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Pulsatile gonadotropin-releasing hormone therapy induces spermatogenesis in pituitary stalk interruption syndrome:A case report and review of the literature

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World Journal of Clinical Cases 2024年第20期12卷 4348-4356页

作者： Jin-Long Xie Hai-Ying Zhu Yang Dong Ping-Ping Sun dan-dan Qi Su-Xian Luan Yan Zhang hua-Gang Ma The Reproductive Medicine Centre Weifang People's HospitalWeifang 261000Shandong ProvinceChina Department of Radiology Weifang People's HospitalWeifang 261000Shandong ProvinceChina

BACKGROUND Pituitary stalk interruption syndrome(PSIS)is a rare anatomical defect of the pituitary gland falling under the spectrum of holoprosencephaly *** is characterized by a deficiency in anterior pituitary hormones,such as growth hormone,gonadotropins,and thyroid *** to the syndrome's rarity and nonspecific manifestations,there is a lack of standardized treatment ***,early diagnosis through imaging and on-time intervention are crucial for improving patients’*** SUMMARY A 30-year-old man presented with absent secondary sexual characteristics and *** evaluation revealed a deficiency in gonadotropins,while thyroid function was mostly within normal *** resonance imaging of the pituitary gland showed pituitary stalk agenesis,hypoplasia of the anterior pituitary,and ectopic posterior pituitary,leading to the diagnosis of ***,the patient underwent 6 mo of gonadotropin therapy without significant changes in hormone levels and secondary sexual *** gonadotropin-releasing hormone therapy was then administered,resulting in the detection of sperm in the semen analysis within 3 *** 6 mo,routine semen tests showed normal semen *** couple faced challenges in conceiving due to abstinence and underwent three cycles of artificial insemination,which was *** also attempted in vitro fertilization,but unfortunately,the woman experienced a miscarriage 10 wk after the embryo *** Early detection,accurate diagnosis,and timely treatment are crucial in improving the quality of life and fertility of PSIS patients.

关键词： Pituitary stalk interruption syndrome Hypogonadotropic hypogonadism Spermatogenesis Pulsatile gonadotropinreleasing hormone therapy Case report

Tumour response following preoperative chemotherapy is affected by body mass index in patients with colorectal liver metastases

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 331-342页

作者： hua-Chuan Song Hang-Cheng Zhou Ping Gu Bing Bao Quan Sun Tian-Ming Mei Wei Cui Kang Yao huan-Zhang Yao shen-Yu Zhang Yong-Shuai Wang Rui-Peng Song Ji-Zhou Wang Department of General Surgery Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastrointestinal Surgery Tongcheng People’s HospitalTongcheng 231400Anhui ProvinceChina Department of Gastrointestinal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of General Surgery Xuancheng People’s HospitalXuancheng 242000Anhui ProvinceChina

BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of *** chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases(CRLMs).Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of ***,the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative *** mass index(BMI)is one of the factors affecting the tumori-genesis and progression of colorectal cancer as well as prognosis after various antitumour *** studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight,particularly when receiving first-line chemotherapy regimens in combination with *** To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for *** A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July *** and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological *** Kaplan-Meier method with log rank test was used to compare progression-free survival(PFS)between patients with high and low ***<24.0 kg/m^(2) was defined as low BMI,and tumour regression grade 1-2 was defined as complete tumour *** Low BMI was observed in 74(58.7%)patients and complete tumour response was found in 27(21.4%)*** rate of complete tumour response was significantly higher in patients with low BMI(29.7%vs 9.6%,P=0.007).Multivariate analysis revealed that low BMI[odds ratio(OR)=4.56,95%confidence interval(CI):1

关键词： Colorectal liver metastases Body mass index Tumour regression grade Preoperative chemotherapy Hepatectomy

Integrated gut microbiota,plasma metabolomics and network pharmacology to reveal the anti-ischemic stroke effect of cooked rhubarb

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Traditional Medicine Research 2024年第9期9卷 1-13页

作者： Ting Li Lan-Fang Tan Lin shen Jie-Hui Kuang Si-Kai Zhan Bang Liu Jia-Le Cai sheng-Wang Liang Ming-hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization Guangxi Institute of BotanyChinese Academy of SciencesGuilin 541006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527300China

Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum *** Balf.)with millet *** is used as a traditional Chinese medicine for treating cerebral stroke,where patients often face severe *** study explored the pharmacological effects and mechanisms of CR against ischemic stroke(IS)in *** used integrated analysis of gut microbiota,metabolomics,and network ***:The compounds in CR were identified using LC-MS/*** impact of CR on rat middle cerebral artery occlusion/reperfusion(MCAO/R)-induced cerebral infarct size and brain tissue pathology was assessed through 2,3,5-triphenyl tetrazolium chloride and HE *** in hemorheology were measured by evaluating blood viscosity,and serum levels of pro-inflammatory cytokine were also *** microbiota composition was analyzed through 16S rRNA gene *** metabolites were examined using untargeted metabolomics and Spearman correlation *** pseudo-germ-free test was used to determine whether tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)improvement in IS are dependent on gut ***:In vivo studies showed CR enhances neurobehavioral function in MCAO/R rats and reduces cerebral infarction *** also ameliorates brain and intestinal barrier damage caused by *** also decreased inflammation and oxidative stress in IS ***,CR promotes the growth of Akkermansia and Verrucomicrobia,aiding in intestinal barrier ***,CR primarily influences the primary bile acid biosynthesis *** pseudo-germ-free experiment and network pharmacology confirmed TNF-αand IL-1βas potential *** relies on gut microbiota for its anti-inflammatory effects to improve ***:Cooked rhubarb offers neuroprotective benefits by enhancing beneficial bacteria abundance and regulating bile acid *** emerges as a potential therapeutic agent for

关键词： cooked rhubarb ischemic stroke gut microbiota metabolomics

耳穴压籽联合中医护理路径在肝病患者护理中的应用

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医学信息 2024年第11期37卷 146-149页

作者：黄江华龚丹丹安义县中医院内科

目的研究耳穴压籽联合中医护理路径在肝病患者护理中的应用效果。方法选取2021年1月-2023年1月在我院治疗的64例肝病患者为研究对象，采用随机数字表法分为观察组和对照组，每组32例。对照组给予常规护理，观察组采用耳穴压籽联合中... 详细信息

目的研究耳穴压籽联合中医护理路径在肝病患者护理中的应用效果。方法选取2021年1月-2023年1月在我院治疗的64例肝病患者为研究对象，采用随机数字表法分为观察组和对照组，每组32例。对照组给予常规护理，观察组采用耳穴压籽联合中医护理路径干预。比较两组临床症状（肋痛、腹胀、黄疸、纳呆）评分、肝功能指标[血清总胆红素（TBiL）、天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）]、生活质量评分及护理满意度。结果两组肋痛、腹胀、黄疸、纳呆评分均低于干预前，且观察组低于对照组（P<0.05）；两组TBiL、AST、ALT均低于干预前，且观察组低于对照组（P<0.05）；两组心理功能、躯体功能、社会功能、物质生活状态评分均高于干预前，且观察组高于对照组（P<0.05）；观察组护理满意度（96.88%）高于对照组（81.25%）(P<0.05)。结论耳穴压籽联合中医护理路径在肝病患者护理中效果确切，可减轻患者临床症状，改善肝功能，提高其生活质量水平，应用有效性和可行性良好。

关键词：耳穴压籽中医护理路径肝病

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水下地形匹配导航研究综述

科学技术与工程 2024年第14期24卷 5690-5706页

作者：丁鹏杨申申王磊沈丹中国船舶科学研究中心无锡214082 深海载人装备国家重点实验室无锡214082 深海技术科学太湖实验室无锡214082

地形辅助导航系统以地形高程特征为定位信息源,可为水下航行器提供有界的定位误差,并能显著地抑制捷联惯性导航系统的误差漂移。而地形匹配算法是地形辅助导航系统的关键技术,其输出的匹配位置可作为组合导航滤波器的观测值以修正导航参... 详细信息

地形辅助导航系统以地形高程特征为定位信息源,可为水下航行器提供有界的定位误差,并能显著地抑制捷联惯性导航系统的误差漂移。而地形匹配算法是地形辅助导航系统的关键技术,其输出的匹配位置可作为组合导航滤波器的观测值以修正导航参数,地形匹配精度直接决定了整个导航系统性能。首先概述了现有水下导航定位技术,然后阐述了地形辅助导航基本原理与组成,最后详细总结了中外地形辅助导航系统和地形匹配算法的研究进展,为中国地形辅助导航系统的开发和研制提供有益参考和支撑。

关键词：水下航行器惯性导航地形辅助导航地形匹配组合导航

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左腰部肿物

中华病理学杂志 2006年第6期35卷 375-376页

作者：鲍冬梅汪湛沈丹华北京大学人民医院病理科 100044 北京大学人民医院放射科 100044

1.病例简介:患者女,46岁.左腰部肿物术后左髋部疼痛、麻木,逐渐加重3年,于2003年11月10日入院.继往史:40年前无明显诱因出现左腰部肿物,无不适感,手术切除;约20年前左腰部再次出现肿物,予以切除;3年前出现肿物,切除后左髋部疼痛、麻木,... 详细信息

1.病例简介:患者女,46岁.左腰部肿物术后左髋部疼痛、麻木,逐渐加重3年,于2003年11月10日入院.继往史:40年前无明显诱因出现左腰部肿物,无不适感,手术切除;约20年前左腰部再次出现肿物,予以切除;3年前出现肿物,切除后左髋部疼痛、麻木,逐渐加重,于当地穿刺病理诊断为纤维肉瘤.体检:左髋部感觉减退。

关键词：左腰部肿物髋部疼痛手术切除病理诊断为病例简介感觉减退纤维肉瘤出现不适感

Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB

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Biomedical and Environmental Sciences 2024年第3期37卷 303-314页

作者： YANG Liu WANG Shi Yu JIANG Ting Ting DENG Wen CHANG Min WU Shu Ling CAO Wei hua LU Yao shen Ge LIU Ru Yu GAO Yuan Jiao XU Meng Jiao HU Lei Ping ZHANG Lu XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Infectious Diseases Second Affiliated Hospital of Air Force Medical UniversityXi'an 710038ShaanxiChina Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China

Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and *** This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow *** In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<*** Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.

关键词： CHB Dendritic Cells Intermittent Interferon Therapy Plateau Phase

Efficacy of graphene nanocomposites for air disinfection in dental clinics: A randomized controlled study

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World Journal of Clinical Cases 2024年第28期12卷 6173-6179页

作者： Ya-Qiong Ju Xiang-hua Yu Jing Wu Ying-Hui Hu Xiang-Yong Han dan Fang Department of Nursing Minhang District Dental ClinicShanghai 201107China Department of Medical Sciences Minhang District Dental ClinicShanghai 201107China Department of Orthopedics Center for Spinal Minimally Invasive ResearchShanghai Jiao Tong UniversityShanghai 201107China

BACKGROUND Aerosols containing disease-causing microorganisms are produced during oral diagnosis and treatment can cause secondary *** To investigate the use of graphene material for air disinfection in dental clinics by leveraging its adsorption and antibacterial *** Patients who received ultrasonic cleaning at our hospital from April 2023 to April *** were randomly assigned to three groups(n=20 each):Graphene nanocomposite material suction group(Group A),ordinary filter suction group(Group B),and no air suction device group(Group C).The air quality and air colony count in the clinic rooms were assessed before,during,and after the ***,bacterial colony counts were obtained from the air outlets of the suction devices and the filter screens in Groups A and *** Before ultrasonic cleaning,no significant differences in air quality PM2.5 and colony counts were observed among the three ***,significant differences in air quality PM2.5 and colony counts were noted among the three groups during ultrasonic cleaning and after ultrasonic ***,the number of colonies on the exhaust port of the suction device and the surface of the filter were significantly lower in Group A than in Group B(P=0.000 and P=0.000,respectively).CONCLUSION Graphene nanocomposites can effectively sterilize the air in dental clinics by exerting their antimicrobial effects and may be used to reduce secondary pollution.

关键词： Graphene Nanocomposites Oral clinic Air disinfection Secondary contamination

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宫颈腺样基底细胞癌10例临床病理分析

中华肿瘤防治杂志 2018年第21期25卷 1528-1532页

作者：张晓波沈丹华北京大学人民医院病理科

目的宫颈腺样基底细胞癌(adenoid basal carcinoma,ABC)发病罕见,易和其他疾病混淆,本研究观察和分析宫颈ABC的临床病理学特征、免疫组化表达等,以期对该病有更深入的了解。方法回顾性分析10例ABC患者的临床病理资料,分析其病理组织学... 详细信息

目的宫颈腺样基底细胞癌(adenoid basal carcinoma,ABC)发病罕见,易和其他疾病混淆,本研究观察和分析宫颈ABC的临床病理学特征、免疫组化表达等,以期对该病有更深入的了解。方法回顾性分析10例ABC患者的临床病理资料,分析其病理组织学特点及免疫组化表达,结合相关文献总结病理学特征。结果选取2008-02-01-2017-08-31北京大学人民医院诊治的10例ABC患者,年龄53~76岁,中位年龄63.3岁。2例因绝经后阴道出血就诊,5例因绝经后阴道分泌物异常就诊,其他3例无特异性症状。6例高危型人乳头瘤病毒(human papillomavirus,HPV)检测为阳性,细胞学检测4例为高级别鳞状上皮内病变(high grade squamous intraepithelial lesions,HSIL),1例为低级别鳞状上皮内病变(low grade squamous intraepithelial lesions,LSIL)。7例行全子宫(伴或不伴有双侧附件)切除术,2例行宫颈锥形切除术。镜下,肿瘤细胞呈巢状、条索状在宫颈间质中浸润性生长。癌巢边缘呈栅栏状排列,细胞体积较小,形态较一致。术后病理,5例伴随HSIL,2例伴宫颈鳞状细胞癌(squamous cell carcinoma,SCC),1例伴癌肉瘤,1例为单纯的ABC。8例免疫组化CK、CK5/6、p63、p40、p16均为阳性,6例p53阳性,7例CEA阳性,Ki-67增殖指数为5%~20%。10例病例FIGO分期均为IA期。仅1例因合并癌肉瘤,术后复发转移而死亡,1例失访,其余8例均无复发和转移。结论宫颈ABC好发于绝经后中老年妇女,多无特殊临床表现,常伴有高危型HPV感染及鳞状上皮内病变,在诊断时需与腺样囊性癌、基底细胞样鳞癌等鉴别,整体预后较好。

关键词：宫颈腺样基底细胞癌临床病理免疫组化预后