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High performance organic transistors and phototransistors based on diketopyrrolopyrrole-quaterthiophene copolymer thin films fabricated via low-concentration solution processing

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Chinese Chemical Letters 2018年第11期29卷 1675-1680页

作者： Pengcheng Gu Mengxiao Hu Shang Ding Guangyao zhao Yifan Yao Feng Liu Xiaotao Zhang Huanli Dong Xiangke Wang Wenping Hu Beijing Key Laboratory for Optical Materials and Photonic Devices Department of Chemistry Capital Normal University Beijing 100048 China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) & department of Chemistry School of Science Tianjin University Tianjin 300072 China College of Environmental Science and Engineering North China Electric Power University Beijing 102206 China department of physics &Astronautics Shonghai {2. tong university Shanghai 200240 China

Conjugated polymers have received considerable attentions over the past years due to their large-area potential applications via low-cost solution processing. Improving crystallinity of conjugated polymer molecules in solution-processed thin films is crucial for their efficient charge transport and thus high performance optoelectronic devices. Herein, with diketopyrrolopyrrole-quaterthiophene （PDQT） copo/ymer as an example, it is found that by simply reducing the solution concentration for spincoating meanwhile with the assistance of post-annealing, significantly enhanced film crystallinity with formation of typical single crystalline domains is obtained, which benefits from the enough space for better molecular assembly especially at the semiconductor/dielectric interface. High performance polymer transistors and phototransistors were finally constructed based on the optimal lowconcentration （2.mg/mL） spin-coated PDQT films （～12.nm）, which giving a high charge carrier mobility of 2.2. cm2.V-1 s-1 and a photoresponse on/off ratio of 2.1 ×107 at VG = 0 V under white light irradiation of 6mW/cm2. The results suggest that the bright future of PDQT crystalline films for large-area flexible integrated optoelectronic devices and the application of effective low-concentration processing approach in solution-processed organic electronics with reduced material waste.

关键词： Conjugated polymer Thin film Low-concentration processing Crystallinity Molecular orders Mobility Optoelectronic property

胸痛中心认证对急性ST段抬高型心肌梗死患者救治的影响

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第二军医大学学报 2019年第8期40卷 898-901页

作者：赵英英徐浩胡国勇高玮沈兵上海交通大学附属第一人民医院急诊危重病科上海200080 上海交通大学附属第一人民医院心内科上海200080 上海交通大学附属第一人民医院消化科上海200080 上海交通大学附属第一人民医院老年医学科上海200080 上海交通大学附属第一人民医院泌尿外科上海200080

目的比较胸痛中心模式认证前与认证后急性ST段抬高型心肌梗死(STEMI)的救治情况,为胸痛中心的建设提供依据。方法回顾分析上海交通大学附属第一人民医院胸痛中心认证前与认证后的急性STEMI患者救治数据,将2.17年1月至2.17年12.救治的11... 详细信息

目的比较胸痛中心模式认证前与认证后急性ST段抬高型心肌梗死(STEMI)的救治情况,为胸痛中心的建设提供依据。方法回顾分析上海交通大学附属第一人民医院胸痛中心认证前与认证后的急性STEMI患者救治数据,将2.17年1月至2.17年12.救治的119例患者纳入认证前组,2.18年1月至2.19年4月救治的160例患者纳入认证后组,比较两组患者基线资料、患者首次医疗接触到首份心电图时间、首份心电图确认时间、肌钙蛋白报告时间、导管室激活时间、入院到球囊扩张时间、住院时间、住院药品费、住院检查费、住院检验费、住院总费用、救治效果等的差异。结果两组患者性别、年龄、高血压病史和糖尿病史等一般资料差异均无统计学意义(P均>0.05)。两组患者导管室激活时间差异无统计学意义(P>0.05);认证后组患者首次医疗接触到首份心电图时间(Z=-7.2.7,P1)、首份心电图确认时间(Z=-5.072.P1)、肌钙蛋白报告时间(Z=-3.2.0,P=0.001)、入院到球囊扩张时间(Z=-7.02.,P1)均短于认证前组,差异均有统计学意义。两组患者住院时间、住院药品费、住院检查费、住院检验费、住院总费用和死亡率等指标差异均无统计学意义(P均>0.05)。结论通过胸痛中心模式认证和规范化运行可缩短急性STEMI患者救治时间。

关键词：胸痛中心急性ST段抬高型心肌梗死入院到球囊扩张时间经皮冠状动脉介入治疗

植入CIED患者选择社区随访的影响因素及其效果初探

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中华全科医师杂志 2023年第2期22卷 187-193页

作者：黄嘉慧沈红赵云玲叶晓景方红李悦赵伟沈娟范红利邱朝晖上海交通大学医学院附属同仁医院心血管内科上海200336 天山路街道社区卫生服务中心上海200336 仙霞街道社区卫生服务中心上海200336 周家桥街道社区卫生服务中心上海200336 虹桥街道社区卫生服务中心上海200336 北新泾街道社区卫生服务中心上海200336 程家桥街道社区卫生服务中心上海200336 新泾镇社区卫生服务中心上海200336

目的探讨植入心脏植入式电子器械(CIED)患者选择社区随访的影响因素及其效果。方法该研究为前瞻性队列研究。入选2.2.年2.至2.2.年2.在上海交通大学医学院附属同仁医院心内科CIED门诊及其签约的10家社区卫生服务中心进行随访的植入了C... 详细信息

目的探讨植入心脏植入式电子器械(CIED)患者选择社区随访的影响因素及其效果。方法该研究为前瞻性队列研究。入选2.2.年2.至2.2.年2.在上海交通大学医学院附属同仁医院心内科CIED门诊及其签约的10家社区卫生服务中心进行随访的植入了CIED的患者。在CIED门诊进行随访的患者纳入常规门诊随访组,有1次及以上社区卫生服务中心随访经历的患者纳入社区随访组。社区随访组与常规门诊随访组按照1∶3的比例进行匹配。通过问卷调查收集入选患者的基线临床资料,问卷由基本情况、随访情况、社区医疗情况3方面内容组成。通过CarelinkExpress电子随访平台及同仁医院CIED门诊信息系统提取患者随访相关数据。随访时调整了治疗方案或CIED参数定义为采取行动的随访(VWA),社区随访时发生了转诊也定义为VWA。随访终点为发生主要不良事件。采用多因素logistic回归模型分析患者选择社区随访的影响因素。结果共入选患者132.,其中社区随访组33例,男性16例(48.5%),年龄(79.5±8.0)岁;常规门诊随访组99例,男性48例(48.5%),年龄(80.8±7.2.岁。两组患者平时于社区卫生服务中心就诊频率差异有统计学意义,社区随访组患者社区医师签约率高于常规门诊随访组(均P2.143,95%CI:1.103~4.166,P=0.02.)。132.患者共计随访469次,其中社区随访45次,门诊随访42.次。社区随访组与常规门诊随访组发生VWA、主要不良事件和计划外随访的次数占比差异均无统计学意义(均P>0.05)。社区随访组步行至医院的患者占比明显高于常规门诊随访组(P<0.05),常规门诊随访组患者的主要交通方式为公交和打车,占比均高于社区随访组(均P<0.05)。社区随访组患者诊室外等待时间和单次随访所需总时间均明显短于常规门诊随访组(均P<0.05)。结论是否与社区医师签约是植入CIED患者选择社区随访的独立影响因素。此类患者社区随访的安全性与有效性与常规门诊随访相当,但社区随访更为便捷。

关键词：社区卫生服务随访心脏植入式电子器械

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.jiao J.K.jiao Z.jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy physics Chinese Academy of SciencesBeijing 100049China Beihang university Beijing 100191China Bochum Ruhr-university D-44780 BochumGermany Budker Institute of Nuclear physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon university PittsburghPennsylvania 15213USA Central China Normal university Wuhan 430079China Central South university Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China university of Geosciences Wuhan 430074China Chung-Ang university Seoul06974Republic of Korea COMSATS university Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan university Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal university Guilin 541004China Guangxi university Nanning 530004China Hangzhou Normal university Hangzhou 310036China Hebei university Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal university Xinxiang 453007China Henan university Kaifeng 475004China Henan university of Science and Technology Luoyang 471003China Henan university of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal university Changsha 410081China Hunan university Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana university BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia university Hohhot 010021China Institute of Modern physics Lanzhou 730000China Institute of physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(12.0)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2.ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2.1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.02._(stat.)±0.02._(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

经皮导管介入封堵治疗膜周部室间隔缺损合并主动脉瓣脱垂的疗效及预后

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中国实用儿科杂志 2019年第8期34卷 675-679页

作者：赵文婥傅立军沈捷吉炜陈轶维李奋上海交通大学医学院附属上海儿童医学中心心血管内科

目的分析经皮导管介入封堵膜周部室间隔缺损合并主动脉瓣脱垂(aortic valve prolapse,AVP)的疗效及预后。方法回顾2.11年1月至2.17年1月上海交通大学医学院附属上海儿童医学中心收治的1108例经皮介入治疗膜周部室间隔缺损患儿的临床资料... 详细信息

目的分析经皮导管介入封堵膜周部室间隔缺损合并主动脉瓣脱垂(aortic valve prolapse,AVP)的疗效及预后。方法回顾2.11年1月至2.17年1月上海交通大学医学院附属上海儿童医学中心收治的1108例经皮介入治疗膜周部室间隔缺损患儿的临床资料,主要包括手术前后超声心动图、术中造影、封堵器型号及社会人口(年龄、体重、性别)等资料。组间比较计量资料采用独立样本t检验、非参数Mann-Whitney U检验;配对设计计量资料不符合正态分布采用非参数Wilcoxon符号秩检验。计数资料采用Fisher确切概率法;成组设计R×C表格采用MonteCarlo近似确切概率法。多元Logistic回归分析术前合并AVP患儿术后主动脉瓣反流(aortic regulation,AR)出现或加重的危险因素。结果55例术前合并AVP患儿中8例(14.5%)发生术后AR出现或加重。1053例术前不合并AVP的患儿中10例(0.9%)发生术后AR出现或加重,但AR加重情况多发生在术后远期(>1年),且无一例中度以上的AR出现。合并AVP患儿介入手术前后左心室射血分数、左室短轴缩短率及AR加重程度均无统计学意义。结论在选择合适封堵器类型及大小、操作规范并具有相当相关操作经验的儿童心血管中心,经皮导管介入封堵合并AVP的膜周部室间隔缺损可成为外科手术的有效替代方案。

关键词：室间隔缺损主动脉瓣脱垂间隔封堵器回顾性研究

Overexpression of mechanical sensitive miR-337-3p alleviates ectopic ossification in rat tendinopathy model via targeting IRS1 and Nox4 of tendon-derived stem cells

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Journal of Molecular Cell Biology 2020年第4期12卷 305-317页

作者： Yiyun Geng Xiaoying zhao Jiajia Xu Xudong Zhang Guoli Hu Sai-Chuen Fu Kerong Dai Xiaodong Chen Yung shu-huang Patrick Xiaoling Zhang department of Orthopedic Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China shenzhen Key Laboratory of Tissue Engineering Shenzhen Second People's Hospital(The First Hospital Affiliated to Shenzhen University)Shenzhen 518035China The Key Laboratory of Stem Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China department of Orthopaedics and Traumatology Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina

Tendinopathy,which is characterized by the ectopic ossification of tendon,is a common disease occurring in certain population,such as athletes that suffer from repetitive tendon ***,the molecular mechanism underlying the pathogenesis of tendinopathy caused by the overuse of tendon is still ***,we found that the mechanosensitive miRNA,miR-337-3p,had lower expression under uniaxial cyclical mechanical loading in tendon-derived stem cells(TDSCs)and negatively controlled chondro-osteogenic differentiation of ***,downregulation of miR-337-3p expression was also observed in both rat and human calcified tendons,and overexpressing miR-337-3p in patellar tendons of rat tendinopathy model displayed a robust therapeutic ***,we found that the proinflammatory cytokine interleukin-1^was the upstream factor of miR-337-3p that bridges the mechanical loading with its ***,the target genes of miR-337-3p,NADPH oxidase 4,and insulin receptor substrate 1,activated chondro-osteogenic differentiation of TDSCs through JNK and ERK signaling,***,these findings not only provide novel insight into the molecular mechanisms underlying ectopic ossification in tendinopathy but also highlight the significance of miR-337-3p as a putative therapeutic target for clinic treatment of tendinopathy.

关键词： mechanosensitive miRNA tendon-derived stem cells mechanical loading chondro-osteogenesis tendinopathy

PandaX: a liquid xenon dark matter experiment at CJPL

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Science China(physics,Mechanics & Astronomy) 2014年第8期57卷 1476-1494页

作者： CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael shen ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO Mengjiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao {2. HaiYing {2. Li ZHOU XiaoPeng ZHU ZhongHua shanghai Institute of Applied physics The Institute of Nuclear and Particle physics Astronomy and Cosmology (INPAC) and Department of Physics and AstronomyShanghai Jiao Tong University Yalong River Hydropower Development Company Ltd. School of physics and Key Laboratory of Particle physics and Particle Irradiation (MOE) Shandong University School of physics Peking University department of physics University of Maryland College Park MD 20742 USA School of Mechanical Engineering Shanghai Jiao Tong University department of physics University of Michigan Ann Arbor MI 48109 USA

PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay *** central vessel was designed to accommodate a staged target volume increase from initially 12. kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton *** experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,*** detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional *** this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented.

关键词： dark matter liquid xenon detector underground experiment time projection chamber

经皮氧饱和度测定结合心脏超声远程会诊筛查新生儿危重先天性心脏病

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上海交通大学学报（医学版） 2018年第11期38卷 1349-1354页

作者：沈奕赵莉晴刘晓青郁燕刘岚武育蓉上海交通大学医学院附属新华医院崇明分院儿科上海202150 上海交通大学医学院附属新华医院小儿心血管科上海200092

目的·探讨经皮氧饱和度测定结合心脏超声远程会诊在偏远地区新生儿危重型先天性心脏病(critical congenital heart disease,CCHD)筛查及转诊中的价值。方法·以上海崇明区2.14—2.16年的活产新生儿为筛检对象,于生后2.～48 h进行经皮... 详细信息

目的·探讨经皮氧饱和度测定结合心脏超声远程会诊在偏远地区新生儿危重型先天性心脏病(critical congenital heart disease,CCHD)筛查及转诊中的价值。方法·以上海崇明区2.14—2.16年的活产新生儿为筛检对象,于生后2.～48 h进行经皮氧饱和度测定筛检CCHD,同时按照先天性心脏病分段诊断方法录制标准切面,将心脏超声图像通过微信平台远程会诊后进行初步确诊。结果·共4 450例活产新生儿接受筛检,阳性11例,经心脏超声远程会诊初步确诊CCHD 6例,筛检阴性者中1例后经心脏超声诊断为肺动脉闭锁伴室间隔缺损。经皮氧饱和度筛检CCHD的敏感度为85.71%,特异度为99.89%,假阳性率为0.11%,假阴性率为14.2.%,ROC曲线下面积为0.92.。结论·经皮氧饱和度测定可以有效筛查出CCHD,结合微信平台心脏超声远程会诊可以初步确诊CCHD,既可及时转诊,又可避免不必要的转诊。该筛查模式简便易行,在缺少先天性心脏病诊治专业医技人员的偏远地区有实用价值。

关键词：先天性心脏病氧饱和度筛查心脏超声远程会诊

Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge zhao Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan shen Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU sheng Li YANG Tao DENG Hua Cong zhao Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of Jilin university Changchun 130021JinlinChina Qilu Hospital of Shandong university Jinan 250012ShandongChina Affiliated Hospital of Guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to shanghai jiao{2. university School of Medicine Shanghai 200092China tongji Hospital.tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of Zhengzhou university Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical university Luzhou 646099SichuanChina Fujian Provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of Wenzhou Medical university Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical university Nanning 530021GuangxiChina Jiangxi Provincial People's Hospital Affiliated to Nanchang university Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical university Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central Hospital of shanghai Jiading District Shanghai 201800China Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical university Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2.hour postload glucose(2.h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,92. community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62.361 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2.h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status