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Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ

Frontiers of Medicine 2024年第3期18卷 465-483页

作者： Fei Xu Han Chen Changyi Zhou Tongtong Zang Rui Wang Shutong shen Chaofu Li Yue Yu Zhiqiang Pei Li shen Juying Qian Junbo ge Department of Cardiology and Laboratory of Heart Valve Disease West China HospitalSichuan UniversityChengdu610041China Department of Cardiology Zhongshan HospitalFudan UniversityResearch Unit of Cardiovascular Techniques and DevicesChinese Academy of Medical SciencesShanghai200032China Shanghai Institute of Cardiovascular Diseases Shanghai200032China National Clinical Research Center for Interventional Medicine&Shanghai Clinical Research Center for Interventional Medicine(19MC1910300) Shanghai200032China

Atherosclerosis is a chronic artery disease that causes various types of cardiovascular *** smooth muscle cells(VSMCs),the main components of atherosclerotic plaque,switch from contractile to synthetic phenotypes during *** is crucial in regulating VSMC phenotypes in atherosclerosis,and it can be reversely regulated by ***,the specific effects of deubiquitinases on atherosclerosis have not been thoroughly *** this study,RNAi screening in human aortic smooth muscle cells was performed to explore the effects of OTU family deubiquitinases,which revealed that silencing OTUB1 inhibited PDGF-BB-stimulated VSMC phenotype *** in vivo studies using Apoe−/−mice revealed that knockdown of OTUB1 in VSMCs alleviated atherosclerosis plaque burden in the advanced stage and led to a stable plaque ***,VSMC proliferation and migration upon PDGF-BB stimulation could be inhibited by silencing OTUB1 in *** RNA-sequencing data indicated that knocking down OTUB1 influenced VSMC differentiation,adhesion,and *** spectrometry of ubiquitinated protein confirmed that proteins related to cell growth and migration were differentially ***,we found that OTUB1 recognized the K707 residue ubiquitylation of PDGFRβwith its catalytic triad,thereby reducing the K48-linked ubiquitylation of PDGFRβ.Inhibiting OTUB1 in VSMCs could promote PDGFRβdegradation via the ubiquitin–proteasome pathway,so it was beneficial in preventing VSMCs’phenotype *** findings revealed that knocking down OTUB1 ameliorated VSMCs’phenotype switch and atherosclerosis progression,indicating that OTUB1 could be a valuable translational therapeutic target in the future.

关键词： atherosclerosis vascular smooth muscle cell ubiquitylation deubiquitinase OTUB1 PDGFRβ

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Research and Development of Ceramic Cutting Tools in China

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航空制造技术 2007年第Z1期50卷 333-341页

作者： shen Weiping ge Changchun Bai Ling Yan Qingzhi

The research and development of various classes of ceramic cutting tools in China are described,because manufacturing efficiency is fundamental to the growth of China's economy.

关键词： Ceramic Cutting tools Alumina Silicon nitride

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欠发达地区新农村建设路径探讨——对景宁畲族自治县雁溪乡常年外出人口状况的调查与思考

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人口与经济 2007年第5期 56-60,55页

作者：葛深渭浙江师范大学工商学院农村研究中心浙江金华321004

当前,新农村建设的目标虽然已经明确,但是由于各地环境条件、基础设施等方面的差异,导致已有的一些新农村建设的成功经验和模式不能被简单借鉴。本文正是基于此种认识,在对欠发达山区的个案研究的基础上,从人口学的角度提出山区欠发达... 详细信息

当前,新农村建设的目标虽然已经明确,但是由于各地环境条件、基础设施等方面的差异,导致已有的一些新农村建设的成功经验和模式不能被简单借鉴。本文正是基于此种认识,在对欠发达山区的个案研究的基础上,从人口学的角度提出山区欠发达乡村新农村建设必须因地制宜,探索适合自身条件的特殊路径:梯次移民—集聚人口—村庄重构—发展集群农业—鼓励能人乡村创业—新乡村发展。

关键词：欠发达乡镇人口外流新农村建设

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梯次移民:协调欠发达地区经济发展的现实途径

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经济地理 2005年第2期25卷 180-184页

作者：葛深渭浙江师范大学工商管理学院中国浙江金华321004

区域经济的协调发展是完成我国全面建设小康社会重大任务的关键。我国各区域之间不协调的根本之处在于欠发达地区与发达地区之间、城乡之间的差距在不断扩大。这种扩大直接表现为农民收入的绝对数在增加,但相对数增长缓慢甚至下降,其根... 详细信息

区域经济的协调发展是完成我国全面建设小康社会重大任务的关键。我国各区域之间不协调的根本之处在于欠发达地区与发达地区之间、城乡之间的差距在不断扩大。这种扩大直接表现为农民收入的绝对数在增加,但相对数增长缓慢甚至下降,其根本原因在于农民人口的基数过大。当前要保持各区域之间协调的根本点在于在现有生产力条件下,尽力保持各区域之间的差距不再进一步扩大,并努力创造条件,缩小差距。合理、稳妥、有效地减少农民人口,其最有效的途径是实施"梯次移民"。

关键词：地区经济发展现实途径移民全面建设小康社会欠发达地区协调发展区域经济农民收入增长缓慢创造条件减少农民不协调绝对数相对数生产力根本点人口城乡

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我国德育政策的去成人化转向——基于小学德育课程的分析

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教育科学 2012年第1期28卷 17-21页

作者：申卫革扬州大学教育科学学院江苏扬州225002

德育政策的价值取向主要通过德育纲要、德育课程标准、德育教材而体现,我国当下的德育改革扭转了传统德育的成人化倾向。通过对小学德育课程结构、课程标准和德育教材以及德育课程实践形式的分析,反思了我国当下德育政策的去成人化转向。

关键词：小学德育课程德育政策去成人化

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教师专业标准中“教师作为知识分子”角色的缺失

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陕西师范大学学报（哲学社会科学版） 2014年第6期43卷 165-169页

作者：申卫革扬州大学教育科学学院江苏扬州225002

我国中小学教师专业标准忽视了"教师作为知识分子"角色。教师专业标准是技术理性的产物,技术理性抑制了教师的批判性思维向度,异化了教育过程中教师和学生的关系,解构了"教师作为知识分子"的社会角色。公民教育承担者和专业实践反思者是... 详细信息

我国中小学教师专业标准忽视了"教师作为知识分子"角色。教师专业标准是技术理性的产物,技术理性抑制了教师的批判性思维向度,异化了教育过程中教师和学生的关系,解构了"教师作为知识分子"的社会角色。公民教育承担者和专业实践反思者是"教师作为知识分子"的应然角色,从批判教育学的视角对教师专业标准中"教师作为知识分子"角色予以建构是必要的。

关键词：教师专业标准知识分子技术理性批判教育学

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Multiscale urban design based on the optimization of the wind and thermal environments:A case study of the core area of Suzhou Science and Technology City

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Frontiers of Architectural Research 2024年第4期13卷 822-841页

作者： Hua Liu Xin Zhou Xin ge Dongqing Han Weiren Zhuang Ying Tang Xiaohan shen Architects&Engineers CO. LTD of Southeast UniversityNanjing 210096China School of Architecture Southeast UniversityNanjing 210096China

New methods are need to coordinate the conflicting spatial demands through urban design research and strategies from the perspective of multi-scale urban climate *** integrate windethermal environment with urban design,we propose three scale levels,namely the district-superblock,superblock-block,and block-building levels,and divide the urban design elements into voids and ***,we establish a multiscale methodological framework in which the urban design contents are clarified by each scale,and the information transmitted between scales is obtained to ensure consistent value propositions and strategic *** microclimate shaping of the urban open space is transformed into guiding strategies and quantitative indicators of the spatial form of the solid *** is transmitted between the scales through the windethermal indicators of windward side and the morphological indicators of solid ***,the methodology was applied to the project in the core area of Suzhou Science and Technology City,and the findings preliminarily verify the effectiveness and feasibility of the *** research influences urban climate studies and urban design practice in three ways:1)improving understanding of the correlation between scales;2)facilitating interaction between the two domains;and 3)providing tools for urban design practices.

关键词： Multiscale transmission Windethermal environment optimization Urban design strategy Urban form

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High-stability double-layer polymer-inorganic composite electrolyte fabricated through ultraviolet curing process for solid-state lithium metal batteries

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Frontiers of Materials Science 2024年第2期18卷 117-128页

作者： Xinghua Liang Pengcheng shen Lingxiao Lan Yunmei Qin ge Yan Meihong Huang Xuanan Lu Qiankun Hun Yujiang Wang Jixuan Wang Guangxi Key Laboratory of Automobile Components and Vehicle Technology Guangxi University of Science&TechnologyLiuzhou 545006China Guangxi Automobile Group Co. Ltd.Liuzhou 545006China School of Automotive Engineering Guangdong Polytechnic of Industry and CommerceGuangzhou 510510China

Electrolyte interface resistance and low ionic conductivity are essential issues for commercializing solid-state lithium metal batteries(SSLMBs).This work details the fabrication of a double-layer solid composite electrolyte(DLSCE)for *** composite comprises poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)and poly(methyl methacrylate)(PMMA)combined with 10 wt.%of Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO),synthesized through an ultraviolet curing *** ionic conductivity of the DLSCE(2.6×10^(-4) S·cm^(-1))at room temperature is the high lithium-ion transference number(0.57),and the tensile strength is 17.8 *** this DLSCE was assembled,the resulted LFP/DLSCE/Li battery exhibited excellent rate performance,with the discharge specific capacities of 162.4,146.9,93.6,and 64.0 mA·h·g^(-1) at 0.1,0.2,0.5,and 1 C,***,the DLScE demonstrates remarkable stability with lithium metal batteries,facilitating the stable operation of a Li/Li symmetric battery for over 200 h at both 0.1 and 0.2 mA-cm^(-2).Notably,the formation of lithium dendrites is also effectively inhibited during *** work provides a novel design strategy and preparation method for solid composite electrolytes.

关键词： electrochemicalreliability lithium metal battery lithium-ion transference number double-layer solid composite electrolyte

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Association between stress hyperglycemia ratio and in-hospital outcomes:findings from the improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome(CCC-ACS)Project

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Journal of geriatric Cardiology 2024年第6期21卷 658-668页

作者： Wen-Jie WANG Ke-Xin WANG Jia-Long NIU Yi-Xuan LIU Hai-Long ge Hua shen On behalf of CCC-ACS investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

BACKGROUND Stress hyperglycemia ratio(SHR)could provide accurate information on the acute status of *** relationship between SHR and acute coronary syndrome(ACS)prognosis remains *** study was conducted to identity the association between SHR and in-hospital outcomes in patients with *** A total of 12,010 patients were eventually enrolled in the *** relationship between SHR and in-hospital major adverse cardiovascular events(MACEs)was then modeled by restricted cubic spline(RCS)curves,and all patients were divided into three groups according to the *** multivariate logistic regression analysis was used to determine the associations between the SHR and in-hospital outcomes,described as odds ratios(ORs)and 95%confidence intervals(CIs).Subgroup analyses were also performed on different *** The median age of this cohort was 63(54,71)years old,and 8942(74.5%)were *** 1 was defined as SHR1(n=5763).Compared with Group 2,Group 1(OR=1.891,95%CI:1.028-3.479,P<0.001)and Group 3(OR=1.868,95%CI:1.434-2.434,P<0.001)had higher risks of suffering from in-hospital *** was associated with higher risks of in-hospital MACEs in the subgroups of DM[OR=2.282,95%CI:1.477-3.524).CONCLUSIONS Both low and high SHR levels were independently associated with in-hospital *** males with DM,hypertension,and decreased renal function had much higher risks of suffering from SHR-correlated MACEs.

关键词： acute cardiovascular finding

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A direct polymeric carbon nitride/tungsten oxide Z-scheme heterostructure for efficient photocatalytic hydrogen generation via reforming of plastics into value-added chemicals

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Rare Metals 2024年第8期43卷 3771-3783页

作者： Rui-Zhe Wang Zhi Lin Yi-Qing Wang Kai-Ni Zhang ge-Hong Zhang Jie Zhang Samuel S.Mao Shao-Hua shen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'an 710049China School of Civil and Architecture Engineering Xi'an Technological UniversityXi'an 710021China Department of Mechanical Engineering University of California at BerkeleyBerkeleyCA94720USA

To promote charge transfer and separation for efficient photocatalysis,a direct Z-scheme heterostructure was constructed by coupling polymeric carbon nitride(PCN) and WO_(3).Interestingly,the obtained PCN/WO_(3)Z-scheme heterostructure could photocataly tic ally produce hydrogen and value-added chemicals(e.g.,formate and acetate) by reforming of plastic polylactic acid(PLA) in alkaline aqueous *** optimizing WO_(3) contents and reaction conditions,the obtained PCN/WO_(3)heterostructure exhibits much increased photocatalytic activity for PLA photoreforming under visible light,with hydrogen evolution rate reaching 402.90 μmol·g~(-1)·h~(-1),which is 3.5 times that of *** is revealed that the Z-scheme charge transfer between PCN and WO_(3) mainly contributes to the promoted charge separation and thus the improved photocatalytic ***,with h+and·OH experimentally evidenced as the predominant active species,a possible reaction pathway for the reforming of PLA into value-added chemicals(e.g.,formate and acetate)over PCN/WO_(3) Z-scheme heterostructure is cleared by monitoring the reaction intermediates and *** work paves a carbon neutrality and scalable route toward the synergistical production of hydrogen and value-added chemicals by utilizing and recycling plastic waste.

关键词： Carbon nitride Z-scheme heterojunction Plastic waste conversion Photocatalytic H_(2)production Value-added chemicals

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