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Rapid screening and identification of sesquiterpene lactones in Kudiezi injection based on high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry

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Chinese Journal of Natural Medicines 2018年第2期16卷 150-160页

作者： LIU Rong-Rong zhanG Xiu-Ping WANG Fang shang zhan-peng WANG Fei LIU Ying LU Jian-Qiu zhanG Jia-Yu School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing Research Institution of Chinese Medicine Beijing University of Chinese Medicine Library of Beijing University of Chinese Medicine Beijing University of Chinese Medicine

Sesquiterpene lactones are considered as the major active compounds in Kudiezi injection in virtue of their special structures and activities. Herein, an analytical method was developed for rapid screening and identification of sesquiterpene lactones in Kudiezi injection using high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry(HPLC-LTQ-Orbitrap) in negative ion mode. First, two sesquiterpene lactone reference standards were analyzed to obtain their characteristic ESI-MS/MS fragmentation patterns. Second, based on extracted ion chromatography(EIC) data-mining method and characteristic fragmentation pathways analysis, sesquiterpene lactones in Kudiezi injection were rapidly screened and identified. Finally, an important parameter Clog P was adopted to discriminate the isomers of sesquiterpene lactones. As a result, 50 sesquiterpene lactones were characterized, including 9 sesquiterpene lactone aglycones, 39 sesquiterpene lactone glycosides, and 2 amino acid-sesquiterpene lactone conjugates. Among them, 13 compounds were tentatively identified as new compounds. The results demonstrated that the established method would be a rapid, effective analytical tool for screening and identification of sesquiterpene lactones in the complex system of natural medicines.

关键词： HPLC-LTQ-Orbitrap Sesquiterpene lactones Characteristic fragmentation pathways Kudiezi injection

Danshen: a phytochemical and pharmacological overview

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Chinese Journal of Natural Medicines 2019年第1期17卷 59-80页

作者： MEI Xiao-Dan CAO Yan-Feng CHE Yan-Yun LI Jing shang zhan-peng ZHAO Wen-Jing QIAO Yan-Jiang zhanG Jia-Yu School of Chinese Pharmacy Beijing University of Chinese Medicine College of Pharmaceutical Science Yunnan University of Traditional Chinese Medicine College of Basic Medicine Jinzhou Medical University Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine

Danshen, the dried root or rhizome of Salvia miltiorrhiza Bge., is a traditional and folk medicine in Asian countries, especially in China and Japan. In this review, we summarized the recent researches of Danshen in traditional uses and preparations, chemical constituents, pharmacological activities and side effects. A total of 201 compounds from Danshen have been reported, including lipophilic diterpenoids, water-soluble phenolic acids, and other constituents, which have showed various pharmacological activities, such as anti-inflammation, anti-oxidation, anti-tumor, anti-atherogenesis, and anti-diabetes. This article intends to provide novel insight information for further development of Danshen, which could be of great value to its improvement of utilization.

关键词： Danshen Traditional uses Chemical constituents Quality control Pharmacological activities

UHPLC-LTQ-Orbitrap-based metabolomics coupled with metabolomics pathway analysis method for exploring the protection mechanism of Kudiezi injection in a rat anti-ischemic cerebral reperfusion damage model

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Chinese Journal of Natural Medicines 2017年第12期15卷 955-960页

作者： LIU Si-Yi CAI Wei WANG Fei LIU Ying shang zhan-peng zhanG Xiu-Ping WANG Zi-Jian LU Jian-Qiu zhanG Jia-Yu Beijing Research Institution of Chinese Medicine Beijing University of Chinese Medicine Dong Pharmaceutical Research of Hunan Key Laboratory Hunan University of Medicine

Kudiezi injection has been used extensively in the treatment of cerebrovascular and cardiovascular diseases. However, its therapeutic effects and underlying mechanism of action are not fully understood. The aim of the present study was to clarify the protective mechanisms of Kudiezi injection on cerebral ischemic injury, using metabolomics methods. Middle cerebral artery occlusion(MCAO) was introduced in rats to build the cerebral ischemic damage. UHPLC-LTQ-Orbitrap-based analytical method was established for analysis of the metabolites. The raw mass data of all samples were normalized with Sieve 2.2 software and then introduced to orthogonal partial least squares discriminant analysis(OPLS-DA) model. Finally, 23 metabolites in plasma(15 were tentatively identified) were chosen as potential biomarkers, according to accurate mass measurements(< 5 ppm), MS/MS fragmentation patterns, and diagnostic product ions. Furthermore, on the basis of metabolic pathway analysis via metabolomics pathway analysis(Met PA), we first discovered that the protection mechanism in anti-ischemic cerebral reperfusion damage of Kudiezi injection was possibly related to the biosynthesis of phenylalanine, tyrosine, and tryptophan. The present study provided a useful approach for exploring the mechanism of ischemic stroke and evaluating the efficacy of Kudiezi injection or other traditional medicines.

关键词： Metabolomics Kudiezi injection Metabolomics pathway analysis(Met PA) Middle cerebral artery occlusion(MCAO) UHPLC-LTQ-Orbitrap

Pre-reduction of WO_(3)-Co_(3)O_(4)by H_(2)-C_(2)H_4 in a fluidized bed

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Chinese Journal of Chemical Engineering 2024年第2期66卷 273-284页

作者： Huijun shang Hengli Li Weijun Li Feng Pan zhan Du State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of Sciences(CAS)Beijing 100190China College of Chemical Engineering Nanjing Technology UniversityNanjing 211816China School of Chemistry and Chemical Engineering Shihezi UniversityShihezi 832003China College of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Chinalco Environmental Protection and Energy Conservation Group Co. Ltd.Xiong’an 071700China

In order to avoid the formation ofηphase(W_(6)Co_(6)C or W_(3)Co_(3)C)that adversely affects the sintering process and its products in the preparation process of ultra-fine WC-Co powder,a technical route of prereduction of WO_(3)-Co_(3)O_(4)to WO_(2)-Co and then deep reduction carbonization to WC-Co powder has been *** study mainly investigates the influence of gas partial pressure on the pre-reduction process of WO_(3)-Co_(3)O_(4)under a mixed atmosphere of H_(2)-C_(2)H_(4)-Ar at 600℃and establishes the kinetic equations of pre-reduction and carbon *** results indicate that increasing the partial pressure of hydrogen is conducive to the rapid and complete conversion of WO_(3) to WO_(2).High carbon content can be generated by the deposition of C_(2)H_(4),and it hinders the diffusion of the reducing gas;WO_(3)still cannot be completely reduced to WO_(2)as the partial pressure of C_(2)H_(4) increases to 60%.For the carbon evolution of C_(2)H_(4),the carbon amount is positively related to the H_(2)partial pressure,but it shows the highest amount and evolution rate when the ethylene partial pressure is 20%.Based on the reduction rate curves of WO_(3) and carbon evolution rate curves of C_(2)H_(4),the rate equations of pre-reduction and carbon evolution of WO_(3)-Co_(3)O_(4)system at 600℃are *** pre-reduction reaction belongs to the first-order reaction,and its equation is expressed as follows:r=-(dw_(WO_(3)))/dt=(9±0.15)×10^(-2)×P_(H_(2))^(0.44)P_(C_(2)H_(4))&(0.57)The carbon deposition rate equation of C_(2)H_(4) can be expressed as follows:r=-(dc_C)/dt=r_f-r_b≌7.35×10^(-2)×P_(C_(2)H_(4))^(0.31)

关键词： Fluidization WO_(3)-Co_(3)O_(4) Reduction Carbon deposition Rate equation

Twice-yearly lenacapavir demonstrated exceptional efficacy for HIV prevention

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The Innovation 2024年第5期5卷 9-10页

作者： Shujing Xu peng zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China

Acquired immunodeficiency syndrome(AIDS),a contagious illness arising from the human immunodeficiency virus(HIV),presents significant threats to human health and societal *** on genotypic differences,HIV can be divided into two main subtypes,HIV-1 and HIV-2,of which HIV-1 is the dominant global variant characterized by its heightened transmissibility and *** from 2022 indicate that approximately 39 million people are living with HIV globally,with 1.3 million new cases reported that *** combination antiretroviral therapy(cART)has demonstrated significant effectiveness in combating HIV infection,hurdles such as the emergence of multidrug-resistant HIV strains,potential long-term side effects,limited accessibility in economically underprivileged areas,and obstacles to treatment adherence hinder its widespread implementation.1 This necessitates the development of innovative medications with diverse resistance profiles and new therapeutic *** multifunctional HIV-1 capsid protein(CA)has emerged as a highly promising target in HIV-1 medication *** CA has a fullerene-shaped structure,consisting of 250 hexamers and 12 pentamers,which is crucial for viral ***,CA plays essential roles in multiple events during viral replication,including reverse transcription,nuclear entry,integration site distribution,assembly,and maturation.2 Therefore,CA-targeting small molecules can provide antiviral efficacy in both the early and late stages of the viral life cycle.

关键词： prevention exceptional globally

Jun12682,a potent SARS-CoV-2 papain-like protease inhibitor with exceptional antiviral efficacy in mice

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4189-4192页

作者： Mianling Yang Meehyein Kim peng zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJi’nan 250012China Infectious Diseases Therapeutic Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea

Recently,a collaborative research study published in Science,led by Jun Wang,Xufang Deng,Eddy Arnold,and Francesc Xavier Ruiz1,identified a series of potent small molecule inhibitors that specifically target SARS-CoV-2 papain-like protease(PLpro).The study demonstrated nanomolar PLpro inhibitory potency with Ki values ranging from 13.2 to 88.2 nmol/*** employing a structure-based drug design strategy,the researchers discovered an exceptionally promising compound,named Jun12682,that effectively targets both the newly discovered ubiquitin Val70(Val70Ub)-binding site and the known blocking loop(BL2)groove near the S4 subsite of ***,studies on the mechanism of action revealed that Jun12682 inhibits the deubiquitinating and deISGylating activities of PLpro,which are crucial for antagonizing the host’s innate immune response upon viral *** biology studies confirmed the“two-pronged”binding mode of Jun12682,aligning perfectly with their drug design ***,Jun12682 exhibited potent antiviral activity against SARS-CoV-2 and its variants,including nirmatrelvir-resistant mutants,in Caco-2 cells(EC50:0.44e2.02 mmol/L).It is noteworthy that its oral administration significantly improved survival rates and alleviated both lung virus loads and histopathological lesions in a lethal SARS-CoV-2 mouse *** conclusion。

关键词： SARS-CoV-2 Papain-like protease Broad-spectrum Anti-drug resistance Drug candidate

Differences in and factors controlling organic matter enrichment in the Ziliujing Formation shale in the Sichuan Basin

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Petroleum Science 2024年第1期21卷 77-86页

作者： peng Li Zhong-Bao Liu He Bi Tao Jiang Rui-Kang Bian peng-Wei Wang Xiao-Yu shang State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Efficient Development Beijing102206China Key Laboratory of Shale Oil/Gas Exploration and Production Technology SINOPECBeijing102206China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Research Institute of Petroleum Exploration and Development PetroChinaBeijing100083China Chinese Academy of Geological Sciences Beijing100037China No.4 Oil Production Plant in Daqing Oilfield Co Ltd. Daqing163511HeilongjiangChina

Lacustrine shale oil and gas are important fields for unconventional exploration and development in China,and organic-rich shale deposition lays down the critical foundation for hydrocarbon *** are two sets of shale,the Dongyuemiao and Da’anzhai Members,in the Ziliujing Formation in the Sichuan *** identify the differential enrichment characteristics of organic matter and clarify its controlling factors,geochemical analyses of organic and inorganic geochemical analyses were *** results showed that the total organic carbon content of the Dongyuemiao shale(1.36%)is slightly higher than that of the Da’anzhai shale(0.95%).The enrichment of organic matter in the two shales resulted from the comprehensive controls of paleoproductivity,paleoenvironment,and terrigenous input,but different factors have different *** addition,driven by climate,the change in the sulfate concentration in the bottom water further led to the different intensities of bacterial sulfate reduction in early *** made a great difference regarding organic matter accumulation in the two *** general,climate may have played a dominant role in organic matter enrichment in the two sets of shale.

关键词： Lacustrine shale Ziliujing Formation Sichuan Basin Enrichment mechanism of organic matter

Effects of the Resident Basic Medical Insurance Reform on Household Consumption in China

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China & World Economy 2024年第1期32卷 96-129页

作者： Shuheng Yu Xinxin Ma peng zhan School of Public Affairs Institute for Common Prosperity and DevelopmentZhejiang UniversityChina Faculty of Economics Hosei UniversityJapan

This paper investigates the causal relationship between the Urban and Rural Resident Basic Medical Insurance(URRBMI)reform and household consumption in urban China using data from the Chinese Household Income Project survey and employing combination of the propensity score matching and difference-in-differences *** results yield three ***,the reform affected both the amount and share of household ***,the reform led to an increase in total household consumption,encompassing both medical and nonmedical *** these,the proportion of medical consumption increased,while the proportion of nonmedical consumption ***,the impact of the URRBMI reform varied across consumption categories within nonmedical ***,consumption for education and entertainment industries are positively impacted by the URRBMI reform in terms of both quantity and ***,low-income households benefit more from the URRBMI reform compared to middle-and high-income *** main channels through which the URRBMI reform affects household consumption were the price effect and the crowding out effect on precautionary savings.

关键词： household consumption nonmedical consumption out-of-pocket expenses reimbursement ratio

A review of microwave-metal discharge interaction:Mechanism,regulation,and application for synthesis of nanomaterials

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Nano Research 2024年第10期17卷 9225-9254页

作者： Yixuan Xie Ruiqian Shi Benwei Fu Chengyi Song Wen shang peng Tao Tao Deng State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Engineering Research Center of Special Equipment and Power System for Ship and Marine Engineering Shanghai 200030China

Placing metals within microwave ovens has been generally viewed as a dangerous practice because of occurrence of violent discharge,but in recent years such discharge phenomenon has attracted increasing attention and has enabled a variety of exciting *** this work,we provide a comprehensive review of fundamental understanding of microwave-metal discharge interaction and its state-of-the-art application for nanomaterials *** introduce the microscopic interaction between different categories of materials and the electric and magnetic field of *** microwave-metal interaction,we highlight its size-dependence and point out the influence of the oxide layer on the surface of *** discuss the required conditions for occurrence of discharge,microscopic formation mechanism,and characteristic features of microwave-metal discharge *** analyzing the influence from the microwave input,discharging metals,and surrounding discharging media,we discuss the strategy for systematical regulation of the discharge *** describe the applications of the microwave-metal discharge for facile synthesis of various functional nanomaterials including core-shell carbon/metal,metal oxides,metal chalcogenides,intermetallic compounds,metallic nanoparticles and metallic compounds,and organic ***,the challenges in precise characterization and dynamic regulation of the discharge process as well as exciting application opportunities are discussed.

关键词： microwave-metal interaction discharge microwave heating skin depth nanomaterial synthesis