检索结果-南通市图书馆

EBV-Mir-BART5-5p targets p53 independent pathway in cytoplasm:Potential role in EBV lymphomagenesis

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第4期10卷 1154-1156页

作者： Wei-Ting Wang Jing-Ran Guo Li Wang Jia-Zhu Wu Hao-rui shen Yi-Lin Kong Yi Xia Jian-Yong Li Jin-Hua Liang Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China

EBV-positive diffuse large B-cell lymphoma(DLBCL),which has a clonal EBV carrying proliferation of B-cells,defines a new DLBCL subtype and predicts a poor *** studies are needed to explore the underlying mechanisms in EBV *** encoded microRNAs(miRNAs)have been proven to contribute to the pathogenesis and oncogenesis of EBV-associated malignancies.^(1)In this study,research has focused on the pathological roles of miRNAs in EBV-positive DLBCL progression and survival,which might provide ideas for therapeutic decision to improve the prognosis.

关键词： lymphoma EBV pathogenesis

长尾理论模式下的图书分销业引入风险投资的可行性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

出版发行研究 2007年第4期 34-38页

作者：申睿四川大学新闻传播研究所

在目前的图书分销市场上,占据绝大多数的是利润微薄或难收成本的小众图书,这些图书的销售就真的是“赔本的买卖”?事实证明,依据“长尾”理论建立的营销模式是可以改变这种状况的。然而这一创新模式的建立需要相当大的投入,本文提出了... 详细信息

在目前的图书分销市场上,占据绝大多数的是利润微薄或难收成本的小众图书,这些图书的销售就真的是“赔本的买卖”?事实证明,依据“长尾”理论建立的营销模式是可以改变这种状况的。然而这一创新模式的建立需要相当大的投入,本文提出了利用风险投资的思路,并对其可行性进行了深入分析与探讨,其理论价值与实践意义值得业界关注。

关键词：风险投资图书长尾理论分销业分销市场事实证明营销模式

RNA m6A dynamic modification mediated by nucleuslocalized FTO is involved in follicular reserve

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第2期45卷 415-428页

作者： Jiao-Na Zhang rui-Ting Wang Francesca-Gioia Klinger Shun-Feng Cheng Wei shen Xiao-Feng Sun College of Life Sciences Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of ShandongQingdao Agricultural UniversityQingdaoShandong 266109China Department of Biomedicine and Prevention University of Rome Tor VergataRome 00133Italy

In eukaryotic organisms,the most common internal modification of messenger RNA(m RNA)is N6-methyladenosine(m6A).This modification can be dynamically and reversibly controlled by specific enzymes known as m6A writers and *** fat-mass and obesity-associated protein(FTO)catalyzes RNA demethylation and plays a critical role in various physiological and pathological *** research identified dynamic alterations in both m6A and FTO during the assembly of primordial follicles,with an inverse relationship observed for m6A levels and nuclear-localized FTO *** of Fto small interfering RNA(si RNA)altered the expression of genes related to cell proliferation,hormone regulation,and cell chemotaxis,and affected RNA alternative *** of the full-length Fto gene led to changes in m6A levels,alternative splicing of Cdk5,cell proliferation,cell cycle progression,and proportion of primordial ***,overexpression of Fto lacking a nuclear localization signal(NLS)did not significantly alter m6A levels or primordial follicle *** findings suggest that FTO,localized in the nucleus but not in the cytoplasm,regulates RNA m6A demethylation and plays a role in cell proliferation,cell cycle progression,and primordial follicle *** results highlight the potential of m6A and its eraser FTO as possible biomarkers and therapeutic targets.

关键词： m6A FTO Ovary Primordial follicle assembly Alternative splicing

Impact of myocardial perfusion imaging on in-hospital coronary angiography and revascularization of patients with suspected coronary artery disease

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第11期124卷 1603-1609页

作者： HAN Ping-ping TIAN Yue-qin FANG Wei YANG Min-fu ZHANG Xiao-li shen rui SUN Xiao-xin QIAO Shu-bin YANG Yue-jin HE Zuo-xiang Depamnent of Nuclear Medicine (Han PP Tian YQ Fang W YangMF Zhang XL Shen R Sun XX and He ZX) Department ofCardiology (Qiao SB and Yang YJ) Fuwai Hospital andCardiovascular Institute Chinese Academy of Medical Sciences &Peking Union Medical College Beijing 100037 China

Background Noninvasive cardiac imaging is now central to the diagnosis and management of patients with moderate probability for coronary artery disease. The aim of this study was to assess the impact of stress myocardial perfusion single photon emission computerized tomography （SPECT） on in-hospital coronary angiography and revascularization for such patients. Methods Between January 2005 and June 2007, 1053 consecutive in-hospital patients （423 women,

关键词： stress single photon emission computerized tomography coronary angiography revascularization hospitalization

Gallbladder polypoid lesions: Current practices and future prospects

在线全文

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 2024年第14期137卷 1674-1683页

作者： Wang Kun Xu Qingpeng Xia Lu Sun Jianing shen Kanger Liu Haoran Xu Linning Li rui Department of Gastroenterology The First Affiliated Hospital of Soochow University Suzhou Jiangsu China

Gallbladder polypoid lesions (GPLs) refer to any elevated lesion of the mucosal surface of the gallbladder wall, and the prevalence is estimated to be between 0.9% and 12.1%. GPLs include benign polyps and malignant polyps. Benign polyps are further classified as non-neoplastic polyps and neoplastic polyps. Cholesterol polyps are the most common benign polyps and adenocarcinoma is the main type of malignant polyp. Hepatitis B virus infection, liver function abnormalities, dyslipidemia, and obesity are the main risk factors for GPLs. Studies of biological mechanisms have focused on malignant gallbladder polyps, the development of which is regulated by hormone levelsin vivo, gut microbiota, inflammation, oxidative stress,Salmonella typhimurium, and related molecules. Diagnostic modalities include chemical examination and imaging examination, with imaging examination currently being the mainstay. Treatment of patients with GPLs is based on the presence or absence of symptoms, age, size of the polyps, tendency of the polyp to increase, and risk factors for symptomatic malignancy to determine whether surgery should be performed.

关键词： Gallbladder neoplasms Benign polyps Malignant polyps Risk factors Biological mechanism Diagnosis Treatment

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

微流控结晶系统制备窄分布微米级硝胺炸药

含能材料 2024年第3期32卷 256-269页

作者：夏皓轩石锦宇刘津搏周星屹费翼鹏宁爵勇刘立朱朋沈瑞琪南京理工大学化学与化工学院江苏南京210094 微纳含能器件工业和信息化部重点实验室江苏南京210094 中国工程物理研究院化工材料研究所四川绵阳621999

为了在安全临界尺度下实现炸药结晶的调控与批量生产,基于微流控技术组建了ZS-1型微流控结晶系统,并选用二甲亚砜(DMSO)和去离子水分别作为溶剂与反溶剂,通过改变两相流量比、炸药相浓度与总流量等结晶过程参数,在微尺度下进行了环三亚... 详细信息

为了在安全临界尺度下实现炸药结晶的调控与批量生产,基于微流控技术组建了ZS-1型微流控结晶系统,并选用二甲亚砜(DMSO)和去离子水分别作为溶剂与反溶剂,通过改变两相流量比、炸药相浓度与总流量等结晶过程参数,在微尺度下进行了环三亚甲基三硝胺(RDX)的粒度控制研究和环四亚甲基四硝胺(HMX)的粒度与晶型控制研究,探索了结晶参数的高通量筛选。在ZS-1型微流控结晶系统上进行了微米级RDX的批量制备实验。结果表明,经系统重结晶细化的RDX样品的D_(50)为3.35μm,跨度(粒径分布)为0.956,纯度为99.80%,平均粒径较原料RDX缩小了22.2倍,且产量可达每小时百克量级,验证了微尺度下窄分布微米级炸药批量制备的可行性。

关键词：微流控硝胺类炸药重结晶调控柔性制造

Tandem hydroalkylation and deoxygenation of lignin-derived phenolics to synthesize high-density fuels

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第2期66卷 104-109页

作者： rui Yu Zhensheng shen Yanan Liu Chengxiang Shi Juncong Qu Lun Pan Zhenfeng Huang Xiangwen Zhan g Ji-Jun Zou Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Collaborative Innovative Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Lignin is the most abundant naturally phenolic biomass,and the synthesis of high-performance renewable fuel from lignin has attracted significant *** propose the efficient synthesis of high-density fuels using simulated lignin cracked oil in tandem with hydroalkylation and deoxygenation ***,we investigated the reaction pathway for the hydroalkylation of phenol,which competes with the hydrodeoxygenation form *** then,we investigated the effects of metal catalyst types,the loading amount of metallic,acid dosage,and reactant ratio on the reaction *** phenol hydroalkylation and hydrodeoxygenation were balanced when 180℃ and 5 MPa H_(2)with the alkanes yield of 95%.By extending the substrate to other lignin-derived phenolics and simulated lignin cracked oil,we obtained the polycyclic alkane fuel with high density of 0.918 g·ml^(-1)and calorific value of41.2 MJ·L^(-1).Besides,the fuel has good low-temperature properties(viscosity of 9.3 mm^(2)·s^(-1)at 20℃ and freezing point below-55℃),which is expected to be used as jet *** work provides a promising way for the easy and green production of high-density fuel directly from real lignin oil.

关键词： High-density fuel Biofuel Hydrogenation Alkylation Lignin Phenolics

基于动力非线性有限元法的索-梁相关振动研究

在线全文

学校读者我要写书评

暂无评论

振动与冲击 2015年第5期34卷 159-167页

作者：王涛沈锐利西南交通大学土木工程学院桥梁系成都610031

根据考虑结构几何非线性的有限元动力时程积分算法,开发了有限元程序SD_FEM。使用该程序建立了精细的索-梁组合结构有限元模型,计算了结构的自振特性与结构在外部动力荷载作用下的振动响应。分别讨论了当整体结构自振频率与拉索局部自... 详细信息

根据考虑结构几何非线性的有限元动力时程积分算法,开发了有限元程序SD_FEM。使用该程序建立了精细的索-梁组合结构有限元模型,计算了结构的自振特性与结构在外部动力荷载作用下的振动响应。分别讨论了当整体结构自振频率与拉索局部自振频率有1∶1、2∶1和不成倍数关系时,索-梁相关振动导致拉索振动的状况。分析了数值计算结果,总结了索-梁相关振动的本质规律。

关键词：拉索振动动力特性几何非线性有限元方法

基于在线评论的产品需求偏好判别与客户细分——以智能手机为例

在线全文

学校读者我要写书评

暂无评论

中国管理科学 2023年第3期31卷 217-227页

作者：孙冰沈瑞哈尔滨工程大学经济管理学院黑龙江哈尔滨150001

在数据为王的时代背景下,在线评论因具有信息多样性和参与群体性的特征而备受国内外学者的关注。本文以京东和天猫网络购物平台上的4款智能手机为研究对象,获取有效的在线评论26489条。首先,采用BAE判定算法提取了手机产品的特征词,借... 详细信息

在数据为王的时代背景下,在线评论因具有信息多样性和参与群体性的特征而备受国内外学者的关注。本文以京东和天猫网络购物平台上的4款智能手机为研究对象,获取有效的在线评论26489条。首先,采用BAE判定算法提取了手机产品的特征词,借助基于互信息和语义相似度的相关性分析对消费者的产品需求偏好进行了归类与判别。其次,基于情感倾向分析得出消费者的7个需求偏好维度的分值,形成了用于表征消费者的多维分值向量,并采用改进的两步聚类法对智能手机的消费者进行了群组划分,总结了各类消费者群组的特征,进而对4款智能手机的消费者群组的构成进行了分析和比较。最后,根据研究结果得出了相关管理启示。

关键词：在线评论产品需求偏好消费者群组 BAE判定算法多维分值向量