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Lead-free perovskites-based photonic synaptic devices with zero electric energy consumption

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Science China(Information Sciences) 2024年第6期67卷 433-441页

作者： Dandan hao Di YANG Haixia LIANG Jia HUANG Fukai shan College of Electronics and Information Qingdao University Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of Sciences School of Materials Science and Engineering Tongji University National Key Laboratory of Autonomous Intelligent Unmanned Systems Tongji University

The von Neumann bottleneck is a critical limitation in synaptic devices. Therefore, artificial synaptic devices resembling biological neuromorphic synapses have been developed to overcome the von Neumann bottleneck. However, synaptic devices require voltages, which results in considerable energy consumption. Here, photonic synaptic devices with the vertical structure of indium tin oxide（ITO）/SnO2/Al2O3/CsBi3I10/Au are fabricated, which can work in the self-powered mode owing to the photovoltaic effect endowed by a vertical multilayer structure. Several fundamental synaptic functions, such as excitatory postsynaptic current, paired-pulse facilitation, short-term plasticity（STP）, long-term plasticity（LTP）, pulse-frequency-dependent plasticity, transition of STP to LTP, and the learning experience are emulated. Moreover, Morse-coded external light information is decoded by self-powered photonic synaptic devices. The results indicate that self-powered photonic synaptic devices based on lead-free perovskites exhibit great potential for efficient neuromorphic computing and optical wireless communication.

关键词： photonic synaptic devices lead-free perovskites zero energy consumption synaptic plasticity Morse code

Modified Tong Xie Yao Fang relieves solitary rectal ulcer syndrome:A case report

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World Journal of Clinical Cases 2019年第15期7卷 2058-2064页

作者： Li-Li Zhang Wan-shan hao Meng Xu Chang Li Yuan-Yuan Shi School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China Teaching and Research Section of shanghan Beijing University of Chinese MedicineBeijing 100029China Traditional Chinese Medicine Department Beijing Baicaoyuan Hospital of Traditional Chinese MedicineBeijing 100107China

BACKGROUND Solitary rectal ulcer syndrome(SRUS)is a rare rectal disorder characterized by bloody mucus in the stool,difficulty in defecation,pain,and anal *** date,the etiology of this syndrome remains not well understood and the diagnosis is frequently confused with other disorders,making treatment a clinical *** SUMMARY A 50-year-old woman presented to our hospital with a 40-d history of bloody mucus in the stool and anal *** was *** revealed a large,severe ulcerous ***,the lesion was characterized as chronic ulcer without clear tumor cells,and the final diagnosis of SRUS was *** patient was treated with Chinese medicine therapy,with administration of Tong Xie Yao *** 3 wk of treatment,the symptoms improved *** 2-mo follow-up,rectoscopy in a local hospital showed healed ulcer scars without obvious protrusion 3 cm from the anal *** Chinese medicine therapy represents a potential treatment of SRUS with predominant rectal bleeding,mucinous discharge,and anal swelling pain.

关键词： Solitary rectal ulcer syndrome Chinese formulas Tong Xie Yao Fang Er Shen Wan Ding Zhi Xiao Wan Chinese medicine therapy Case report

A living cell-based fluorescent reporter for high-throughput screening of anti-tumor drugs

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Journal of Pharmaceutical Analysis 2021年第6期11卷 808-814页

作者： Ningning Tang Ling Li Fei Xie Ying Lu Zifan Zuo hao shan Quan Zhang Lianwen Zhang College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai UniversityTianjin300350China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China

Suppression of cellular O-linkedβ-N-acetylglucosaminylation(O-Glc NAcylation)can repress proliferation and migration of various cancer cells,which opens a new avenue for cancer *** on the regulation of insulin gene transcription,we designed a cell-based fluorescent reporter capable of sensing cellular O-Glc NAcylation in HEK293 T *** fluorescent reporter mainly consists of a reporter(green fluorescent protein(GFP)),an internal reference(red fluorescent protein),and an operator(neuronal differentiation 1),which serves as a"sweet switch"to control GFP expression in response to cellular OGlc NAcylation *** fluorescent reporter can efficiently sense reduced levels of cellular OGlc NAcylation in several cell *** the fluorescent reporter,we screened 120 natural products and obtained one compound,sesamin,which could markedly inhibit protein O-Glc NAcylation in He La and human colorectal carcinoma-116 cells and repress their migration in ***,the present study demonstrated the development of a novel strategy for anti-tumor drug screening,as well as for conducting gene transcription studies.

关键词： Fluorescent reporter High-throughput screening O-linkedβ-N-acetylglucosaminylation Anti-tumor drug Gene transcriptional regulation

构建以病种管理为核心的临床医师业务能力评价体系

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现代医院管理 2024年第2期22卷 64-66页

作者：刘潇潇赵昂陈善豪曹卫军上海市肺科医院上海市200433

目的构建以病种管理为核心的临床医师业务能力评价体系,并进行初步应用。方法运用文献研究法和焦点组访谈法建立初步指标体系,运用Delphi专家咨询法和层次分析法修正体系,获得权重。结果获得了由4个一级指标、4个二级指标、26个三级指... 详细信息

目的构建以病种管理为核心的临床医师业务能力评价体系,并进行初步应用。方法运用文献研究法和焦点组访谈法建立初步指标体系,运用Delphi专家咨询法和层次分析法修正体系,获得权重。结果获得了由4个一级指标、4个二级指标、26个三级指标在内的临床医师工作业务档案库体系,初步应用后与医院现行临床医师聘任结果一致程度较高。结论以病种管理为核心的临床医师业务能力评价体系对临床医生评价具有一定的创新性。

关键词：病种管理临床医师业务能力评价指标体系

Coexistence of All-Order Topological States in a Three-Dimensional Phononic Topological Crystalline Insulator

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Research 2024年第2期2023卷 511-518页

作者： Hua-shan Lai hao Chen Chu-hao Xia Si-Yuan Yu Cheng He Yan-Feng Chen National Laboratory of Solid State Microstructures&Department of Materials Science and Engineering Nanjing UniversityNanjng 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjng 210093China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University Nanjing 210093China

Classical-wave topological materials lacking intrinsic half-integer spins are less robust while more ***,we explore a single 3-dimensional phononic topological crystalline insulator that simultaneously exhibits a whole family of first-order quadratic surface,second-order hinge,and third-order corner states within the same *** a topological crystalline insulator hosting all-order phases originates from the different topological nature when hierarchically projected onto different facets and lower dimensions,thus free from trivial cladding *** work offers an ideal platform for either robust wave propagation or localization in on-demand dimensions and may facilitate dimension division multiplexing technology.

关键词： topological dimensions crystalline

Interactions of acetylcholinesterase with salvianolic acid B and rosmarinic acid from Salvia miltiorhiza water extract investigated by NMR relaxation rate

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Chinese Chemical Letters 2008年第6期19卷 747-751页

作者： GuoWei Yin Yi Ming Li Wei Wei shan hao Jiang Da Yuan Zhu Wei Hong Du Department of Chemistry Renmin University of China 59 Zhong Guan Cun Street Beijing 100872 China School of Pharmacy Shanghai University of Traditional Chinese Medicine 1200 Cailun Road Shanghai 201203 China State Key Laboratory for Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China

In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase （ACHE） inhibition, two main ingredients, salvianolic acid B （1） and rosmarinic acid （2）, which were isolated from S. miltiorhiza water extract, were investigated in vitro by NMR relaxation rate in this work. The results showed that the proton selective relaxation rates and the molecular rotational correlation time of proton pairs for compounds 1 and 2 increased significantly by adding of AChE in mixing solution. The study reveals that the two compounds might bind to the enzyme and have ACHE inhibitory effect, which could contribute to the ameliorating effect at some extent on old ages memory disorder.

关键词： AChE inhibitors Salvianolic acid B Rosmarinic acid NMR relaxation rate

Experimental investigation of engineered geopolymer composite for structural strengthening against blast loads

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Defence Technology（防务技术） 2024年第2期32卷 496-509页

作者： shan Liu Chunyuan Liu Yifei hao Yi Zhang Li Chen Zhan Li Key Laboratory of Coast Civil Structure Safety of Ministry of Education Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Prefabricated Buildings and Intelligent Construction Hebei University of TechnologyTianjin 300400China Institute of Defense Engineering AMSPLABeijing 100850China Engineering Research Center of Safety and Protection of Explosion&Impact of Ministry of Education Southeast UniversityNanjing 211189JiangsuChina State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of the PLANanjing 210007JiangsuChina

The recent increase in blast/bombing incidents all over the world has pushed the development of effective strengthening approaches to enhance the blast resistance of existing civil *** geopolymer composite(EGC)is a promising material featured by eco-friendly,fast-setting and strain-hardening characteristics for emergent strengthening and ***,the fiber optimization for preparing EGC and its protective effect on structural elements under blast scenarios are *** this study,laboratory tests were firstly conducted to evaluate the effects of fiber types on the properties of EGC in terms of workability,dry shrinkage,and mechanical properties in compression,tension and *** experimental results showed that EGC containing PE fiber exhibited suitable workability,acceptable dry shrinkage and superior mechanical properties compared with other types of *** that,a series of field tests were carried out to evaluate the effectiveness of EGC retrofitting layer on the enhancement of blast performance of typical *** tests include autoclaved aerated concrete(AAC)masonry walls subjected to vented gas explosion,reinforced AAC panels subjected to TNT explosion and plain concrete slabs subjected to contact *** was found that EGC could effectively enhance the blast resistance of structural elements in different *** AAC masonry walls and panels,with the existence of EGC,the integrity of specimens could be maintained,and their deflections and damage were significantly *** plain concrete slabs,the EGC overlay could reduce the diameter and depth of the crater and spallation of specimens.

关键词： Engineered geopolymer composites Fiber optimization Strengthening material Blast resistance Masonry wall Reinforced AAC panel Plain concrete slab

Reversal of complete atrioventricular block in dialysis patients following parathyroidectomy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1313-1319页

作者： shan-shan Xu Li-Hai hao Yan-Meng Guan Hemodialysis Center Weifang People’s HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic *** calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular *** case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular *** SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus *** developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular ***,she underwent parathyroidectomy(PTX)with ***,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was *** This case revealed that metastatic cardiac calcification can result in complete atrioventricular *** parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular *** is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.

关键词： Secondary hyperparathyroidism Ectopic calcification Atrioventricular block Reversal Case report

Synthesis and acetone gas sensing properties of α-Fe_2O_3 nanotubes

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Science China Chemistry 2013年第12期56卷 1722-1726页

作者： shan hao LIU ChangBai LIU Li WANG LianYuan LI ShouChun ZHANG XiaoBo BO XiaoQing CHI Xiao State Key Laboratory of Superhard Materials College of Physics Jilin University College of Electronic Science & Engineering Jilin University

α-Fe2O3 nanotubes was successfully prepared by single nozzle electrospinning method. Scanning electron microscope （SEM） was used to characterize the morphology of α-Fe2O3 nanotubes. The gas sensing properties of α-Fe2O3 nanotubes were investigated in detail. The results exhibit relatively good sensing properties to acetone at 240℃. The response and recovery times are about 3 and 5 s, respectively. The structure of nanotubes is beneficial to the gas sensing properties, which will enlarge the surface-to-volume ratio of α-Fe2O3 and then be available for the transfer of gas, and thus improved the sensor performance consequentially.

关键词： nanotubes gas sensor electrospinning