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Asian Journal of Andrology 2005年第2期7卷 217-220,页

作者： Takuya Akashi Hideki Fuse Yasuo kojima Mikiko Hayashi Sachiko Honda Department of Urology Faculty of MedicineToyama Medical and Pharmaceutical UniversityToyamaJapan Department of Obsterics and Gynecology Toyama Prefectural Central HospitalToyamaJapan Toyama Institute of Health ToyamaJapan

Aim:To report a birth after intracytoplasmic sperm injection (ICSI) of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome detected by fluorescence in situ hybridization (FISH) ***:A 35-year- old man with a normal appearance consulted our hospital because of sterility over a 5-year *** analysis showed low-incidence mosaic Klinefelter's *** FISH,96 % hyperploidy of the lymphocytes was *** examined the sex chromosome of the ejaculated *** FISH,we examined 200 ejacu- lated spermatozoa and no hyperploidy was ***:The 33-year-old female partner of the male patient underwent an uncomplicated controlled ovarian hyperstimulation sequence using a combined recombinant-follicle stimulating hormone (rec-FSH) + human menopausal gonadotrophin (hMG) protocol,following late luteal phase pituitary down *** culminated in the retrieval of seven oocytes,six of which were fertilized with ICSI. One ICSI attempt led to clinical pregnancy with a healthy baby ***:We report a male patient with low- incidence mosaic Klinefelter's syndrome whose ejaculated spermatozoa were identified as being haploid by FISH before ICSI,leading to the successful pregnancy of his wife and the birth of a healthy baby girl.

关键词： Klinefelter's syndrome intracytoplasmic sperm injection fluorescence in situ hybridization

Growth hormone releasing peptide 2 reverses anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing mice

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World Journal of Gastroenterology 2008年第41期14卷 6303-6305页

作者： Simona Perboni Cyril Bowers Shinya kojima Akihiro Asakawa Akio Inui Unità Operativa Day Hospital Area Medica Azienda Ospedaliera di Desenzano sul Garda Ospedale di Manerbio Tulane University Health Science Center New Orleans Department of Psychosomatic Internal Medicine Kagoshima University Graduate School of Medical and Dental Sciences

The cancer-associated anorexia-cachexia syndrome is observed in 80% of patients with advanced-stage cancer, and is one of the major obstacles in chemo- therapy. Ghrelin is a orexigenic hormone that has been proposed to prevent anorexia. Aim of the study was to determine whether the addition of the ghrelin agonist growth hormone releasing peptide 2 (GHRP-2) to cytotoxic therapy with 5-fluoruracil (5-FU) prevents the anorexia associated with chemotherapy in cancer cachectic mice. Thirty-three BALB/c female tumourbearing mice were randomized to receive a solution containing: (a) placebo; (b) GHRP-2; (c) 5-FU; or (d) 5-FU + GHRP-2. Ten BALB/c no tumour-bearing mice received placebo solution. Food intake and survival were checked. Six hours after the drug injection the cumulative food intake was signifi cantly increased in mice treated with the combination of 5-FU + GHRP-2 versus the 5-FU alone (P = 0.0096). On day 3, the cumulative food intake of mice treated with GHRP-2,5-FU and 5-FU + GHRP-2 signifi cantly increased com- pared with naive and vehicle groups (P = 0.0007, P = 0.0038 and P = 0.0166, respectively). The median survival time was longer in 5-FU + GHRP-2 treated mice than in those with 5-FU, although it was not signifi cant (18 d versus 15.5 d, P = 0.7). For the fi rst time, we demonstrated that the addition of GHRP-2 to cytotoxic therapy with 5-FU improved appetite in tumour-bearing mice with anorexia/cachexia syndrome in early stage. These data suggest that GHRP-2 may improve the effi cacy of therapy and the quality of life of cancer patients thank to the amelioration of their nutritional state.

关键词： GHS Ghrelin Cancer anorexia-cachexia syndrome Food intake Chemotherapy Colon cancer cell line Murine model

Aerodynamic Study on Supersonic Flows in High-Velocity Oxy-Fuel Thermal Spray Process

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Journal of Thermal Science 2005年第2期14卷 126-129页

作者： Hiroshi KATANODA Takeshi MATSUOKA seiji KURODA Jin KAWAKITA Hirotaka FUKANUMA Kazuyasu MATSUO The University of Kitakyushu 1-1 Hibikino Wakamatsu-kuKitakyushuFukuoka808-0135 JapanTakagi Precision Dies Co. Ltd.2-4-1 IshidaminamiKokuraminami-kuKitakyushuFukuoka802-0836 JapanNational Institute for Materials Science 1-2-1SengenTsukubaIbaraki305-0047 JapanNational Institute for Materials Science 1-2-1SengenTsukubaIbaraki305-0047 JapanPlasma Giken Co. Ltd.2-1-12BijogiTodaSaitama335-0031 JapanThe University of Kitakyushu 1-1 HibikinoWakamatsu-kuKitakyushuFukuoka808-0135 Japan

To clarify the characteristics of gas flow in high velocity oxy-fuel (HVOF) thermal spray gun, aerodynamic research is performed using a special gun. The gun has rectangular cross-sectional area and sidewalls of optical glass to visualize the internal flow. The gun consists of a supersonic nozzle with the design Mach number of 2.0 followed by a straight passage called barrel. Compressed dry air up to 0.78 MPa is used as a process gas instead of combustion gas which is used in a commercial HVOF gun. The high-speed gas flows with shock waves in the gun and jets are visualized by schlieren technique. Complicated internal and external flow-fields containing various types of shock wave as well as expansion wave are visualized.

关键词：超声流冲击波热喷涂内流热处理

Applications of image analysis in plant chromosome and chromatin structure study

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Quantitative Biology 2022年第3期10卷 226-238页

作者： Nobuko Ohmido Astari Dwiranti seiji Kato Kiichi Fukui Graduate School of Human Development and Environment Kobe UniversityKobe 657-8501Japan Cellular and Molecular Mechanisms in Biological System(CEMBIOS)Research Group Department of BiologyFaculty of Mathematics and Natural SciencesUniversitas IndonesiaDepok CampusWest Java 16424Indonesia Graduate School of Pharmaceutical Sciences Osaka UniversitySuitaOsaka 565-0871Japan

Background:The use of image analysis to understand the structure of chromosome and chromatin is critical to the study of genetic evolution and ***,a detailed chromosome map and the structure of chromatin in the nucleus may contribute to the plant breeding and the study of fundamental biology and genetics in ***:In plants with a fully annotated genome project,such as the Leguminosae species,the integration of genetic information,including DNA sequence data,a linkage map,and the cytological quantitative chromosome map could further improve their genetic *** numerical parameters of chromocenters in 3D can provide useful genetic information for phylogenetic studies of plant diversity and heterochromatic markers whose epigenetic changes may explain the developmental and environmental changes in the plant *** DNA fibers combined with fluorescence in situ hybridization revealed the highest spatial resolution of the obtained genome ***,image analysis at the nano-scale level using a helium ion microscope revealed the surface structure of chromatin,which consists of chromatin fibers compacted into plant ***:The studies described in this review sought to measure and evaluate chromosome and chromatin using the image analysis method,which may reduce measurement time and improve ***,we discussed the development of an effective image analysis to evaluate the structure of chromosome and *** effective application study of cell biology and the genetics of plants using image analysis methods is expected to be a major propeller in the development of new applications.

关键词： CHIAS chromosome chromatin extended DNA fiber helium ion microscopy nucleus plants

Development of massively parallel electron beam direct write lithography using active-matrix nanocrystalline-silicon electron emitter arrays

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Microsystems & Nanoengineering 2015年第1期1卷 44-51页

作者： Masayoshi Esashi Akira kojima Naokatsu Ikegami Hiroshi Miyaguchi Nobuyoshi Koshida World Premier International Research Center Advanced Institute for Materials Research(WPI-AIMR) Tohoku University519-1176 Aramaki-Aza-AobaAoba-kuSendaiMiyagi 980-0845Japan Micro System Integration Center Tohoku University519-1176 Aramaki-Aza-AobaAoba-kuSendaiMiyagi 980-0845Japan Department of Electrical and Electronic Engineering Tokyo University of Agriculture&Technology2-24-16 Naka-choKoganei-shiTokyo 184-8588Japan

Nanoscale lithographic technologies have been intensively studied for the development of the next generation of semiconductor manufacturing *** mask-less/direct-write electron beam(EB)lithography methods serve as a candidate for the upcoming 10-nm node approaches and beyond,it remains difficult to achieve an appropriate level of *** innovative features of the multiple EB system that involve the use of a thermionic source have been ***,a blanking array mechanism is required for the individual control of multiple beamlets whereby each beamlet is deflected onto a blanking object or passed through an *** paper reviews the recent developments of our application studies on the development of a high-speed massively parallel electron beam direct write(MPEBDW)*** emitter array used in our study includes nanocrystalline-Si(nc-Si)ballistic electron *** are drifted via multiple tunnelling cascade transport and are emitted as hot *** transport mechanism allows one to quickly turn electron beamlets on or *** emitter array is a micro-electro-mechanical system(MEMS)that is hetero-integrated with a separately fabricated active-matrix-driving complementary metal-oxide semiconductor(CMOS)large-scale integration(LSI)system that controls each emitter *** basic function of the LSI was confirmed to receive external writing bitmap data and generate driving signals for turning beamlets on or *** emitted beamlet(10×10μm^(2))is converged to 10×10 nm^(2) on a target via the reduction electron optic system under *** paper presents an overview of the system and characteristic evaluations of the nc-Si emitter *** examine beamlets and their electron emission characteristics via a 1:1 exposure test.

关键词： direct write lithography electron beam lithography electron emitter array multiple electron beams nanocrystalline Si

Protective effect of alcohol consumption for fatty liver but not metabolic syndrome

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World Journal of Gastroenterology 2012年第2期18卷 156-167页

作者： Masahide Hamaguchi Takao kojima Akihiro Ohbora Noriyuki Takeda Michiaki Fukui Takahiro Kato Immunology Frontier Research Center Osaka UniversityOsaka 565-0871Japan Department of Gastroenterology Murakami Memorial HospitalAsahi UniversityGifu 500-8523Japan Department of Endocrinology and Metabolism Murakami Memorial HospitalAsahi UniversityGifu 500-8523Japan Department of Endocrinology and Metabolism Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan

AIM:To investigate the effect of alcohol on the metabolic syndrome (MS) and fatty liver in Japanese men and ***:A cross-sectional study was conducted in a medical health checkup program at a general *** study involved 18 571 Japanese men and women,18-88 years of age,with a mean body mass index of 22.6 kg/m 2.A standardized questionnaire was *** total amount of alcohol consumed per week was calculated,and categorized into four *** liver was examined by ultrasound modified criteria of the revised National Cholesterol Educa-tion Program Adult Treatment Panel Ⅲ and the new International Diabetes ***:The prevalence of fatty liver decreased in men and women with light to moderate alcohol consumption,whereas the prevalence of MS was not so *** prevalence of fatty liver of any grade in men was lower than that in those with no or minimal alcohol *** women with light to moderate alcohol consumption,prevalence of fatty liver was lower than that in women with no or minimal alcohol *** logistic regression analysis,the odds ratio (OR) for MS in women with light alcohol consumption was decreased to < 1.0,but this change was not clear in *** OR for fatty liver was clearly < 1.0 in men with any level of alcohol consumption and in women with light to moderate ***:Light to moderate alcohol consumption has a favorable effect for fatty liver,but not for MS in Japanese men and women.

关键词： Alcoholic hepatitis Epidemiology Fatty liver Metabolic syndrome Alcohol consumption

Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women

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World Journal of Gastroenterology 2012年第3期18卷 237-243页

作者： Masahide Hamaguchi Takao kojima Akihiro Ohbora Noriyuki Takeda Michiaki Fukui Takahiro Kato Immunology Frontier Research Centerat Osaka University Department of Gastroenterology Murakami Memorial Hospital Asahi University Department of Endocrinology and Metabolism Murakami Memorial Hospital Asahi University Department of Endocrinology and Metabolism Graduate School of Medical Science Kyoto Prefectural University of Medicine

AIM: To clarify the relationship between age, menopause, and nonalcoholic fatty liver disease (NAFLD) in women. METHODS: We conducted a follow-up study on non-alcoholic fatty liver disease by using abdominal ultrasonography, and investigated the relationship of age and menopause with the development of NAFLD in women. We followed 1829 women and 2572 men (response rate, 86%) selected in 2001 to represent the non-institutionalized adult population of Gifu, Japan. Data collected included self-reported medical history, lifestyle factors, and menopausal status. The postmenopausal state was defined as beginning 1 year after the cessation of menses. We diagnosed NAFLD with the aid of abdominal ultrasonography by using diagnostic criteria describedRESULTS: The prevalence of NAFLD in women increases with age, but does not alter with age in men. Furthermore, the prevalence of NAFLD in premenopausal women (6%) was lower than that in men (24%) and in postmenopausal women (15%). The associations of the postmenopausal state and hormone replacement therapy with NAFLD were statistically significant in a univariate logistic regression model. At the follow-up examination, 67 women (5%) were newly diagnosed with NAFLD. The incidence of NAFLD was 3.5% (28/802) in premenopausal women, 7.5% (4/53) in menopausal women, 6.1% (24/392) in postmenopausal women, and 5.3% (11/206) in women receiving hormone replacement therapy. The weight gain in premenopausal women was equal to that in postmenopausal women. Metabolic syndrome and weight gain were independent risk factors for NAFLD in pre-and postmenopausal women, but age was an independent risk factor in premenopausal women only. CONCLUSION: Aging is a risk factor for NAFLD in premenopausal women, independent of weight gain or influence of metabolic syndrome.

关键词： Nonalcoholic fatty liver disease Cardiovascular disease Risk factor Steatohepatitis Postmenopausal women

Molecular Phylogeny and Evolution of Two Rhacophorus Species Endemic to Mainland Japan

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Asian Herpetological Research 2019年第2期10卷 86-104页

作者： Masafumi MATSUI Yasuhiro KAWAHARA Kanto NISHIKAWA seiji IKEDA Koshiro ETO Yusuke MIZUNO Graduate School of Human and Environmental Studies Kyoto UniversityYoshida Nihonmatsu-choSakyo-kuKyoto 606-8501Japan Hagi City Museum Horiuchi 355HagiYamaguchi 758-0057Japan Hiroshima University Museum Kagamiyama 1-1-1Higashi Hiroshima CityHiroshima 739-8524Japan Kitakyushu Museum of Natural History and Human History Higashida 2-4-1Yahatahigashi-kuKitakyushuFukuoka 805-0071Japan Takahari 4-1002 Meito-kuNagoya 465-0061Japan

We conducted molecular phylogenetic analyses of Japanese Rhacophorus species, especially of R. schlegelii and R. arboreus from the mainland, based on samples encompassing their known distribution ranges, and discussed about evolutionary history of Rhacophorus species within Japan. The common ancestor of Japanese Rhacophorus, except for R. owstoni from southern Ryukyus, was estimated to have diverged from a lineage occurring mainly in China about 7 MYBP. Both R. schlegelii and R. arboreus are genetically largely divergent between regions of eastern and western Japan, and this seems to have been promoted mainly by retreat to refugia. Retreats of the two species to different refugia sometimes in the past seem to have led restricted distribution of R. schlegelii in eastern and R. arboreus in western Japan, and brought their intraspecific variation patterns in morphology and breeding habit.

关键词： glacial period mitochondrial DNA differentiation refugia Rhacophorus arboreus Rhacophorus schlegelii

First principles calculation of stable structure and adhesive strength of plated Ni/Fe(100) or Cu/Fe(100) interfaces

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中国有色金属学会会刊：英文版 2009年第4期19卷 988-991页

作者： Ryota NAKANISHI Koji SUEOKA seiji SHIBA M akoto HINO Koji MURAKAMI Ken MURAOKA Department of System Engineering Okayama Prefectural University Metallic Materials Group Department of Mechanical EngineeringIndustrial Technology Center of Okayam a Prefecture

A study the with first principles calculation of the interfaces of the Ni layer or Cu layer on the Fe(100) surface formed with metal plating was *** or Cu atoms were shown to adopt the corresponding position to the bcc structure of the Fe(100) *** calculations showed that the interfaces of Ni(5 atomic layers)/Fe(100)(5 layers) or Cu(5 atomic layers)/Fe(100)(5 layers) had square *** orientation relationship of Ni/Fe(100) interface corresponds to fcc-Ni(100)//bcc-Fe(100),Ni[011]//Fe[010],and Ni[011]//Fe[001].Similar results were obtained for Cu/Fe(100) *** structure was supported by TEM analysis of plated Ni layer on Fe(100) *** adhesion strength of the Ni/Fe(100) interface evaluated by first principles calculation was higher than that of the Cu/Fe(100) *** experimental results of Hull cell iron plated with Ni or Cu supported the results of the *** results indicate that the first principles calculation,which deals with the ideal interface at the atomic scale,has the potential to evaluate the adhesion strength of metallic material interfaces.

关键词：第一原理计算接口处理稳定结构粘接强度铜原子镀镍胶粘剂界面结合强度

Diabetic neuropathy research: from mouse models to targets for treatment

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Neural Regeneration Research 2019年第11期14卷 1870-1879页

作者： Vuong M. Pham Shinji Matsumura Tayo Katano Nobuo Funatsu seiji Ito Department of Medical Chemistry Kansai Medical UniversityHirakataOsakaJapan Singapore Institute for Neurotechnology (SINAPSE) National University of SingaporeSingapore Department of Anesthesiology Osaka Medical CollegeTakatsukiOsakaJapan

Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment.

关键词： brain derived neurotrophic factor diabetes extrinsic factors nerve growth factor nerve regeneration neurotrophic factors non-obese type 2 diabetes phosphatase and tensin homolog stem cell streptozotocin