检索结果-南通市图书馆

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

引用

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang shao-yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Elastoplastic pipe-soil interaction analyses of partially-supported jointed water mains

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第11期9卷 1497-1506页

作者： yu shao Tu-qiao ZHANG Department of Civil Engineering Zhejiang University Hangzhou 310027 China

Water distribution networks are essential components of water supply systems. The combination of pipe structural deterioration and mechanics leads to the failure of pipelines. A physical model for estimating the pipe failure must include both the pipe deterioration model and mechanics model. Winkler pipe-soil interaction (WPSI), an analytical mechanics model developed by Rajani and Tesfamariam (2004), takes external and internal loads, temperature changes, loss of bedding support, and the elastoplastic effect of soil into consideration. Based on the WPSI model, a method to evaluate the elastic and plastic areas was proposed in the present study. An FEM model based on pipe-soil interaction (PSI) element was used to verify the analytical model. Sensitivity analyses indicate that the soft soil, long pipe and high temperature induced the axial plastic deformation more likely, which, however, may not occur in normal scenarios. The soft soil, pipes in small diameters, long unsupported bedding are prone to form flexural plastic area. The results show that the pipes subjected to the same loads have smaller stresses in the elastoplastic analysis than elastic analysis. The difference, however, is slight.

关键词： Elastoplastic soil Winkler pipe-soil interaction (WPSI) Jointed water mains

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unconventional 2D Periodic Nanopatterns Based on Block Molecules

引用

Chinese Journal of Polymer Science 2023年第10期41卷 1508-1524页

作者： Bo Hou Wen-Bin Zhang yu shao Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry&Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

This review summarizes the self-assembly of block molecules forming unconventional two-dimensional(2D)periodic ***,we emphasize the structural evolution from simple columnar phases to complex 2D tiling morphologies in soft materials including block copolymers,liquid crystals,giant molecules,***,the state-of-the-art nanofabrication technologies for making sophisticated nanostructures with specific functions via combining both bottom-up assembly and top-down lithography-based methods are discussed,highlighting the use of directed self-assembly ***,we provide our perspective on this *** further increasing the complexity of block molecules and the designability of lithography,low-dimensional ordered morphologies will be particularly promising for further application in nanotechnology.

关键词： Two-dimensional ordered morphologies Block molecules Directed self-assembly Nanofabrication Tilings and patterns

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Normal Ordering Expansion of Hermite Polynomials of Radial Coordinate Operator in Three-Dimensional Coordinate Space

引用

Communications in Theoretical Physics 2008年第4期49卷 866-870页

作者： shao yu-Chong FAN Hong-Yi Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China Special Class for the Gifted Young University of Science and Technology of China Hefei 230026 China Department of Physics Shanghai Jiao Tong University Shanghai 200030 China

For Hermite polynomials of radial coordinate operator in three-dimensional coordinate space we derive its normal ordering expansion, which are new operator identities. This is done by virtue of the technique of integr... 详细信息

关键词： normal ordering expansion Hermite polynomial IWOP technique

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enantioselective three-component Ugi reaction catalyzed by chiral phosphoric acid

引用

Science China Chemistry 2020年第1期63卷 47-54页

作者： Jian Zhang Yi-Yan Wang He Sun shao-yu Li shao-Hua Xiang Bin Tan School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China Department of Chemistry and Shenzhen Grubbs Institute Southern University of Science and TechnologyShenzhen 518055China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China

A catalytic enantioselective three-component Ugi reaction was ***-derived phosphoric acid with bulky 2,4,6-tricyclohexylphenyl groups at the 6,6′positions was found to be the best catalyst to affordα-amino amide derivatives in good to excellent yields(62%to 99%)and enantiocontrol(81%to>99%enantiomeric excess).This asymmetric reaction was applicable well to an array of aliphatic *** gram-scale synthesis,modification of dapsone,and enantioselective synthesis of(R)-Lacosamide underline the general utility of this *** of dihedral angles and substituents of the chiral phosphoric acids on the enantioselectivity was also discussed in this article.

关键词： α-amino amide Ugi reaction chiral phosphoric acid enantioselectivity Lacosamide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk of Developing Non-Alcoholic Fatty Liver Disease Over Time in a Cohort of the Elderly in Qingdao,China

引用

Biomedical and Environmental Sciences 2023年第8期36卷 760-767页

作者： LIU Li shao yu Han FENG En Qiang shao Zhu Gang XING Dong Ming Cancer Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao 266071ShandongChina Qingdao Cancer Institute Qingdao 266071ShandongChina Qingdao Municipal Center for Disease Control and Prevention Qingdao 266033ShandongChina Qingdao Institute of Preventive Medicine Qingdao 266033ShandongChina Shandong Muhua Medical Technology Co. LtdQingdao 266109ShandongChina School of Life Sciences Tsinghua UniversityBeijing 100084China

Nonalcoholic fatty liver disease(NAFLD)is characterized by fat accumulation in the liver in the absence of alcohol consumption and comprises a variety of conditions such as simple steatosis,nonalcoholic steatohepatitis,fibrosis,and cirrhosis^([1]).More than one-quarter of the world’s population experience NAFLD^([2]).The prevalence of NAFLD in China increased from 23.8%in 2001 to 32.9%in 2018,indicating that hepatitis B virus is the primary cause of chronic liver disease^([3]).

关键词： NAFLD liver Liver

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of UV/PDS and UV/H_2O_2 processes for the degradation of atenolol in water

引用

Journal of Environmental Sciences 2013年第8期25卷 1519-1528页

作者： Xiaowei Liu Lei Fang Yongchao Zhou Tuqiao Zhang yu shao Institute of Municipal Engineering College of Civil Engineering and Architecture Zhejiang University

UV/H2O2 and UV/peroxodisulfate （PDS） processes were adopted to degrade a typical β-blocker atenolol （ATL）. The degradation efficiencies under various operational parameters （oxidant dosage, pH, HCO3-, humic acid （HA）, NO3- , and Cl-） were compared. Principal factor analysis was also performed with a statistical method for the two processes. It was found that increasing the specific dosage of the two peroxides （[peroxide]0/[ATL]0 ） ranging from 1：1 to 8：1 led to a faster degradation rate but also higher peroxide residual. Within the pH range 3-11, the optimum pH was 7 for the UV/PDS process and elevating pH benefitted the UV/H 2O2 process. The presence of HCO3- , HA, and Cl adversely affected ATL oxidation in both processes. The NO3- concentration 1-3 mmol/L accelerated the destruction of ATL by the UV/PDS process, but further increase of NO3- concentration retarded the degradation process, contrary to the case in the UV/H2O2 process. The rank orders of effects caused by the six operational parameters were pH ≈ specific dosage 〉 [HA]0 〉 [NO3-]0 〉 [HCO3-]0 〉 [Cl-]0 for the UV/H2O2 process and specific dosage 〉 pH 〉 [HA]0 〉 [NO3-]0 〉 [HCO3-]0 〉[Cl-]0 for the UV/PDS process. The UV/PDS process was more sensitive to changes in operational parameters than the UV/H2O2 process but more efficient in ATL removal under the same conditions.

关键词： sulfate radical hydroxyl radical atenolol influencing factors rank order

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Movement behavior and separation of Al_(2)O_(3)from Al melt under rotating magnetic field

引用

China Foundry 2024年第6期21卷 625-633页

作者： Shan-hao Du yu-ting Shen yu-bo Zhang shao-jun yu De-hua Liu Ting-ju Li Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024LiaoningChina Ningbo Institute of Dalian University of Technology Ningbo 315016ZhejiangChina School of Mechanics Dalian University of TechnologyDalian 116024LiaoningChina

The effect of a rotating magnetic field(RMF)on the distribution of Al_(2)O_(3)particles with an Al melt was studied by means of simulation and *** results show that Al_(2)O_(3)particles(diameter of 1-10μm,1wt.%)are significantly agglomerated at the top of ingots when subjected to an RMF,and their distribution is influenced by both the intensity and the duration of RMF *** optimal separation efficiency is achieved with the magnetic intensity of 12 mT for 120 *** number of the particles at the bottom and the middle decreases by 64.5%and 69.7%,respectively,while that at the top increases by 242.5%compared to the condition without an ***,if further increase the intensity or the duration of RMF,it can induce turbulent flows that draw some of the separated Al_(2)O_(3)particles back into the melt,reducing separation *** calculation results show that as the magnetic intensity increases from 6 mT to 18 mT,the velocity difference between the particles and the Al melt flow quadruples,increasing from 0.013 m·s^(-1)to 0.066 m·s^(-1).Driven by this velocity difference,centrifugal motion,and secondary circulation,Al_(2)O_(3)particles tend to migrate upwards within the melt,facilitating the separation of impurity particles and enhancing the purity of the melt.

关键词： Al_(2)O_(3)particles rotating magnetic field numerical simulation electromagnetic purification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents

引用

Chinese Chemical Letters 2011年第9期22卷 1036-1038页

作者： Xin Jian Song yu shao Xing Gao Dong Key Laboratory of Biological Resources Protection and Utilization of Hubei Province Hubei University for Nationalities Enshi 445000 China Medical School Hubei University for Nationalities Enshi 445000 China

A facile microwave-assisted procedure for synthesis of novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole is described. This protocol presented such advantages as short reaction time, high yields, simple purification and environmentally benign procedures. Their antitumor activities were evaluated against HL-60 by an MTT assay. The preliminary results indicated that some title compounds exhibit more potent antitumor inhibitory activity than doxorubicin （DOX）.

关键词： Pyrazolo[3,4-d]pyrimidine 1,3,4-Thiadiazole Microwave-assisted synthesis Antitumor activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental Study on Tensile Behavior of Cement Paste, Mortar and Concrete under High Strain Rates

引用

Journal of Wuhan University of Technology(Materials Science) 2015年第6期30卷 1268-1273页

作者：陈徐东 shao yu XU Lingyu CHEN Chen College of Civil and Transportation Engineering Hohai University

Effects of the strain rate on cement paste, mortar and concrete were studied. A modified SHPB testing technique with fl attened Brazilian disc（FBD） specimen was developed to measure the dynamic tensile stress-strain curve of materials. A pulse-shaped split Hopkinson pressure bar（SHPB） was employed to determine the dynamic tensile mechanical responses and failure behavior of materials under valid dynamic testing conditions. Quasi-static experiments were conducted to study material strain rate sensitivity. Strain rate sensitivity of the materials was measured in terms of the stress-strain curve, elastic modulus, tensile strength and critical strain at peak stress. Empirical relations between dynamic increase factor（DIF） and the material properties were derived and presented.

关键词： tensile behavior cement-based materials experimental study split Hopkinson pressure bar

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：