检索结果-南通市图书馆

Hyperglycemia in COVID-19 infection without diabetes mellitus:Association with inflammatory markers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第6期11卷 1287-1298页

作者： Harinivaas Shanmugavel Geetha Garima Singh Abinesh sekar Maya Gogtay Yuvaraj Singh George MAbraham Nitin Trivedi Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Hospice and Palliative Medicine University of Texas HealthSan AntonioTX 78229United States Department of Internal Medicine University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States

BACKGROUND New onset hyperglycemia is common in patients with severe coronavirus disease 2019(COVID-19)*** storm due to COVID-19 infection is an essential etiology for new-onset hyperglycemia,but factors like direct severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced pancreaticβ-cell failure have also been postulated to play a *** We plan to investigate further the mechanisms underlying SARS-CoV-2 infection-induced hyperglycemia,particularly the rationale of the cytokine-induced hyperglycemia hypothesis,by evaluating the association between inflammatory markers and new onset hyperglycemia in non-diabetic patients with COVID-19 *** We conducted a retrospective case-control study on adults without diabetes mellitus hospitalized for COVID-19 *** serum levels of glucose and inflammatory markers at presentation before initiation of corticosteroid were *** was defined as glucose levels≥140 mg/dL.C-Reactive protein(CRP)≥100 mg/L,ferritin≥530 ng/mL,lactate dehydrogenase(LDH)≥590 U/L,and D-dimer≥0.5 mg/L were considered *** used theχ2 test for categorical variables and the Mann-Whitney U test for continuous variables and calculated the logistic regression for *** Of the 520 patients screened,248 met the inclusion *** demographics were equally distributed between patients with hyperglycemia and those who were *** inflammatory markers in patients with or without new-onset hyperglycemia were elevated as follows:CRP(58.1%vs 65.6%,P=0.29),ferritin(48.4%vs 34.9%,P=0.14),D-dimer(37.1%vs 37.1%,P=0.76)and LDH(19.4%vs 11.8%,P=0.02).Logistic regression analysis showed LDH odds ratio(OR)=1.623(P=0.256).We observed significantly higher mortality(24.2%vs 9.1%,P=0.001;OR=2.528,P=0.024)and length of stay(8.89 vs 6.69,P=0.026)in patients with *** Our study showed no association between CRP,ferritin,LDH,D-dimer levels,and new-onset hyperg

关键词： COVID-19 Inflammatory markers Hyperglycemia C-reactive protein Mortality Severity Mechanisms Diabetes mellitus

Effect of Magnesium on the Mechanical and Bioactive Properties of Biphasic Calcium Phosphate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Minerals and Materials Characterization and Engineering 2012年第10期11卷 982-988页

作者： Ponnusamy Kanchana Chinnathambi sekar Department of Bioelectronics and Biosensors Alagappa University Karaikudi India

Incorporation of trace elements into calcium phosphate structure is of great interest for the development of artificial bone implants. Biphasic calcium phosphate (BCP) composed of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) have been synthesized in the presence of magnesium (5 M% - 20 M%) by gel method under physiological conditions. Crystallization of Mg-BCP in the gel medium mimics the Mg intake in the human body. Powder X-ray dif- fraction and Fourier transform infrared analyses confirmed that the Mg doping leads to the enrichment of β-TCP phase and suppresses the HA content in BCP. Nanoindentation studies indicate a significant decrease in hardness and elastic modulus values of BCP due to Mg doping. In vitro bioactivity study has confirmed the formation of apatite layer on the Mg doped samples making it suitable for bone replacement. The results suggest that the optimum Mg doping promotes the bioactivity which is perquisite for biomedical applications.

关键词： Biphasic Calcium Phosphate Crystal Growth X-Ray Diffraction Mechanical Properties

Junker: An Intergenic Explorer for Bacterial Genomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2011年第4期9卷 179-182页

作者： Jayavel Sridhar Radhakrishnan Sabarinathan Shanmugam Siva Balan Ziauddin Ahamed Rafi Paramasamy Gunasekaran Kanagaraj sekar Centre of Excellence in Bioinformatics School of Biotechnology Madurai Kamaraj University UGC-Networking Resource Centre in Biological Sciences School of Biological Sciences Madurai Kamaraj University Bioinformatics Centre Indian Institute of Science

In the past few decades, scientists from all over the world have taken a keen interest in novel functional units such as small regulatory RNAs, small open reading frames, pseudogenes, transposons, integrase binding attB/attP sites, repeat elements within the bacterial intergenic regions （IGRs） and in the analysis of those ＂junk＂ regions for ge- nomic complexity. Here we have developed a web server, named Junker, to facilitate the in-depth analysis of IGRs for examining their length distribution, four-quadrant plots, GC percentage and repeat details. Upon selection of a particular bacterial genome, the physical genome map is displayed as a multiple loci with options to view any loci of interest in detail. In addition, an IGR statistics module has been created and implemented in the web server to analyze the length distribution of the IGRs and to understand the disordered grouping of IGRs across the genome by generating the four-quadrant plots. The proposed web server is freely available at the URL http：//***/junker/.

关键词： bacterial genome intergenic region web server statistics module

Learner Autonomy and Attribution： A Paradigm Shift in ELT in India

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sino-US English Teaching 2013年第8期10卷 583-592页

作者： J. John sekar The American College Madurai India

Learner autonomy and attribution impact English language acquisition. Learners should be encouraged to take the responsibility for their success or failure, and achievement or underperformance in the acquisition of English as an L2 （second language）. A paradigm shift can be visible on the part of teachers and students of English only when they are metamorphosed voluntarily into classroom facilitators and autonomous learners with changed duties and responsibilities. As facilitators, teachers closely monitor learners＇ attributions to their success/failure in English language courses. ＂Attribution＂ means ＂how learners learn about themselves and order uncertain environments＂. Teachers are very often unaware of learner attributions; so it becomes essential for them to increase their awareness of learner attributions so that they can become facilitators. Interaction is the only medium for acquisition of English in the classroom, and teachers can play the role of a catalyst only when they allow students to become leamers with autonomy and right kind of learner attributions. Autonomy implies accountability. Very often, learner attributions clash with teacher attributions. As long as there is a clash, teachers can never claim themselves as facilitators of learning. This paper identifies the attributions of Indian learners of English, and studies if they clash with those of teachers. It also finds out the means of minimizing the negative and undesirable attributions of both facilitators and learners. Two standardized research questionnaires were developed and administered among students and teachers to identify the attributions, and to detect the desirability and feasibility of learner autonomy in the Indian context.

关键词： paradigm shift learner autonomy leamer attributions facilitator learner self-access center

Larvicidal efficacy of Catharanthus roseus Linn.(Family:Apocynaceae)leaf extract and bacterial insecticide Bacillus thuringiensis against Anopheles stephensi Liston.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 847-853页

作者： Chellasamy Panneerselvam Kadarkarai Murugan Kalimuthu Kovendan Palanisamy Mahesh Kumar sekar Ponarulselvam Duraisamy Amerasan Jayapal Subramaniam Jiang-Shiou Hwang DRDO-BU Center for Life Sciences Bharathiar UniversityCoimhatore 641046Tamil NaduIndia Division of Entomology Department of ZoologySchool of Life SciencesBharathiar UniversityCoimbatore 641046Tamil NaduIndia Institute of Marine Biology National Taiwan Ocean UniversityKeelung 202-24Taiwan

Objective:To explore the larvicidal activity of Catharanthus roseus(***) leaf extract and Raeillus thuringiensis(***) against the malarial vector Anopheles stephensi(An. stephensi),when being used alone or ***:The larvicidal activity was assayed at various concentrations under the laboratory and field *** LC_(50) and LC_(90) values of the *** leaf extract were determined by probit ***:The plant extract showed larvicidal effects after 24 h of exposure;however,the highest larval mortality was found in the petroleum ether extract of *** against the first to fourth instars larvae with LC_(50)=3.34,4.48, 5.90 and 8.17 g/L,respectively;*** against the first to fourth instars larvae with LC_(50)=1.***.1.93.2.17 and 2.42 g/***:and the combined treatment with LC_(50)=2.***.2.41. 2.76 and 3.22 g/L,*** mortality was observed in the ***:The petroleum ether extract of *** extract and *** have potential to be used as ideal eco-friendly agents for the control of *** in vector control *** combined treatment with this plant crude extract and bacterial toxin has better larvicidal efficacy against ***.

关键词： Catharanthus roseus Bacillus thuringiensis Anopheles stephensi Larvicidal activity

Deciphering the role of microRNA 21 in cancer stem cells(CSCs)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2016年第4期3卷 277-281页

作者： Durairaj sekar Ramalingam Krishnan Mani Panagal Pethanen Sivakumar Vincent Gopinath Venugopal Basam Narayana Medical College and Hospital ChinthareddypalemNellore 524002India Stem Cell Division Cryovault Biotech India Pvt LtdBangalore 560018India Department of Biotechnology Annai College of Arts and ScienceKumbakonamTamil NaduIndia Department of Zoology Arumugam Pillai Seethai Ammal CollegeTiruppatturTamil NaduIndia

Irrespective of positive developments of cancer treatment,the mortality due to various cancers remains high and the mechanisms of cancer initiation and the development also remains *** we know that microRNAs are considered to be a short noncoding RNA molecules consisting of 21e25 nucleotides(nt)in length and they silence their target genes by inhibiting mRNA translation or degrading the mRNA molecules by binding to their 30-untranslated(UTR)region and play a very important role in cancer *** evidences indicate that miR-21 is over expressed in cancer stem cells and plays a vital role in cell proliferation,apoptosis,and *** though an increased expression level of miR-21 has been observed in cancer stem cells,studies related to the role of miR-21 in cancer stem cells are *** main aim of this mini review is to explain the potency of miR-21 in various cancer stem cells(CSCs)and as a new target for therapeutic interventions of cancer progression.

关键词： CSCs Cancer stem cells miR-21 miRNAs RNAs UTR

Acoustic Properties of Micro-Perforated Panels Made from Oil Palm Empty Fruit Bunch Fiber Reinforced Polylactic Acid

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sound & Vibration 2021年第4期55卷 343-352页

作者： Vignesh sekar Se Yong Eh Noum Azma Putra Sivakumar Sivanesan Kok Chun Chin Yi San Wong Dg Hafizah Kassim School of Computer Science and Engineering Taylor’s UniversitySubang Jaya47500Malaysia Centre for Advanced Research on Energy Universiti Teknikal Malaysia Melaka(UTeM)Melaka76100Malaysia Fakulti Kejuruteraan Mekanikal Universiti Teknikal Malaysia Melaka(UTeM)Melaka76100Malaysia

This paper presents the development and performance of micro-perforated panels(MPP)from natural fiber reinforced *** MPP is made of Polylactic Acid(PLA)reinforced with Oil Palm Empty Fruit Bunch Fiber(OPEFBF).The investigation was made by varying the fiber density,air gap,and perforation ratio to observe the effect on the Sound Absorption Coefficient(SAC)through the experiment in an impedance *** is found that the peak level of SAC is not affected,but the peak frequency shifts to lower frequency when the fiber density is *** phenomenon might be due to the presence of porosity in the inner wall of the *** or decreasing the air gap and perforation ratio shifts the peaks of acoustic absorption either way.

关键词： Acoustics micro-perforated panel natural fiber reinforced composite laser cutting impedance tube

Homepeptide Repeats:Implications for Protein Structure,Function and Evolution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2012年第4期10卷 217-225页

作者： Muthukumarasamy Uthayakumar Bowdadu Benazir Sanjeev Patra Marthandan Kirti Vaishnavi Manickam Gurusaran Kanagarajan Sureka Jeyaraman Jeyakanthan Kanagaraj sekar Supercomputer Education and Research Centre Indian Institute of ScienceBangalore 560012India Department of Bioinformatics Alagappa UniversityKaraikudi 630003India

Analysis of protein sequences from Mycobacterium tuberculosis H37Rv （Mtb H37Rv） was performed to identify homopeptide repeat- containing proteins （HRCPs）. Functional annotation of the HRCPs showed that they are preferentially involved in cellular metabolism. Furthermore, these homopeptide repeats might play some specific roles in protein-protein interaction. Repeat length differences among Bacteria, Archaea and Eukaryotes were calculated in order to identify the conservation of the repeats in these divergent kingdoms. From the results, it was evident that these repeats have a higher degree of conservation in Bacteria and Archaea than in Eukaryotes. In addi- tion, there seems to be a direct correlation between the repeat length difference and the degree of divergence between the species. Our study supports the hypothesis that the presence of homopeptide repeats influences the rate of evolution of the protein sequences in which they are embedded. Thus, homopeptide repeat may have structural, functional and evolutionary implications on proteins.

关键词： Homopeptide repeats Disordered regions Replication slippage Protein domains Rate of evolution

Students＇ Motivation to Study Accounting Subjects： Difference Between Japan and Indonesia

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Accounting and Auditing 2013年第8期9卷 1018-1031页

作者： Masako Saito sekar Mayangsari Kazuo Hiramatsu Osaka Sangyo University Osaka Japan Trisakti University Jakarta Indonesia Kwansei Gakuin University Hyogo Japan

This study investigates the differences between Japanese and Indonesian students＇ motivation to study accounting subjects. In addition, it examines the factors that can significantly influence students＇ motivation to study accounting subjects. Needless to say, the expansion of International Financial Reporting Standards （IFRS） depends on the quality of education in higher academic institutions. For several academic institutions, it is clear that the topic of students＇ motivation is still a meaningful concern, because the improvement of students＇ motivation and ability would enhance these institutions＇ academic performance in a competitive environment. In this study, the authors developed the theoretical model for students＇ motivation to study accounting subjects. This research showed that self-efficacy, accounting self-concept, mastery goals＇ perception, performance goals＇ perception, and social goals＇ perception had a significant influence on students＇ motivation to study accounting subjects. Furthermore, nationality had an impact on students＇ motivation. Japanese students are more motivated to study accounting subjects than Indonesian students. Another result clarified that goals＇ perception influences the relationship among self-efficacy, accounting self-concept, and students＇ motivation.

关键词： students' motivation self-efficacy goals' perception accounting education