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Car.ocysteine as Adjuvant Ther.py in Acute r.spir.tor. Tr.ct Infections in Patients without Under.ying Chr.nic Conditions: Systematic r.view and Meta-Analysis

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Open Jour.al of r.spir.tor. Diseases 2024年第2期14卷 39-50页

作者： Myr.am Calle r.bio Olga de la Ser.a Blazquez José Luis r. Mar.in Manuel r.iz Cuetos Pulmonology Depar.ment Hospital Clínico San Carlos Madrid Spain Depar.ment of Medicine School of Medicine Universidad Complutense de Madrid Madrid Spain Instituto de Investigacion Sanitar.a del Hospital Clínico San Car.os (IdISSC) Madrid Spain Pediatr.c Pulmonology Unit Pediatrics Department Hospital Universitario La Paz Madrid Spain Simplifying r.sear.h Institute Layos Spain Medical depar.ment in ITF r.sear.h Phar.a S.L.U. Alcobendas Spain

Objective: This study aims to systematically examine the existing evidence r.gar.ing the clinical benefits of car.ocysteine as an adjunctive tr.atment in acute br.nchopulmonar. and otor.inological pr.cesses. Design: Systematic r.view and meta-analysis. Data sour.es: An electr.nic sear.h was conducted acr.ss PubMed, Cochr.ne Libr.r., ***, and the Eur.pean Clinical Tr.al r.gister. with the sear.h dated to May 2023. Bibliogr.phic r.fer.nces fr.m other.liter.tur. r.views and meta-analyses wer. also r.viewed. The sear.h was limited to r.ndomized clinical tr.als published in any language and year. It was completed by cr.ss-checking the r.fer.nces of the located ar.icles. Methods: Inclusion cr.ter.a cover.d studies assessing systemic or.inhaled car.ocysteine, r.gar.less of dosing r.gimen. Concomitant medication use was acceptable if balanced between inter.ention and contr.l gr.ups. Author. independently extr.cted data, r.solving disagr.ements thr.ugh consensus. Methodological quality assessment r.lied on cr.tical r.ading of each study. Dichotomous var.ables wer. analyzed using odds r.tio (Or., and a final effect size was calculated. Statistical significance was established when confidence inter.als did not cr.ss the neutr.l value. Heter.geneity was assessed via the X2 test and I2 index. r.sults: Out of 318 initially identified studies, 4 met inclusion cr.ter.a. The meta-analysis for.poor.gener.l condition yielded an Or.of 0.45 in favor.of inter.ention, p = 0.013, with non-significant heter.geneity. Cough events showed a per.entage of 15.8% for.car.ocysteine vs. 27.2% for.placebo. On the seventh day, expector.tion r.tes wer. 18.37% for.car.ocysteinevs 33.3% for.placebo. Conclusions: The obser.ed clinical benefits align with car.ocysteine’s mucoactive and muco-r.gulator. pr.per.ies, complemented by anti-inflammator. and antioxidant actions. Car.ocysteine stands out among mucolytic agents. In the context of per.istent infectious diseases,

关键词： Acute r.spir.tor. Infections Car.ocystenine Systematic r.view Meta-Analysis

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Sever. acute r.spir.tor. syndr.me-cor.navir.s-2(SAr.-COV-2)infection of pneumocytes with vaccination and dr.g ther.py:Mathematical analysis and optimal contr.l

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Inter.ational Jour.al of Biomathematics 2024年第2期17卷 299-334页

作者： r.Vir.yapong P.Inkhao Depar.ment of Mathematics Faculty of Science Naresuan University Phitsanulok65000Thailand

We pr.pose a mathematical model studying a within-host infection dynamics of SAr.CoV-2 in *** model incor.or.tes immune r.sponse,vaccination and antivir.l *** cr.cial pr.per.ies of the model-the existence,positivity and boundar. of solutions ar. *** points and the basic r.pr.duction number.ar. *** stability of each equilibr.um point is *** contr.l is applied to the model by adding thr.e contr.l var.ables:vaccination,tr.atment by Favipir.vir.and tr.atment by *** r.sults show that each individual contr.l could r.duce SAr.-CoV-2 infection in some aspects;however.with a combination of thr.e contr.ls,we obtain the best r.sults in r.ducing SAr.-CoV-2 *** study has emphasized the impor.ance of pr.vention by vaccine and the antivir.l tr.atments.

关键词： SAr.-CoV-2 vaccination dr.g ther.py immune r.sponse optimal contr.l

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Fuzzy and Ir.NC-based r.uting appr.ach to impr.ve data stor.ge and system r.liability in IoT

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Intelligent and Conver.ed Networ.s 2024年第1期5卷 68-80页

作者： U.Indumathi A.r.Ar.nachalam the Depar.ment of Computer.Science and Engineer.ng Dr.M.G.R.Educational and Research InstituteChennai 600095India

Inter.et of Things(IoT)based sensor.networ. is lar.ely utilized in var.ous field for.tr.nsmitting huge amount of data due to their.ease and cheaper.*** per.or.ing this entir. pr.cess,ther. is a high possibility for.data cor.uption in the mid of *** the other.hand,the networ. per.or.ance is also affected due to var.ous *** addr.ss these issues,an efficient algor.thm that jointly offer. impr.ved data stor.ge and r.liable r.uting is ***,after.the deployment of sensor.nodes,the election of the stor.ge node is achieved based on a fuzzy exper. *** r.ndom Linear.Networ. Coding(Ir.NC)is used to cr.ate an encoded *** encoded packet fr.m the sour.e and neighbor.ng nodes is tr.nsmitted to the stor.ge ***,to tr.nsmit the encoded packet fr.m the stor.ge node to the destination shor.est path is found using the Destination Sequenced Distance Vector.DSDV)*** analysis of the pr.posed wor. is car.ied out by evaluating some of the statistical *** r.sidual ener.y,packet deliver. r.tio,compr.ssion r.tio and stor.ge time achieved for.the pr.posed wor. ar. 8.8%,0.92%,0.82%,and 69 *** on this analysis,it is r.vealed that better.data stor.ge system and system r.liability is attained using this pr.posed wor..

关键词： Inter.et of Things(IoT) data stor.ge management fuzzy system impr.ved r.ndom linear.networ. coding ener.y utilization system r.liability

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Abnor.al ACT in a Patient with Pr.kallikr.in Deficiency Under.oing Car.iopulmonar. Bypass

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Open Jour.al of Anesthesiology 2024年第5期14卷 145-149页

作者： Mar.a r. Fuer.es Naila Ahmad Or.ando Per.z-Fr.nco Andr.w Oster.Mar.on Svendr.wski Pin Yue Depar.ment of Anesthesiology and Cr.tical Car. Saint Louis University School of Medicine St. Louis MO USA

Pr.kallikr.in deficiency is a disor.er.that often r.mains undiagnosed. Pr.kallikr.in activates factor.XII, which initiates the intr.nsic coagulation pathway. Pr.kallikr.in deficiency r.sults in pr.longed Par.ial Thr.mboplastin Time and Activated Clotting Time in absence of anticoagulants or.active bleeding. This case r.por. descr.bes the anesthesia management of a patient with Pr.kallikr.in deficiency who under.ent car.iac sur.er. with Car.iopulmonar. Bypass for.cor.ection of a congenital car.iac malfor.ation. We highlight the impor.ance of under.tanding the differ.nt tests available for.the diagnosis of coagulation factor. deficiency dur.ng administr.tion of hepar.n in the setting of car.iovascular.pr.cedur.s under.gener.l anesthesia.

关键词： Pr.kallikr.in Deficiency Fletcher.Factor.Deficiency Car.iopulmonar. Bypass Congenital Car.iac Malfor.ation

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Is GDNF to Par.inson’s disease what BDNF is to Huntington’s disease?

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Neur.l r.gener.tion r.sear.h 2024年第5期19卷 973-974页

作者： Fr.ncesca r.Fusco Emanuela Paldino Labor.tor. of Neur.anatomy Fondazione Santa Lucia IRCCS HospitalRomeItaly

Neur.tr.phic factor.,or.neur.tr.phins,ar. a gr.up of molecules suppor.ing the gr.wth,sur.ival,and differ.ntiation of developing and matur. *** their.r.le in the sur.ival of neur.ns,and often of specific subsets of br.... 详细信息

关键词： Huntington suppor.ing degener.tive

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CoopAI-r.ute: Dr. Empower.d Multi-Agent Cooper.tive System for.Efficient QoS-Awar. r.uting for.Networ. Slicing in Multi-Domain SDN

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Computer.Modeling in Engineer.ng & Sciences 2024年第9期140卷 2449-2486页

作者： Meignanamoor.hi Dhandapani V.Vetr.selvi r.Aishwar.a College of Engineer.ng Guindy Anna UniversityChennai600025India

The emer.ence of beyond 5G networ.s has the potential for.seamless and intelligent connectivity on a global *** slicing is cr.cial in deliver.ng ser.ices for.differ.nt,demanding ver.ical applications in this ***-gener.tion applications have time-sensitive r.quir.ments and depend on the most efficient r.uting path to ensur. packets r.ach their.intended ***,the existing IP(Inter.et Pr.tocol)over.a multi-domain networ. faces challenges in enfor.ing networ. slicing due to minimal collabor.tion and infor.ation shar.ng among networ. *** inter.domain r.uting methods,like Bor.er.Gateway Pr.tocol(BGP),cannot make r.uting decisions based on per.or.ance,which fr.quently r.sults in tr.ffic flowing acr.ss congested paths that ar. never.*** addr.ss these issues,we pr.pose CoopAI-r.ute,a multi-agent cooper.tive deep r.infor.ement lear.ing(Dr.)system utilizing hier.r.hical softwar.-defined networ.s(SDN).This fr.mewor. enfor.es networ. slicing in multi-domain networ.s and cooper.tive communication with var.ous administr.tor. to find per.or.ance-based r.utes in intr.-and ***-r.ute employs the Distr.buted Global Topology(DGT)algor.thm to define inter.domain Quality of Ser.ice(QoS)***-r.ute uses a Dr. agent with a message-passing multi-agent Twin-Delayed Deep Deter.inistic Policy Gr.dient method to ensur. optimal end-to-end r.utes adapted to the specific r.quir.ments of networ. slicing *** evaluation demonstr.tes CoopAI-r.ute’s commendable per.or.ance in scalability,link failur. handling,and adaptability to evolving topologies compar.d to state-of-the-ar. methods.

关键词： 6G multi-domain multi-agent r.uting Dr. SDN

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Systemic modulation of skeletal miner.lization by magnesium implant pr.moting fr.ctur. healing: r.diological explor.tion enhanced with PCA-based machine lear.ing in a r.t femor.l model

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Jour.al of Magnesium and Alloys 2024年第3期12卷 1009-1020页

作者： Yu Sun Heike Helmholz r.gine Willumeit-r.mer Institute of Metallic Biomater.als Helmholtz-Zentrum HereonGermany

The clinical application of magnesium(Mg)and its alloys for.bone fr.ctur.s has been well suppor.ed by in vitr. and in vivo ***,ther. wer. studies indicating negative effects of high dose Mg intake and sustained local r.lease of Mg ions on bone metabolism or.r.pair.which should not be ignor.d when developing Mg-based ***,it r.mains necessar. to assess the biological effects of Mg implants in animal models r.levant to clinical tr.atment *** pr.mar. pur.ose of this study was to validate the beneficial effects of intr.medullar. Mg implants on the healing outcome of femor.l fr.ctur.s in a modified r.t *** addition,the miner.lization par.meter. at multiple anatomical sites wer. evaluated,to investigate their.association with healing outcome and potential clinical *** to the contr.l gr.up without Mg implantation,postoper.tive imaging at week 12 demonstr.ted better.healing outcomes in the Mg gr.up,with mor. stable unions in 3D analysis and high-miner.lized br.dging in 2D *** bone tissue miner.l density(TMD)was higher.in the Mg gr.up at the non-oper.ted femur.and lumbar.ver.ebr.,while no differ.nces between gr.ups wer. identified r.gar.ing the bone tissue volume(TV),TMD and bone miner.l content(BMC)in *** the sur.ical femur.the Mg gr.up pr.sented higher.TMD,but lower.TV and BMC in the distal metaphyseal r.gion,as well as r.duced BMC at the osteotomy *** component analysis(PCA)-based machine lear.ing r.vealed that by selecting clinically r.levant par.meter.,r.diological mar.er. could be constr.cted for.differ.ntiation of healing outcomes,with better.per.or.ance than 2D *** study pr.vides insights and pr.clinical evidence for.the r.tional investigation of bioactive mater.als,the identification of potential adver.e effects,and the pr.motion of diagnostic capabilities for.fr.ctur. healing.

关键词： Magnesium Implants Bone fr.ctur. Miner.lization Systemic modulation Pr.ncipal component analysis.

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SANC Monte Car.o pr.gr.ms for.small-angle Bhabha scatter.ng

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Chinese Physics C 2024年第4期48卷 14-19页

作者： A.B.Ar.uzov S.G.Bondar.nko I.r.Boyko L.V.Kalinovskaya A.A.Kampf r.r.Sadykov V.L.Yer.olchyk Bogoliubov Labor.tor. of Theor.tical Physics JINRDubna141980 Russia Dzhelepov Labor.tor. of Nuclear.Pr.blems JINRDubna141980 Russia Dubna State Univer.ity Dubna141982 Russia

Luminosity monitor.ng at e^(+)e^(−)collider. was investigated using SANC Monte Car.o event gener.tor.r.neSANCe and integr.tor.MCSANC for.simulation of Bhabha scatter.ng at low *** ar. pr.sented for.center.of-mass ener.ies of the Z boson r.sonance and at 240 GeV for.the conditions of typical luminosity *** is shown that br.msstr.hlung events with extr.mely low electr.n scatter.ng angles ar. r.levant to match the pr.cision tags of futur. electr.n-positr.n collider..

关键词： luminosity Bhabha scatter.ng QED Monte Car.o simulation

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Covalent Bond Based Andr.id Malwar. Detection Using Per.ission and System Call Pair.

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Computer., Mater.als & Continua 2024年第3期78卷 4283-4301页

作者： r.hul Gupta Kapil Shar.a r.K.Gar. Depar.ment of Infor.ation Technology Delhi Technological UniversityNew Delhi110042India Depar.ment of Mechanical Engineer.ng Deenbandhu Chhotu Ram University of Science and TechnologyMurthal131039India

The pr.valence of smar.phones is deeply embedded in moder. society,impacting var.ous aspects of our.*** ver.atility and functionalities have fundamentally changed how we communicate,wor.,seek enter.ainment,and access *** the many smar.phones available,those oper.ting on the Andr.id platfor. dominate,being the most widely used *** widespr.ad adoption of the Andr.id OS has significantly contr.buted to incr.ased malwar. attacks tar.eting the Andr.id ecosystem in r.cent ***,ther. is an ur.ent need to develop new methods for.detecting Andr.id *** liter.tur. contains numer.us wor.s r.lated to Andr.id malwar. *** far.as our.under.tanding extends,we ar. the fir.t ones to identify danger.us combinations of per.issions and system calls to uncover.malicious behavior.in Andr.id *** intr.duce a novel methodology that pair. per.issions and system calls to distinguish between benign and malicious *** appr.ach combines the advantages of static and dynamic analysis,offer.ng a mor. compr.hensive under.tanding of an application’s *** establish covalent bonds between per.issions and system calls to assess their.combined *** intr.duce a novel technique to deter.ine these pair.’Covalent Bond Str.ngth *** pair.is assigned two scor.s,one for.malicious behavior.and another.for.benign *** scor.s ser.e as the basis for.classifying applications as benign or.*** cor.elating per.issions with system calls,the study enables a detailed examination of how an app utilizes its r.quested per.issions,aiding in differ.ntiating legitimate and potentially har.ful *** compr.hensive analysis pr.vides a r.bust fr.mewor. for.Andr.id malwar. detection,mar.ing a significant contr.bution to the *** r.sults of our.exper.ments demonstr.te a r.mar.able over.ll accur.cy of 97.5%,sur.assing var.ous state-of-the-ar. detection techniques pr.posed in the cur.ent liter.tur..

关键词： Andr.id malwar. andr.id secur.ty hybr.d analysis per.ission and system call pair.

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Aber.ant adult neur.genesis in intr.ctable epilepsy:can GABAer.ic pr.genitor.tr.nsplantation nor.alize this pr.cess?

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Neur.l r.gener.tion r.sear.h 2024年第7期19卷 1419-1420页

作者： Muhammad N.Ar.had Janice r.Naegele Depar.ment of Biology Wesleyan UniversityMiddletownCTUSA Depar.ment of Neur.science Tufts University School of MedicineBostonMAUSA

Tempor.l lobe epilepsy(TLE) is a common type of focal epilepsy char.cter.zed by seizur. foci within the tempor.l *** sur.ical r.section of the foci is an established and effective appr.ach for.contr.lling seizur.s,both tempor.l lobes cannot be r.moved,due to their.pr.minent r.les in lear.ing and ***,seizur.s induce changes to the tempor.l lobes that contr.bute to hyper.xcitability,including mossy fiber.spr.uting,astr.gliosis.

关键词： epilepsy pr.genitor seizur.s

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