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Mechanism of Anti-tumor Effects of Viola Medicinal Materials Based on Network Pharmacology and Molecular Docking

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Medicinal Plant 2024年第3期15卷 9-15页

作者： Xiaoyong HE Liniu shaMA Dongmei sha Shuaicong NI jing WEN Xinjia YAN Yuan LIU College of Pharmacy Southwest Minzu UniversityChengdu 610041China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225China School of Pharmacy Sichuan College of Traditional Chinese MedicineMianyang 621000China

[Objectives]To explore the relationship between anti-tumor components,targets,and pathways involved in Viola medicinal materials,study its main active components,and evaluate its inhibitory activity.[Methods]Through network pharmacological analysis,molecular docking simulation experiments and in vitro experiments,the main components and corresponding targets of Viola were screened out,and their anti-tumor signaling pathways were *** colorimetric assay was used to investigate the inhibitory effect of different extraction layers of Viola on the growth of tumor cells.[Results]18 anti-tumor active components such as 2α,19α-Dihydroxyursolic acid,Corlumine,Madolin U,Trifolirhizin and etc.,and 52 action targets such as PTGS2,PTGS1,P2RX7,MMP1,and GABRB3,and anti-tumor signaling pathways were *** results of molecular docking showed that all the selected Viola compounds had good binding *** results of MTT colorimetric assay showed that the petroleum ether layer and n-butanol layer had a good inhibitory effect on the growth of tumor cell lines.[Conclusions]Viola medicinal materials have the potential of anti-tumor,triterpenoids and flavonoids may be the main active components,and the petroleum ether layer and n-butanol layer have better inhibitory effect on the growth of tumor cells.

关键词： Viola medicinal materials Anti-tumor Network pharmacology Molecular docking MTT

Explosion of research on psychopathology and social media use after COVID-19:A scientometric study

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World Journal of Psychiatry 2024年第5期14卷 742-759页

作者： Meng-Di Zhang Rong-quan He Jia-Yuan Luo Wan-Ying Huang jing-Yu Wei Jian Dai Hong Huang Zhen Yang Jin-Liang Kong Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Psychology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Division of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Despite advances in research on psychopathology and social media use,no comprehensive review has examined published papers on this type of research and considered how it was affected by the coronavirus disease 2019(COVID-19)*** To explore the status of research on psychopathology and social media use before and after the COVID-19 *** We used Bibliometrix(an R software package)to conduct a scientometric analysis of 4588 relevant studies drawn from the Web of Science Core Collection,PubMed,and Scopus *** Such research output was scarce before COVID-19,but exploded after the pandemic with the publication of a number of high-impact *** authors and institutions,located primarily in developed countries,maintained their core positions,largely uninfluenced by COVID-19;however,research production and collaboration in developing countries increased significantly after *** the analysis of keywords,we identified commonly used methods in this field,together with specific populations,psychopathological conditions,and clinical *** have devoted increasing attention to gender differences in psychopathological states and linked COVID-19 strongly to depression,with depression detection becoming a new *** in research on psychopathology and social media use are unbalanced and uncoordinated across countries/regions,and more indepth clinical studies should be conducted in the *** After COVID-19,there was an increased level of concern about mental health issues and a changing emphasis on social media use and the impact of public health emergencies.

关键词： Psychopathology Social media Bibliometrics Web of Science PubMed Scopus

Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-Xizang Plateau,China,2000–2022

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China CDC weekly 2024年第4期6卷 69-74,I0006页

作者： Qun Duan Xiaojin Zheng Zhiqiang Gan Dongyue Lyu Hanyu sha Xinmin Lu Xiaoling Zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao Xi Di Wu Peng Zhang Deming Tang Zhaokai He Huaiqi jing Biao Kan Xin Wang National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Akesai Kazak Autonomous County Center for Disease Control and Prevention Jiuquan CityGansu ProvinceChina Jiuquan Center for Disease Control and Prevention Jiuquan CityGansu ProvinceChina Gansu Provincial Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina

Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic *** change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in ***:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang *** data spanned from 2000 to *** describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s ***:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(***)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),***,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in *** regards to climate,there was little variation,and a decreasing trend in blowing-sand days was *** temperature in the previous year showed a negative correlation with the *** isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current *** average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of *** from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of ***,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics.

关键词： Plague epidemiology Plateau

Insights into varicella-zoster virus assembly from the B-and C-capsid at near-atomic resolution structures

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hLife 2024年第2期2卷 64-74页

作者： Lei Cao Nan Wang Zhe Lv Wenyuan Chen Zhonghao Chen Lifei Song Xueyan sha Guiqiang Wang Yaling Hu Xiaojun Lian Guoliang Cui Jinyan Fan Yaru quan Hongrong Liu Hai Hou Xiangxi Wang CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijingChina Key Laboratory for Matter Microstructure and Function of Hunan Province Key Laboratory of Low-dimensional Quantum Structures and Quantum ControlSchool of Physics and ElectronicsHunan Normal UniversityHunanChina Institute of Medical Research Northwestern Polytechnical UniversityShanxiChina Sinovac(Dalian)Vaccine Technology Co. Ltd.LiaoningChina Sinovac Biotech Ltd. BeijingChina National Institutes for Food and Drug Control BeijingChina

Varicella-zoster is a highly communicable virus that can be transmitted through the airborne *** one quarter of people are infected with this *** studies have described the structure of A-capsid and a blurred reconstruction of the C-capsid with icosahedral *** this study,we have determined the more precise detailed structures of the varicella-zoster virus(VZV)B-and C-capsid in icosahedral symmetry using a combination of block-based reconstruction and symmetry relaxation *** addition,we are reporting structural details of the portal vertex reconstructions in five-fold symmetry and portal reconstructions in twelve-fold *** structures unveil the basis for the high thermal stability of the VZV *** conformational flexibility of structural elements of the capsid plays a role in the assembly of the capsid and drives processes critical for the viral life *** results of the study open up new avenues for the development of drugs against a highly prevalent and contagious pathogen.

关键词： varicella-zoster virus capsid structure virus assembly

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考虑质量传导的项目调度与人员配置集成优化

系统管理学报 2024年第2期33卷 356-367页

作者：陶莎刘洋周晶南京大学工程管理学院南京210093

研究表明,质量问题是项目返工的主要原因之一,而人员技能水平是影响项目活动完成质量的关键因素。基于一般性的多技能资源受限项目调度问题,综合考虑人员技能水平以及活动间质量传导作用对活动完成质量的影响,进一步数学表达级联作用下... 详细信息

研究表明,质量问题是项目返工的主要原因之一,而人员技能水平是影响项目活动完成质量的关键因素。基于一般性的多技能资源受限项目调度问题,综合考虑人员技能水平以及活动间质量传导作用对活动完成质量的影响,进一步数学表达级联作用下的返工子网以及重构的项目网络,并结合一个大型船舶制造项目案例进行实验分析。对比实验结果表明:所提出的模型可有效平衡有限人力资源在不同活动间的分配,有利于减少返工风险的级联,缩短项目总工期。进一步,通过质量评估区间和人员技能水平参数波动的随机实验,验证模型对两类参数波动具有一定的鲁棒性。

关键词：项目调度多技能质量传导返工子网级联效应

Entanglement dynamics in κ-deformed spacetime

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 33-54页

作者： Xiaobao Liu Zehua Tian Jiliang jing Department of Physics and Electrical Engineering Liupanshui Normal UniversityLiupanshui 553004China School of Physics Hangzhou Normal UniversityHangzhou 311121China CAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationSynergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China

We treat two identical and mutually independent two-level atoms that are coupled to a quantum field as an open quantum *** master equation that governs their evolution is derived by tracing over the degree of freedom of the *** this,we compare the entanglement dynamics of the two atoms moving with different trajectories inκ-deformed and Minkowski ***,when the environment-induced interatomic interaction does not exist,the entanglement dynamics of two static atoms inκ-deformed spacetime are reduced to that in Minkowski spacetime in the case that the spacetime deformation parameterκis sufficiently large as theoretically ***,if the atoms undergo relativistic motion,regardless of whether inertial or non-inertial,their entanglement dynamics inκ-deformed spacetime behave differently from that in Minkowski spacetime even whenκis *** investigate various types of entanglement behavior,such as decay and generation,and discuss how different relativistic motions,such as uniform motion in a straight line and circular motion,amplify the differences in the entanglement dynamics between theκ-deformed and Minkowski spacetime *** addition,when the environment-induced interatomic interaction is considered,we find that it may also enhance the differences in the entanglement dynamics between these two ***,in principle,one can tell whether she/he is inκ-deformed or Minkowski spacetime by checking the entanglement behavior between two atoms in certain circumstances.

关键词： quantum entanglement -deformed spacetime relativistic motion environment-induced interatomic interaction quan-tum field theory in curved spacetime

木质素改性方法及其制备碳纤维的应用研究进展

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复合材料学报 2024年第4期41卷 1764-1775页

作者：沈聪浩章沈翀李靖郭大亮李静沙力争浙江科技大学环境与资源学院杭州310023

木质素作为自然界最丰富的芳香族化合物,其含碳量达30%~40%,是制备碳纤维的优质原料。然而由于存在非晶态化学结构、低分子量、宽分子量分布和排列不良等特性,其复杂的非均质结构和固有的易絮凝特质需通过改性以克服。本文介绍了木质素... 详细信息

木质素作为自然界最丰富的芳香族化合物,其含碳量达30%~40%,是制备碳纤维的优质原料。然而由于存在非晶态化学结构、低分子量、宽分子量分布和排列不良等特性,其复杂的非均质结构和固有的易絮凝特质需通过改性以克服。本文介绍了木质素的基本结构单元与特征,并在此基础上详细描述了物理混合、化学改性、生物作用等改性过程工艺条件及其对木质素结构及木质素基碳纤维的强度、电化学、过滤、透气等性能影响,并在此基础上对碳纤维在交通建筑、航空航天、生命健康及新能源等领域应用进行了拓展探讨。此外,拓展概述了木质素的定向官能团改性、绿色改性方法及改性过程表达等可行性,为木质素基碳纤维复合材料的进一步研究和开发提供思考,并推动其实现工业化应用。

关键词：木质素物化改性碳纤维力学性能电化学性能

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基于局部高斯分布模型的图像配准方法

工程数学学报 2024年第3期41卷 421-431页

作者：张婧全婷婷天津城建大学理学院天津300384

提出了一种基于统计和变分相结合的非刚体图像配准新模型。假设残差图像服从具有不同均值和方差的局部高斯分布,由此得到一个双重能量泛函,再结合变分的正则化方法,得到了一种配准新模型。该方法的新颖之处在于,保真项中引入了权重函数... 详细信息

提出了一种基于统计和变分相结合的非刚体图像配准新模型。假设残差图像服从具有不同均值和方差的局部高斯分布,由此得到一个双重能量泛函,再结合变分的正则化方法,得到了一种配准新模型。该方法的新颖之处在于,保真项中引入了权重函数和一些控制参数。其中权重函数可以自动有效地区分残差图像中灰度对比度不同的区域,控制参数的引入提高了算法的鲁棒性。合成图像、二维肺部CT及三维大脑MRI图像的配准结果证明了这一方法的有效性和准确性。

关键词：非刚体图像配准局部高斯分布加性算子分裂交替极小化算法

基于肿瘤靶向的水飞蓟宾-氨基酸席夫碱的合成及性质研究

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分子科学学报 2015年第2期31卷 134-139页

作者：赵佳楠张宇李响沙靖全张羽男王朝兴黑龙江省高校生物药制剂重点实验室佳木斯大学药学院黑龙江佳木斯154007

以水飞蓟宾和氨基酸为原料,通过常规方法合成了一系列具有靶向性的水飞蓟宾-氨基酸席夫碱,并对其抗肿瘤作用进行研究.采用核磁共振碳谱、质谱和红外光谱对已合成的水飞蓟宾-氨基酸席夫碱(氨基酸=甘氨酸(1)、丙氨酸(2)、赖氨酸(3)、苯丙... 详细信息

以水飞蓟宾和氨基酸为原料,通过常规方法合成了一系列具有靶向性的水飞蓟宾-氨基酸席夫碱,并对其抗肿瘤作用进行研究.采用核磁共振碳谱、质谱和红外光谱对已合成的水飞蓟宾-氨基酸席夫碱(氨基酸=甘氨酸(1)、丙氨酸(2)、赖氨酸(3)、苯丙氨酸(4)、谷氨酸(5)、半胱氨酸(6))进行结构表征.采用MTT法对化合物1-6及水飞蓟宾进行抗肝癌细胞SMMC-7721的活性研究,抑制率分别为70.2%,53.7%,47.8%,55.6%,49.2%,51.8%,33.3%.体外抗肿瘤活性实验表明,水飞蓟宾-氨基酸席夫碱系列化合物对人肝癌细胞株SMMC-7721均有抑制作用,且明显高于水飞蓟宾母核.实现了以氨基酸为载体,将具有抗肿瘤活性的天然药物靶向运输至癌细胞内,极具肝靶向药物开发潜力.

关键词：水飞蓟宾氨基酸席夫碱抗肿瘤靶向