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Microbiota-based treatments in alcoholic liver disease

World Journal of Gastroenterology 2016年第29期22卷 6673-6682页

作者： Hotaik Sung seung woo kim Meegun Hong Ki Tae Suk Department of Molecular and Cell Physiology University of Cincinnati College of Medicine Department of Biomedical Science Hallym University College of Medicine Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Hallym University College of Medicine

Gut microbiota plays a key role in the pathogenesis of alcoholic liver disease(ALD). Consumption of alcohol leads to increased gut permeability, small intestinal bacterial overgrowth, and enteric dysbiosis. These factors contribute to the increased translocation of microbial products to the liver via the portal tract. Subsequently, bacterial endotoxins such as lipopolysaccharide, in association with the Toll-like receptor 4 signaling pathway, induce a gamut of damaging immune responses in the hepatic milieu. Because of the close association between deleterious inflammation and ALD-induced microbiota imbalance, therapeutic approaches that seek to reestablish gut homeostasis should be considered in the treatment of alcoholic patients. To this end, a number of preliminary studies on probiotics have confirmed their effectiveness in suppressing proinflammatory cytokines and improving liver function in the context of ALD. In addition, there have been few studies linking the administration of prebiotics and antibiotics with reduction of alcoholinduced liver damage. Because these preliminary results are promising, large-scale randomized studies are warranted to elucidate the impact of these microbiotabased treatments on the gut flora and associated immune responses, in addition to exploring questions about optimal delivery. Finally, fecal microbiota transplant has been shown to be an effective method of modulating gut microbiota and deserve further investigation as a potential therapeutic option for ALD.

关键词： Alcoholic liver disease Gut Microbiota Probiotics Treatment

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Frequency comb-to-comb stabilization over a 1.3-km free-space atmospheric optical link

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Light(Science & Applications) 2022年第9期11卷 2207-2216页

作者： JAEWON YANG DONG IL LEE DONG-CHEL SHIN JAEHYUN LEE BYUNG SOO kim HYUN JAY KANG YOUNG-JIN kim seung-woo kim Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Presently with Korea Research Institute of Standards and Science(KRISS) 267 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

Stabilizing a frequency comb to an ultra-stable optical frequency reference requires a multitude of optoelectronic peripherals that have to operate under strict ambient ***,the frequency comb-to-comb stabilization aims to synchronize a slave comb to a well-established master comb with a substantial saving in required equipment and ***,we report an utmost case of frequency comb-to-comb stabilization made through a 1.3 km free-space optical(FSO)link by coherent transfer of two separate comb lines along with a feedback suppression control of atmospheric phase *** FSO link offers a transfer stability of 1.7×10-15 at 0.1 s averaging,while transporting the master comb,s stability of 1.2×10-15 at 1.0 s over the entire spectrum of the slave *** remote comb-to-comb stabilization is intended to expedite diverse long-distance ground-to-ground or ground-to-satellite applications;as demonstrated here for broadband molecular spectroscopy over a 6THz bandwidth as well as ultra-stable microwaves generation with phase noise of-80dBc Hz-1 at 1 Hz.

关键词： optical stabilization microwave

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Ultra-thin light-weight laser-induced-graphene (LIG) diffractive optics

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Light(Science & Applications) 2023年第7期12卷 1268-1300页

作者： Younggeun Lee Mun Ji Low Dongwook Yang Han Ku Nam Truong-Son Dinh Le seung Eon Lee Hyogeun Han seunghwan kim Quang Huy Vu Hongki Yoo Hyosang Yoon Joohyung Lee Suchand Sandeep Keunwoo Lee seung-woo kim Young-Jin kim Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daehak-roYuseong-guDaejeon 34141Republic of Korea School of Mechanical and Aerospace Engineering Nanyang Technological University(NTU)50 Nanyang Avenue639798 SingaporeSingapore Panasonic Factory Solutions Asia Pacific(PFSAP) 285 Jalan Ahmad Ibrahim639931 SingaporeSingapore Department of Aerospace Engineering Korea Advanced Institute of Science and Technology(KAlST)Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Mechanical System Design Engineering Seoul National University of Science and Technology(Seuoltech)232 Gongneung-roNowon-guSeoul 01811Republic of Korea LASER N GRAPN INC 193 Munj-roYuseong-guDaejeon 34051Republicof Korea

The realization of hybrid optics could be one of the best ways to fulfll the technological requirements of compact,light-weight,and multi-functional optical systems for modern *** diffractive lens(PDL)such as diffractive lenses,photonsieves,and metasurfaces can be patterned on ultra-thin flexible and stretchable substrates and be conformally attached on top of arbitrarily shaped *** this review,we introduce recent research works addressed to the design and manufacturing of ultra-thin graphene optics,which will open new markets in compact and light-weight optics for next-generation endoscopic brain imaging,space internet,real-time surface proflometry,and multi-functional mobile *** provide higher design flexibility,lower process complexity,and chemical-free process with reasonable investment cost,direct laser writing(DLW)of laser-induced-graphene(LIG)is actively being applied to the patterning of *** realizing the best optical performances in DLW,photon-material interactions have been studied in detail with respect to different laser parameters;the resulting optical characteristics have been evaluated in terms of amplitude and phase.A series of exemplary laser-written 1D and 2D PDL structures have been actively demonstrated with different base materials,and then,the cases are being expanded to plasmonic and holographic *** combination of these ultra-thin and light-weight PDL with conventional bulk refractive or reflective optical elements could bring together the advantages of each optical *** integrating these suggestions,we suggest a way to realize the hybrid PDL to be used in the future micro-electronics surface inspection,biomedical,outer space,and extended reality(XR)industries.

关键词： optics weight holographic

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Nonparaxial Fresnel diffraction from oblique end facets of optical fibers

Nonparaxial Fresnel diffraction from oblique end facets of o...

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Photonics Asia 2004;Optics and Lasers

作者： Hagyong Kihm seung-woo kim Dept.of Mechanical Engineering Korea Advanced Institute of Science and Technology Dept.of Mechanical Engineering Korea Advanced Institute of Science and Technology

When optical fibers are connected with other optical or opto-mechanical components, free space propagation phenomena of the light emitted from cleaved end facets of fiber need to be precisely known to

关键词： Single-mode fiber, point diffraction, wave front sphericity, Fizeau interferometer

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Measurement of sub-fm/Hz^(1/2) displacement spectral densities in ultrahigh-Q single-crystal microcavities with hertz-level lasers

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Photonics Research 2022年第5期10卷 1202-1209页

作者： YOON-SOO JANG JINKANG LIM WENTING WANG seung-woo kim ANATOLIY SAVCHENKOV ANDREY BMATSKO CHEE WEI WONG Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCalifornia 90095USA Division of Physical Metrology Korea Research Institute of Standards and Science(KRISS)Daejeon 34113Republic of Korea CACI-LGS Labs Florham ParkNew Jersey 07932USA Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea OEwaves Inc. PasadenaCalifornia 91107USA Jet Propulsion Laboratory California Institute of TechnologyPasadenaCalifornia 91109USA

Tracing a resonance frequency of a high quality factor(Q)optical cavity facilitates subpicometer displacement measurements of the optical cavity via Pound-Drever-Hall(PDH)locking scheme,tightly synchronizing a laser frequency to the optical *** we present observations of subfemtometer displacements on a ultrahigh-Q single-crystal MgF_(2)whispering-gallery-mode microcavity by frequency synchronization between a 1 Hz cavity-stabilized laser and a resonance of the MgF_(2) cavity using PDH laser-cavity *** characterize not only the displacement spectral density of the microcavity with a sensitivity of 1.5×10^(-16) m/Hz^(1/2) over the Fourier offset frequency ranging from 15 mHz to 100 kHz but also a 1.77 nm displacement fluctuation of the microcavity over 4500 *** measurement capability not only supports the analysis of integrated thermodynamical and technical cavity noise but allows for minute displacement measurements using laser-cavity locking for ultraprecise positioning,metrology,and sensing.

关键词： synchronization displacement cavity

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A Vacuum-Compatible Air Bearing:Design Analysis and Optimization

A Vacuum-Compatible Air Bearing:Design Analysis and Optimiza...

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亚洲精密工程、微纳技术国际会议

作者： Gyungho Khim Chun-Hong Park Husang Lee seung-woo kim Korea Advanced Institute of Science and Technology (KAIST) Daejeon S.Korea Korea Institute of Machinery and Materials (kimM) Daejeon S.Korea Korea Institute of Machinery and Materials (kimM) Daejeon S.Korea Korea Advanced Institute of Science and Technology (KAIST) Daejeon S.Korea

This paper describes a vacuum-compatible air bearing designed with a cascaded exhaust scheme to minimize the leakage of air in a vacuum environment. The design of the air bearing, including the differential exhaust system, required great care because several design parameters, such as the number of exhaust stages, diameter and length of the exhaust tube, pumping speed and ultimate pressure of the vacuum pump, and seal length and gap (or bearing clearance) greatly influenced the leakage of air and thus the degree of vacuum. A leakage analysis was performed to estimate the chamber pressure and an optimization method based on the genetic algorithm was proposed under several constraint conditions. The results showed that the degree of vacuum improved dramatically compared to the initial design, and that the distribution of the spatial design parameters and technical limit of the pumping speed was well achieved.

关键词： Vacuum-compatible air bearing Leakage analysis Degree of vacuum Optimal design Genetic algorithm

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin Xu Jong seung kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Volume Estimation of Small Scale Debris Flows Based on Observations of Topographic Changes Using Airborne LiDAR DEMs

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Journal of Mountain Science 2014年第3期11卷 578-591页

作者： Hosung kim seung woo LEE Chan-Young YUNE Gihong kim Department of Civil Engineering Gangneung-Wonju National University

This paper describes a geographic information system(GIS)-based method for observing changes in topography caused by the initiation, transport, and deposition of debris flows using highresolution light detection and ranging(LiDAR) digital elevation models(DEMs) obtained before and after the debris flow events. The paper also describes a method for estimating the volume of debris flows using the differences between the LiDAR DEMs. The relative and absolute positioning accuracies of the LiDAR DEMs were evaluated using a real-time precise global navigation satellite system(GNSS) positioning method. In addition, longitudinal and cross-sectional profiles of the study area were constructed to determine the topographic changes caused by the debris flows. The volume of the debris flows was estimated based on the difference between the LiDAR DEMs. The accuracies of the relative and absolute positioning of the two LiDAR DEMs were determined to be ±10 cm and ±11 cm RMSE, respectively, which demonstrates the efficiency of the method for determining topographic changes at an scale equivalent to that of field investigations. Based on the topographic changes, the volume of the debris flows in the study area was estimated to be 3747 m3, which is comparable with the volume estimated based on the data from field investigations.

关键词： Debris flow Topographic change LiDAR DEM Volume estimation Global navigation satellitesystem (GNSS)

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Estimation of marine winds in and around typhoons using multi-platform satellite observations: Application to Typhoon Soulik (2018)

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Frontiers of Earth Science 2022年第1期16卷 175-189页

作者： seung-woo LEE Sung Hyun NAM Duk-Jin kim School of Earth and Environmental Sciences College of Natural SciencesSeoul National UniversitySeoul 08826Republic of Korea Research Institution of Oceanography College of Natural SciencesSeoul National UniversitySeoul 08826Republic of Korea

Estimating horizontal winds in and around typhoons is important for improved monitoring and prediction of typhoons and mitigating their ***,we present a new algorithm for estimating typhoon winds using multiple satellite observations and its application to Typhoon Soulik(2018).Four kinds of satellite remote sensing data,along with their relationship to typhoon intensity,derived statistically from hundreds of historical typhoon cases,were merged into the final product of typhoon wind(MT wind):(1)geostationarysatellite-based infrared images(IR wind),(2)passive microwave sounder(MW wind),(3)feature-tracked atmospheric motion vectors,and (4)scatterometer-based sea surface winds(SSWs).The algorithm was applied to two cases(A and B)of Typhoon Soulik and validated against SSWs independently retrieved from active microwave synthetic aperture radar(SAR)and microwave radiometer(AMSR2)images,and vertical profiles of wind speed derived from reanalyzed data and dropsonde *** Case A(open ocean),the algorithm estimated the realistic maximum wind,radius of maximum wind,and radius of 15 m/s,which could not be estimated using the reanalysis data,demonstrating reasonable and practical ***,for Case B(when the typhoon rapidly weakened just before making landfall in the Korean Peninsula),the algorithm significantly overestimated the parameters,primarily due to the overestimation of typhoon *** study highlights that realistic typhoon winds can be monitored continuously in real-time using multiple satellite observations,particularly when typhoon intensity is reasonably well predicted,providing timely analysis results and products of operational importance.

关键词： sea surface wind multi-platform satellites Typhoon Soulik(2018)

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A Study of BERT-Based Classification Performance of Text-Based Health Counseling Data

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Computer Modeling in Engineering & Sciences 2023年第4期135卷 795-808页

作者： Yeol woo Sung Dae seung Park Cheong Ghil kim Namseoul University CheonanChungcheongnam-doKorea

The entry into a hyper-connected society increases the generalization of communication using ***,research to analyze big data accumulated in SNS and extractmeaningful information is being conducted in various *** particular,with the recent development of Deep Learning,the performance is rapidly improving by applying it to the field of Natural Language Processing,which is a language understanding technology to obtain accurate contextual *** this paper,when a chatbot system is applied to the healthcare domain for counseling about diseases,the performance of NLP integrated withmachine learning for the accurate classification ofmedical subjects from text-based health counseling data becomes *** the various algorithms,the performance of Bidirectional Encoder Representations from Transformers was compared with other algorithms of CNN,RNN,LSTM,and *** this purpose,the health counseling data of Naver Q&A service were crawled as a *** was used to classify medical subjects according to symptoms and the accuracy of classification results was *** simulation results show that KoBERTmodel performed high performance by more than 5%and close to 18%as large as the smallest.

关键词： BERT NLP deep learning healthcare machine learning

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