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Inactivation of Poliovirus by Ozone and the Impact of Ozone on the Viral Genome

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Biomedical and Environmental Sciences 2019年第5期32卷 324-333页

作者： JIANG Han Ji CHEN Na shen Zhi Qiang YIN jing qiu Zhi Gang MIAO jing yang Zhong Wei SHI dan yang wang hua Ran wang Xin Wei LI Jun Wen yang Dong JIN Min Department of Environment and Health Tianjin Institute of Environmental & Operational Medicine Key Laboratory of Risk Assessment and Control for Environment & Food Safety

Objective To investigate the mechanisms underlying ozone-induced inactivation of poliovirus type 1(PV1). Methods We used cell culture, long‐overlapping RT‐PCR, and spot hybridization assays to verify and accurately locate the sites of action of ozone that cause PV1 inactivation. We also employed recombinant viral genome RNA infection models to confirm our observations. Results Our results indicated that ozone inactivated PV1 primarily by disrupting the 5′-non‐coding region(5′‐NCR) of the PV1 genome. Further study revealed that ozone specifically damaged the 80‐124 nucleotide(nt) region in the 5′-NCR. Recombinant viral genome RNA infection models confirmed that PV1 lacking this region was non‐infectious. Conclusion In this study, we not only elucidated the mechanisms by which ozone induces PV1 inactivation but also determined that the 80‐124 nt region in the 5′‐NCR is targeted by ozone to achieve this inactivation.

关键词： Poliovirus Poliomyelitis Ozone Disinfection

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夏直播棉花产量与冠层微环境的关系

作物学报 2024年第9期50卷 2371-2382页

作者：彭杰谢晓麒张钊姚晓芬邱深陈丹丹顾晓娜王玉洁王晨晨杨国正华中农业大学植物科学技术学院湖北武汉430070

夏直播棉花能够在较短生育期内获得与常规模式相当的产量,但其产量高效形成的机理及其与冠层微环境的关系仍不清楚。因此,本试验采用完全随机区组设计,设置6个种植密度(7.50株m^(–2)、8.25株m^(–2)、9.00株m^(–2)、9.75株m^(–2)、10... 详细信息

夏直播棉花能够在较短生育期内获得与常规模式相当的产量,但其产量高效形成的机理及其与冠层微环境的关系仍不清楚。因此,本试验采用完全随机区组设计,设置6个种植密度(7.50株m^(–2)、8.25株m^(–2)、9.00株m^(–2)、9.75株m^(–2)、10.50株m^(–2)和11.25株m^(–2)),于2022-2023年在湖北武汉进行了大田试验。采用温湿度仪记录从现蕾到拔杆期间冠层温度和湿度,冠层分析仪测定结铃期冠层不同高度光辐射强度,手工收获计产。结果表明,棉花产量随种植密度增加先升后降,其中9.75株m^(–2)最高(籽棉3246.5 kg hm^(–2)、皮棉1203.2 kg hm^(–2)), 2年平均较7.50株m^(–2)提高(15.0%和17.8%)。冠层日均温、最高温、最低温随种植密度增加而降低,而冠层相对湿度、最高湿度、最低湿度随种植密度增加而增加。冠层透光率,水平方向呈“V”型分布,棉行中间最大;垂直方向中下部(离地10^50cm)随种植密度增加而减小,上部(离地50^70cm)随种植密度增加而增大。群体叶面积指数随种植密度增加先升后降,其中9.75株m^(–2)最高,2年平均为2.6。相关分析表明,棉花产量随冠层日均温和最高温升高而降低,随冠层相对湿度和最高湿度增加而增加;随冠层中下部透光率增大而减小,随上部透光率增加而增大。综上,棉花夏直播种植模式,适当增加种植密度(9.75^11.25株m^(–2))有利于提高单位面积成铃数,改善冠层微环境,如冠层透光率70cm处85%以上,50 cm处37%^40%,30 cm处14%^16%,10 cm处9%以下,冠层温度26.5^27.0℃,冠层湿度74%^77%,从而提高棉花产量。

关键词：夏直播产量冠层微环境种植密度叶面积指数

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen shao-Long Chen shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui zhaoyuan Cui Brunella D'Anzi Ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Association between antiplatelet medication and cerebral microbleeds in stroke-free population

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Journal of Geriatric Cardiology 2022年第6期19卷 409-417页

作者： Miao-Xin YU Ya-Nan JIA dan-dan yang Run-hua ZHANG Yong JIANG Gui-Tao ZHANG Hui-Yu QIAO hua-Lu HAN Rui shen Zi-Han NING Xi-hai zhao Gai-Fen LIU Yong-Jun wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology the Third Hospital of Hebei Medical UniversityShijiazhuangChina Department of Radiology Beijing Geriatric HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Center for Biomedical Imaging Research Department of Biomedical EngineeringTsinghua UniversityBeijingChina Beijing Institute of Brain Disorders Capital Medical UniversityBeijingChina

BACKGROUND Cerebral microbleeds(CMBs)may increase the risk of future intracerebral hemorrhage and ischemic ***,It is unclear whether antiplatelet medication is associated with *** study aimed to investigate the association between antiplatelet medication and CMBs in a community-based stroke-free *** In this cross-sectional study,stroke-free participants aged 18-85 years were recruited from a community in Beijing,***,clinical,and antiplatelet medication data were collected through a questionnaire,and all participants underwent blood tests and brain magnetic resonance imaging at *** presence,count,and location of CMBs were evaluated using susceptibility-weighted *** association between antiplatelet medication and the presence of CMBs was analyzed using multivariable logistic *** associations between antiplatelet medication and CMBs by location(lobar,deep brain or infratentorial,and mixed regions)were also analyzed using multinomial logistic regression.A linear regression analysis was conducted to determine the association between antiplatelet medication and the log-transformed number of *** Of the 544 participants(mean age:58.65±13.66 years,217 males),119 participants(21.88%)had CMBs,and 64 participants(11.76%)used antiplatelet *** medication was found to be associated with CMBs at any location[odds ratio(OR)=2.39,95%CI:1.24-4.58]and lobar region(OR=2.83,95%CI:1.36-5.86),but not with the number of CMBs(β=0.14,95%CI:-0.21-0.48).Among antiplatelet medications,aspirin use was found to be associated with any CMB(OR=3.17,95%CI:1.49-6.72)and lobar CMBs(OR=3.61,95%CI:1.57-8.26).CONCLUSIONS Antiplatelet medication was associated with CMBs in stroke-free participants,particularly lobar *** antiplatelet medications,aspirin use was associated with any CMB and lobar *** findings suggest that it might be essential to optimize the management of antiplatelet medication in t

关键词： medication 3.0T antiplatelet

Evaluation of a new frequency-volume chart for children with primary monosymptomatic nocturnal enuresis:a prospective,comparative study

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World Journal of Pediatrics 2021年第6期17卷 643-652页

作者： jing-jing wang Dong-Jie wang hai-Dong Fu De-Xuan wang Qing yang Xiao-Jie Peng Rui Fu huan-dan yang Rui-Feng Zhang Xiao-Wen wang Jiang-Wei Luan Fei zhao qiu-Xia Chen Fang-Fang Liang Lu Cao Jian-Jiang Zhang Ying-Jie Li yang Dong Hui-Mei huang Ying Bao Xiao-Yu shen Wei Zhou Guang-hai Cao Cui-hua Liu Yan-Yan Jin Mei-Lin Ma Li Jiang Qian shen Hong Xu Jian-hua Mao Department of Nephrology TChildren's Hospital of Zhejiang University School of MedicineNational Clinical Research Center of Child HealthHangzhouChina Department of Nephrology The Second Attiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhouChina Department of Nephrology Jiangxi Provincial Children's HospitalNanchangChina Department of Nephrology Xuzhou Children's HospitalXuzhou Medical UniversityXuzhouChina Department of Nephrology Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Nephrology Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Rheumatology Shenzhen Children's HospitalShenzhenChina Department of Pediatrics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Nephrology Guangzhou Women and Children's Medical CenterGuangzhouChina Department of Nephrology Anhui Provincial Children's HospitalHefeiChina Department of Nephrology The Affiliated Children Hospital of Xi'an Jiaotong UniversityXi'anChina Department of Nephrology Shanghai Children's Medical CenterShanghaiChina Department of Nephrology and Rheumatology Children's Hospital Affiliated to ZhengZhou UniversityHenan Children's HospitalZhengZhou Children's HospitalZhengZhouChina Medical Affairs Department Ferring Pharmaceuticals(Asia)Company LimitedShanghaiChina Marketing Department Ferring Pharmaceuticals(Asia)Company LimitedShanghaiChina Department of Nephrology The Children's Hospital of Fudan UniversityShanghaiChina

Introduction To improve compliance with voiding diaries in children with primary monosymptomatic nocturnal enuresis(PMNE),a new modified 3-day weekend frequency-volume chart(FVC)was designed,and the compliance and validity of this modified FVC was evaluated by comparing with the International Children's Continence Society(ICCS)recommended voiding *** A total of 1200 patients with PMNE were enrolled in the study from 13 centers in China and were randomly assigned to record this modified FVC or the ICCS-recommended voiding *** primary outcome measure was the compliance,assessed by comparing the completing index and the quality score of diaries between two *** secondary outcome measure was the validity,evaluated by comparing the constituent of subtypes,micturition parameters and response rate to *** Among the 1200 participants enrolled in the study,447 patients completed the ICCS-recommended voiding diary and 469 completed the modified *** diurnal completing index and the quality score of the modified FVC group were better than those of the ICCS *** addition,there was no significant difference between these two groups in the subtype classification,or in the response rate to *** The modified FVC could be applied to obtain the voiding characteristics of children with PMNE as the ICCS-recommended voiding diary does and offers a reasonable and better choice for children with PMNE from the unselected population in the future.

关键词： Children Compliance Nocturnal enuresis Voiding diary

VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment

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Signal Transduction and Targeted Therapy 2020年第1期5卷 852-864页

作者： Pei-Shan Hu Ting Li Jin-Fei Lin Miao-Zhen qiu De-shen wang Ze-Xian Liu Zhan-Hong Chen Lu-Ping yang Xiao-Long Zhang Qi zhao Yan-Xing Chen yun-Xin Lu Qi-Nian Wu Heng-Ying Pu zhao-Lei Zeng dan Xie huai-Qiang Ju Hui-Yan Luo Rui-hua Xu Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center510060 GuangzhouPeople’s Republic of China Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences510060 GuangzhouPeople’s Republic of China Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease the Third Affiliated Hospital of Sun Yat-sen University510060 GuangzhouPeople’s Republic of China

The acidic tumor microenvironment provides an energy source driving malignant tumor *** of cells to an acidic environment leads to the emergence of cancer stem *** expression of the vitamin D receptor(VDR)is closely related to the initiation and development of colorectal carcinoma(CRC),but its regulatory mechanism in CRC stem cells is still *** study revealed that acidosis reduced VDR expression by downregulating peroxisome proliferator-activated receptor delta(PPARD)*** of VDR effectively suppressed the stemness and oxaliplatin resistance of cells in *** nuclear export signal in VDR was sensitive to acidosis,and VDR was exported from the *** immunoprecipitation(ChIP)and assay for transposase-accessible chromatin with high-throughput sequencing(ATAC-seq)analyses showed that VDR transcriptionally repressed SRY-box 2(SOX2)by binding to the vitamin D response elements in the promoter of SOX2,impairing tumor growth and drug *** demonstrated that a change in the acidic microenvironment combined with overexpression of VDR substantially restricted the occurrence and development of CRC in *** findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling,resulting in a lack of efficacy of vitamin D in antineoplastic process.

关键词： SOX2 vitamin colorectal

Introduction to cognitive assessment scales in screening for mild cognitive impairment after stroke: A review

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TMR Integrative Nursing 2019年第5期3卷 166-172页

作者： Luo yang Hong Guo Yan-Ling shen Li Li hai-Yan wang shao-hua Gong You-hua Liu Xiao-Ping Yi dan zhao Hui Ju School of Nursing Beijing University of Chinese MedicineBeijingChina Surgical Intensive Care Unit China-Japan Friendship HospitalBeijingChina Department of Neurology China-Japan Friendship HospitalBeijingChina.

Objective:In order to improve the quality of life of patients more effectively,this paper introduces the types and usages of scales for screening mild cognitive dysfunction after stroke and provides a basis for early identification of mild cognitive ***:Read,analyze,summarize,and sort out relevant ***:The mild cognitive impairment assessment scales are broadly divided into two categories:the comprehensive rating scales and the special assessment *** are 7 comprehensive assessment scales for the comprehensive rating scales,among which the Mini-mental State of Examination and the Montreal Cognitive Assessment Scale are the most widely *** special assessment scales are mainly evaluated by the symptoms of cognitive dysfunction and can be divided into five ***:Early diagnosis and intervention in patients with cognitive dysfunction will help improve the prognosis of *** assessment scale has its advantages and limitations in both sensitivity and *** use of appropriate scales to diagnose cognitive dysfunction and to screen early,to prevent early,to treat early can effectively improve the quality of life of elderly patients.

关键词： Stroke Mild cognitive dysfunction Rating scale

Effects and mechanisms of glucose-insulin-potassium on post-procedural myocardial injury after percutaneous coronary intervention

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Journal of Geriatric Cardiology 2020年第9期17卷 554-560页

作者： Yi-dan HAO Peng HAO Zheng wang Ying-Xin zhao Zhi-Ming ZHOU Yu-yang LIU De-An JIA Hong-Ya HAN Bin HU hua shen Fei GAO Guo-Zhong PAN Zhen-Feng GUO Shi-Wei yang Yu-Jie ZHOU Beijing Anzhen Hospital Capital Medical UniversityBeijing Institute of HeartLung and Blood Vessel Diseasethe Key Laboratory of Remodeling-related Cardiovascular DiseaseMinistry of EducationBeijingChina Peking University Third Hospital BeijingChina Dongzhimen Hospital Eastern Affiliated to Beijing University of Chinese Medicine BeijingChina Benq Medical Center Nanjing Medical UniversityNanjingChina

Objective To evaluate the effects and mechanisms of glucose-insulin-potassium(GIK)on post-procedural myocardial injury(PMI)after percutaneous coronary intervention(PCI).Methods A total of 200 non-diabetic patients with documented coronary heart disease(CHD)were divided into the Group GIK and Group G,with 100 patients in each *** in Group G were given intravenous infusion of glucose solution 2 hours before *** compared,patients in Group GIK were given *** Both post-procedural creatine phosphokinase isoenzyme MB(CK-MB;62.1±47.8 vs.48.8±52.6 U/L,P=0.007)and cTnI(0.68±0.83 vs.0.19±0.24 ng/mL,P3 times,which were significantly lower than those in Group GIK(14.0%and 7.0%,respectively;all P values3 times,which were also significantly lower than those in Group GIK(21.0%and 13.0%,respectively;all P3 ***,pre-procedural RBG levels<5.0mmol/L were significantly associated with higher risk of post-procedural increases in both CK-MB and cTnI *** In non-diabetic patients with CHD,the administration of GIK may increase the risk of PMI due to hypoglycemia induced by GIK.

关键词： Glucose-insulin-potassium Post-procedural myocardial injury Percutaneous coronary intervention Hypoglycemia

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu dan-dan Li Wei Dong Yu-Qi Liu yang Wu Da-Xuan Tang Fu-Chun Zhang Meng qiu Qi hua jing-Yu He Jun Li Bai Du Ting-hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen yang-Gan wang hai-Rong wang Qin Yu jing He Yi-Lin Mao Xiao-Fang Bin Yue Deng Yu-dan Tian Qing-hua Han Da-Jin Liu Li-Qin Duan Ming-Jun zhao Cui-Ying Zhang hai-Ying Dai Ze-hua Li Ying Xiao You-Zhi Hu Xiao-Yu huang Kun Xing Xin Jiang Chao-Feng Liu jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying yang Yao-Rong Dong Lei Zhang Guang Fu Ying Li Shu-Wei huang Li-Ping Dou Lan-Jun Sun Ying-Qiang zhao Jie Li yun Xia Jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan yang Lin Ya-Bin Zhou Jian-Fei yang Guo-Qing Ma Hui-Jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu Xiao-Jia Luo Xiao-Hong Bin Ya-Nan Yu hai-Xia dang Bing Li Fei Teng wang-Min Qiao Xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti shen Yong-Yan wang yun-Dai Chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch