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Development and application of traffic accident density estimation models using kernel density estimation

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Journal of Traffic and Transportation Engineering(English Edition) 2016年第3期3卷 262-270页

作者： seiji Hashimoto Syuji Yoshiki Ryoko Saeki Yasuhiro Mimura Ryosuke Ando Shutaro Nanba Graduate School of Environmental and Life Science Okayama UniversityOkayama 700-0807Japan Department of Civil Engineering Fukuoka UniversityFukuoka 814-0180Japan Fukuyama Consultants Co.Ltd. Futeuotea 812-0013Japan International Development Consultants Co.Ltd. Aichi 460-0008Japan Toyota Transportation Research Institute Aichi 471-0024Japan

Traffic accident frequency has been decreasing in Japan in recent years. Nevertheless, many accidents still occur on residential roads. Area-wide traffic calming measures including Zone 30, which discourages traffic by setting a speed limit of 30 km/h in residential areas, have been implemented. However, no objective implementation method has been established. Development of a model for traffic accident density estimation explained by GIS data can enable the determination of dangerous areas objectively and easily, indicating where area-wide traffic calming can be implemented preferentially. This study examined the relations between traffic accidents and city characteristics, such as population, road factors, and spatial factors. A model was developed to estimate traffic accident density. Kernel density estimation （KDE） techniques were used to assess the relations efficiently. Besides, 16 models were developed by combining accident locations, accident types, and data types. By using them, the applicability of traffic accident density estimation models was examined. Results obtained using Spearman rank correlation show high coefficients between the predicted number and the actual number. The model can indicate the relative accident risk in cities. Results of this study can be used for objective determination of areas where area-wide traffic calming can be implemented preferentially, even if sufficient traffic accident data are not available.

关键词： Traffic safety Kernel density estimation (KDE) Hotspots Zone 30

Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis

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World Journal of Gastroenterology 2006年第16期12卷 2523-2529页

作者： Kazutaka Kurokohchi Tsutomu Masaki Takashi Himoto Akihiro Deguchi seiji Nakai Asahiro Morishita Hirohito Yoneyama Yasuhiko Kimura Seishiro Watanabe Shigeki Kuriyama Third Department of Internal Medicine Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan

AIM： Although the pathogenic mechanism underlying autoimmune hepatitis （AIH） remains unclear, the immune system is thought to be critical for the progression of the disease. Cellular immune responses may be linked to the hepatocellular damage in AIH. Recently, much attention has been focused on the critical functions of costimulatory molecules expressed on mononuclear cells in the generation of effective T cell-mediated immune responses. Analysis of costimulatory molecule expressed on mononuclear cells from the patients with AIH may give us insight into the pathogenic mechanism of hepatocellular damage in AIH. METHODS： Peripheral blood mononuclear cells （PBMC） were taken from the patients with AIH （34 cases） and healthy controls （25 cases）. Uver infiltrating mononuclear cells （LIMCs） were taken from the patients with AIH （18 cases）, the patient with chronic hepatitis C （CH-C）（13 cases） and the patients with fatty liver （2 cases）. Using flow cytometry, the cells were analyzed for the expression of costimulatory molecules, such as CD80, CD86, and CD152 （CTLA-4）. The results were compared with clinical data such as the level of gammaglobulin, histological grade, presence or absence of corticosteroids administration and the response to corticosteroids. RESULTS： The levels of CD80＋, CD86＋ and CD152＋ PBMC were significantly reduced in the patients with AIH as compared with healthy controls. By contrast, those cells were significantly higher in LIMC than in PBMC of the patients with AIH. Especially, the level of CD86＋ LIMC showed a marked increase irrespective of the degree of disease activity in the patients with AIH,although CD86＋ cells were rarely present in PBMC. The levels of CD86＋ cells were present in significantly higher frequency in patients with AIH than in the patients with CH-C. Furthermore, the patients with AIH with high levels of CD86＋ LIMC showed good responses to corticosteroids, whereas 2 cases of AIH with low levels of CD86＋ LIMC did not respond well. C

关键词： Autoimmune hepatitis Costimulatory molecule CD86 molecule Peripheral blood mononuclear cells Liver infiltrating mononuclear cells Flow cytometry

Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence

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World Journal of Gastroenterology 2007年第16期13卷 2283-2288页

作者： Reigetsu Yoshikawa Yoshinori Fujiwara Kenji Koishi Syoudou kojima Tomohiro Matsumoto Hidenori Yanagi Takehira Yamamura Tomoko Hashimoto-Tamaoki Takashi Nishigami Tohru Tsujimura Second Department of Surgery Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Institute for Advanced Medical Sciences Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Second Department of Surgery Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Institute for Advanced Medical Sciences Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Department of Genetics Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Second Department of Pathology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan

AIM： To investigate the relationship between cycloo- xygenase-2 （COX-2）, and vascular endothelial growth factor （VEGF）, and to determine the clinical significance of this relationship in esophageal cancer patients undergoing chemoradiotherapy （CRT）. METHODS： Immunohistochemical staining was used to evaluate COX-2 and VEGF expression in 40 patients with histologically-confirmed esophageal squamous carcinoma （ESCC） who were undergoing preoperative CRT. RESULTS： Fourteen out of 40 ESCC patients showed a pathological complete response （CR） after CRT. COX-2 and VEGF protein expressions were observed in the cytoplasm of 17 and 13 tumors, respectively, with null expression in 9 and 13 tumors, respectively. COX-2 expression was strongly correlated with VEGF expression （P 〈 0.05）. There were also significant associations between COX-2 expression, tumor recurrence, and lymph-node involvement （P = 0.0277 and P = 0.0095, respectively）. COX-2 expression and VEGF expression had significant prognostic value for disease-free survival （log-rank test; P = 0.0073 and P = 0.0341, respectively）, but not for overall survival, as assessed by univariate analysis. expression correlates with VEGF expression and might be a useful prognostic factor for more frequent tumor recurrence in ESCC patients undergoing neoadjuvant CRT. These findings support the use of anti-angiogenic COX-2 inhibitors in the treatment of ESCC.

关键词： Chemoradiotherapy Cyclooxygenase-2 Esophageal cancer Metastasis Vascular endothelial growth factor

盘型激光焊金属蒸汽特征色调-色饱和度-亮度分析法研究

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物理学报 2012年第14期61卷 416-423页

作者：高向东汪润林龙观富 Katayama seiji 广东工业大学机电工程学院广州510006 日本大阪大学接合科学研究所大阪567-0047

对于大功率盘型激光焊,金属焊件表面在激光束辐射下强烈汽化并形成等离子体状的金属蒸汽羽状物.该金属蒸汽羽状物可逆向激光束传输,对激光有明显的屏蔽作用,降低激光辐射至焊件的能量密度,影响焊接效率和质量.因此研究金属蒸汽特征变化... 详细信息

对于大功率盘型激光焊,金属焊件表面在激光束辐射下强烈汽化并形成等离子体状的金属蒸汽羽状物.该金属蒸汽羽状物可逆向激光束传输,对激光有明显的屏蔽作用,降低激光辐射至焊件的能量密度,影响焊接效率和质量.因此研究金属蒸汽特征变化规律及其与焊接质量之间的关联,可实现由金属蒸汽特征实时监测激光焊接状态.以10 kW大功率盘型连续激光焊接304不锈钢钢板为试验对象,应用高速摄像机摄取金属蒸汽动态图像,将其转换至色调-色饱和度-亮度空间,提取金属蒸汽面积、激光束受影响路径长度等相关特征量,以焊缝熔宽的变化作为衡量焊接状态稳定性的参数.通过金属蒸汽特征值的均值统计和方差分析,试验证明根据金属蒸汽面积和激光束受影响路径长度等金属蒸汽特征可有效地反映熔宽质量,从而对焊接状况做出动态评估.

关键词：大功率盘型激光焊金属蒸汽色调-色饱和度-亮度空间

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大功率盘形激光焊飞溅特征分析

物理学报 2012年第9期61卷 490-496页

作者：高向东龙观富汪润林 Katayama seiji 广东工业大学机电工程学院广州510006 日本大阪大学接合科学研究所大阪567-0047

焊接过程的在线监控是保证激光焊接质量的关键,为此,首先要找到焊接过程传感特征量变化规律以及与焊缝质量间的关系.飞溅是大功率盘型激光焊接过程中的一个重要现象,其特征与焊接质量、焊接过程稳定性以及能量利用率等有着密切的联系.... 详细信息

焊接过程的在线监控是保证激光焊接质量的关键,为此,首先要找到焊接过程传感特征量变化规律以及与焊缝质量间的关系.飞溅是大功率盘型激光焊接过程中的一个重要现象,其特征与焊接质量、焊接过程稳定性以及能量利用率等有着密切的联系.以大功率盘形激光焊接304不锈钢为试验对象,研究焊接过程中的飞溅特征.在紫外波段和可见光波段应用高速摄像机摄取焊接过程中产生飞溅的瞬态特征,通过计算机图像处理技术分析飞溅的数量、面积、行程和质心高度特征参量.以焊件熔宽作为衡量焊接质量与焊接过程稳定性的因素,对飞溅特征量进行线性和高次拟合,研究飞溅特征参量的波动规律,并与焊件熔宽的变化对比,探索焊接过程的飞溅特征参量变化规律.试验结果表明,根据飞溅特征量变化规律能够对大功率盘形激光焊接304不锈钢板焊接质量做出动态评估,为实现焊接质量的在线监控提供了试验依据.

关键词：大功率盘形激光焊接飞溅图像识别

A Comparative Visualization Strategy of Probabilistic Susceptibility Maps for Analyzing Different Types of Slope Failures

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Journal of Earth Science and Engineering 2012年第8期2卷 451-460页

作者： Hirohito kojima Ryo Nozaki Department of Civil Engineering Faculty of Science & Technology Tokyo University of Science Chiba 278-8510 Japan

This paper presents a comparative visualization strategy of slope failure susceptibility maps for analyzing different types of simultaneous occurrences of slope failures. Through the SEM （structural equation modeling）, slope failure susceptibility maps are produced by using causal factors （i.e., geographical information, satellite remotely sensed data）. As for a conventional pair-wise comparative procedure, the differences between susceptibility maps are delineated on difference maps, that can be, however, applied for evaluating differences only between pairs of susceptibility maps. One of the strong requirements from specialists working on slope stability evaluation is a comparative and visualization strategy of susceptibility maps with respect to ＂different types of simultaneous slope failures＂, for which the discussion is insufficient in the previous research activities for constructing the quantitative models for slope failure hazard mapping. As a measure, a color composite map based on susceptibility maps has been produced. The combination of assigning susceptibility maps to RGB-color planes is determined based on an index of ＂NCCT （normalized correlated color temperature）＂ which represents the relationship between chromaticity and human visual perception. Through the cases examined, the result indicates that the proposed color composite map, as a heuristic visualization strategy, is useful for simultaneously evaluating the hazardous areas affected by ＂different types of slope failures＂.

关键词： Types of slope failures simultaneous slope failures hazard mapping spatial data integration structural equationmodeling remote sensing.

Renal amyloidosis as a late complication of Crohn's disease:a case report and review of the literature from Japan

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World Journal of Gastroenterology 2000年第3期6卷 461-464页

作者： Osamu Saitoh Keishi kojima Tsutomu Teranishi Ken Nakagawa Masanobu Kayazawa Masashi Nanri Yutaro Egashira Ichiro Hirata Ken-ichi Katsu Second Department of Internal Medicine Osaka Medical CollegeTakatsukiJapan First Department of Pathology Osaka Medical CollegeTakatsukiJapan

INTRODUCTION Secondary amyloidosis is a rare but seriouscomplication of Crohn’s disease(CD).Theincidence of the association of secondaryamyloidosis in patients with CD has been reportedto be 0.5%-8% in Western ***,in Japan,the number of patients with CDcomplicated by amyloidosis is *** of their clinical manifestations andthe incidence of association are ***,we report herein a patient with

关键词： Crohn’s disease/complication renal amyloidosis amyloid deposits

Energy Consumption and Thermal Performance in Different Residential Building Types in Hot-Summer and Cold-Winter Zone

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Journal of Civil Engineering and Architecture 2017年第3期11卷 240-248页

作者： Haiqiang Liu Shoichi kojima

In China, REC （residential energy consumption） is the second largest energy use category （10%） following the industry. To fulfill the Chinese government＇s commitment that Chinese CO2 emissions would peak in 2030, as a result, improving the energy efficiency and reducing the emissions from the building sector is significantly important. A survey, in the form of a questionnaire, of energy consumption and thermal situation in different residential building types （detached house, multi-story building, high-rise building）, was undertaken in three cities （Shanghai, Hangzhou, and Changzhou） in hot-summer and cold-winter regions, these three cities were selected to represent the most flourishing economic provinces. This region in China was selected for the evaluation of EETP （energy and thermal performance analysis）, because of its special weather conditions, huge energy consumption （as both heating in winter and cooling in summer are necessary）, and other regional characteristics. 183 households were sampled and experiments were separately done in typical examples of three different building types. Systematic evaluation on EETP for three different residential building types, were put forward to assess the energy efficiency and thermal performance of three different building types.

关键词： Hot-summer and cold-winter thermal comfort PMV evaluation of energy and thermal performance residential buildingtype.

Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma

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World Journal of Gastroenterology 2012年第43期18卷 6263-6268页

作者： Takehiro Tanaka Atsushi Fujimura Koichi Ichimura Hiroyuki Yanai Yasuharu Sato Katsuyohi Takata Hiroyuki Okada seiji Kawano Shunsuke Tanabe Tadashi Yoshino Department of Pathology Okayama University Hospital Okayama 700-8558 Japan Department of Physiology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Pathology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Endoscopy Okayama University Hospital Okayama 700-8558 Japan Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan

AIM:To compare the clinicopathological characteristics of human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative Barrett's adenocarcinoma in Japan. METHODS:We performed immunohistochemical analysis of HER2 in 30 samples taken from patients with Barrett's adenocarcinoma and dual color in situ hybridization in cases showing 2+ reactions. We compared the clinicopathological characteristics of HER2-positive and HER2-negative ***:HER2 positivity was identified in 8 (27%) carcinoma samples. We found that HER2 expression was associated with p53 overexpression (100% vs 52.6% in pT1 tumor; 100% vs 54.5% in all stage tumor, P < 0.05) and protruding lesions at the early disease stage. There was no association between the mucin phenotype of the carcinomas and prognosis. HER2 expression and low clinical stage were unexpectedly different between Barrett's adenocarcinoma patients and gastric cancer patients, but the macroscopic features may be associated with earlier diagnosis in these patients. CONCLUSION:Our results suggest that HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage.

关键词： Barrett's adenocarcinoma Human epidermal growth factor receptor 2 p53 Mucin phenotype