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Bone marrow mesenchymal stem cell-induced autophagy ameliorates TNBS-induced experimental colitis by downregulating the NLRP3 inflammasome

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BIOCELL 2023年第12期47卷 2627-2639页

作者： JINJIN FU XIAOYUE FENG JUAN WEI XIANG GENG YU GONG FENGDONG LI shaohua zhuang JIN HUANG FANGYU WANG Department of Gastroenterology The Affiliated Changzhou No.2 People’s HospitalNanjing Medical UniversityChangzhouChina Department of Gastroenterology Jinling HospitalNanjing Medical UniversityNanjingChina

This study aimed to elucidate the potential mechanisms through which bone marrow-derived mesenchymal stem cells(BM-MSCs)may be effective in alleviating experimental colitis induced by treatment with 2,4,6-trinitrobenzene-sulfonate acid(TNBS),specifically through autophagy ***:BM-MSCs were collected from BALB/c mice for subsequent *** study employed cell counting kits(CCK-8)to investigate the impact of the MSC-conditioned medium(M medium)on the proliferation of RAW264.7 *** GFP-mRFP-LC3 adenovirus was transfected into RAW264.7 to detect autophagic *** gene expression of cytokines was assessed through quantitative reverse transcription polymerase chain reaction(qRT-PCR).Western blot analysis was employed to determine the presence of a binding interaction between NOD-like receptor protein 3(NLRP3)and ***,a colitis mouse model was established by TNBS *** disease activity score was assessed regularly,and histological and morphometric analyses were performed on colonic *** serum cytokines were identified using an enzyme-linked immunosorbent ***:BM-MSCs significantly promoted the proliferation of *** vitro lipopolysaccharide(LPS)-stimulated RAW264.7 cells,treated with BM-MSCs,triggered autophagy and inhibited cytokine mRNA ***,in LPS-induced RAW264.7,BM-MSCs enhanced the Beclin1 protein expression and the microtubule-associated protein 1 light chain 3(LC3)-II to LC3-I ratio while suppressing the protein levels of NLRP3 and apoptosis-associated speck-like protein(ASC).Nevertheless,3-methyladenine(3-MA),an inhibitor of autophagy,prevented the impact of BM-MSCs by reducing the levels of NLRP3 and ASC proteins,suggesting that autophagy triggered the inhibition of the NLRP3 *** comparison to the mice in the TNBS group,the mice in the TNBS+MSC group displayed a more acute form of colitis,and the IL1βand IL18 cytokines in their serum were

关键词： RAW264.7 3-Methyladenine(3-MA) IL1β IL18

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以结肠鳞状细胞癌为首发表现的Lynch综合征1例

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南京医科大学学报（自然科学版） 2024年第7期44卷 1031-1034页

作者：章坤徐克群周晓莉庄少华顾文贤程羽青南京医科大学附属常州第二人民医院病理科江苏常州213003 南京医科大学附属常州第二人民医院肿瘤科江苏常州213003 南京医科大学附属常州第二人民医院消化科江苏常州213003

以结肠鳞状细胞癌为首发表现的Lynch综合征(Lynch syndrome,LS)较为罕见,国内外仅有2例Lynch综合征伴有肠鳞状细胞癌的报道。本文报道1例以结肠鳞状细胞癌为首发表现的LS,以期提高临床对于LS中少见的结肠鳞状细胞癌的认识。

关键词：结肠肿瘤 Lynch综合征鳞状细胞癌二代测序

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A novel trajectory planning strategy for aircraft emergency landing using Gauss pseudospectral method

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Control Theory and Technology 2014年第4期12卷 393-401页

作者： shaohua MENG Jinwu XIANG Zhangping LUO Yiru REN Nanjian zhuang School of Aeronautic Science and Engineering Beihang University College of Mechanical and Vehicle Engineering Hunan University College of Air Traffic Management Civil Aviation University of China

To improve the survivability during an emergency situation, an algorithm for aircraft forced landing trajectory planning is proposed. The method integrates damaged aircraft modelling and trajectory planning into an optimal control framework, in order to deal with the complex aircraft flight dynamics, a solving strategy based on Gauss pseudospetral method （GPM） is presented. A 3-DOF nonlinear mass-point model taking into account the wind is developed to approximate the aircraft flight dynamics after loss of thrust. The solution minimizes the forced landing duration, with respect to the constraints that translate the changed dynamics, flight envelope limitation and operational safety requirements. The GPM is used to convert the trajectory planning problem to a nonlinear programming problem （NLP）, which is solved by sequential quadratic programming algorithm. Simulation results show that the proposed algorithm can generate the minimum-time forced landing trajectory in event of engine-out with high efficiency and precision.

关键词： Aircraft Forced landing Trajectory planning Gauss pseudospectral method Nonlinear programming

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以慢性假性肠梗阻为首发表现的小细胞肺癌一例

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中华炎性肠病杂志（中英文） 2023年第4期7卷 382-384页

作者：吴昕橦卢爽爽王炳健姚新宇张伟马俊方庄少华黄健金雨舟刘文佳南京医科大学附属常州市第二人民医院消化内科常州213003 大连医科大学研究生院大连116044

本文报道常州市第二人民医院收治的1例以慢性假性肠梗阻为首发表现的小细胞肺癌病例,复习相关文献报道,以期提高临床医生对小肠梗阻相关副肿瘤综合征的认识,减少漏诊、误诊。

关键词：慢性假性肠梗阻小细胞肺癌抗利尿激素分泌失调综合征副肿瘤神经综合征

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ABI5–FLZ13 module transcriptionally represses growth-related genes to delay seed germination in response to ABA

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Plant Communications 2023年第6期4卷 277-295页

作者： Chao Yang Xibao Li Shunquan Chen Chuanliang Liu Lianming Yang Kailin Li Jun Liao Xuanang Zheng Hongbo Li Yongqing Li shaohua Zeng Xiaohong zhuang Pedro L.Rodriguez Ming Luo Ying Wang Caiji Gao Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement&Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life SciencesSouth China Normal University(SCNU)Guangzhou 510631China School of Life Sciences Centre for Cell and Developmental BiologyThe Chinese University of Hong KongShatinNew TerritoriesHong KongChina Instituto de Biologia Molecular y Celular de Plantas Consejo Superior de Investigaciones Cientificas-Universidad Politecnica de Valencia46022 ValenciaSpain

The bZIP transcription factor ABSCISIC ACID INSENSITIVE5(ABI5)is a master regulator of seed germination and post-germinative growth in response to abscisic acid(ABA),but the detailed molecularmechanism by which it represses plant growth remains *** this study,we used proximity labeling to map the neighboring proteome of ABI5 and identified FCS-LIKE ZINC FINGER PROTEIN 13(FLZ13)as a novel ABI5 interaction *** analysis of flz13 mutants and FLZ13-overexpressing lines demonstrated that FLZ13 acts as a positive regulator of ABA *** analysis revealed that both FLZ13 and ABI5 downregulate the expression of ABA-repressed and growth-related genes involved in chlorophyll biosynthesis,photosynthesis,and cell wall organization,thereby repressing seed germination and seedling establishment in response to *** genetic analysis showed that FLZ13 and ABI5 function together to regulate seed ***,our findings reveal a previously uncharacterized transcriptional regulatorymechanismby which ABA mediates inhibition of seed germination and seedling establishment.

关键词： ABA ABI5 FLZ gene expression seed germination

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基于中医证候与精液质量相关参数构建精子DNA碎片预测模型与验证

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中国组织工程研究 2025年第13期29卷 2661-2668页

作者：周超庾广聿阳绍华高磊磊金珍蒋月园李欢广西壮族自治区南溪山医院生殖中心广西壮族自治区桂林市541000 浙江省人民医院生殖中心浙江省杭州市310000 中国人民解放军联勤保障部队第九二四医院检验科广西壮族自治区桂林市54100

背景:中医证候与精液质量相关参数相结合,共同预测精子DNA碎片指数(DNA fragmentation index,DFI)异常增高的发生并绘制列线图,能显著提高临床的实操性与应用效能,为临床全面评估精液质量,采取积极干预措施以改善临床结局及制定个体化... 详细信息

背景:中医证候与精液质量相关参数相结合,共同预测精子DNA碎片指数(DNA fragmentation index,DFI)异常增高的发生并绘制列线图,能显著提高临床的实操性与应用效能,为临床全面评估精液质量,采取积极干预措施以改善临床结局及制定个体化医疗方案提供依据。目的:探讨基于中医证候与精液质量相关参数构建精子DNA碎片的预测模型与验证。方法:回顾性分析2019年7月至2021年7月在广西壮族自治区南溪山医院中医男科接受中医证候诊断及精子DNA碎片率检查的不育患者共420例,据《人类精液检查与处理实验室手册》(第6版),将其中137例精子DFI>30%患者纳入精子DFI异常增高组,将283例精子DFI≤30%作为对照组;首先采用单因素分析筛选精子DFI异常增高的影响因素,然后采用套索算法(LASSO)校正因子共线性问题并筛选出最佳匹配因子后,将其纳入多因素向前逐步Logistic回归找出其独立影响因素并绘制列线图,最后采用受试者工作曲线、校准曲线、临床决策曲线、临床影响曲线对该预测模型进行区分度与准确度及临床应用效能验证。结果与结论:①单因素分析结果显示,年龄、体质量指数、前向运动率、精子总活率、精子浓度、精子形态学、肾阳虚衰证、湿热下注证、肾精不足证为引发精子DFI异常增高的影响因子(P0.05,表明该模型预测发生精子DFI异常增高的概率与实际发生精子DFI异常增高的概率无显著统计学差异,证实该模型具有较好的准确度;⑥临床决策曲线与临床影响曲线显示,模型组与验证组分别在阈概率值为0.08-0.84与0.09-0.78时具有临床最大净获益,且在该阈概率范围内具有较好的临床应用效能;⑦结果表明,年龄、体质量指数、精子浓度、精子总活率、湿热下注证、肾阳虚衰证为引发精子DFI异常增高的独立影响因素,通过其构建的临床预测模型列线图具有较好的临床预测价值与临床应用效能,可为临床全面评估精液质量、预后与干预及个体化医疗服务提供依据。

关键词：精子DNA碎片精子DNA完整性中医证候精子DNA碎片指数预测模型

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Basic leucine zipper gene VvbZIP61 is expressed at a quantitative trait locus for high monoterpene content in grape berries

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Horticulture Research 2023年第9期10卷 55-67页

作者： Yuyu Zhang Cuixia Liu Xianju Liu Zemin Wang Yi Wang Gan-yuan Zhong shaohua Li Zhanwu Dai Zhenchang Liang Peige Fan Beijing Key Laboratory of Grape Science and Enology and CAS Key Laboratory of Plant ResourcesInstitute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China Centre for Special Economic Plant Studies Guangxi Institute of BotanyGuangxi Zhuang Autonomous Region and Chinese Academy of SciencesGuilin 541006GuangxiChina College of Life Science and Technology Gansu Agricultural UniversityLanzhou 730070China Grape Genetics Research Unit USDA-ARSGeneva 14456USA

The widely appreciated muscat flavor of grapes and wine is mainly attributable to the monoterpenes that accumulate in ripe grape *** identify quantitative trait loci(QTL)for grape berry monoterpene content,an F1 mapping population was constructed by a cross between two grapevine genotypes,one with neutral aroma berries(cv.‘Beifeng’)and the other with a pronounced muscat aroma(elite Vitis vinifera line‘3–34’).A high-density genetic linkage map spanning 1563.7 cM was constructed using 3332 SNP markers that were assigned to 19 linkage *** were extracted from the berry of the F1 progeny,then identified and quantified by gas chromatography–mass *** stable QTLs associated with the amounts of 11 monoterpenes in berries were thus *** parallel,the levels of RNA in berries from 34 diverse cultivars were estimated by RNA sequencing and compared to the monoterpene content of the *** expression of five genes mapping to stable QTLs correlated well with the monoterpene content of *** genes,including the basic leucine zipper VvbZIP61 gene on chromosome 12,are therefore considered as potentially being involved in monoterpene *** of VvbZIP61 in Vitis amurensis callus through Agrobacterium-mediated transformation significantly increased the accumulation of several monoterpenes in the callus,including nerol,linalool,geranial,geraniol,β-myrcene,and *** is hypothesized that VvbZIP61 expression acts to increase muscat flavor in *** results advance our understanding of the genetic control of monoterpene biosynthesis in grapes and provide important information for the marker-assisted selection of aroma compounds in grape breeding.

关键词： content linkage neutral

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急诊科护士正念自我照护分型及影响因素分析

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护理学杂志 2024年第7期39卷 22-25页

作者：阿婷婷庄冬梅胡少华安徽医科大学护理学院安徽合肥230032 安徽医科大学第一附属医院护理部

目的调查急诊科护士正念自我照护现状,分析急诊科护士正念自我照护分型及影响因素。方法便利选取425名急诊科护士为研究对象,采用一般资料调查表、中文版简短正念自我照护量表、一般自我效能感量表和领悟社会支持量表进行调查。结果急... 详细信息

目的调查急诊科护士正念自我照护现状,分析急诊科护士正念自我照护分型及影响因素。方法便利选取425名急诊科护士为研究对象,采用一般资料调查表、中文版简短正念自我照护量表、一般自我效能感量表和领悟社会支持量表进行调查。结果急诊科护士正念自我照护总分为(77.17±13.91)分,可分为消极正念自我照护型(8.9%)、中等正念自我照护型(44.9%)和积极正念自我照护型(46.1%)3个潜在剖面,其影响因素包括健康自评、领悟社会支持、自我效能感(均P<0.05)。结论急诊科护士正念自我照护整体处于中等水平,分为3个类别。护理管理者应重点关注消极正念自我照护型护士,制定基于环境和个人的针对性干预策略,加强急诊科护士的正念自我照护实践,从而帮助护士更好地应对高压的工作环境。

关键词：急诊科护士正念自我照护自我效能社会支持潜在剖面分析健康状况心理健康

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China’s 10-year progress in DC gas-insulated equipment:From basic research to industry perspective

iEnergy

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iEnergy 2022年第4期1卷 400-433页

作者： Chuanyang Li Changhong Zhang Jinzhuang Lv Fangwei Liang Zuodong Liang Xianhao Fan Uwe Riechert Zhen Li Peng Liu Jianyi Xue Cheng Pan Geng Chen Lei Zhang Zheming Wang Wu Lu Hucheng Liang Zijun Pan Weijian zhuang Giovanni Mazzanti Davide Fabiani Bo Liu shaohua Cao Jianying Zhong Yuan Deng Zhenle Nan Jingen Tang Jinliang He State Key Laboratory of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Maintenance&Test Center of EHV Power Transmission Company China Southern Power Grid Guangzhou 510663China EHV Power Transmission Company China Southern Power Grid Guangzhou 510663China Hitachi Energy Switzerland Ltd ZürichSwitzerland Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China School of Electrical Engineering and Automa-tion Hefei University of TechnologyHefei 230009China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China Department of Electrical Engineering Shanghai University of Electric PowerShanghai 200090China School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China Department of Electrical Electronic and Information EngineeringUniversity of BolognaBologna 40136Italy Shandong Taikai Electrical Insulation Co. Ltd.Tai’an 271000China PingGao Group CO. Ltd.Pingdingshan 467001China China XD Group Co. Ltd.Xi’an 710075China Jiangsu Jinxin Electric Appliance Co. Ltd.Yangzhou 225202China

The construction of the future energy structure of China under the 2050 carbon-neutral vision requires compact direct current(DC)gas-insulation equipment as important nodes and solutions to support electric power transmission and distribution of long-distance and *** paper reviews China's 10-year progress in DC gas-insulated *** progresses in basic research and industry perspective are presented,with related scientific issues and technical bottlenecks being *** progress in DC gas-insulated equipment worldwide(Europe,Japan,America)is also reported briefly.

关键词： DC gas-insulated switchgear(GIS) DC gas-insulated power transmission line(GIL) surface charge flashover metal particle offshore projects

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癌症病人家庭照顾者照顾能力评估工具的研究进展

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循证护理 2024年第2期10卷 265-267页

作者：庄冬梅胡少华安徽医科大学护理学院安徽230022 安徽医科大学第一附属医院

对国内外研发的癌症病人家庭照顾者照顾能力评估工具进行综述,概括各评估工具的维度、条目、评价内容、评分方式、信效度、应用现状及优缺点等,旨在为临床医务人员选择合适的评估工具、开展相关研究提供参考。

关键词：癌症病人家庭照顾者照顾能力评估工具综述

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