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Periodic Variations of the Jet Flow Lorentz Factor in 3C 273

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Chinese Journal of Astronomy and Astrophysics 2001年第3期1卷 236-244页

作者： shan－jieqian Xi－ZhenZhang 等 Max－Planck－InstitutfuerRadioastronomie AufdemHuegel69D－53121BonnGermany BeijingAstronomicalObservat

C 273 has been observed with VLBI for more than 30 years. The entire data have shown that the position angle of the superluminal knots ejected from the core varies periodically with a period of ~15 years. Moreover, their apparent velocity observed during the period 1963 -- 1997 has systematically decreased by a factor of 2. These remarkable properties are explained in terms of a precessing jet model, in which the ejection Lorentz factor of the superluminal knots has been decreasing during the last thirty years and has superposed on it a short-term (~5 year) oscillation. The periodic variations derived by the model-fitting are compared with the variations in the optical flux density. Binary black hole models are briefly discussed to show possible relations of the observed periods to the periods involved in a binary system (orbital motion, spin of black hole, accretion-disk rotation and Newtonian-driven precession etc.).

关键词： Galaxies: jets - quasars: individual: 3C273 - Galaxies: nuclei - Radio Continuum: galaxies - Radiation mechanisms: nonthermal

Multifrequency Polarization Variations in the Quasar 0917+624

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Chinese Journal of Astronomy and Astrophysics 2002年第4期2卷 325-346页

作者： shan－jieqian A.Kraus 等 NationalAstronomicalObservatories ChineseAcademyofSciencesBeijing100012 Max－Planck－InstitutfuerRadioastronomie AufdemHuegel6953121BonnGermany

We present a detailed analysis of multi-frequency observations of linear polarization in the intraday variable quasar 0917+624 (z = 1.44). The observations were made in May 1989 at five frequencies (1.4, 2.7, 5.0, 8.3 and 15GHz) with the VLA and the Effelsberg 100 m-telescope and in December 1988 at two frequencies (2.7 and 5.0 GHz) with the latter. It is shown that the relationship between the variations of the polarized and total flux density is highly wavelength dependent, and the multi-frequency polarization behavior may be essential for investigating the mechanisms causing these variations. It is shown that the variations observed at 20 cm can be interpreted in terms of refractive interstellar scintillation. However, after subtracting the variation due to scintillation, three 'features' emerged in the light-curve of the polarized flux density, indicating an additional variable component. Interestingly, these features are shown to be correlated with the variations at 2-6 cm, thus indicating that these features and the associated variations are due to some intrinsic causes. Moreover, a very rapid polarization angle swing of - 180° observed in December 1988 which cannot be explained by refractive interstellar scintillation, may also be produced by an intrinsic mechanism. Accordingly, we use a shock model to explain the polarization variations observed at the higher frequencies, although scintillation could also exist. The shock model can explain not only the variation of intensity, but also the time variation of its degree and angle of polarization, including the rapid swing of the polarization angle. It is shown that the degree and angle of polarization of the shock need only vary slightly in order to account for the observed complicated behaviour of polarization.

关键词： radio continuum: galaxies - polarization - quasars: individual (QSO0917+624)

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： shan Luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Establishing a new testing protocol of the electrochemical stability window for electric double-layer capacitors

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Science China Chemistry 2025年第1期68卷 217-225页

作者： Ruilin Hou Xiaoxi Zhao Tingting Liang Qingyun Dou shan Xu Xingbin Yan School of Materials Science and Engineering Sun Yat-sen University Laboratory of Clean Energy Chemistry and Materials Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Engineering and Applied Sciences Nanjing University Center of Industrial Analysis and Testing Guangdong Academy of Science

The electrochemical stability window(ESW) is crucial for determining the energy density of electric double-layer capacitors(EDLCs). However, current ESW testing protocols of EDLCs are strongly affected by artificial factors, thereby leading to unreliable result. To solve this problem, we first identify the key shortcomings of the traditional protocols by analyzing their test principles. Subsequently, taking an aqueous carbon-based EDLC as an example, we design a side reaction descriptor to represent the response difference in the charging capacitance to side reactions between the cyclic voltammetry and galvanostatic chargedischarge methods. With the aid of this descriptor, we propose a new ESW testing protocol, which is not only able to completely avoid the adverse influence of subjective factors but also fully consider the operating condition limitations. The protocol can be extended from the single electrode to the full device. This work proposes a more rigorous definition of ESW and provides a reliable protocol for evaluating the ESW of EDLCs.

关键词： electric double-layer capacitors electrochemical stability window testing protocol side reaction descriptor operating limitation

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期68卷 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming Guo shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping Yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu shan Ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai shan Guoliang Li Xuechun Chen Wen Zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

BL Lacertae: Hard Optical Spectrum and GeV γ-ray Emission

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Chinese Journal of Astronomy and Astrophysics 2004年第3期4卷 231-246页

作者： shan-jieqian Xi-ZhenZhang T.P.Krichbaum NationalAstronomicalObservatories ChineseAcademyofSciencesBeijing100012 Max-Planck-InstitutfürRadioastronomie AufdemHügel6953121BonnGermany

The spectral energy distribution (SED) of the γ-ray flare observed inJuly 1997 in BL Lacertae is re-considered. It is pointed out that the optical observa-tions made by Webb et al. showed the associated optical flare has a hard spectrum(the average spectral index αopt～ 0.48, F_v∝v^(-α)), and the ASCA observationsmade by Tanihata et al. showed very steep spectra in the soft X-ray band (0.7-1.5 keV) (α_x～3-4). We find that the flux densities and spectral indices in both theoptical and soft X-ray bands are closely consistent with a ‘canonical' synchrotronspectrum emitted by relativistic electrons of a power-law energy distribution witha high energy cutoff, and thus the peak of the SED of the synchrotron radiation (inrepresentation of vF_v) is located in the EUV -- soft X-ray bands. Therefore, theGeV γ-ray emission observed in the July 1997 outburst may be mainly due to thesynchrotron self-Compton (SSC) process, contrasting with the current explanationsin terms of external radiation Compton (ERC) process, in which the seed photonsare mostly taken to be the UV emission from the clouds of the broad emission lineregion. We argue that the hard optical spectra observed during the γ-ray outburstmay be an important signature for the acceleration of high energy electrons (γ_e～10~4)in the γ-ray emitting region.

关键词： galaxies:compact gamma rays:observations quasars:individual:BL Lacertae