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Products of methotrexate during chlorination

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Journal of Environmental Sciences 2017年第5期29卷 100-108页

作者： Jie Yin Yumin Niu bing shao Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Research Center for Preventive Medicine Beijing 100013 China.

Methotrexate （MTX） is a cytotoxic drug widely used in the treatment of tumors, autoimmune diseases and severe asthma, jen00883This drug has been frequently detected in the aquatic environment with concentrations up to μg/L levels. The MTX present in environmental water might be transformed and removed during chlorination disinfection treatment. In this work, the fate of MTX during aqueous chlorination was investigated in laboratory batch experiments, and the transformation products of MTX were identified. Aqueous solutions of MTX （1 mg/L） were chlorinated by sodium hypochlorite solution at room temperature under neutral pH conditions. Chlorinated products were pre-concentrated with solid-phase extraction （SPE） cartridges and determined by liquid chromatography electrospray ionization tandem mass spectrometry （LC-ESI-MS/MS）. The reaction of MTX chlorination exhibited pseudo-first-order kinetics and the half-life time of MTX degradation was calculated to be 1.65 min, when the initial chlorine concentration was 2 mg/L. Two chlorinated MTX congeners, 4-amino-3-chlorinated-N10-methylpteroylglutamic （monochloro-MTX） and 4-amino-3,5-dichloro-N10-methylpteroylglutamic （dichloro-MTX） were found in the chlori- nated solution. Monochloro-MTX was successfully fractionated by high performance liquid chromatography （HPLC） and its structure was further identified using 1H nuclear magnetic resonance （NMR） analysis. The presence of the two products in real hospital wastewater was then examined and both compounds were detected. Finally, the effects of MTX and monochloro-MTX on the cell cycle progression in vitro were evaluated using zebrafish liver cell line. It was found that both compounds could inhibit the proliferation of zebrafish liver cells through S phase arrest and their effects on the cell cycle profile had no significant difference.

关键词： Methotrexate Chlorination Chlorinated methotrexate Cell cycle arrest

Yield potential and nitrogen use efficiency of China's super rice

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Journal of Integrative Agriculture 2017年第5期16卷 1000-1008页

作者： WANG Fei PENG shao-bing National Key Laboratory of Crop Improvement Huazhong Agricultural UniversityWuhan 430070P.R.China Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze River Ministry of Agriculture/College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070P.R.China

In 1996, a mega project that aimed to develop rice varieties with super-high yield potential （super rice） was launched by the Ministry of Agriculture （MOA） in China using a combination of the ideotype approach and intersubspecific heterosis. Significant progress has been made in the last two decades, with a large number of super rice varieties being approved by the MOA and the national average grain yield being increased from 6.21 t ha^-1 in 1996 to 6.89 t ha^-1 in 2015. The increase in yield potential of super rice was mainly due to the larger sink size which resulted from larger panicles. Moreover, higher photosynthetic capacity and improved root physiological traits before heading contributed to the increase in sink size. However, the poor grain filling of the later-flowering inferior spikelets and the quickly decreased root activity of super rice during grain filling period restrict the achievement of high yield potential of super rice. Furthermore, it is widely accepted that the high yield potential of super rice requires a large amount of N fertilizer input, which has resulted in an increase in N consumption and a decrease in nitrogen use efficiency （NUE）, although it remains unclear whether super rice per se is responsible for the latter. In the present paper, we review the history and success of China＇s Super Rice Breeding Pro- gram, summarize the advances in agronomic and physiological mechanisms underlying the high yield potential of super rice, and examine NUE differences between super rice and ordinary rice varieties. We also provide a brief introduction to the Green Super Rice Project, which aims to diversify breeding targets beyond yield improvement alone to address global concerns around resource use and environmental change. It is hoped that this review will facilitate further improvement of rice production into the future.

关键词： super rice yield potential nitrogen use efficiency Green Super Rice

Recent Progress in Shape Memory Polymers for Biomedical Applications

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Chinese Journal of Polymer Science 2018年第8期36卷 905-917页

作者： Hong-Mei Chen Lin Wang shao-bing Zhou College of Chemistry and Materials Science Sichuan Normal University Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong University

Shape memory polymers （SMPs） as one type of the most important smart materials have attracted increasing attention due to their promising application in the field of biomedicine, textiles, aerospace et al. Following a brief intoduction of the conception and classification of SMPs, this review is focused on the progress of shape memory polymers for biomedical applications. The progress includes the early researches based on thermo-induced SMPs, the improvement of the stimulus, the development of shape recovery ways and the expansion of the applications in biomedical field. In addition, future perspectives of SMPs in the field of biomedicine are also discussed.

关键词： Shape memory polymers Biomedicical application Biodegradable

Rational Homotopy Theory and Nonnegative Curvature

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Acta Mathematica Sinica,English Series 2006年第1期22卷 23-26页

作者： Jian Zhong PAN shao bing WU Institute of Mathematics Academy of Mathematics and Systems Science Chinese Academy of Science Beijing 100080 P. R. China Department of Education Suqian College Suqian 223800 P. R. China

in this note, we answer positively a question by Belegradek and Kapovitch about the relation between rational homotopy theory and a problem in Riemannian geometry which asks that total spaces of which vector bundles o... 详细信息

关键词： Curvature Derivation Homotopy equivalence

Serum Ferritin and the Risk of Metabolic Syndrome:A Systematic Review and Dose-Response Meta-Analysis of Cross-sectional Studies

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Biomedical and Environmental Sciences 2021年第8期34卷 623-631页

作者： ZHANG Wei Chun Bai XING Yang shao bing Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Center for Disease Prevention and ControlBeijing 100013China School of Public Health Capital Medical UniversityBeijing 100069China Beijing Research Center for Preventive Medicine Beijing 100013China

Objective This study aims to assess the dose-response relationship between serum ferritin(SF)and metabolic syndrome(MetS)in the two *** We searched for articles on PubMed,the Cochrane Library,EMBASE,and the Web of Science databases that were published from 1950 to *** summary odds ratio(OR)and 95%confidence interval(CI)of the association between SF and MetS were estimated using a random-effects model through a *** on the methods described by Greenland and Longnecker,we explored the dose-response relationship between the two *** This study included 14 studies and 74,710 *** results of the classical meta-analysis showed that SF was positively associated with MetS(OR=1.77,95%CI:1.59–1.98).Regarding the components of MetS(8 studies included),the results showed that SF was positively associated with abdominal obesity(OR=1.42,95%CI:1.24–1.62),elevated fasting plasma glucose(OR=1.84,95%CI:1.50–2.25),elevated blood pressure(OR=1.17,95%CI:1.08–1.26),elevated triglycerides(OR=2.09,95%CI:1.72–2.54),and reduced high-density lipoprotein cholesterol(OR=1.33,95%CI:1.19–1.49).In the linear dose-response meta-analysis,the ORs of males,females,and postmenopausal females were 1.14(95%CI:1.13–1.16),1.32(95%CI:1.26–1.39),and 1.34(95%CI:1.22–1.47),*** Our study shows that SF is significantly and positively associated with MetS,and the risk in the male population is higher than that in the female *** finding also supports the recommendation of using SF as an early warning marker of MetS.

关键词： Serum ferritin Metabolic syndrome Meta-analysis Dose-response relationship

One-pot synthesis of Sb-Fe-carbon-fiber composites with in situ catalytic growth of carbon fibers

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International Journal of Minerals,Metallurgy and Materials 2012年第6期19卷 542-548页

作者： Jiart Xie Wen-tao Song Gao-shao Cao Xin-bing Zhao Department of Materials Science and Engineering Zhejiang University Hangzhou 310027 China

A Sb-Fe-carbon-fiber （CF） composite was prepared by a chemical vapor deposition （CVD） method with in situ growth of CFs us- ing Sb203/Fe2O3 as the precursor and acetylene （C2H2） as the carbon source. The Sb-Fe-CF composite was characterized by X-ray diffraction （XRD）, field emission scanning electron microscopy （FESEM） and transmission electron microscopy （TEM）, and its electrochemical per- formance was investigated by galvanostatic charge-discharge cycling and electrochemical impedance spectroscopy. The Sb-Fe-CF composite shows a better cycling stability than the Sb-amorphous-carbon composite prepared by the same CVD method but using Sb2O3 as the precur- sor. Improvements in cycling stability of the Sb-Fe-CF composite can be attributed to the formation of three-dimensional network structure by CFs, which can connect Sb particles firmly. In addition, the CF layer can buffer the volume change effectively.

关键词： composite materials antimony alloys carbon fibers chemical vapor deposition catalytic growth network structures lithiumbatteries anodes

Study on the performance of lightweight roadway wall thermal insulation coating containing EP-GHB mixed ceramsite

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Building Simulation 2024年第5期17卷 785-798页

作者： Yongliang Zhang Shili Yin Hongwei Mu Xilong Zhang Qinglei Tan bing shao Key Lab of Industrial Fluid Energy Conservation and Pollution Control Ministry of EducationQingdao University of TechnologyQingdaoShandong266520China College of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdaoShandong266520China

As the mining depth increases,the problem of high-temperature thermal damage mainly caused by heat dissipation of surrounding rock is becoming more and more *** is very important to solve the environmental problem of mine heat damage to improve the efficiency of mineral resource exploitation and protect the physical and mental health of *** can apply thermal insulation coating on the walls of mine roadways as a means of implementing active heat *** this paper,expanded perlite(EP)and glazed hollow bead(GHB)are used as the main thermal insulation materials,ceramsite and sand as aggregate,plus glass fiber and sodium dodecyl sulfate to develop a new lightweight composite thermal insulation coating through orthogonal experiment *** to the plate heat flow meter method and mechanical test method,the thermal insulation and mechanical properties of EP-GHB mixed ceramsite coating were studied by making specimens with different parameter ratios,and according to the analysis of the experimental results,the optimal mix ratio of the coating was *** addition,Fluent numerical simulation software was used to establish the roadway model,and the thermal insulation effect of the coating in the roadway under different working conditions was *** results show that the thermal conductivity of the prepared composite thermal insulation coating material is only 8.5% of that of ordinary cement mortar,and the optimal thickness of adding thermal insulation coating is 0.2 m,which can reduce the outlet air temperature of the roadway with a length of 1000 m by 4.87 K at this *** thermal insulation coating developed in this study has the advantages of simple technology and strong practicability,and has certain popularization and application value in mine heat damage control.

关键词： high-temperature mine thermal insulation coating orthogonal experimental optimal fit ratio numerical simulation

Occurrence of sulfonamide antibiotics in sewage treatment plants

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Chinese Science Bulletin 2008年第4期53卷 514-520页

作者： CHANG Hong HU JianYing WANG LeZheng shao bing College of Environmental Sciences Peking University Beijing 100871 China Beijing Center for Disease Prevention and Control Beijing 100013 China

The occurrence of sulfonamide antibiotics(SAs) was investigated in the six sewage treatment plants(STPs) of Beijing,*** the 13 objective antibiotics,sulfamethoxazole,sulfapyridine,sulfamerazine,sulfadiazine and sulfamethizol were detected in the influents with the average concentrations of 1.2 ± 0.45,0.29 ± 0.25,0.048 ± 0.012,0.35 ± 0.52 and 0.33 ± 0.21 μg·L-1,respectively,and those in the effluents were 1.4 ± 0.74,0.22 ± 0.19,0.021 ± 0.008,0.22 ± 0.21and 0.01± 0 μg·L-1,*** was the predominant compound detected,and was found in all wastewater samples with the other two compounds sulfapyridine and *** should be noted that sulfadiazine was first reported in wastewaters,and the concentration levels of all detected compounds except for sulfamethizol(detected once in the effluent samples) in the influents were observed to be similar to those in the *** the data in this study,it can be found that sulfamethoxazole,sulfapyridine,sulfamerazine and sulfadiazine could be partly removed in anoxic and aerobic treatment unit and vice versa in anaerobic process,which led to their low or even negative removal rates in the *** increase on the concentrations of sulfamethoxazole and sulfapyridine in the effluents was found probably due to the biotransformation of their acetylated forms in anaerobic treatment *** addition,it was observed that the biodegradation of sulfamethoxazole and sulfapyridine could partly occur during the anoxic and aerobic process,while sulfamerazine was partly eliminated in the anaerobic and anoxic units.

关键词：污水处理生物转化城市污水处理厂磺胺类药抗生素

Synthesis of Flower-like Zinc Oxalate Microspheres in Ether-water Bilayer Refluxing Systems and Their Conversion to Zinc Oxide Microspheres

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Journal of Materials Science & Technology 2011年第6期27卷 563-569页

作者： Liang Ni Lei Wang bing shao Yinjue Wang Wenli Zhang Yong Jiang School of Chemistry and Chemical Engineering Jiangsu University Zhenjiang 212013 China

Flower-like zinc oxalate with a mean diameter of 50 μm was synthesized via the reaction of zinc acetate and dimethyl oxalate in ether-water bilayer refluxing systems at low ***-like zinc oxalate microspheres can be further transformed into the similar morphology to zinc oxide by the decomposition of zinc oxalate at 500℃.Scanning electron microscopy（SEM）,X-ray diffraction（XRD）,thermogravimetric analysisdifferential scanning calorimetric（TG-DSC）,energy dispersive X-ray spectrum（EDX） and Fourier transforminfrared spectroscopy（FT-IR） were used to characterize the structure features and chemical compositions of the as-synthesized *** UV-Vis and photoluminescence spectrum of flower-like zinc oxide microspheres were *** experimental results showed that flower-like zinc oxalate microspheres may be self-assembled by the zinc oxalate *** ether-water volume ratio of 4：1 and refluxing temperature of 40℃ were considered to favor the preparation of flower-like zinc oxalate microspheres.

关键词： Bilayer refluxing system Zinc oxalate Zinc oxide Flower-like microspheres