检索结果-南通市图书馆

Chinese Journal of Integrative Medicine 2022年第8期28卷 753-761页

作者： YUAN Jia-yao FU Yu FENG Zhi-hai SANG Feng shao ming-yi LI Lei-lei School of First Clinical Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Gastroenterology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)is an intracellular sensor that detects endogenous danger signals and environmental irritants to assemble into the NLRP3 *** of the NLRP3 inflammasome leads to the secretion of the proinflammatory cytokines interleutkin(IL)-1β and IL-18 and induces *** studies have shown that the NLRP3 inflammasome participates in the initiation and progression of diabetic atherosclerosis through pathological mechanisms such as β-cell dysfunction,insulin resistance,endothelial cell dysfunction,monocyte adhesion and infiltration,and smooth muscle cell proliferation and *** diabetic atherosclerosis,Chinese medicine has been proven effective for the inflammatory response mediated by the NLRP3 *** review summarizes the latest progress on the NLRP3 inflammasome in the pathogenesis and potential Chinese medicine treatment of diabetic atherosclerosis.

关键词： Chinese medicine diabetic atherosclerosis NLRP3 inflammasome interleukin-1β TXNIP pyroptosis

Transient CD4-cell-depletion therapy for HIV/AIDS cure

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Chinese Medical Journal 2021年第16期134卷 1930-1932页

作者： Min Wei yi-ming shao Department of Pathogenic Biology School of MedicineNankai UniversityTianjin 300071China Nankai University Second People’s Hospital Nankai UniversityTianjin 300192China State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China.

Human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)is still a threat to global public health,with around 38 million people living with HIV by the end of 2019(http://***).Until now,there is not a routine cure therapy available for HIV/AIDS.[1]Anti-HIV inhibitors,such as reverse transcriptase inhibitors,protease inhibitors,integrase inhibitors,and entry inhibitors,were all applied in HIV/AIDS patients.[1]Combined antiretroviral therapy(cART)can effectively control HIV replication,but cannot eradicate the HIV reservoir.[1]HIV reservoir is the major barrier for HIV cure and is the major cause for HIV rebound after anti-HIV treatment interruption.

关键词： HIV/AIDS routine immunodeficiency

Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG Rong-rong shao ming-yi FU Yu ZHAO Rui-xia WANG Jing-wen FANG Yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

HIV/AIDS research in China:arising up from skyline

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Chinese Medical Journal 2006年第23期119卷 1939-1940页

作者： shao yi-ming State Key Laboratory for Infectious Disease Prevention andControl National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention Beijing100050 China

One of the major advances and few real breakthroughs in HIV/AIDS research is the discovery of anti-retroviral drugs and highly active anti-retroviral therapy （HAART）. HAART, achieved by the collective efforts of many scientists and industrials, has significantly improved life expectancy and quality of life of people living with HIV/AIDS. It has also been proven that effective treatment for viral infection is possible. HIV-1 infection chronically depletes CD4~ T lymphocytes and compromises normal function of the immune system of infected persons.1 May et al2 have found that impaired immune function could be restored with continuous HAART. The global HIV/AIDS epidemic is characterized by a great diversity of HIV clades prevalent in various parts of the world.3 The host immune responses to the diversified HIV strains as well as the metabolic patterns to the drugs are also various. Therefore, simply taking the data collected from the other countries＇ HAART is not recommended. It is important that indigenous scientists and clinicians in their respective countries start their own HAART program to conduct research on their patients to obtain local treatment data. Such kinds of research efforts by several Chinese research groups have been published in this issue of Chinese Medical Journal

关键词： HIV 感染获得性免疫缺陷综合征抗逆转录病毒治疗高效亚洲大陆世系人群药用制剂胰岛素中国

Computational Medicine:Past,Present and Future

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Chinese Journal of Integrative Medicine 2022年第5期28卷 453-462页

作者： LYU Lan-qing CUI Hong-yan shao ming-yi FU Yu ZHAO Rui-xia CHEN Qiu-ping The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou(450003)China

Computational medicine is an emerging discipline that uses computer models and complex software to simulate the development and treatment of *** in computer hardware and software technology,especially the development of algorithms and graphics processing units(GPUs),have led to the broader application of computers in the medical *** vision based on mathematical biological modelling will revolutionize clinical research and diagnosis,and promote the innovative development of Chinese medicine,some biological models have begun to play a practical role in various types of *** paper introduces the concepts and characteristics of computational medicine and then reviews the developmental history of the field,including Digital Human in Chinese ***,this study introduces research progress in computational medicine around the world,lists some specific clinical applications of computational medicine,discusses the key problems and limitations of the research and the development and application of computational medicine,and ultimately looks forward to the developmental prospects,especially in the field of computational Chinese medicine.

关键词： computational medicine model computational Chinese medicine artificial intelligence big data

Molecular Characterization of HIV-1-circulating Strains among Pre-Treatment Patients in Tibet

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Biomedical and Environmental Sciences 2020年第12期33卷 953-958页

作者： Dorjiwangmo GAN Meng Ze DONG Ao Bo Baimayangjin Tashibazong LIU Lei LIAO Ling Jie RUAN Yu Hua shao yi ming FENG yi XING Hui Tibet Autonomous Region Center for Disease Control and Prevention Lhasa 850000TibetChina State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijing 102206China

The Tibet Autonomous Region(referred to as‘Tibet’)is located in southwestern China,bordering the Yunnan Province,Sichuan Province,Xinjiang Uygur Autonomous Region,and other provinces with high HIV/AIDS prevalence,as well as India,Nepal,and other high-risk border *** 1994,the first patient with HIV-1 infection was detected at Zhangmu port,Namu County,Shigatse,Tibet.

关键词： Tibet southwestern border

Benefits of Early and Immediate Initiation of Antiretroviral Therapy among HIV Patients in Chongqing, China

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Biomedical and Environmental Sciences 2020年第4期33卷 282-285页

作者： ZHOU Chao ZHANG Wei LU Rong Rong OUYANG Lin XING Hui shao yi ming WU Guo Hui RUAN Yu Hua Chongqing Municipal Center for Disease Control and Prevention Chongqing 400042China State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijing 102206China

In an effort to end the HIV epidemic by 2030, the Joint United Nations Program on HIV/AIDS(UNAIDS)set the ‘90-90-90’ target and aimed to expand the timely use of ART worldwide. By the end of 2017,21.7 million people living with HIV, amounting to59% of HIV patients worldwide, were receiving antiretroviral therapy(ART)[1]. In China, the National Free Antiretroviral Treatment Program(NFATP),which was initiated in 2002, continued to progress.

关键词： Therapy Chongqing continued

HIV Cure and HIV Reservoirs

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Biomedical and Environmental Sciences 2014年第6期27卷 478-480页

作者： yiN Qian Qian shao yi ming MA Li ying State Key Laboratory for Infection Disease Prevention and Control National Center for AIDS/STD Control and Prevention (NCAIDS) Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseas Chinese Center for Disease Control and Prevention (China-CDC)

The success of combined antiretroviral therapy （cART） has dramatically improved the clinical outcomes of HIV infection and made HIV infection a chronic disease. Nonetheless, cART alone cannot eliminate viral reservoirs and fully recover patients＇ health, so the patients have to receive this treatment for lifetime. Therefore, researchers have focused their efforts on the cure for HIV infection. In recent years, some intriguing and inspiring cases indicated that the cure of HIV infection （HIV cure） or durable alleviation of HIV infection may not be a dream any more. ＇Berlin Patient＇＇Mississippi Baby＇, and probably ＇Long Beach Baby＇ have brought great hope to the HIV cure. Many scientists believe that the HIV cure is just a question of time.

关键词： HIV Cure and HIV Reservoirs ZFN

Effects of Cotrimoxazole Prophylaxis Initiation and Discontinuation on Mortality and Attrition Rates among HIV Patients Who Initiate ART in Southwest China:An Observational Cohort Study

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Biomedical and Environmental Sciences 2021年第8期34卷 646-649页

作者： ZHU Jin Hui RUAN Yu Hua PAN Stephen YANG Wen Min ZHU Qiu ying CHEN Huan Huan SHEN Zhi Yong LAN Guang Hua XING Hui shao yi ming LI Li ming School of Public Health Peking UniversityBeijing 100191China Guangxi Center for Disease Control and Prevention Nanning 530028GuangxiChina State Key Laboratory of Infectious Disease Prevention and Control(SKLID) Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and Preventio n(China CDC)Beijing 100032China Department of Health and Environ mental Sciences Xi'an Jiaotong-Liverpool UniversitySuzhou 215123JiangsuChina

Combination antiretroviral therapy(ART)reduced AIDS-related mortality and increased survival among patients living with HIV by interrupting HIV replication,enhancing immune recovery,and preventing the onset of opportunistic infections[1].In China,ART has rapidly been scaled up since the beginning of the National Free Antiretroviral Treatment Program(NFATP)in 2003[2].By the end of 2016,489,411 individuals diagnosed with HIV were receiving free antiretroviral treatment in *** is firmly committed to reducing overall AIDS-related mortality and HIV incidence within the ***,similar to other low-and middle-income countries,the NFATP is challenged by high mortality and attrition shortly after patients initiate ART[3].

关键词： mortality Observation continuation

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考虑出行环境的居住满意度结构方程模型

交通运输系统工程与信息 2020年第1期20卷 130-136页

作者：钟异莹邵毅明陈坚重庆交通大学重庆400074 重庆大学建筑城规学院重庆400044

为解决居住满意度缺少定量涵盖出行环境的问题,从出行环境、地理区位、社区环境、住房条件4个维度提取居住满意度的影响因素,构建涵盖5个潜变量、21个测量变量的居住满意度结构方程模型,描述出行环境对居住满意度的影响及相互作用关系.... 详细信息

为解决居住满意度缺少定量涵盖出行环境的问题,从出行环境、地理区位、社区环境、住房条件4个维度提取居住满意度的影响因素,构建涵盖5个潜变量、21个测量变量的居住满意度结构方程模型,描述出行环境对居住满意度的影响及相互作用关系.结果表明:出行环境、地理区位、社区环境、住房条件对居住满意度均有显著的正向影响,地理区位对出行环境也存在显著的正向影响;各维度总的影响效应呈现出地理区位(0.913),出行环境(0.877),社区环境(0.748),住房条件(0.532)依次递减的趋势,但出行环境对居住满意度的直接影响最大,其值为0.887.

关键词：城市交通出行环境结构方程模型因子分析居住满意度