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Coupling coordinated development among digital economy,regional innovation,and talent employment:A case study in the Hangzhou Metropolitan Circle,China

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Regional Sustainability 2024年第1期5卷 93-106页

作者： QIU Luyi Sharina OSMAN hua Yidi Department of International Trade and Economics Ningbo PolytechnicNingbo315800China Business School Universiti Kuala LumpurKuala Lumpur50250Malaysia Research Institute of Digital Culture and Tourism Ningbo PolytechnicNingbo315800China School of International Studies University of Nottingham Ningbo ChinaNingbo315400China

Coordinative development across various systems,particularly the economic,social,cultural,and human resources subsystems,is a key aspect of urban sustainability and has a direct impact on the quality of *** Hangzhou Metropolitan Circle,comprising Hangzhou City,Huzhou City,Jiaxing City,and shaoxing City,was the first metropolitan circle approved by the National Development and Reform Commission(NDRC)as a demonstration of economic transformation in *** evaluate the coupling coordination degree of the four cities and analyze the coordinative development in three systems(including digital economy,regional innovation,and talent employment),we collected panel data during 2015–2022 from these four *** development level of the three systems was evaluated by the standard deviation method and comprehensive development *** results are as follows:(1)the level of coupling coordinated development of the three systems in the Hangzhou Metropolitan Circle was relatively low;(2)the coupling coordination degree of the four cities in the Hangzhou Metropolitan Circle showed significant regional differences,among which Hangzhou City was in the leading position,and Huzhou,Jiaxing,and shaoxing cities made steady but slow progress in the coupling development of the three systems;and(3)the development of digital economy and talent employment needs to be *** study contributes to the coordinative development of Hangzhou Metropolitan Circle by innovatively focusing on the coupling coordination relationship among digital economy,regional innovation,and talent employment,which also meets the industrial layout of Hangzhou Metropolitan *** this way,the optimal allocation and sustainable development of digital economy,regional innovation,and talent employment in the Hangzhou Metropolitan Circle can be achieved.

关键词： Digital economy Regional innovation Talent employment Coupling coordination degree Hangzhou Metropolitan Circle

扁蒴藤素调节YAP/TAZ信号通路对创伤性关节炎大鼠的治疗作用研究

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四川医学 2024年第5期45卷 491-496页

作者：余华李少星刘相杰成都医学院第一附属医院四川成都610500

目的探究扁蒴藤素(PM)调节Yes相关蛋白(YAP)/转录共激活因子PDZ结合基序(TAZ)信号通路对创伤性关节炎(PTOA)大鼠的治疗作用。方法将SD雄性大鼠随机分为对照组、PTOA组、低剂量PM组(PM-L组,100 mg/kg PM)、高剂量PM组(PM-H组,200 mg/kg ... 详细信息

目的探究扁蒴藤素(PM)调节Yes相关蛋白(YAP)/转录共激活因子PDZ结合基序(TAZ)信号通路对创伤性关节炎(PTOA)大鼠的治疗作用。方法将SD雄性大鼠随机分为对照组、PTOA组、低剂量PM组(PM-L组,100 mg/kg PM)、高剂量PM组(PM-H组,200 mg/kg PM)和高剂量PM+YAP抑制剂VTPF组(PM-H+VTPF组,200 mg/kg PM+10 mg/kg VTPF),每组12只。记录大鼠热痛阈值、压痛阈值的变化。HE染色观察大鼠软骨组织病理学变化,并进行Mankin s评分,酶联免疫吸附试验(ELISA)检测大鼠软骨组织中炎症因子一氧化氮(NO)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)和基质金属蛋白酶(MMP)-1、MMP-3水平。TUNEL染色观察大鼠软骨组织细胞凋亡的情况。实时荧光定量PCR(RT-qPCR)实验检测大鼠软骨组织TAZ、IL-1β、TNF-αmRNA水平。Western Blot检测大鼠软骨组织YAP/TAZ信号通路相关蛋白的表达情况。结果与对照组相比,PTOA组大鼠热痛阈值、压痛阈值、软骨组织YAP磷酸化水平、TAZ蛋白水平与mRNA水平显著降低(P<0.05),软骨组织IL-1β、TNF-α及其mRNA水平、NO、MMP-1、MMP3水平、细胞凋亡率、Mankin s评分显著升高(P<0.05),HE显示软骨层变薄,结构不清晰,软骨细胞大量丢失、排列紊乱。与PTOA组相比,PM-L组、PM-H组大鼠相关指标变化与上述相反(P<0.05),软骨组织病变减轻。YAP抑制剂VTPF减轻了PM对PTOA的治疗作用。结论PM可能通过激活YAP/TAZ信号通路,对PTOA大鼠具有一定的治疗作用。

关键词：扁蒴藤素 Yes相关蛋白/转录共激活因子PDZ结合基序信号通路创伤性关节炎治疗

Heteroepitaxial growth of Au@Pd core–shell nanocrystals with intrinsic chiral surfaces for enantiomeric recognition

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Rare Metals 2024年第1期43卷 225-235页

作者： Feng-Xia Wu Feng-hua Li Xia-Li Lv Qi-Xian Zhang Guo-Bao Xu Wen-Xin Niu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China shaoxing Institute of Technology Shanghai UniversityShaoxing 312000China University of Science and Technology of China Hefei 230026China School of Materials Science and Engineering Shanghai UniversityShanghai 200436China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314113China University of Chinese Academy of Sciences Beijing 100039China

Noble metal surfaces with intrinsic chirality serve as an ideal candidate for investigating enantioselective chemistry due to their superior chemical durability and high catalytic ***,significant advance has been made in synthesizing metal nanocrystals with intrinsic ***,the majority reports are limited to ***,through a heteroepitaxial growth strategy,the synthesis of metal nanocrystals with intrinsic chirality to palladium was extended for the first time and their application in enantioselective recognition was *** heteroepitaxial growth strategy allows for transferring the chirality of homochiral Au nanocrystals to Au@Pd core–shell *** employing the chiral Au@Pd nanocrystals as enantiomeric recognizing elements,a series of electrochemical sensors for chiral discrimination were *** optimal conditions,the peak potential between D-dihydroxyphenylalanine(D-DOPA)and L-dihydroxyphenylalanine(L-DOPA)is about 80 m V,and the peak current of D-DOPA is 2 times as much as that of L-DOPA,which enables the determination of the enantiomeric excess(EE,%)of ***,this report not only introduces a heteroepitaxial growth strategy to synthesize metal nanocrystals with intrinsic chirality,but also demonstrates the superior capability of integrating intrinsic chirality and catalytic properties into metal nanocrystals for chiral recognition.

关键词： Core–shell nanostructures Chirality transfer Electrochemical sensors Chiral recognition Chiroplasmonics

RELIABILITY ANALYSIS OF CRANE BRAKE PARAMETERS

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Chinese Journal of Mechanical Engineering 2002年第3期15卷 209-212页

作者： hua Xiaoyang School of Engineering, shaoxing College of Arts arid Sciences, shaoxing 312000, China School of Engineering Shaoxing College of Arts and Sciences Shaoxing 312000

The high failure rate of crane brake results from improper choice of brakingtorque. The mathematical model of reliability for the crane brake parameters is introduced. Based onlarge amount of actual data the parameter reliabilities of 5 approx 50 t general overheadtravelling cranes are calculated, the probabilities that the braking torque is less than the statictorque acting on the axle when the load moves down are obtained. Moreover, the ways to improve thereliability of brake parameters are discussed, the most reasonable values of braking safetycoefficient are given.

关键词： Cranes Brakes Braking torque Parameter reliability

Design and analysis of an untethered micro flapping robot which can glide on the water

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Science China(Technological Sciences) 2022年第8期65卷 1749-1759页

作者： CHEN YanHong LIU YiDe LIU TaiShan LI hua QU shaoxing YANG Wei State Key Laboratory of Fluid Power&Mechatronic System Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvincesCenter for X-MechanicsDepartment of Engineering MechanicsZhejiang UniversityHangzhou 310027China

Flapping-wing flying insects possess various advantages,such as high agility and *** design and manufacture of insect-scale flapping-wing micro aerial vehicle(FWMAV)have attracted increasing attention in recent *** to the limitations of size and weight,the FWMAV with an onboard battery which can fully mimic insect flight has not been *** this work,we design and fabricate a highly integrated flapping-wing microrobot named *** Robomoth consists of a carbon chassis,customized power and control devices,and two piezoelectric ceramic actuators symmetrically distributed in the thorax and controlled *** weighs 2.487 g,spans 5.9 cm in length,possesses 9 cm of wingspan,and carries a 0.355 g rechargeable lithium *** demonstrate the mobility of the Robomoth through untethered gliding and making turns on the water surface.A simplified dynamic model of the flapping system is proposed to explain the relationship between the driving frequency and the flapping *** Robomoth is one new untethered bioinspired flapping-wing robot that can perform stable water surface motion,which holds potential applications such as search and rescue on the *** robot can also provide insight for designing insect-scale flying vehicles.

关键词： micro/nanorobots biologically inspired robots flapping-wing flying piezoelectric ceramic actuator

Arbuscular mycorrhizal fungi-mediated resistance to salt spray in Cinnamomum camphora seedlings enhanced by leaf functional traits

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Soil Ecology Letters 2024年第3期6卷 163-175页

作者： Xiao Li Duo Zheng Naili Zhang Lijia Dong Aiping Wu Qiqian Wu hua Liu Mingshui Zhao Yan Li Xinping Wang Yanhong Wang State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China State Key Laboratory of Efficient Production of Forest Resources and the Key Laboratory of Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083China School of Life and Environmental Sciences Shaoxing UniversityShaoxing 312000China Ecology Department College of Environment and EcologyHunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake AreaHunan Agricultural UniversityChangsha 410128China Zhejiang Tianmu Mountain National Nature Reserve Administration Hangzhou 311311China

Salt spray is a natural disturbance in coastal *** mycorrhizal fungi(AMF)are recognized as bio-ameliorators of soil salinity in ***,the mechanism through which AMF protects Cinnamomum camphora against aerial salinity remains *** address this knowledge gap,plants were subjected to four fungal regimes,namely sterilized fungal inoculum,Glomus tortuosum,Funneliformis mosseae,or a combination of these two fungi,and exposed to three sprayed-salt regimes(0,7,or 14 mg NaCl cm−2 d−1)in a *** spray significantly decreased photosynthetic capabilities,total dry weight,and salinity tolerance of non-mycorrhizal *** inoculation,particularly a combination of *** and ***,evidently mitigated the detrimental effects induced by salt ***,mycorrhiza-mediated protection depended on the intensity of sprayed salt and the identity of fungal ***,the enhanced resistance of mycorrhizal *** seedlings to aerial salinity was mainly owing to increased leaf thickness and photosynthetic *** findings imply that inoculation with combined fungi could be an optimal strategy for cultivating *** plants in coastal *** results gained hold the potential to offer both theoretical and practical guidance for the managers of coastal ecosystems in soil restoration and conservation.

关键词： arbuscular mycorrhizal fungi leaf thickness photosynthetic capability salinity-tolerance salt spray

Nitric oxide-generating compound and bio-clickable peptide mimic for synergistically tailoring surface anti-thrombogenic and anti-microbial dual-functions

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Bioactive Materials 2021年第6期6卷 1618-1627页

作者： Han Yu shaoxing Yu hua Qiu Peng Gao Yingzhong Chen Xin Zhao Qiufen Tu Minggang Zhou Lin Cai Nan huang Kaiqin Xiong Zhilu Yang Key Laboratory of Advanced Technology for Materials of the Education Ministry School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031China Department of Cardiology Third People’s Hospital of Chengdu Affiliated to Southwest Jiaotong UniversityChengdu610031China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomHong KongChina

Application of extracorporeal circuits and indwelling medical devices has saved many ***,it is accompanied with two major complications:thrombosis and *** address this issue,we apply therapeutic nitric oxide gas(NO)and antibacterial peptide for synergistically tailoring such devices for surface anti-thrombogenic and antifouling dual *** functional surface is realized by stepwise conjugation of NO-generating compound of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid(DOTA)chelated copper ions(Cu-DOTA)and dibenzylcyclooctyne-(DBCO-)modified antimicrobial peptide based on carbodiimide and click chemistry *** integration of peptide and Cu-DOTA grants the modified surface the ability to not only efficiently inhibit bacterial growth,but also catalytically generate NO from endogenous s-nitrosothiols(RSNO)to reduce adhesion and activation of platelets,preventing the formation of *** envision that the stepwise synergistic modification strategy by using anticoagulant NO and antibacterial peptide would facilitate the surface multifunctional engineering of extracorporeal circuits and indwelling medical devices,with reduced clinical complications associated with thrombosis and infection.

关键词： Nitric oxide Bio-clickable peptide mimic Synergic modification Anti-thrombosis Anti-infection

县域数字政府公共价值创造的理论基础、构成维度与实践逻辑

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贵州省党校学报 2024年第2期 117-128页

作者：何花中共诸暨市委党校浙江绍兴312000

县域数字政府建设是国家数字政府建设的基础。以公共价值创造为视角,基于穆尔的战略三角模型,结合县域数字政府的特殊性,从公共价值、上部与外部的授权环境和内部与下部的运作管理能力三个维度分析县域数字政府公共价值创造的基本内容,... 详细信息

县域数字政府建设是国家数字政府建设的基础。以公共价值创造为视角,基于穆尔的战略三角模型,结合县域数字政府的特殊性,从公共价值、上部与外部的授权环境和内部与下部的运作管理能力三个维度分析县域数字政府公共价值创造的基本内容,建构一个内外部叠加的公共价值战略大三角模型。实现公共价值,在价值寻求方面要收集社会集中偏好与期望,找到具体实质性的公共价值;在价值论证方面要获得上级政府的政治合法性与社会合法性授权;在价值实现方面要以优化的组织结构、先进的数字技术和协同共治的网络治理推进县域数字政府公共价值创造。未来研究进路包括公共价值失范、特殊的授权环境、评估体系及县级党委政府的角色与行为。

关键词：公共价值创造数字政府县域数字政府数字化治理

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儿童胃食管返流的检查方法及临床X线分析

实用放射学杂志 2006年第12期22卷 1511-1513页

作者：裘华兴浙江省绍兴市妇幼保健院影像诊断科浙江绍兴312000

目的探讨小儿胃食管返流(gastroesophageal reflux,GER)的检查方法与X线表现,提高诊断水平。方法对132例GER患儿临床、X线进行回顾性分析。采用胃肠钡餐造影或与食管动态造影(35例)相结合诊断GER,并对儿童GER作X线分级。结果GERⅠ级29例... 详细信息

目的探讨小儿胃食管返流(gastroesophageal reflux,GER)的检查方法与X线表现,提高诊断水平。方法对132例GER患儿临床、X线进行回顾性分析。采用胃肠钡餐造影或与食管动态造影(35例)相结合诊断GER,并对儿童GER作X线分级。结果GERⅠ级29例,Ⅱ级58例,Ⅲ级21例,Ⅳ级15例,Ⅴ级9例。临床上,132例中102例有呕吐;其他合并症如食管炎27例,食管裂孔疝9例,先天性肥厚性幽门狭窄1例,胃炎、十二指肠球炎6例,胃排空延迟22例。结论X线胃肠造影或与食管动态造影(EDR)结合,能对GER直接作出诊断并作X线分级,检查接近生理状态,易为患儿接受,方法简单,为临床首选的检查手段。

关键词：胃食管返流儿童 X线摄影术