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ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3523-3535页

作者： Xiao-Hui Ma Jiang-Han-Zi Liu Chun-Yu Liu Wan-Yang Sun Wen-Jun Duan guan Wang Hiroshi Kuriara Rong-Rong He Yi-Fang Li Yang Chen Hongcai shang guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibilty Jinan UniversityGuangzhou 510632China guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China international Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) Jinan UniversityGuangzhou 510632China institute of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830054China Sinnovation Center of Nursing Research Nursing Key Laboratory of Sichuan ProvinceState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China College of Pharmacy Guangzhou University of Chinese Medicine Guangzhou 510405China Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese Medicine100700 BeijingChina

Myocardial ischemia/reperfusion(/R)injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell *** is believed that irreversible myocardial damage resulted from I/R occurs due to oxidative stress evoked during the reperfusion *** we demonstrate that ischemia triggers a specific redox reaction of polyunsaturated fatty acids(PUFA)-phospholipids in myocardial cells,which acts as a priming signaling that initiates the outbreak of robust oxidative damage in the reperfusion *** animal and in vitro models,the crucial lipid species in I/R injury were identifed to be oxidized PUFAs enriched *** multi-omics,arachidonic acid 15-lipoxygenase-1(ALOx15)was identified as the primary mediator of ischemia-provoked phospholipid peroxidation,which was further confirmed using chemogenetic ***,our results reveal that ALOx15 induction in the ischemia phase acts as a"burning point"to ignite phospholipid oxidization into ferroptotic *** finding characterizes a novel molecular mechanism for myocardial ischemia injury and offers a potential therapeutic target for early intervention of V/R injury.

关键词： peroxidation ischemia damage

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Research on an Thermal Management System and its Control Strategy for Electric Vehicles

Research on an Thermal Management System and its Control Str...

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2020中国汽车工程学会年会暨展览会

作者： shang Xuanqing Ma Xu Zhang Chunqiu Li yonggang Xu Zhenpeng Dongfeng Motor Co. Ltd.Dongfeng Nissan Passenger Vehicle Company

As the demand for EV’s range increasing,the energy density of power battery is getting higher than before,and the thermal management of battery is becoming more and more *** article introduces a kind of management system of A/C and battery thermal,and how it *** addition,the control strategies and parameter settings of core components are *** system and control strategy have been experimentally verified and practically applied to certain electric *** results prove that the liquid-cooled control system and its control strategy described in this paper can well meet the comfort requirements of the passenger *** it can provide a suitable charging and discharging temperature environment for the power battery.

关键词： electric vehicles battery thermal management e-compressor PTC EXV

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Relationship between Toll-like receptor 2 on polymorphonuclear neutrophil and postoperative systemic inflammatory response syndrome in patients undergoing orthotopic liver transplantation

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中华麻醉学杂志 2010年第B2期30卷 15-18页

作者： CHI Xin-jin LI shang-rong CHENG Nan HEI Zi-qing LUO Gang-jian guan Jian-qiang ZHANG Rui ZHANG Qi Department of Anesthesiology Third Affiliated Hospital SUN Yat-Sen University Guangzhou 510630 China

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Distributed Control Software for the Active Surface System of Tian-ma Radio Telescope

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Research in Astronomy and Astrophysics 2023年第11期23卷 225-231页

作者： Dong Zhang Rong-Bing Zhao Zhen Yan Wei-Hua shang-guan Qian Ye Zhi-Qiang Shen Qing-Hui Liu Jin-Qing Wang Li Fu Chu-Yuan Zhang Dong-Fang Song Si-Yu Liu shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China Chongqing Jiaotong University Chongqing 400074China

The Tian-ma Radio Telescope(TMRT) applies an Active Surface System(ASFS), which corrects for large-scale deformations due to gravity and thermal on the primary reflector. The centralized and automated management of the ASFS using software has become a challenge, for which we have developed the TMRT Active Surface System Control Software(TASCS). This paper describes the design and implementation of TASCS for device control,status monitoring, human-computer interaction, and data management functionalities. TASCS adopts the opensource Tango Controls framework and distributes middleware technology to realize real-time automated adjustment of the primary reflector through remote centralized control of a large number of actuators. At present, it has been successfully deployed on the TMRT and has played an important role in Event Horizon Telescope observations.

关键词： Astronomical Instrumentation Methods and Techniques telescopes instrumentation:high angular resolution techniques:high angular resolution

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Metal-organic framework IRMOFs coated with a temperaturesensitive gel delivering norcantharidin to treat liver cancer

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World Journal of Gastroenterology 2021年第26期27卷 4208-4220页

作者： Xiu-Yan Li Qing-Xia guan Yu-Zhou shang Yan-Hong Wang Shao-Wa Lv Zhi-Xin Yang Rui Wang Yu-Fei Feng Wei-Nan Li Yong-Ji Li College of Pharmacy Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina

BACKGROUND Norcantharidin(NCTD)is suitable for the treatment of primary liver cancer,especially early and middle primary liver *** compound can reduce tumors and improve immune ***,the side effects of NCTD have limited its *** is a marked need to reduce the side effects and increase the efficacy of *** To develop a nanomaterial carrier,NCTD-loaded metal-organic framework IRMOF-3 coated with a temperature-sensitive gel(NCTD-IRMOF-3-Gel),aiming to improve the anticancer activity of NCTD and reduce the drug *** NCTD-IRMOF-3-Gel was obtained by a coordination *** apparent characteristics and in vitro release of NCTD-IRMOF-3-Gel were *** cytotoxicity assays,flow cytometry,and apoptosis experiments in mouse hepatoma(Hepa1-6)cells were used to determine the anti-liver cancer activity of NCTD-IRMOF-3-Gel in in vitro *** The particle size of NCTD-IRMOF-3-Gel was 50-100 nm,and the particle size distribution was *** release curve showed that NCTD-IRMOF-3-Gel had an obvious sustained-release *** cytotoxicity assays showed that the free drug NCTD and NCTD-IRMOF-3-Gel treatments markedly inhibited Hepa1-6 cell proliferation,and the inhibition rate increased with increasing drug *** flow cytometry,NCTD-IRMOF-3-Gel was observed to block the Hepa1-6 cell cycle in the S and G2/M phases,and the thermosensitive gel nanoparticles may inhibit cell proliferation by inducing cell cycle *** experiments showed that NCTD-IRMOF-3-Gel induced the apoptosis of Hepa1-6 *** Our results indicated that the NCTD-IRMOF-3-Gel may be beneficial for liver cancer disease treatment.

关键词： Norcantharidin Metal-organic frameworks IRMOF-3 Temperature-sensitive gel Drug delivery Liver cancer

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基于量子行为遗传算法的船体局部结构优化设计

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船舶力学 2017年第4期21卷 484-492页

作者：刘波林焰吕振望管官纪卓尚大连理工大学工业装备结构分析国家重点实验室辽宁大连116024 大连理工大学船舶工程学院辽宁大连116024

采用遗传算法解决船舶复杂结构中混合设计变量优化问题时,其效果很有效,且能获得全局最优可行解。然而,简单遗传算法局部搜索能力差且易于早熟。为了提高对船舶复杂结构设计变量解空间的搜索能力,该文设计了一种基于二进制编码的适用于... 详细信息

采用遗传算法解决船舶复杂结构中混合设计变量优化问题时,其效果很有效,且能获得全局最优可行解。然而,简单遗传算法局部搜索能力差且易于早熟。为了提高对船舶复杂结构设计变量解空间的搜索能力,该文设计了一种基于二进制编码的适用于混合变量的量子行为遗传算法,比较适合于复杂函数的全局寻优,且搜索能力优于标准遗传算法。通过三个算例对算法的寻优能力进行测试,实验结果表明,采用量子行为遗传算法进行的船体局部结构优化设计具有较好的计算质量与计算效率。

关键词：量子行为遗传算法船体局部结构结构优化设计混合设计变量搜索能力

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负载钛酸钙取向性静电纺聚己内酯/丝素蛋白支架促进周围神经再生

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中国组织工程研究 2025年第28期29卷 6070-6082页

作者：柳小军商雨情管文超许琳琳李贵才河南省药品医疗器械检验院河南省郑州市450018 国家药监局医用生物防护及植入器械质量评价重点实验室河南省郑州市450018 南通大学神经再生教育部重点实验室江苏省南通市226001

背景:取向性聚己内酯/丝素蛋白共混静电纺丝支架修复周围神经损伤可促进神经再生,但修复效果有限,还需要进一步结合生物活性材料、生长因子等因素制备仿生神经支架。钛酸钙纳米颗粒具有促进施万细胞间黏附的能力,已被广泛运用于生物医... 详细信息

背景:取向性聚己内酯/丝素蛋白共混静电纺丝支架修复周围神经损伤可促进神经再生,但修复效果有限,还需要进一步结合生物活性材料、生长因子等因素制备仿生神经支架。钛酸钙纳米颗粒具有促进施万细胞间黏附的能力,已被广泛运用于生物医学材料领域。目的:采用静电纺丝技术制备取向性聚己内酯/丝素蛋白-钛酸钙功能化支架,进一步探索该支架对施万细胞活力与黏附的影响。方法:采用静电纺丝技术制备聚己内酯/丝素蛋白支架,通过调整制备过程中的注射器流速、接收装置转速、纺丝时间筛选最优参数进行后续实验。在最优参数下,采用静电纺丝技术制备随机取向聚己内酯/丝素蛋白支架(记为PCL/SF-R)、取向性聚己内酯/丝素蛋白支架(记为CTO-0)及含0.1,0.5,1.0 mg/mL聚多巴胺修饰钛酸钙的取向性聚己内酯/丝素蛋白支架(依次记为CTO-1、CTO-5、CTO-10),表征5组支架的物理性能。将5组支架浸提液分别与大鼠成纤维细胞系(L929)共培养,采用MTT法检测细胞增殖。将大鼠施万细胞系(RSC96)分别接种于5组支架上,进行细胞活力、细胞骨架染色及细胞骨架与细胞黏附相关基因检测。结果与结论:①制备静电纺丝支架的最优参数为:注射器流速15μL/min,接收装置转速1800 r/min,纺丝时间1 h;②PCL/SF-R组水接触角最大、弹性模量最小,CTO-0组水接触角最小、弹性模量最大;CTO-0组支架降解速率低于CTO-1组,并且随着取向性支架中钛酸钙质量浓度的增加,支架的降解速率降低;③5组支架对L929细胞无毒性作用,具有良好的生物相容性;CCK-8检测结果显示,CTO-10可提升RSC96细胞活力;细胞骨架染色结果显示,取向性支架上细胞的长宽比和细胞突起长度均高于随机取向支架;qPCR检测结果显示,CTO-5组、CTO-0组YAP、Cntn2 mRNA表达均高于PCL/SF-R组(P<0.05);④结果表明,取向性聚己内酯/丝素蛋白-钛酸钙支架具有良好的生物相容性、力学性能及亲水性,可提升施万细胞的活力与迁移能力,促进周围神经再生。

关键词：钛酸钙取向性静电纺丝聚己内酯丝素蛋白周围神经再生工程化神经材料

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启蒙思潮与“阿Q”的精神谱系

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东北师大学报（哲学社会科学版） 2009年第5期 139-142页

作者：关尚杰吉林省经济管理干部学院吉林长春130036

五四之后,启蒙思潮从原先寻求文化变革的思想启蒙变换为一种召唤暴力的阶级性革命启蒙,这种阶级性革命启蒙一直延续到十七年文学叙事之中;改革开放之后,启蒙思潮重新兴起,主要表现为经济意识的启蒙和受抑制的人性解放。从20世纪中国启... 详细信息

五四之后,启蒙思潮从原先寻求文化变革的思想启蒙变换为一种召唤暴力的阶级性革命启蒙,这种阶级性革命启蒙一直延续到十七年文学叙事之中;改革开放之后,启蒙思潮重新兴起,主要表现为经济意识的启蒙和受抑制的人性解放。从20世纪中国启蒙思潮视角,观照20世纪乡土中国文学典型作品,解读《阿Q正传》等文本所构成的"阿Q精神谱系"与启蒙思潮的内在关系,分析中国农民走向现代性的外部压抑性结构和内在思想阻力,对于探寻新世纪历史语境下"新启蒙主义"与农民思想解放的可能性具有重要意义。

关键词：启蒙思潮阿Q精神谱系农民 “新启蒙主义”

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无重叠视场多相机组安装关系的灵活标定

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中国激光 2017年第6期44卷 201-207页

作者：王刚尚洋关棒磊于起峰国防科学技术大学航天科学与工程学院湖南长沙410073 图像测量与视觉导航湖南省重点实验室湖南长沙410073

在多相机组合测量应用场景中,各相机之间常常存在没有重叠视场的特殊情况,该条件下多相机组安装关系的标定极具挑战性。针对传统基于全站仪的标定方法过于繁琐的缺点,基于机器人领域里手眼标定与多相机组安装关系标定的等价关系,给出了... 详细信息

在多相机组合测量应用场景中,各相机之间常常存在没有重叠视场的特殊情况,该条件下多相机组安装关系的标定极具挑战性。针对传统基于全站仪的标定方法过于繁琐的缺点,基于机器人领域里手眼标定与多相机组安装关系标定的等价关系,给出了求解多相机组安装关系的基础方程,推导了利用四元数描述旋转矩阵下基础方程的解算步骤,提出了一种基于手眼标定的无重叠视场多相机组标定方法。实验结果表明,与传统标定方法相比,该方法在不降低测量精度的前提下,无需其他测量传感器的辅助,极大减少了人工作业量,操作更加简单灵活,工作效率更高。

关键词：测量外参数标定手眼标定无重叠视场

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Analysis of vegetation dynamics and driving forces in Ordos: 2000-2019

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Ecological Economy 2020年第3期16卷 162-175页

作者： ZHAO Chuan-wu YAN Yue-guan GUO Wei GAO shang-qing College of Geoscience and Surveying Engineering China University of Mining and TechnologyBeijing 100083CHINA Graduate School of Education Beijing Foreign Studies UniversityBeijing 100089CHINA

As a typical resource-based city,Ordos has a rapid economic *** studies mostly focused on vegetation changes monitoring,and rarely discuss socioeconomic impacts on vegetation *** on MOD13Q1 data,climate data and 11 socioeconomic indicators from 2000 to 2019,combined with GIS technology and statistical methods,the spatiotemporal changes of Ordos vegetation and its influencing factors were *** results show that:(1)In the past 20 years,the NDVI value of Ordos ranged from 0.233 to 0.395,showing a fluctuating growth trend with a growth rate of 0.058/10a;the NDVI values of the eight counties under its jurisdiction also showed a fluctuating growth trend,but there were differences among regions.(2)Spatially,the vegetation in Ordos is high in the northeast and low in the *** area of low vegetation area is 54200 km2,accounting for 62.39%of the total area of *** area of high vegetation area is only 19900 km2,mainly concentrated in the Yellow River impact area in the north of Dalate Banner.(3)In terms of spatial changes,the area of the vegetation improvement area is much larger than that of the vegetation degradation area,accounting for 52.38%of the total area of ordos,while the vegetation degradation area only accounts for 4.10%.(4)NDVI value showed a significant positive correlation with rainfall,the correlation coefficient is 0.802(P0.05);the correlation coefficient with sunshine hours and humidity is negative;the correlation coefficient between the change of NDVI and the accumulated rainfall in the month is larger,and the correlation coefficient with the temperature of one month ago is larger.(5)The NDVI change was extremely significantly positively correlated with the 11 socioeconomic indicators,with a correlation of 0.728-0.796(P<0.01).From 2000 to 2019,the restoration effect of Ordos vegetation was *** and temperature are the main factors affecting

关键词： ordos NDVI climate factors lag effect economic indicators

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