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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang shao-Yuan Zhang Lu Lv Tao Long Hui-Wen pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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功能易适数字化全口义齿的自主创新研发

北京大学学报（医学版） 2020年第2期52卷 390-394页

作者：孙玉春王勇邓珂慧陈虎李伟伟赵一姣潘韶霞叶红强周永胜北京大学口腔医学院·口腔医院口腔医学数字化研究中心口腔修复教研室国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 北京大学口腔医学院·口腔医院修复科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081

根据《第四次全国口腔健康流行病学调查报告》(2018),我国各类无牙颌患者超过2100万人[1]。牙齿全部缺失后如果未能及时修复,会导致咀嚼功能障碍、营养摄入障碍,易导致颞下颌关节疾病甚至诱发心血管疾病等全身系统性疾病[2]。近年来在... 详细信息

根据《第四次全国口腔健康流行病学调查报告》(2018),我国各类无牙颌患者超过2100万人[1]。牙齿全部缺失后如果未能及时修复,会导致咀嚼功能障碍、营养摄入障碍,易导致颞下颌关节疾病甚至诱发心血管疾病等全身系统性疾病[2]。近年来在世界范围兴起的种植义齿能较好地恢复和重建无牙颌患者的口腔功能,但由于患者全身状况、颌骨条件、心理因素和经济状况等各方面的限制,经典的黏膜支持式全口义齿仍是无牙颌患者口颌功能重建的重要治疗手段,并在无牙颌种植修复的术前诊断设计、术中定位以及骨整合期过渡修复等阶段发挥非常重要的作用[3]。传统全口义齿修复治疗的临床操作复杂、患者就诊次数多、制作周期长、对医生和技师的经验依赖程度较高、义齿戴入后功能不容易适合等因素导致愿意做且能做好全口义齿修复的医师越来越少,这种现状导致了巨大的供需矛盾,亟待通过全口义齿技术的创新研发寻找突破口。

关键词：全口义齿计算机辅助设计与计算机辅助制造无牙颌印模颌关系记录

Analytical Solutions for an Isotropic Elastic Half-Plane with Complete Surface Effects Subjected to a Concentrated/Uniform Surface Load

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Acta Mechanica Solida Sinica 2024年第3期37卷 371-384页

作者： xia-Hui pan School of Civil Engineering Henan Polytechnic UniversityJiaozuo454003China

Within the context of Gurtin-Murdoch surface elasticity theory,closed-form analytical solutions are derived for an isotropic elastic half-plane subjected to a concentrated/uniform surface *** the effects of residual surface stress and surface elasticity are *** stress function method and Fourier integral transform technique are *** solutions are provided in a compact manner that can easily reduce to special situations that take into account either one surface effect or none at *** results indicate that surface effects generally lower the stress levels and smooth the deformation profiles in the *** elasticity plays a dominant role in the in-plane elastic fields for a tangentially loaded half-plane,while the effect of residual surface stress is fundamentally crucial for the out-of-plane stress and displacement when the half-plane is normally *** the remaining situations,combined effects of surface elasticity and residual surface stress should be *** results for a concentrated surface force serve essentially as fundamental solutions of the Flamant and the half-plane Cerruti problems with surface *** solutions presented in this work may be helpful for understanding the contact behaviors between solids at the nanoscale.

关键词： Surface effects Residual surface stress Surface elasticity Half-plane Analytical solutions

糖化血红蛋白和尿微量白蛋白肌酐比值联合检测在2型糖尿病肾病早期诊断中的临床研究

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中外医疗 2018年第11期37卷 182-184页

作者：梁妙芝黄诗茵潘少霞王飞马广东省清远市中医院检验科广东清远511500

目的探讨糖化血红蛋白(Hb Alc)与尿蛋白肌酐比值(Um Alb/Ucr)联合检测对早期诊断2型糖尿病肾病的临床价值。方法方便选取2016年1月—2017年4月期间该院收治49例确诊为2型糖尿病肾病患者作为研究组,另选取同期于该院门诊进行健康体检49... 详细信息

目的探讨糖化血红蛋白(Hb Alc)与尿蛋白肌酐比值(Um Alb/Ucr)联合检测对早期诊断2型糖尿病肾病的临床价值。方法方便选取2016年1月—2017年4月期间该院收治49例确诊为2型糖尿病肾病患者作为研究组,另选取同期于该院门诊进行健康体检49名位正常人作为对照组,两组均进行Hb Alc联合Um Alb/Ucr检测,对比两组Hb Alc、Um Alb/Ucr检测结果及Hb Alc控制理想组与不理想组的Hb Alc、Um Alb/Ucr水平。结果研究组Hb Alc、Um Alb/Ucr水平分别为(8.28±2.33)%、(498.18±984.61)mg/g,对照组患者为(5.54±0.40)%、(13.62±9.96)mg/g,差异有统计学意义(t=8.113、3.445,P<0.05);Hb Alc控制理想组Hb Alc、Um Alb/Ucr检测结果分别为(5.48±0.36)%、(137.96±411.71)mg/g;控制不理想组Hb Alc、Um Alb/Ucr检测结果分别为(10.10±1.58)%、(529.92±1 243.42)mg/g,差异有统计学意义(t=-20.710、-2.117,P<0.05)。结论 Hb Alc、Um Alb/Ucr联合检测具有互补作用,早期进行Hb Alc、Um Alb/Ucr联合检测可为疾病的定性、疗效评估、预后判断等方面提供有价值参考,可行性及安全性均较高,具备较高临床运用价值。

关键词：糖化血红蛋白尿微量白蛋白肌酐比值联合检测 2型糖尿病肾病早期诊断

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卡他莫拉菌151株耐万古霉素结果分析

中国厂矿医学 2007年第2期20卷 103-104页

作者：潘韶霞刘新风刘振军程世亮郑文山东省交通医院山东省济南市250031

目的探讨卡他莫拉菌对万古霉素的耐药性。方法从各类痰标本中用常规鉴定法分离鉴定出151株卡他莫拉菌，采用纸片扩散法（K-B法），按照美国临床试验室标准委员会（NCCLS）临床及实验室标准协会（CLSI）2005年提出的标准对其进行药敏检... 详细信息

目的探讨卡他莫拉菌对万古霉素的耐药性。方法从各类痰标本中用常规鉴定法分离鉴定出151株卡他莫拉菌，采用纸片扩散法（K-B法），按照美国临床试验室标准委员会（NCCLS）临床及实验室标准协会（CLSI）2005年提出的标准对其进行药敏检测。结果卡他莫拉菌对万古霉素呈82．12％的耐药，敏感的只占16．56％；青霉素类、克林霉素呈70％以上的耐药，喹诺酮类呈40％以上耐药，三代头孢菌素类呈现80％以上敏感，大环内酯类呈60％以上敏感，氨基糖苷类呈现70％以上敏感，含酶抑制剂的舒氨新（氨苄西林加舒巴坦）、邦达（哌拉西林加他唑巴坦）、舒普深（头孢哌酮加舒巴坦）呈80％～90％以上敏感。结论卡他莫拉菌属革兰阴性球菌，对万古霉素有如此高的耐药，不单纯是因该菌产生β-内酰胺酶及超广谱β-内酰胺酶所致，其机制有待进一步探讨。

关键词：卡他莫拉菌万古霉素耐药性

Geochronology and Geochemistry of Wangjiadashan Quartz Syenite Porphyry in Suizao Area of Hubei Province in the Tongbai-Dabie Orogenic Belt

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Journal of Earth Science 2023年第3期34卷 790-805页

作者： pan-pan Niu shao-Yong Jiang State Key Laboratory of Geological Processes and Mineral Resources School of Earth ResourcesChina University of GeosciencesWuhan 430074China Key Laboratory of Geological Survey and Evaluation of Ministry of Education China University of GeosciencesWuhan 430074China Collaborative Innovation Center for Exploration of Strategic Mineral Resources China University of GeosciencesWuhan 430074China

The Wangjiadashan area in Suizhou-Zaoyang region of Hubei Province in the Tongbai-Dabie orogenic belt hosts important copper-gold deposits and contains a large number of quartz syenite porphyry dykes,occurring mostly along the NEE-trend *** this study,we used LA-ICP-MS zircon U-Pb dating method and obtained an age of 143.6±1.4 Ma,which represents the emplacement of these quartz syenite porphyry dykes was at the Yanshanian,but it was slightly earlier than the previously reported ages(139-135 Ma)for granites widespreading in Suizao *** geochemical data of the Wangjiadashan quartz syenite porphyry show high K_(2)O,CaO,Na_(2)O and Al_(2)O_(3)contents but extremely low MgO contents(0.01 wt.%-0.46 wt.%).The geochemical characteristics indicate that these quartz syenite porphyry dykes belong to the typical C-type adakite and were possibly formed in the post-collisional ***-isotopic(Sr-Nd-Pb-Hf)analyses indicate that these quartz syenite porphyry dykes were originated from crust without distinct mantle materials *** is suggested that the Wangjiadashan quartz syenite porphyry was generated from partial melting of the thickened lower continental crust,and garnet but no plagioclase was left as residual *** with the widespread granites of the Tongbai area,the Wangjiadashan quartz syenite porphyry formed earlier and derived from more juvenile and K-rich lower crust,while they all belong to intensive magmatism concentrated during the Early Cretaceous epoch in the Tongbai area.

关键词： quartz syenite porphyry zircon U-Pb dating geochemistry Sr-Nd-Pb-Hf isotopes petrogenesis Wangjiadashan Tongbai Orogen

Structure and Combustion Characteristics of Methane/Air Premixed Flame under the Action of Wall

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Energy Engineering 2021年第4期118卷 1135-1154页

作者： Feiyang Li Jianfeng pan Chenxin Zhang Evans K.Quaye xia shao School of Energy and Power Engineering Jiangsu UniversityZhenjiang212013China

In order to obtain the combustion characteristics of the CH4/Air premixed flame under the action of the wall interaction,a study on the impact of the jet flame on the wall at different separation distances was carried *** separation distance from the burner outlet to the lower surface of the wall is changed and the flame structure is obtained through *** temperature,velocity and reaction rate are obtained through numerical simulation,and the law of flame characteristics change is obtained through *** results show that as the separation distance increases,the premixing cone inside the flame gradually changes from a horn shape to a complete cone shape and the length of the premixing cone profile ***,the peak temperature and velocity of the mixture in the axial direction gradually increase,and the temperature and velocity in the radial direction first increase and then *** temperature gradient and velocity reach the maximum when the separation distance is 11 *** peaks of reactants(CH_(4))net reaction rate intermediate products(CO)and products(CO_(2),H_(2)O)on the axis and the axial distance corresponding to the peaks increase *** chemical reaction rate near the wall also gradually decreases with the increase of the separation distance.

关键词： Flame-wall interaction separation distance flame structure air flow temperature flow velocity reaction rate

Research Review of Principles and Methods for Ultrasonic Measurement of Axial Stress in Bolts

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Chinese Journal of Mechanical Engineering 2020年第1期33卷 44-59页

作者： Qinxue pan Ruipeng pan Chang shao Meile Chang xiaoyu Xu School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Fundamental Science for Advanced Machining Beijing Institute of TechnologyBeijing 100081China

Bolts are important fasteners indispensable in the manufacturing field for their advantages, which include convenient assembly and disassembly, easy maintenance, refastenability to prevent looseness, and the avoidance of a phase change in the connected material composition. The precise control of the tightening force in bolts is closely related to the safety and reliability of the connected equipment or structure. Although there are many methods for estimating the tightening force applied to a bolt during assembly, poor accuracy in controlling the preload during the tightening process and a lack of monitoring to determine the residual axial force in service remain issues in evaluating the safety of bolted assemblies. As a nondestructive testing technology, ultrasonic measurement can be applied to successfully address these issues. In order to help researchers understand the theoretical basis and technological development in this field and to equip them to conduct further in-depth research, in this review, the basic knowledge describing the state of stress and deformation of bolts, as well as conventional testing methods are summarized and analyzed. Then, through a review of recent research of the ultrasonic measurement of the axial stress in bolts, the influence of the e ective stressed length and temperature are analyzed and proposed methods of calibration and compensation are reviewed. In order to avoid coupling errors caused by traditional piezoelectric transducers, two newly proposed ultrasonic coupling technologies, the electromagnetic acoustic transducer(EMAT) and the permanent mounted transducer system(PMTS), are reviewed. Finally, the new direction of research of the detection of residual axial stress in in-service bolts that have been assembled to yield is discussed.

关键词： Bolted connections Axial stress Ultrasonic waves Influencing factors Coupling techniques

General variational solution for seismic and static active earth pressure on rigid walls considering soil tensile strength cut-off

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第5期24卷 432-449页

作者： Shiguo xiaO Yuan QI pan xia Key Laboratory of High-Speed Railway Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 60031China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Department of Geological Engineering Southwest Jiaotong UniversityChengdu 610031China

According to the limit equilibrium state of soils behind rigid walls and the pseudo-static approach,a general closed-form solution to seismic and static active earth pressure on the walls,which considers shear and tension failure of the retained soil,is put forward using a variational calculus *** application point of the active resultant force specified in the proposed method is explained with a clear physical meaning related to possible movement modes of the *** respect of the derived nine dependent equations reflecting the functional characteristics of the earth pressure,the proposed method can be performed easily via an implicit *** are 13 basic factors related to the retained soils,walls,and external loads to be involved in the proposed *** tension crack segment of the slip surface is obviously influenced by these parameters,apart from vertical seismic coefficient and geometric bounds of the surcharge,but the shear slip segment maintains an approximately planar shape almost uninfluenced by these ***,the proposed method quantitatively reflects that the resultant of the active earth pressure is always within a limited range under different possible movements of the same wall.

关键词： Active earth pressure Tensile strength cut-off Variational calculus method Pseudo-static method Strip surcharge