaluated. RESULTS: Thirty-one (63.3%) cases showed LOH with at least one microsatellite marker. LOH frequency was 37.0% at D9S1751, 37.5% at D9S1846, 42.1% at D9S942, and 24.2% at D9S1748. There was a higher LOH frequency of D9S942 in high-risk than in non-highrisk tumors (P 18/20) of the GIST patients in the high risk group showed LOH with at least one of the 9p21 markers, while 57.1% (8/14) in the intermediate risk group and 33.3% (5/15) in the very low and low risk groups, respectively (P 12.16). Eight (28.5%) of 31 patients with LOH and 1 (5.6%) of 18 patients without LOH died of the disease during the follow-up period. Loss of p16 protein expression occurred in 41.2%, but in 60% of the high risk group and 23.5% of the very low and low risk groups (P 16 loss was associated with poor prognosis (P 18): the 3and 5-year overall survival rates were 84.8% and 70.8% for p16-negative and 100% and 92.0% for p16-positive patients, respectively. CONCLUSION: LOH at 9p21 appears to play an important role in GIST progression; decreased p16 expression in GIST is highly predictive of poor outcome.

关键词： Gastrointestinal stromal tumor Loss of heterozygosity p16 Prognosis Tumor suppressor gene

Angle-Resolved Plasmonic Properties of Single Gold Nanorod Dimers

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Nano-Micro Letters 2014年第4期6卷 372-380页

作者： Jian Wu Xuxing Lu Qiannan Zhu Junwei zhao Qishun shen Li Zhan Weihai Ni department of physics and Astronomy Key Laboratory for Laser Plasmas (Ministry of Education) State Key Lab of Advanced Optical Communication Systems and NetworksShanghai Jiao Tong University Division of i-Lab Key Laboratory for Nano-Bio Interface Research & Collaborative Innovation Center of Suzhou Nano Science and Technology Suzhou Institute of Nano-Tech & Nano-Bionics Chinese Academy of Sciences

Through wet-chemical assembly methods, gold nanorods were placed close to each other and formed a dimer with a gap distance *1 nm, and hence degenerated plasmonic dipole modes of individual nanorods coupled together to produce hybridized bonding and antibonding resonance modes. Previous studies using a condenser for illumination result in averaged signals over all excitation angles. By exciting an individual dimer obliquely at different angles, we demonstrate that these two new resonance modes are highly tunable and sensitive to the angle between the excitation polarization and the dimer orientation, which follows cos2 u dependence. Moreover, for dimer structures with various structure angles, the resonance wavelengths as well as the refractive index sensitivities were found independent of the structure angle. Calculated angle-resolved plasmonic properties are in good agreement with the measurements. The assembled nanostructures investigated here are important for fundamental researches as well as potential applications when they are used as building blocks in plasmon-based optical and optoelectronic devices.

关键词： Plasmonics Gold nanorods Self-assembly

Identification and analysis of a minority fraction in a U87 cell line Do side-population cells represent bona fide stem cell-like cancer cells?

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Neural Regeneration Research 2009年第11期4卷 805-813页

作者： Changwei Gu Qingfang Sun Jiang Zhu Liuguan Bian Weiguo zhao Jiankang shen HengGao Dongxia Feng l lnternational Cooperation of Neuro-centre in Jiangyin People's HospitaI Jiangyin 214400 Jiangsu Province China department of Neurosurgery Ruijin Hspitaal School of Medicine Shanghai Jiao Tong University Shanghai 200025 China shanghai Institute of Hematology Ruijin Hospital Shanghai 200025 China

BACKGROUND： Overwhelming evidence suggests that tumor bulks are comprised of differentiated tumor cells and cancer stem cells （CSCs）. The stem cell-like side-population （SP） cells account for a minor fraction of the total tumor cells, yet are apparently the cells capable of tumor initiation, growth, maintenance, and recurrence. OBJECTIVE： To identify potential stem cell-like cancer cells in a U87 human brain glioma cell line on the basis of dye efflux, clone formation, and multi-drug resistance capacity. DESIGN, TIME AND SETTING： The cellular and molecular biology experiment was performed at the Laboratory of shanghai Institute of Hematology and Laboratory of shanghai Institute of Endocrinology in Ruijin Hospital; in vivo contrast observational animal trial was performed at Experimental Animal Center, School of Medicine, shanghai jiao tong university from June 2007 to May 2008. MATERIALS： The U87 cell line was provided by the shanghai Institute of Cancer Research, Chinese Academy of Science; DMEM/F12 （1 ： 1） and fetal bovine serum were purchased from Gibco Invitrogen, USA; human recombinant basic fibroblast growth factors were purchased from BD Bioscience, USA; Hoechst 33342, Verapamil, and methyl thiazolyl tetrazolium were purchased from Sigma, USA; phycoerythrin-labeled anti-human-CD133 was purchased from Milteny Biotec, Germany; SYBR PrimeScriptTM RT-PCR kit was purchased from TaKaRa Biotechnology, Dalian, china. METHODS： Monolayer cultured cells were harvested by 0.25% Trypsin-EDTA and suspended at a 1 ×10^6/mL dilution in PBS containing 2% FBS, and were stained with Hoechst 33342 dye, either alone or in combination with Verapamil. Following fluorescence-activated cell sorting, SP and non-SP subsets were cultivated with serum-containing （DMEM plus 10% fetal bovine serum） or serum-free culture medium [DMEM/F12 （1： 1）＋ 1× B27 supplement ＋ 10 ng/mL basic fibroblast growth factors ＋ 1× L-glutamine] to determine growth characteristics in vitro. Finally, single free

关键词： cancer stem cells tumor-initiating cells side population glioma CD133

Weak decays of doubly heavy baryons:"decay constants"

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Chinese physics C 2018年第12期42卷 9-18页

作者： Xiao-Hui nu Yue-Long shen Wei Wang Zhen-Xing zhao INPAC Shanghai Key Laboratory for Particle Physics and CosmologyMOE Key Laboratory for Particle PhysicsAstrophysics and CosmologySchool of Physics and AstronomyShanghai Jiao-Tong UniversityShanghai 200240China College of Information Science and Engineering Ocean University of ChinaQingdao 266100China

Inspired by the recent observation of the ∑c^＋c^＋ by the LHCb Collaboration, we explore the ＂decay constants＂ of doubly heavy baryons in the framework of QCD sum rules. With the ∑cc,∑bb, and Ωcc,Ωbc,Ωbb baryons interpolated by three-quark operators, we calculate the correlation functions using the operator product expansion and include the contributions from operators up to dimension six. On the hadron side, we consider both contributions from the lowest-lying states with J^P 1/2^＋ and from negative parity baryons with JP=1/2^-. We find that the results are stable and the contaminations from negative parity baryons are not severe. These results are ingredients for the QCD study of weak decays and other properties of doubly-heavy baryons.

关键词： doubly heavy baryons decay constant QCD sum rules

The galaxy luminosity function in the LAMOST Complete Spectroscopic Survey of Pointing Area at the Southern Galactic Cap

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Research in Astronomy and Astrophysics 2019年第8期19卷 69-80页

作者： Pin-Song zhao Hong Wu Cong Kevin Xu Ming Yang Fan Yang Yi-Nan Zhu Man I Lam Jun-Jie Jin Hai-Long Yuan Hao-tong Zhang Shi-Yin shen Jian-Rong Shi A-Li Luo Xue-Bing Wu Yong-Heng zhao Yi-Peng Jing Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing100049China Chinese Academy of Sciences South America Center for Astronomy China-Chile Joint Center for AstronomyCamino El Observatorio1515Las CondesSantiagoChile IAASARS National Observatory of AthensVas.Pavlou&I.MetaxaPenteli15236Greece Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy ofSciencesShanghai200030China department of Astronomy School of PhysicsPeking UniversityBeijing100871China School of physics and Astronomy Shanghai Jiao Tong UniversityShanghai200240China

We present optical luminosity functions(LFs) of galaxies in the0.1 g,0.1 r,0.1 i bands, calculated using data in40 deg2 sky area of the LAMOST Complete Spectroscopic Survey of Pointing Area(LaCoSSPAr) in the Southern Galactic Cap. Redshifts for galaxies brighter than r = 18.1 were obtained mainly with LAMOST. In each band, LFs derived using both parametric and non-parametric maximum likelihood methods agree well with each other. In the0.1 r band, our fitting parameters of the Schechter function are φ*=(1.65 ± 0.36) × 10-2 h3 Mpc-3, M*=-20.69 ± 0.06 mag and α =-1.12 ± 0.08,which agree with previous studies. Separate LFs are also derived for emission line galaxies and absorption line galaxies. The LFs of absorption line galaxies show a dip at0.1 r 18.5 and can be fitted well by a double-Gaussian function, suggesting a bimodality in passive galaxies.

关键词： galaxies:luminosity function,mass function galaxies:statistics galaxies:distances and redshifts

老年男性2型糖尿病患者游离三碘甲状腺原氨酸水平与左心室舒张功能不全相关

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诊断学理论与实践 2024年第2期23卷 155-161页

作者：缪婕王巍赵雅洁张凤如沈琳辉上海交通大学医学院附属瑞金医院老年病科上海200025

目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)老年男性患者的甲状腺激素水平与其左心室舒张功能不全(left ventricular diastolic dysfunction,LVDD)间的相关性。方法:选取2020年1月至2021年11月在我院老年病科住院的208例老年男... 详细信息

目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)老年男性患者的甲状腺激素水平与其左心室舒张功能不全(left ventricular diastolic dysfunction,LVDD)间的相关性。方法:选取2020年1月至2021年11月在我院老年病科住院的208例老年男性T2DM患者(≥60岁),根据超声心动图组织多普勒及血流多普勒结果,参照2020年《超声心动图评估心脏收缩和舒张功能临床应用指南》将其分为LVDD组(112例)和左心室舒张功能正常对照组(对照组,96例),比较2组间的基线资料、甲状腺激素水平、超声心动图指标。再根据游离三碘甲状腺原氨酸(free triiodothyronine,FT_(3))四分位数水平,将全部患者分为F1组(2.43 pmol/L1 pmol/L1 pmol/L,52例),比较4组间的基线资料和超声心动图指标。采用Pearson相关分析观察FT_(3)与超声指标间的相关性,用多因素logistic回归分析FT_(3)与LVDD间的关系,绘制受试者工作特征(receiver operating characteristic,ROC)曲线,评估FT_(3)和logistic回归模型诊断LVDD的效能。结果:老年男性T2DM患者中,LVDD组较对照组FT_(3)水平降低[(3.51±0.24)pmol/L比(4.72±0.33)pmol/L,P1]。根据FT_(3)水平四分位数分组,4组间的LVDD百分比(P1)、超声心动图参数二尖瓣口舒张早期血流峰值速度E峰与二尖瓣环舒张早期运动峰值速度e’峰比值(E/e’)(P1)差异均有统计学意义。Pearson相关分析显示,FT_(3)水平与E/e’、左房最大容积指数(left atrial volume index,LAVI)呈显著负相关(P均1)。多因素Logistic回归分析显示,随着老年男性T2DM患者的FT_(3)水平递减,其发生LVDD的风险逐渐增加(F3组OR=2.29;F2组OR=3.36;F1组OR=4.95,P均1c)水平、糖尿病病程、FT_(3)水平进入Logistic回归分析模型,ROC曲线分析显示,FT_(3)和Logistic回归分析模型诊断LVDD的曲线下面积为0.742和0.858;FT_(3)的临界值取3.37 pmol/L时,其提示患者出现LVDD的灵敏度为66.2%,特异度为75.0%。结论:老年男性T2DM患者的FT_(3)水平降低时,LVDD风险上升,检测FT_(3)可能有助于早期筛查LVDD。

关键词： 2型糖尿病左心室舒张功能不全游离三碘甲状腺原氨酸

^(18)F-FDG PET/CT RECIL与Lugano标准对弥漫大B细胞淋巴瘤中期疗效与预后评估的价值

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国际放射医学核医学杂志 2024年第3期48卷 141-148页

作者：乔文礼汪太松孙娜沈丽娟赵晋华上海交通大学医学院附属第一人民医院核医学科上海200080

目的探讨^(18)F-氟脱氧葡萄糖(FDG)PET/CT淋巴瘤疗效评价标准(RECIL)与Lugano标准对弥漫大B细胞淋巴瘤(DLBCL)中期疗效与预后评估的价值。方法回顾性分析2008年1月至2020年12月于上海交通大学医学院附属第一人民医院经组织病理学检查证... 详细信息

目的探讨^(18)F-氟脱氧葡萄糖(FDG)PET/CT淋巴瘤疗效评价标准(RECIL)与Lugano标准对弥漫大B细胞淋巴瘤(DLBCL)中期疗效与预后评估的价值。方法回顾性分析2008年1月至2020年12月于上海交通大学医学院附属第一人民医院经组织病理学检查证实为DLBCL且在治疗前及中期(3~4个疗程)化疗后行^(18)F-FDG PET/CT检查的82例患者的临床资料和影像资料,其中男性40例、女性42例,年龄(53.9±16.6)岁。依据RECIL在中期化疗后对所有患者进行疗效评价,包括完全缓解(CR)、部分缓解(PR)、轻微缓解(MR)、疾病稳定(SD)、疾病进展(PD),将MR患者分别定义为PR或SD。再依据Lugano标准在中期化疗后对所有患者进行疗效评价,包括CR、PR、SD、PD。CR和PR患者归为缓解组,SD和PD患者归为未缓解组。采用Kappa检验比较RECIL和Lugano标准的一致性;采用Kaplan-Meier生存分析比较RECIL和Lugano标准缓解组与未缓解组患者的预后;采用Log-rank检验比较RECIL和Lugano标准的组间差异;采用单因素、多因素Cox比例风险回归分析筛选影响患者预后的因素。结果当MR患者定义为PR时,RECIL与Lugano标准的一致性为92.7%(76/82),一致性较好(Kappa值=0.855,P1)。当MR患者定义为SD时,二者的一致性为90.2%(74/82),一致性也较好(Kappa值=0.811,P1)。Lugano标准、RECIL(MR定义为PR)、RECIL(MR定义为SD)缓解组患者的2年无进展生存(PFS)率(69.7%对0、71.4%对0、71.2%对0)和总生存(OS)率(88.2%对33.3%,87.0%对40.0%,90.4%对33.3%)均明显高于未缓解组,且差异均有统计学意义(χ2=14.540~65.446,均P1)。多因素Cox比例风险回归分析显示,年龄、RECIL(MR患者定义为SD)均是影响DLBCL患者中期治疗后PFS率的危险因素[风险比(HR)=1.050、3.527,均P1],RECIL未缓解组患者进展的风险是缓解组患者的3.527倍。年龄、Ann Arbor分期、RECIL(MR患者定义为SD)均是影响DLBCL患者中期治疗后OS率的危险因素(HR=1.097、1.884、4.739,均P<0.05),RECIL未缓解组患者死亡的风险是缓解组患者的4.739倍。结论RECIL与Lugano标准对DLBCL患者中期治疗后疗效评估的一致性较好,RECIL能在DLBCL患者的预后预测中提供有价值的信息。

关键词：淋巴瘤,大B细胞,弥漫性氟脱氧葡萄糖F18 正电子发射断层显像术体层摄影术,X线计算机治疗反应预后

原发性胸膜弥漫大B细胞淋巴瘤伴免疫性血小板减少症一例并文献复习

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白血病．淋巴瘤 2018年第4期27卷 238-242页

作者：吴文王黎沈杨赵维莅童建华上海交通大学医学院附属瑞金医院血液科 200025 上海交通大学医学院附属瑞金医院中心实验室 200025

目的探讨原发性胸膜弥漫大B细胞淋巴瘤（DLBCL）的临床特征、实验室检查及诊治经过，分析免疫性血小板减少症（ITP）与淋巴瘤的关系，以提高对该罕见病的诊断水平。方法分析上海交通大学医学院附属瑞金医院收治的1例原发性胸膜DLBCL伴IT... 详细信息

目的探讨原发性胸膜弥漫大B细胞淋巴瘤（DLBCL）的临床特征、实验室检查及诊治经过，分析免疫性血小板减少症（ITP）与淋巴瘤的关系，以提高对该罕见病的诊断水平。方法分析上海交通大学医学院附属瑞金医院收治的1例原发性胸膜DLBCL伴ITP患者的临床特点、诊治情况，并结合文献进行讨论。结果患者因反复胸闷气促6个月入院，完善相关检查（B型超声、胸部CT、PET-CT、胸腔积液穿刺等），临床主要特征仅发现胸腔积液，无其他部位病变，肝、脾、淋巴结均正常，胸腔积液病理诊断为DLBCL。患者既往诊断ITP30年。确诊后行R-CHOP方案化疗6次，中期评估胸腔积液完全吸收，疗效达完全缓解。结论原发性胸膜DLBCL较罕见，临床表现及影像学缺乏特异性，极易漏诊和误诊，确诊须依据组织病理学证据。ITP可先于淋巴瘤发生，也可以和淋巴瘤同时发生，少数患者可在罹患淋巴瘤的过程中发生ITP。

关键词：淋巴瘤大B-细胞弥漫性胸膜免疫性血小板减少症

磁有序CoH_(2)SeO_(4)薄片中的室温铁电性

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Science china Materials 2024年第5期67卷 1654-1660页

作者：陈璐秋余冰沈阳刘逸飞王号南冯光迪朱秋香罗卫东刘俊明万建国赵庆彪田博博褚君浩段纯刚 Key Laboratory of Polar Materials and Devices(MOE) Shanghai Center of Brain-inspired Intelligent Materials and Devicesand Department of ElectronicsEast China Normal UniversityShanghai200241China Zhejiang Lab Hangzhou310000China Laboratory of Solid State Microstructures and Innovation Center of Advanced Microstructures Nanjing UniversityNanjing210093China Key Laboratory of Artificial Structures and Quantum Control School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai200240China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan430205China State Key Laboratory of Infrared physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai200083China Institute of Optoelectronics Fudan UniversityShanghai200433China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan030006China

本文通过第一性原理计算和实验表征证明了二维CoH_(2)SeO_(4)薄膜的磁有序和滑移铁电性.首先,实验结果证实了粉末CoH_(2)SeO_(4)样品的反铁磁序.同时,第一性原理计算表明单层CoH_(2)SeO_(4)具有反铁磁(AFM-I)基态(TN≈75 K),且预测了二... 详细信息

本文通过第一性原理计算和实验表征证明了二维CoH_(2)SeO_(4)薄膜的磁有序和滑移铁电性.首先,实验结果证实了粉末CoH_(2)SeO_(4)样品的反铁磁序.同时,第一性原理计算表明单层CoH_(2)SeO_(4)具有反铁磁(AFM-I)基态(TN≈75 K),且预测了二维CoH_(2)SeO_(4)薄膜具有以不对称的三重势阱态为特征的滑移铁电性,并在实验中测得了180°压电滞回线、可反转铁电畴和二次谐波信号.此外,在基于二维CoH_(2)SeO_(4)薄膜的电容器中获得铁电材料所特有的电滞回线和蝴蝶状的电容曲线.介电温谱测试表明二维CoH_(2)SeO_(4)薄膜的铁电转变温度约为370 ***_(2)SeO_(4)中滑移铁电性和反铁磁性的出现为获得低维多铁材料指出了一条新的途径.

关键词： two-dimensional materials sliding ferroelectricity multiferroic materials