Background.-migrainous vertigo(mV)is increasingly recognized as a common cause of episodic *** displays several clinical similarities with familial hemiplegic migraine(FHm)and episodic ataxia type 2(EA-2),which have b...
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Background.-migrainous vertigo(mV)is increasingly recognized as a common cause of episodic *** displays several clinical similarities with familial hemiplegic migraine(FHm)and episodic ataxia type 2(EA-2),which have been linked to mutations in 3 genes,CACNA1A,encoding a neuronal calcium channel αsubunit,ATP1A2,encoding a catalytic subunit of a Na +/K+-ATPase,and most recently the voltage-gated sodium channel *** present study explored the hypothesis that mutations in CACNA1A,ATP1A2,SCN1A,and the calcium channel β4 subunit CACNB4 confer susceptibility to ***.-mutation analysis of the coding exons and exon/intron junctions of CACNA1A,ATP1A2,SCN1A,and CACNB4 was performed in 14 unrelated mV patients by conformation sensitive gel electrophoresis and automated sequence ***.-Analysis of the 4 candidate genes in the 14 mV patients resulted in the identification of a total of 26 sequence *** silent substitution D29D in CACNB4 was observed in 2 mV patients and was not present in 46 ethnically matched control DNA *** remaining variants were also observed in control DNA samples and the allele frequencies of variants that resulted in amino acid substitutions were not significantly different between patients and ***.-Based on this group of patients there is no evidence that the genes causing FHm and EA-2 represent major susceptibility loci for mV.
The mechanistic basis of cellulose biosynthesis in plants has gained ground during last decade or *** isolation of plant cDNA clones encoding cotton homologs of the bacterial cellulose
The mechanistic basis of cellulose biosynthesis in plants has gained ground during last decade or *** isolation of plant cDNA clones encoding cotton homologs of the bacterial cellulose
Rock mass has been characterised for many purposes like for drilling, blasting and support design. The characterisation has been normally done to indicate the overall rock mass behaviour against failure. The main obje...
Rock mass has been characterised for many purposes like for drilling, blasting and support design. The characterisation has been normally done to indicate the overall rock mass behaviour against failure. The main objective is to have a simple method to characterise the rock mass including various properties and conditions and subsequently to develop indices or ratings that can be used to predict the failure condition. As rock mass failure in drilling strongly resembles to that in blasting, many researchers have used drilling parameters for rock mass characterisation in blasting. This paper discusses use of Drilling Index to calculate rock factor used in prediction of mean fragment size. An approach with this method has been discussed in light of the existing criteria.
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