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Liver targeting and the delayed drug release of the nanoparticles of adriamycin polybutylcyanoacrylate in mice

Chinese Medical Journal 2006年第15期119卷 1287-1293页

作者： shen Liang-fang ZHANG Yang-de shen hai-ju ZENG Shan WANG Xin WANG Cheng LE Yuan shen Hong Department of Tumor Xiangya Hospital Central South University of China Changsha 410008 China National Key Laboratory of Nanobiological Technology Central South University of China Changsha 410008 China Medical Research Center Xiangya Hospital Central South University of China Changsha 410008 China

Background Liver targeting drug delivery systems can improve the curative effects and relieve the cytotoxicity of the chemotherapy drugs in the treatment of liver diseases. Nanoparticles carrying therapeutic drugs are currently under hot investigation with great clinical significance. This study was aimed to investigate the different tissue distribution of the adriamycin polybutylcyanoacrylate nanoparticle （ADM-PBCA-NP） in the mice body after an injection via lateral tail vein, and to study the liver targeting effects of ADM-PBCA-NP in different diameters on normal mice liver. Methods One hundred and eighty Kunming mice were randomly divided into 6 groups with 30 mice in each group （5 treatment groups of ADM-PBCA-NP in the different diameter ranges, non-conjugated free adriamycin injection was employed as the control group）. A single dose of either conjugated or free adriamycin equaled 2 mg/kg of body weight was delivered via the tail vein. Five mice in each trail were sacrificed at 5, 15, 30 minutes, 1, 5 and 12 hours postinjection, respectively. The adriamycin cOncentrations in the respectively collected liver, kidney, spleen, heart, lung and plasma were demonstrated using a high performance liquid chromatography with fluorescence detector. Results Compared with the control group, adriamycin was hardly detected in the heart muscle of the treatment groups （P〈0.05）. The nanoparticle-conjugated adriamycin was cleaned up quickly from the kidney tissue. The adriamycin concentrations of the mice liver and spleen in the experimental groups were significantly higher than that in the control group, except for the group with the nanoparticles diameters of （22.3 ±6.2） nm （P〈0.05）. The ADM-PBCA-NP in （101.0±20.3） nm diameter had the highest liver distribution, and the second highest adriamycin distribution in liver was the group of （143.0±23.5） run diameter （P〈0.05）. Moreover, adriamycin was released slowly in the liver during the detection period in the experimental groups.

关键词： polybutylcyanoacrylate nanoparticles fiver targeting adriamycin

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阿霉素聚氰基丙烯酸正丁酯纳米粒粒径对肝靶向性的影响

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中南大学学报（医学版） 2006年第5期31卷 732-736,741页

作者：申良方王欣王骋赵凯刘新菊申海菊中南大学湘雅医院肿瘤科长沙410008 中南大学卫生部纳米生物技术重点实验室长沙410008

目的：观察不同粒径的阿霉素聚氰基丙烯酸正丁酯纳米粒（adriamycin polybutylcyanoacrylate nanoparticles，ADM-PBCA-NP）及阿霉素（adriamycin，ADM）经小鼠尾静脉给药后在小鼠体内的生物分布差异，研究不同粒径的ADM-PBCA-NP对正常... 详细信息

目的：观察不同粒径的阿霉素聚氰基丙烯酸正丁酯纳米粒（adriamycin polybutylcyanoacrylate nanoparticles，ADM-PBCA-NP）及阿霉素（adriamycin，ADM）经小鼠尾静脉给药后在小鼠体内的生物分布差异，研究不同粒径的ADM-PBCA-NP对正常肝脏的靶向性，旨在筛选出肝靶向性最好的ADM-PBCA-NP。方法：昆明种小鼠180只，随机分为游离ADM组、（22．3±6．2）nmADM—PBCA-NP组、（48．6±9．2）nmADM-PBCA-NP组、（101．9±20．3）nmADM—PBCA-NP组、（143．5±23．5）nmADM—PBCA-NP组和（194．2±28．4）nmADM-PBCA-NP组。每组30只，经小鼠尾静脉按2mg／kg的剂量分别注射上述ADM-PBCA-NP或游离ADM。每组于给药后5，15，30min，1，5，12h各处死5只小鼠，分别提取肝、肾、脾、心、肺、血浆样品，以高效液相色谱法测定ADM的浓度。结果：12h以内除（22．3±6．2）nm组外，其他纳米粒组小鼠肝脏中的ADM浓度显著高于游离ADM组（P〈0．05），而在心肌组织中未测到或ADM浓度显著低于游离ADM组（P〈0．05），肾脏组织中高浓度ADM维持时间不长；（101．9±20．3）nm组小鼠肝脏中的ADM浓度显著高于其他各组（P〈0．05）；其次为（143．5±23．5）nm组。（22．3±6．2）nm组的ADM浓度在肝、肾、心、脾、肺组织中均未测到。各纳米组小鼠肝脏中ADM浓度在各时间段缓慢释放。结论：（1）一定粒径范围的ADM-PBCA-NP具有良好的肝靶向性，并具有缓慢释药的特点，降低了心脏等脏器的药物分布，是治疗肝癌较理想的给药系统。（2）100～150nm粒径的ADM-PBCA-NP肝靶向性最强，这为临床应用阿霉素聚氰基丙烯酸正丁酯纳米药物治疗肝癌提供了实验依据。

关键词：聚氰基丙烯酸正丁酯纳米粒粒径肝靶向性阿霉素

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen hai-Di Fan Wan Wang Bin Wang ju-Yun Ma Peng-Peng Li hai-Wei Pu Xin-Yian Guo Jian-Gang shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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LabVIEW FPGA实时仿真在现代电力电子技术实验教学中的应用

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实验室研究与探索 2016年第9期35卷 108-113页

作者：茅靖峰申海群顾菊平华亮李学祥南通大学电气工程学院江苏南通226019

为了提高"现代电力电子技术"课程的教学效果,将Lab VIEW FPGA实时仿真技术应用于课程的综合性和研究性实验教学。通过设计基于Lab VIEW FPGA快速原型方式的直流电机H桥PWM调速开/闭环控制教学案例,进一步增进学生对电力电子典型拓扑电... 详细信息

为了提高"现代电力电子技术"课程的教学效果,将Lab VIEW FPGA实时仿真技术应用于课程的综合性和研究性实验教学。通过设计基于Lab VIEW FPGA快速原型方式的直流电机H桥PWM调速开/闭环控制教学案例,进一步增进学生对电力电子典型拓扑电路及其闭环控制系统的理解,强化学生对现代电力电子系统的多学科点交叉应用、整机综合分析、参数设计和测试技能的学习。教学实践表明,采用上述实时仿真教学,有助于学生对现代电力电子技术系统级的把握和工程实践能力培养,教学效果良好。

关键词：现代电力电子技术实时仿真技术 LabVIEW FPGA PWM控制

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On the heterogeneous microstructure development in the welded joint of 12MnNiVR pressure vessel steel subjected to high heat input electrogas welding

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Journal of Materials Science & Technology 2019年第8期35卷 1747-1752页

作者： Yang shen ju Leng Cong Wang School of Metallurgy Northeastern University Shenyang 110819 China shenyang NEU New Industrial Technology Research Institute Co. LTD Shenyang 110819 China

Microstructure features of 12 MnNiVR pressure vessel steel welded joint deposited by the high heat input electrogas welding have been systematically investigated. It is revealed that the welded joint is featured by a heterogeneous juxtaposition. The coarse grained heat-affected zone(CGHAZ) primarily consists of lath bainites and minor granular bainites. The fine grained heat-affected zone(FGHAZ) is dominated by polygonal ferrites, pearlites, and fine cementite particles. Moreover, electron backscatter diffraction results further demonstrate that the CGHAZ is populated by coarse prior austenite grains(PAGs) with high frequency(61.3%) of low angle grain boundaries(LAGBs). On the other hand, the FGHAZ is filled with fine PAGs with a lower frequency(19.6%) of LAGBs. Such microstructural differences may likely contribute to differed mechanical properties for samples tested at designed positions.

关键词： 12MnNiVR pressure vessel steel Electrogas welding High heat input Electron backscatter diffraction

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Efficacy of active compounds of Chanqin granules on airway neurogenic inflammation induced by PM2.5 in vivo

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Journal of Traditional Chinese Medicine 2020年第5期40卷 792-802页

作者： ju Ya shen Ruobing Yu Xiaoping Department of Traditional Chinese Medicine Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200120China

OBJECTIVE:To investigate the efficacy of active compounds of Chanqin(CQ)granules on PM2.5-induced airway neurogenic inflammation in vivo,and to elucidate the underlying mechanisms of ***:The Traditional Chinese Medicine systems pharmacology(TCMSP)database was searched,and the results were combined with oral bioavailability and drug analysis to identify the compounds in CQ *** pharmacophore modeling approach was used to predict the compound targets,and the diseases corresponding to the targets were obtained by searching the therapeutic target database(TTD),pharmacogenomics knowledgebase(Pharm GKB)and Drug Bank *** software was used to construct the network pharmacological charts for Component-Target and Target-Disease interactions of the CQ ***,the mechanisms of action and effectiveness of CQ granules for the treatment of PM2.5-induced airway neurogenic inflammation were ***:A total of 195 compounds and 171 targets were obtained from the analyses.A total of569 corresponding diseases were identified for these ***-target and target-disease networks were *** possible mechanisms and effective components in CQ granules for treating airway neurogenic inflammation were ***,kaempferol and isorhamnetin,beta-sitosterol and sitosterol,which are typically found in the formulation,have extensive pharmacological activities,including anti-inflammatory,antioxidant and antiviral actions and neuroprotective *** these targets,androgen receptor,estrogen receptor,prostaglandin G/H synthase 2,and inducible nitric oxide synthase play important pathological roles,including the induction of neurogenic *** granules may have therapeutic effectiveness for numerous diseases in addition to respiratory diseases,including neoplasms,digestive system diseases,cardiovascular diseases,respiratory tract diseases and nervous system *** vivo,CQ granules are effective in trea

关键词： Neurogenic inflammation Pharmacology Neuropeptides MAP kinase signaling system Ganglia,spinal PM2.5 Chan Qin granules

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A Comparative Study of Fractional Order Models on State of Charge Estimation for Lithium Ion Batteries

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Chinese Journal of Mechanical Engineering 2020年第4期33卷 98-112页

作者： Jinpeng Tian Rui Xiong Weixiang shen ju Wang Department of Vehicle Engineering School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China Faculty of Science Engineering and TechnologySwinburne University of TechnologyHawthornVictoria 3122Australia

State of charge(SOC)estimation for lithium ion batteries plays a critical role in battery management systems for electric *** fractional order models(FOMs)which come from frequency-domain modelling have provided a distinct insight into SOC *** this article,we compare five state-of-the-art FOMs in terms of SOC *** this end,firstly,characterisation tests on lithium ion batteries are conducted,and the experimental results are used to identify FOM *** identification results show that increasing the complexity of FOMs cannot always improve *** model R(RQ)W shows superior identification accuracy than the other four ***,the SOC estimation based on a fractional order unscented Kalman filter is conducted to compare model accuracy and computational burden under different profiles,memory lengths,ambient temperatures,cells and voltage/current *** evaluation results reveal that the SOC estimation accuracy does not necessarily positively correlate to the complexity of *** more complex models can have better robustness against temperature variation,R(RQ),the simplest FOM,can overall provide satisfactory *** results on different cells demonstrate the generalisation ability of FOMs,and R(RQ)outperforms other ***,R(RQ)shows better robustness against truncation error and can maintain high accuracy even under the occurrence of current or voltage sensor drift.

关键词： Electric vehicle Lithium ion battery Fractional order model State of charge

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Influence of Gas Components on the Formation of Carbonyl Sulfide over Water-Gas Shift Catalyst B303Q

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Journal of Natural Gas Chemistry 2007年第1期16卷 53-59页

作者： ju Shangguan Litong Liang Huiling Fan Fang shen Key Laboratory of Coal Science and Technology Taiyuan University of Technology Ministry of Education and Shanxi Province Taiyuan 030024 Shanxi China

Water-gas shift reaction catalyst at lower temperature （200-400 ℃） may improve the conversion of carbon monoxide. But carbonyl sulfide was found to be present over the sulfided cobaltmolybdenum/alumina catalyst for water-gas shift reaction. The influences of temperature, space velocity, and gas components on the formation of carbonyl sulfide over sulfided cobalt-molybdenum/alumina catalyst B303Q at 200-400 ℃ were studied in a tubular fixed-bed quartz-glass reactor under simulated water-gas shift conditions. The experimental results showed that the yield of carbonyl sulfide over B303Q catalyst reached a maximum at 220 ℃ with the increase in temperature, sharply decreased with the increase in space velocity and the content of water vapor, increased with the increase in the content of carbon monoxide and carbon dioxide, and its yield increased and then reached a stable value with the increase in the content of hydrogen and hydrogen sulfide. The formation mechanism of carbonyl sulfide over B303Q catalyst at 200-400 ℃ was discussed on the basis of how these factors influence the formation of COS. The yield of carbonyl sulfide over B303Q catalyst at 200-400 ℃ was the combined result of two reactions, that is, COS was first produced by the reaction of carbon monoxide with hydrogen sulfide, and then the as-produced COS was converted to hydrogen sulfide and carbon dioxide by hydrolysis. The mechanism of COS formation is assumed as follows： sulfur atoms in the Co9Ss-MoS2/Al2O3 crystal lattice were easily removed and formed carbonyl sulfide with CO, and then hydrogen sulfide in the water-gas shift gas reacted with the crystal lattice oxygen atoms in CoO-MoOa/Al2O3 to form Co9S8-MoS2/Al2O3. This mechanism for the formation of COS over water-gas shift catalyst B303Q is in accordance with the Mars-Van Krevelen＇s redox mechanism over metal sulfide.

关键词： formation carbonyl sulfide sulfided cobalt-molybdenum/alumina catalyst water-gas shift

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In vitro evaluation of artificial joints: a comprehensive review

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Advances in Manufacturing 2019年第1期7卷 1-14页

作者： Gang shen ju-Fan Zhang Feng-Zhou Fang Centre of Micro/Nano Manufacturing Technology (MNMTDublin) University College Dublin Dublin Ireland State Key Laboratory of Precision Measuring Technology and Instruments Centre of Micro/Nano Manufacturing Technology (MNMT) Tianjin University Tianjin 300072 People's Republic of China

Development of artificial joints is a great progress for joint replacement operations of human being, but the short longevity of prostheses has concerned both industries and researchers since the advent of modem implants. Thus, continuous improvements have been made alongside the clinical applications. The methodologies to inspect the potential properties of new designs have also seen many advances. The test machines have evolved from easy pin-on-disk configuration to the modem joint simulator. Besides, various wear traces provided by testing machines are investigated greatly, and multi-directional files are recommended as motion profiles for in vitro testing. The typical testing parameters, like sliding speed or loading profile, are discussed in this article, and their working mechanisms are described in detail. Meanwhile, the calf or bovine serum has been regarded as the gold standard for testing lubricant, and the future trend of fluid will be focused on investigating the effects of lubricant composites on the tribological properties. Hard particles and proteins are discussed as well, and their effects on the wear mechanisms are the focus. Finally, various approaches to measure the wear rate, wear factor and the thickness of lubricant film are presented, and suggestions are given for the development in future.

关键词： Artificial joint Methodology Testing parameter Wear rate

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Analysis of influence of observation operator on sequential data assimilation through soil temperature simulation with common land model

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Water Science and Engineering 2018年第3期11卷 196-204页

作者： Xiao-lei Fu Zhong-bo Yu Yong-jian Ding Ying Tang hai-shen Lü Xiao-lei Jiang Qin ju College of Civil Engineering Fuzhou UniversityFuzhou 350116China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Department of Geography Environmentand Spatial SciencesMichigan State UniversityEast LansingMI 48824USA

An observation operator is a bridge linking the system state vector and observations in a data assimilation system. Despite its importance, the degree to which an observation operator influences the performance of data assimilation methods is still poorly understood. This study aimed to analyze the influences of linear and nonlinear observation operators on the sequential data assimilation through soil temperature simulation using the unscented particle filter(UPF) and the common land model. The linear observation operator between unprocessed simulations and observations was first established. To improve the correlation between simulations and observations, both were processed based on a series of equations. This processing essentially resulted in a nonlinear observation operator. The linear and nonlinear observation operators were then used along with the UPF in three assimilation experiments: an hourly in situ soil surface temperature assimilation, a daily in situ soil surface temperature assimilation, and a moderate resolution imaging spectroradiometer(MODIS) land surface temperature(LST) assimilation. The results show that the filter improved the soil temperature simulation significantly with the linear and nonlinear observation operators. The nonlinear observation operator improved the UPF's performance more significantly for the hourly and daily in situ observation assimilations than the linear observation operator did, while the situation was opposite for the MODIS LST assimilation. Because of the high assimilation frequency and data quality, the simulation accuracy was significantly improved in all soil layers for hourly in situ soil surface temperature assimilation, while the significant improvements of the simulation accuracy were limited to the lower soil layers for the assimilation experiments with low assimilation frequency or low data quality.

关键词： Observation operator Unscented particle filter(UPF) Soil temperature MODIS LST Data assimilation

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