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Rabies by Dog Bites in Benin: Determinants of Good Knowledge of the Rabies Risk among Subjects Exposed in the Plateau Department in 2023

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Open Journal of Epidemiology 2024年第2期14卷 378-396页

作者： Benoit sedegnon Agossoukpe Finagnon Armand Wanvoegbe Georgia Barikissou Ignace Coovi Nonwanou Tokpanoude Elvire se Djossou Phinées Adegbola Gilchrist Mègnisse Orphé Laly Tagnon Gautier Raphaël Gnonlonfoun Badirou Aguemon Public Health Unit Faculty of Health Sciences University of Abomey-Calavi Abomey-Calavi Cotonou Department of Internal Medicine Faculty of Health Sciences University of Abomey-Calavi Abomey-Calavi Cotonou National School of Technicians in Public Health and Epidemiology University of Parakou Parakou Benin Comlan Alfred Quenum Regional Institute of Public Health (IRSP-CAQ) Ouidah Benin ITM Antwerp Alumni (Institute of tropical medicine of Antwerp) Antwerp Belgium

Rabies, a viral zoonosis, is one of the neglected tropical diseases (NTDs) that mainly affects poor and vulnerable populations. Human rabies is endemic in Benin. Although listed among the notifiable diseases, it nevertheless remains a neglected and under-reported disease. The objective of this study was to investigate the determinants of knowledge of rabies risk among subjects exposed to human rabies by dog bites in the Plateau department of Benin. Methods: This was a cross-sectional study with an analytical aim which involved a sample of 900 people aged at least 18 years old chosen randomly and residing in the Plateau department for at least six months. A pre-tested and validated digital questionnaire served as a data collection tool. Data analysis was done with R 3.4.1 software. The prevalence ratio was used as a measure of association. The confidence threshold was set at 5%. We carried out a multiple logistic regression using the likelihood ratio (top-down approach) in order to identify the main factors which influenced the good knowledge of human rabies in the population of Plateau. Results: In the study population, 80.89% of the subjects surveyed lived in a rural area. The sex ratio (Male/Female) was 1.11. The average age of the subjects was 40.24 ± 14.52 years. The prevalence of dog bites was 4.11% (95% CI = [3.00;5.63]) or 37 subjects bitten. After evaluation of knowledge of rabies risk in the study population, the main factors which positively influenced good knowledge of human rabies were age (p linear trend 0.01), residence of the subject in the municipality of Pobè (ORa = 8.34;95% CI = 0.83 - 1.23;p secondary (ORa = 5.53;CI 95 = 3.06 - 10.15;p = 0.01), the existence of a veterinary center (ORa = 3.66;CI 95 = 1.07 - 12.43 p = 0.01) and knowledge of a dog bites victim (ORa = 6.55;95% CI = 2.73 - 8.25;p < 0.01). Conclusion: This population study confirm

关键词： Rabies Determinants Knowledge Associated Factors Benin

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Clinical and Therapeutic Aspects of Migraine in Brazzaville

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World Journal of Neuroscience 2024年第1期14卷 56-71页

作者： Motoula Latou Happhia Dinah Boubayi Josue Diatewa Prince Eliot Galieni Sounga Bandzouzi Ghislain Armel Mpandzou Héloïse Stéphanie Ongoly Ikora Karen Lise Obondzo Aloba Paul Macaire Ossou-Nguiet Faculty of Health Sciences Marien Ngouabi University Brazzaville The Republic of the Congo Department of Neurology Brazzaville University Hospital Brazzaville The Republic of the Congo Department of Neurology Loandjili General Hospital Pointe-Noire The Republic of the Congo

Introduction: Migraine is the most common primary headache, and can cause significant disability. There are two types, migraine without aura and migraine with aura. The diagnosis of migraine is essentially clinical. Worldwide prevalence was estimated at 11.6% in 2009. In Africa, it is estimated at 10.4%. Objective: To describe the clinical and therapeutic aspects of migraine in Brazzaville. Patients and Methods: This was a door-to-door cross-sectional study conducted from 1st May to 1 st July 2018 in the city of Brazzaville. Subjects over 18 with clearly expressed consent were included. The questionnaire covered demographic characteristics, diagnostic criteria for migraine according to the IHS, treatments taken. The degree of disability was determined using the Migraine Disability Assessment Scale (MIDAS). Statistical analysis was performed using SPSS 22.0 for MAC. Results: Of the 1017 subjects interviewed in this study, 115 (39.9%) had migraine, including 73 women (63.47%) and 42 men (36.52%). In the group of migraine sufferers, the number of cases of definite migraine was 61 (53.04%) and that of probable migraine 54 (46.95%). For 81 migraine sufferers (70.43%), stress was the triggering factor. The frequency of attacks was weekly and monthly for 30 (26.1%) and 19 (16.5%) sufferers respectively. The location of the migraine was unilateral in 38% of cases and tilted in 24.3%. The intensity of the attack was described as moderate and severe in 41.7% and 57.4% of subjects respectively. Phonophobia/photophobia accompanied the migraine in 65.2% of cases. One hundred and eight subjects were treated. Of these, 106 (98.1%) were on medication. Eleven (10.37%) had received a medical prescription, and ninety-seven (89.8%) were self-medicating. Five and three subjects were under the care of a general practitioner and a neurologist respectively. Conclusion: Migraine is a frequent pathology in Brazzaville. Its preponderance among young people and women call

关键词： Migraine Clinic Therapeutics Brazzaville

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基于广电工程的智能化无线发射系统设计与优化研究

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中国科技纵横 2024年第7期 92-94页

作者：德庆色珍西藏自治区广播电视局031台西藏拉萨 850000

随着无线通信技术的不断发展,智能化无线发射系统的设计与优化成为当前研究的热点.基于广电工程背景,对无线发射系统在智能化方面的设计与优化进行深入分析.广电工程的智能化无线发射系统设计与优化研究是一个综合性的工程,需要从系统... 详细信息

随着无线通信技术的不断发展,智能化无线发射系统的设计与优化成为当前研究的热点.基于广电工程背景,对无线发射系统在智能化方面的设计与优化进行深入分析.广电工程的智能化无线发射系统设计与优化研究是一个综合性的工程,需要从系统设计与实现、系统优化以及技术创新路径等多个方面进行考虑.通过科学的设计和优化,可以大幅提升广播电视节目的播出质量和稳定性,为观众提供更好的观看体验.

关键词：广电工程智能化无线发射系统优化研究

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An Approach to Design MIMO FO Controllers for Unstable Nonlinear Plants

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IEEE/CAA Journal of Automatica Sinica 2016年第3期3卷 338-344页

作者： Arturo Rojas-moreno IEEE Department of Electrical Engineering Universidad de Ingenieriay Tecnologia (www.utec.edu.pe)

This paper develops an approach to control unstable nonlinear multi-inputs multi-output(MIMO) square plants using MIMO fractional order(FO) controllers. The controller design uses the linear time invariant(LTI) state space representation of the nonlinear model of the plant and the diagonal closedloop transfer matrix(TM) function to ensure decoupling between inputs. Each element of the obtained MIMO controller could be either a transfer function(TF) or a gain. A TF is associated in turn with its corresponding FO TF. For example, a D(Derivative) TF is related to a FO TF of the form Dδ, δ =[0, 1]. Two applications were performed to validate the developed approach via experimentation: control of the angular positions of a manipulator, and control of the car and arm positions of a translational manipulator.

关键词： Fractional calculus modeling of nonlinear sys-tem control of manipulator multivariable decoupling multivari-able nonlinear system

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Combining X-ray microtomography with computer simulation for analysis of granular and porous materials

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Particuology 2010年第2期8卷 81-99页

作者： Roberto moreno-Atanasio Richard A. Williams Institute of Particle Science and Engineering School of Process Environmental and Materials Engineering University of Leeds Leeds LS2 9JT UK

The use of X-ray microtomographic （XMT） methods in analysing particulate systems has expanded rapidly in recent years with the availability of affordable desk-top apparatus. This review presents a summary of the major applications in which computer simulations are explicitly coupled with XMT in the area of granular and porous materials. We envisage two main ways of establishing the coupling between both techniques, based on the transference or exchange of information by using physical or geometrical parameters （i.e. a parametric link through fitting to a process model） or through the direct use of3D XMT digital images （i.e. comparing image pixels and features directly）. Examples of coupled applications are shown for the study of transport properties of rocks, particle packing, mechanical loading and sintering. Often, the link between XMT and computer simulations is based on visual comparisons and we conclude that the use of quantitative parameters such as the number of interparticle contacts, force networks or granule shape to link both techniques is still underrepresented in the literature. Strategies to provide a more robust and quantitative approach to optimise the information obtained from such tomography analyses are proposed. 2010 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

关键词： X-ray microtomographyGranular flowComputer modellingLattice Boltzmann methodDiscrete element method

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Biomimetic Control of Mechanical Systems Equipped with Musculotendon Actuators

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Journal of Bionic Engineering 2011年第1期8卷 56-68页

作者： Javicr moreno-Valenzuel Adriana Salinas-Avila Instituto Politecnico Naoional-CITEDl Av. del Parque 1310 Mesa de Otay Tianjuana B.C. 22510 Mexico

This paper addresses the problem of modelling, control, and simulation of a mechanical system actuated by an agonist-antagonist musculotendon subsystem. Contraction dynamics is given by case 1 of Zajac＇s model. Saturated semi positive proportional-derivative-type controllers with switching as neural excitation inputs are proposed. Stability theory of switched system and SOSTOOLS, which is a sum of squares optimization toolbox of Matlab, are used to determine the stability of the obtained closed-loop system. To corroborate the obtained theoretical results numerical simulations are carried out. As additional contribution, the discussed ideas are applied to the biomimetic control of a DC motor, i.e., the position control is addressed assuming the presence of musculotendon actuators. Real-experiments corroborate the expected results.

关键词： biomimetie control musculotendon dynamics neural excitation saturation switched systems

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On the uncertainty of interwell connectivity estimations from the capacitance-resistance model

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Petroleum Science 2014年第2期11卷 265-271页

作者： Gustavo A moreno Larry W Lake YPF Macacha Güemes 515 YPF-Tecnología Baradero S/N (1925) Center for Petroleum and Geosystems Engineering University of Texas at Austin

The capacitance-resistance model （CRM） is an alternative to conventional reservoir simulation. CRM, a simplification of complex numerical models, uses production and injection rates to infer a reservoir description. There is no prior geologic model. The principal output of CRM fitting is the fraction of injected fluid （usually water） that is produced at a producer at steady-state. These fractions are interwell connectivities. Interwell connectivities are fundamental information needed to manage waterfloods in oil reservoirs. The data-driven CRM is a fast tool to estimate these parameters in mature fields and allows one to make full use of the dynamic data available. This paper considers the problem of setting an upper bound on the uncertainty of interwell connectivities for linear-constrained models. Using analytical bounds and numerical simulations, we derive a consistent upper limit on the uncertainty of interwell connections that can be used to quantify the information content of a given dataset.

关键词： Data-driven models capacitance-resistance model secondary recovery waterfloodoptimization interwell connectivities

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恩沃单抗致皮肤系统不良反应的发生规律及特点

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中国新药杂志 2024年第12期33卷 1289-1296页

作者：凌彩色尹月林茂周歧骥张艳华北京大学肿瘤医院暨北京市肿瘤防治研究所药剂科恶性肿瘤发病机制及转化研究教育部重点实验室北京100142 右江民族医学院附属医院药学部百色533000 四川省肿瘤临床医学研究中心/四川省肿瘤医院研究所/四川省癌症防治中心/电子科技大学附属肿瘤医院药学部成都610041

目的:探讨恩沃单抗(enfortumab vedotin,EV)皮肤药物不良反应(cutaneous adverse drug reactions,CADR)的发生规律和临床表现特点,为临床安全合理用药提供参考。方法:检索中国知网、万方、维普、Pubmed和Web of Science等数据库收载的E... 详细信息

目的:探讨恩沃单抗(enfortumab vedotin,EV)皮肤药物不良反应(cutaneous adverse drug reactions,CADR)的发生规律和临床表现特点,为临床安全合理用药提供参考。方法:检索中国知网、万方、维普、Pubmed和Web of Science等数据库收载的EV相关CADR个案进行分析。结果:收集EV相关CADR个案报道15篇,共30例患者,其中男性28例,女性2例,年龄分布在59~78岁,CADR发生于用药后1~44 d。对于11例确诊中毒性表皮坏死综合征(Stevens-Johnson syndrome,SJS)或中毒性表皮坏死(toxic epidermal necrolysis,TEN)患者,主要病理特点是大量角化细胞坏死或凋亡,临床表现为全身大面积红斑及大疱,并累及口腔、眼睛、鼻子、生殖器等黏膜。而对于其他19例CADR患者,其临床表现和病理特点差异较大且不典型,严重者与SJS/TEN相似,而对于某些CADR较轻的患者仅表现为全身瘙痒伴皮疹。糖皮质激素是目前用于治疗EV引起CADR的主要药物,但是总体效果不佳,经治疗后仍有13例患者(43.3%)发生死亡。结论:临床应加强对EV引起CADR的认识和监测,及时诊断与治疗,确保用药安全。

关键词：恩沃单抗皮肤药物不良反应文献分析

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结合数据增强方法的藏文预训练语言模型

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中文信息学报 2024年第9期38卷 66-72页

作者：色差甲班马宝才让加柔特省部共建藏语智能信息处理及应用国家重点实验室青海西宁810008 青海省藏文信息处理工程技术研究中心青海西宁810008

最近在自然语言处理领域中,预训练加微调模式已然成为新的训练范式。在藏文自然语言处理领域中虽缺乏人工标注数据,但预训练语言模型能够缓解下游任务中数据规模不足和模型重新训练时难以收敛等问题。首先,该文收集整理含有46.55亿字符... 详细信息

最近在自然语言处理领域中,预训练加微调模式已然成为新的训练范式。在藏文自然语言处理领域中虽缺乏人工标注数据,但预训练语言模型能够缓解下游任务中数据规模不足和模型重新训练时难以收敛等问题。首先,该文收集整理含有46.55亿字符的藏文文本语料;然后在UniLM模型的基础上,利用藏文文本特征的数据增强方法和预训练技术相结合的方法预训练藏文语言模型。实验表明,该文方法在藏文La格例句分类和藏文文本分类等四个下游任务中获得显著效果。

关键词：藏文预训练语言模型文本数据增强方法 UniLM模型

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聚氮异丙基丙烯酰胺抗菌水凝胶复合棉织物的制备及其性能

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纺织学报 2024年第5期45卷 129-137页

作者：薛宝霞杨色张春艳刘晶刘勇程伟张利牛梅太原理工大学轻纺工程学院山西太原030024 山西浙大新材料与化工研究院山西太原030032 山西白求恩医院(山西医学科学院同济山西医院) 山西太原030032

为扩大含银抗菌水凝胶的应用和实现缓释抗菌,采用水凝胶复合织物的构建策略,将化学交联与紫外光引发相结合,通过聚氮异丙基丙烯酰胺(PNIPAM)/载银氧化石墨烯(GO-Ag)抗菌水凝胶复合棉织物,形成新型水凝胶复合织物一体化敷料,并探讨不同... 详细信息

为扩大含银抗菌水凝胶的应用和实现缓释抗菌,采用水凝胶复合织物的构建策略,将化学交联与紫外光引发相结合,通过聚氮异丙基丙烯酰胺(PNIPAM)/载银氧化石墨烯(GO-Ag)抗菌水凝胶复合棉织物,形成新型水凝胶复合织物一体化敷料,并探讨不同层数棉织物复合水凝胶对敷料结构与抗菌性能、拉伸性能以及生物安全性等的影响。结果表明:PNIPAM/GO-Ag抗菌水凝胶与3层棉织物构筑的一体化敷料的综合性能优异;在湿态下,一体化敷料比单一棉织物的断裂强力提升73.7%,达到370 N;敷料的体外细胞毒性呈0级,溶血率小于5%,显示出良好的生物安全性;其对大肠杆菌和金黄色葡萄球菌的抗菌率均达到98%以上,在24 h内具有缓慢释放银离子的效果;抗菌作用主要通过持续释放银离子、诱导细菌产生活性氧造成其氧化损伤等多种作用,从而破坏细菌细胞结构。

关键词：聚氮异丙基丙烯酰胺水凝胶缓释抗菌纳米银棉织物敷料

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