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Chinese Journal of Natural Medicines 2022年第2期20卷 148-154页

作者： LIU Hong-Yan ZHOU Mi shang ru-yi HONG Li-Li WANG Guang-Hui TIAN Wen-Jing JIAO Wei-Hua CHEN Hai-Feng LIN Hou-Wenu School of Pharmaceutical Sciences Xiamen UniversityXiamen 361102China Research Center for Marine Drugs State Key Laboratory of Oncogene and Related GenesDepartment of PharmacyRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

Four new sesquiterpene quinone meroterpenoids,dysideanones F—G(1—2)and dysiherbols D—E(3—4),were isolated from the marine sponge Dysidea avara collected from the South China *** new structures were elucidated by extensive analysis of spectroscopic data including HR-MS and 1D and 2D NMR spectra,and their absolute configurations were assigned by single-crystal X-ray diffraction and ECD ***-inflammatory evaluation showed that dysiherbols D—E(3—4)exhibited moderate inhibitory activity on TNF-α-induced NF-κB activation in human HEK-293T cells with IC_(50)values of 10.2 and 8.6μmol·L^(-1),respectively.

关键词： Dysidea avara Sesquiterpene quinones Marine sponge Anti-inflammatory Marine natural products

酥脆掘海绵Dysidea fragilis中杂萜类化学成分

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中草药 2021年第17期52卷 5192-5197页

作者：尚如意许婷婷林厚文焦伟华癌基因与相关基因国家重点实验室海洋药物研究中心上海交通大学医学院附属仁济医院沈阳药科大学中药学院

目的研究酥脆掘海绵Dysidea fragilis中杂萜类化学成分。方法采用硅胶柱色谱、反相ODS中压柱色谱以及半制备高效液相色谱等多种色谱技术进行分离纯化,所获得化合物采用HRMS、NMR等波谱方法进行鉴定,绝对构型则通过量子化学计算(ECD)法... 详细信息

目的研究酥脆掘海绵Dysidea fragilis中杂萜类化学成分。方法采用硅胶柱色谱、反相ODS中压柱色谱以及半制备高效液相色谱等多种色谱技术进行分离纯化,所获得化合物采用HRMS、NMR等波谱方法进行鉴定,绝对构型则通过量子化学计算(ECD)法确定。结果从酥脆掘海绵的95%乙醇提取物中分离得到了3个杂萜类化合物和1个二萜类化合物,分别鉴定为酥脆内酯(1)、黑麦草内酯(2)、cavernosine(3)和dictyolE(4)。结论化合物1为新化合物,首次对化合物2的核磁数据进行了全归属,纠正了其C-6和C-8位碳信号归属的错误。

关键词：酥脆掘海绵杂萜酥脆内酯黑麦草内酯海洋天然产物

非心脏非神经外科手术围手术期缺血性卒中的影响因素分析

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解放军医学杂志 2024年第10期49卷 1117-1122页

作者：柏亚真郑童童范孟楠尚益如杜敢琴富奇志河南科技大学临床医学院河南洛阳471003 河南科技大学第一附属医院病案统计室河南洛阳471003 河南科技大学第一附属医院神经内科河南洛阳471003

目的探讨非心脏非神经外科手术围手术期缺血性卒中的发病率、危险因素及其与术前脑血管事件风险评估的相关性,以指导围手术期风险管理。方法回顾性选取2015年1月-2022年1月在河南科技大学第一附属医院接受非心脏非神经外科手术、发生... 详细信息

目的探讨非心脏非神经外科手术围手术期缺血性卒中的发病率、危险因素及其与术前脑血管事件风险评估的相关性,以指导围手术期风险管理。方法回顾性选取2015年1月-2022年1月在河南科技大学第一附属医院接受非心脏非神经外科手术、发生围手术期缺血性卒中、年龄≥18岁的40例患者作为卒中组;按照性别、年龄、手术日期、手术医师匹配,病例比1:4,选取160例未发生围手术期缺血性卒中的患者作为对照组。收集两组患者的临床资料及术前脑血管事件风险评估情况(包括单独或联合应用头颅CT/MRI、经颅多普勒超声、颈动脉超声、神经科会诊)进行统计分析。采用多因素logistic回归分析筛选围手术期缺血性卒中的危险因素。结果围手术期缺血性卒中的发生率为0.042%。多因素logistic回归分析结果显示,高血压(OR=7.858,95%CI 2.175~28.388,P=0.002)、高脂血症(OR=4.457,95%CI 1.320~15.049,P=0.016)、肾功能不全(OR=8.277,95%CI 1.480~46.282,P=0.016)、术中低血压(OR=3.862,95%CI 1.211~12.317,P=0.022)是非心脏非神经外科手术围手术期缺血性卒中的独立危险因素;术前脑血管事件风险评估(OR=0.130,95%CI 0.031~0.542,P=0.005)是非心脏非神经外科手术围手术期缺血性卒中的保护因素。结论围手术期缺血性卒中的发生率较低,但预后较差;其危险因素有高血压、高脂血症、肾功能不全和术中低血压,术前脑血管事件风险评估有利于降低其发生率。

关键词：非心脏非神经外科手术围手术期缺血性卒中危险因素风险评估

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou ru Ye Liyan Zhong Yashuang Xu Junhui Ren yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Estrada index of dynamic random graphs

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Applied Mathematics(A Journal of Chinese Universities) 2023年第2期38卷 159-165页

作者： shang yi-lun Department of Computer and Information Sciences Northumbria UniversityNewcastle NE18STUK

The Estrada index of a graph G on n vertices is defined by EE(G)=∑^(n)_(i=1)^(eλ_(i)),whereλ_(1),λ_(2),···,λ_(n)are the adjacency eigenvalues of *** define two general types of dynamic graphs evolving according to continuous-time Markov processes with their stationary distributions matching the Erd¨os-R´enyi random graph and the random graph with given expected degrees,*** formulate some new estimates and upper and lower bounds for the Estrada indices of these dynamic graphs.

关键词： Estrada index temporary graph Markov process eigenvalue

Directional solidification behavior of turbine blades in DZ125 alloy:design of blade numbers on assembly

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Rare Metals 2021年第5期40卷 1134-1144页

作者： Yong shang Yan-Ling Pei Sheng-Kai Gong yi ru Yuan-Chao Yu ru-Hao Zhou Shu-Suo Li Hui-Bin Xu School of Materials Science and Engineering Beihang UniversityBeijing 100191China

The influence of blades assembly,i.e.,the blade number on the solidification process,heat exchange and grain structure on a directionally solidified Ni-based superalloy DZ125 was investigated by combining the experimental and simulation *** casting process was simulated thermodynamically by ProCAST software,where the interface heat transfer coefficient was precisely determined by a measurement with *** is a good agreement between experimental and simulation *** was interestingly found that with the number of blades increasing from 6 to 10,due to the decrease in radiation absorption efficiency,the maximum temperature and the heating rate decrease in the mold,during the preheat *** the withdrawal procedure,increased assembly numbers reduce the radiation exchange from mold to the enclosure,resulting in the decrease in cooling rate and temperature gradient of the *** the end of withdrawal,the slower cooling rate of the outside balances the temperature distribution of internal and external surfaces on the rabbet of blade.

关键词： Directional solidification Superalloy ProCAST Interfacial heat transfer coefficient

Effect of applied stress on r'-rafting behavior in a Ni-based singlecrystal superalloy:experiments and finite element analysis

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Journal of Iron and Steel Research International 2019年第3期26卷 259-267页

作者： Yuan-chao Yu yi ru Yong shang Yan-ling Pei Shu-suo Li Sheng-kai Gong School of Materials Science and Engineering Beihang University Beijing 100191 China

The effect of applied tensile stress on the r'-rafting behavior for a Ni-based single-crystal superalloy with more negative misfit was *** conducting interrupted creep tests at high temperature,it indicated that the increase in the applied stress accelerates the r'-rafting(directional coarsening of yr phase).In the early stage of rafting,the r'-cubes start interconnecting at the ends of the parallel-to-applied-stress r'-*** distributions of misfit stress,coherent strain and strain energy density of the r/r'phases are then calculated by finite element *** calculation results show that the rafting acceleration is mainly ascribed to the reduced strain energy density in the parallel-to-applied-stress r'-channel that is driven from the couple interaction of external load and misfit *** dislocation network formation,resulting from the misfit-induced increase in resolved shear stress,also contributes to the r'-rafting.

关键词： Ni-based superalloy High lattice misfit Rafting Finite element analysis Misfit stress Strain energy density

Multi-Type Directed Scale-Free Percolation

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Communications in Theoretical Physics 2012年第4期57卷 701-716页

作者： shang yi-Lun Institute for Cyber Security University of Texas at San AntonioTexas 78249USA

In this paper,we study a long-range percolation model on the lattice Z d with multi-type vertices and directed *** vertex x ∈ Z d is independently assigned a non-negative weight Wx and a type ψx,where(Wx) x∈Z d are *** variables,and(ψx) x∈Z d are also *** on weights and types,and given λ,α > 0,the edges are independent and the probability that there is a directed edge from x to y is given by pxy = 1 exp(λφψ x ψ y WxWy /| x-y | α),where φij 's are entries from a type matrix Φ.We show that,when the tail of the distribution of Wx is regularly varying with exponent τ-1,the tails of the out/in-degree distributions are both regularly varying with exponent γ = α(τ-1) /*** formulate conditions under which there exist critical values λ WCC c ∈(0,∞) and λ SCC c ∈(0,∞) such that an infinite weak component and an infinite strong component emerge,respectively,when λ exceeds them.A phase transition is established for the shortest path lengths of directed and undirected edges in the infinite component at the point γ = 2,where the out/in-degrees switch from having finite to infinite *** random graph model studied here features some structures of multi-type vertices and directed edges which appear naturally in many real-world networks,such as the SNS networks and computer communication networks.

关键词： long-range percolation random graph phase transition directed percolation regularly varying chemical distance

Local Natural Connectivity in Complex Networks

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Chinese Physics Letters 2011年第6期28卷 360-363页

作者： shang yi-Lun Institute for Cyber Security University of Texas at San AntonioSan AntonioTX 78249USA

In network theory,a complex network represents a system whose evolving structure and dynamic behavior contribute to its *** natural connectivity is recently proposed as a spectral measure to characterize the robustness of complex *** decompose the natural connectivity of a network as local natural connectivity of its connected components and quantify their contributions to the network *** addition,we compare the natural connectivity of a network with that of an induced subgraph of it based on interlacing *** an application,we derive an inequality for eigenvalues of Erdös-Rényi random graphs.

关键词： connectivity inequality connected

Nanosilver anchored alginate/poly(acrylic acid/acrylamide) double-network hydrogel composites for efficient catalytic degradation of organic dyes

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Frontiers of Chemical Science and Engineering 2023年第7期17卷 893-905页

作者： Fan Zhang Ce Gao shang-ru Zhai Qing-Da An Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefineryCollege of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034China

A novel alginate/poly(acrylic acid/acrylamide)double-network hydrogel composite with silver nanoparticles was successfully fabricated using the sol–gel *** presence of carboxyl and amide groups in the network structure provided abundant active sites for complexing silver ions,facilitating the in situ reduction and confinement of silver *** batch experiments,the optimal silver loading was 20%,and 5 mmol·L^(–1) of p-nitrophenol was completely degraded in 113 s with a rate constant value of 4.057×10^(−2) s^(–1).In the tap water system and simulated seawater system,the degradation time of p-nitrophenol at the same concentration was 261 and 276 s,respectively,with a conversion rate above 99%.In the fixed-bed experiment,the conversion rate remained above 74%after 3 h at a flowing rate of 7 mL·min^(–1).After 8 cycling tests,the conversion rate remained at 98.7%.Moreover,the catalyst exhibited outstanding performance in the degradation experiment of four typical organic dyes.

关键词： double-network hydrogel dye degradation silver nanoparticles alginate