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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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18世纪中国的粮价、社会冲突与公共品供给:地区异质性与政府-社会的互补作用

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经济学（季刊） 2024年第1期24卷 205-219页

作者：颜色刘丛北京大学光华管理学院暨南大学经济与社会研究院 510632

本文使用1742年至1795年的府级面板数据,考察政府与地方士绅提供的公共品是否能缓解粮价波动引起的社会冲突。实证分析发现,虽然粮价上涨在全国范围内引起社会冲突,但这一影响在华北和长江下游地区仅为全国的24%,表明两地可能存在某些... 详细信息

本文使用1742年至1795年的府级面板数据,考察政府与地方士绅提供的公共品是否能缓解粮价波动引起的社会冲突。实证分析发现,虽然粮价上涨在全国范围内引起社会冲突,但这一影响在华北和长江下游地区仅为全国的24%,表明两地可能存在某些社会稳定机制。进一步分析显示,政府在华北粮价平抑中发挥了主导作用,而士绅群体对缓解长江下游地区的粮价波动更为有效;这一差别可能源自两地社会经济结构的差异。

关键词：政府仓储社会组织社会稳定

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Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

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Journal of Integrative Medicine 2024年第5期22卷 600-613页

作者： Mijung Yeom Sora Ahn Dae-Hyun Hahm Sun-Young Jang se Hoon Jang Su-Yang Park Jae-Hwan Jang Jihan Park Ju-Young Oh In-seon Lee Kyuseok Kim Soon-Kyeong Kwon Hi-Joon Park Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Department of Physiology School of MedicineKyung Hee UniversitySeoul 02447Republic of Korea BioNanocomposite Research Center Kyung Hee UniversitySeoul 02447Republic of Korea Department of Science in Korean Medicine College of Korean MedicineGraduate SchoolKyung Hee UniversitySeoul 02447Republic of Korea College of Korean Medicine Kyung Hee UniversitySeoul 02447Republic of Korea Department of Ophthalmology Otorhinolaryngology and Dermatology of Korean MedicineCollege of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju 52828Republic of Korea Department of Anatomy&Information Sciences College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea

Objective Atopic dermatitis(AD)is a chronic inflammatory skin disease that may be linked to changes in the gut *** has been proven to be effective in reducing AD symptoms without serious adverse events,but its underlying mechanism is not completely *** purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut *** AD-like skin lesions were induced by applying MC903 topically to the cheek of the *** was done at the Gok-Ji(LI11)***-like symptoms were assessed by lesion scores,scratching behavior,and histopathological changes;intestinal barrier function was measured by fecal output,serum lipopolysaccharide levels,histopathological changes,and mRNA expression of markers involved in intestinal permeability and *** microbiota was profiled using 16S rRNA gene sequencing from fecal *** Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening,and also significantly altered gut microbiota structure as revealed byβ-diversity indices and analysis of *** beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated ***,AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability,atrophy of the mucosal structure(reduced villus height and crypt depth),decreased expression of tight junctions and mucus synthesis genes,and increased expression of inflammatory mediators in the *** attenuated these abnormalities,which was gut *** Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier,providing new perspective for non-pharmacological strategies for

关键词： Atopic dermatitis Acupuncture Gut microbiota Intestinal barrier function

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Growth of the Earthworm Millsonia omodeoi and Its Capacity to Accumulate Five Heavy Metals (HM) in Soils along a Toll Highway in Côte d’Ivoire

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Open Journal of Soil Science 2024年第1期14卷 115-132页

作者： Mamadou Toure Kpan Kouakou Gains Kpan N’guetta Moïse Ehouman seydou Tiho Laboratory of Ecology and Sustainable Development (LEDD) Department of Natural Sciences (UFR SN) University Nangui ABROGOUA Abidjan C&#244te d’Ivoire

The roads in correlation with the traffic linked to their existences are at the origin of the emission of numerous polluting substances likely to induce disturbances of the growth and the behavioral changes in the organisms living in their vicinities. The purpose of this study is to analyze the growth and capacity accumulation of a common earthworm species (Millsonia omodeoi) in Cu, Cr, Ni, Pb and Zn in soils along a main road called “Autoroute du Nord” in C?te d’Ivoire. Thus, the earthworms were harvested in soils from a distance of 0 m (just after the sidewalk) to a distance of 200 m from the toll highway and in a control soil sampled in Lamto reserve (C?te d’Ivoire). The study was carried out in the soil laboratory at the ecological station of Lamto reserve. The Ford-Walford technique was used to determine the model and parameters most appropriated for describing the growth of earthworms. A pairwise comparison of the growth parameters was carried out using the Kruskal-Wallis test with the STATISTICA 7.1 software. The heavy metals contained in the cultivated soils and earthworms were detected and quantified using a Scanning Electron Micro-scope (MEB FEG Supra 40 VP Zeiss) and an Atomic Absorption Spectrometer SPECTRA 110 (VARIAN). The capacity accumulation of heavy metals in earthworm was determined by the bioaccumulation factor (BAF) calculation. The results of this study showed that Gompertz is the most appropriated model to describe the growth of M. omodeoi. The life cycle of M. omodeoi shows that this earthworm adopts a K type demographic strategy. Cu is the most accumulated heavy metals in M. omodeoi, when Cr is the least accumulated. Concerning heavy metal content in the earthworms, it decreases while moving away from the pavement. These results highlight a possibility of choice of M. omodeoi as 1) indicators of heavy metals pollution and 2) target of biological organisms for environmental impact studies.

关键词： M. omodeoi Bioaccumulation Heavy Metals “Autoroute du Nord” Côte d’Ivoire

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Metallurgical Microstructure Complexity in the Electron Beam Welding (EBW) Joint of Ti6246

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Journal of Minerals and Materials Characterization and Engineering 2024年第2期12卷 100-111页

作者： Daniel moreno Yohanan Nachmana Roei Saraga Tal Rokah Denis Panchenco Michael Mansano Elinor Itzhaky Moshe Shapira Beth Shemesh Engines LTD FAA & EASA Beth Shemesh Israel

Electron Beam Welding (EBW) is employed to both melt and unite materials, influencing their thermal history and subsequently determining the microstructure and properties of the welded joint. Welding Titanium alloys involves undergoing local melting and rapid solidification, subjecting the material to thermal stresses induced by a thermal expansion coefficient of 9.5 × 10 m/m°C. This process, reaching range temperatures from the full melting alloy to room temperature, results in phase formation dictated by the thermodynamic preferences of the alloyed elements, posing a significant challenge. Recent efforts in simulation and calculations have been undertaken elsewhere to address this challenge. This study focuses on a joint of two plates with differing cross-sectional areas, influencing heat transfer during welding. This report presents a case study focusing on the metallurgical changes observed in the microstructure within the welded zone, emphasizing alterations in the cooling rate of the welded joint. The investigation utilizes optical metallography, Vickers’s Hardness testing, and seM (scanning electron microscopy) to comprehensively characterize the observed changes in addition to heat transfer simulation of the welded zone.

关键词： Ti Alloys Welding Phase Formation Hardness Metallography

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Ventriculo-atrial shunt with occlusion of the internal jugular vein: operative experience and surgical technique

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中华神经外科杂志(英文) 2024年第2期10卷 1-8页

作者： Quintero Silvia Tatiana Ramirez-Velandia Felipe moreno Andres Felipe Hortua Vera Lina Rugeles Paula Gonzalez Rafael Augusto Azuero Pontificia Universidad Javeriana Clinica Medilaser S.A.S. Clinica Chicamocha Bucaramanga Santander Colombia Neurology and Neurosurgery Research Group Pontificia Universidad Javeriana Bogotá D.C. Colombia Universidad Industrial de Santander Clinica Chicamocha Bucaramanga Colombia Universidad Autónoma de Bucaramanga Clinica Chicamocha Bucaramanga Colombia Clinica Chicamocha Bucaramanga Santander Colombia

Background Ventricular shunts are one of the most frequent techniques used for the management of hydrocephalus. The ventriculoperitoneal shunt (VPS) is the most commonly performed procedure, and the ventriculoatrial shunt (VAS) is the second option in most medical centers. The main objective of this study is to introduce and describe a surgical approach for VAS outlining our experience and comparing it with traditional shunting *** In this retrospective cohort comparison study, we included patients with hydrocephalus treated with a surgical procedure between January 2010 and February 2021 at a single academic institution. We categorized the procedures into two groups: patients with VPS and conventional VAS grouped together into the conventional technique (CT) group, and the second group was patients with whom we performed VAS with complete internal jugular vein occlusion (IJVOT). We compared the surgical time, postoperative complications, and occurrence of shunt failure among the groups by performing univariate analysis using the Fisher exact *** Out of the 106 patients included in the analysis, IJVOT was performed in 66 patients, and CT in 40 patients. The median surgical time was 60 min (IQR 60-90) for IJVOT versus 100 min (IQR 60-120) for CT (p sent study represents the first cohort evaluating IJVOT, it is imperative to conduct larger prospective studies, along with clinical trials, to fully explore and establish efficacy, long-term outcomes, and an in-depth comparison among shunting techniques

关键词： Hydrocephalus Ventriculoatrial shunting Internal jugular vein Operative time Complications Shunt removal

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将时间维度融入城市规划的呼吁

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国际城市规划 2024年第3期39卷 1-2页

作者：卡洛斯·莫雷诺罗雪瑶(译) 巴黎索邦大学北京大学城市与环境学院

我们一直从空间的角度来认识和建构城市。然而,城市并非仅由空间要素构成,还包含流动性和时间性要素。在过去50年中,城市的流动性和时间性在不断加速。交通方式、通信技术和生活方式的快速发展使得城市始终保持着高度活跃和快速更迭状... 详细信息

我们一直从空间的角度来认识和建构城市。然而,城市并非仅由空间要素构成,还包含流动性和时间性要素。在过去50年中,城市的流动性和时间性在不断加速。交通方式、通信技术和生活方式的快速发展使得城市始终保持着高度活跃和快速更迭状态。同时,由于全球超过一半的人口居住在城市地区,高密度的城市也影响着居民的日常生活质量。此外,依赖于长距离移动的城市模式也带来了严重的污染和环境破坏问题。

关键词：时间维度空间要素日常生活质量时间性环境破坏问题流动性长距离融入城市

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Influence of Continental Atmospheric Forcing on the Decadal Variability of the West African Monsoon

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Atmospheric and Climate Sciences 2024年第1期14卷 1-28页

作者： Adjoua Moïse Landry Famien Sandrine Djakouré Bi Tra Jean Claude Youan serge Janicot Abé Delfin Ochou Arona Diedhiou Département des Sciences et Techniques Université Alassane Ouattara de Bouaké Bouaké C&#244te d’Ivoire LASMES-UFR SSMT Université Félix Houphou&#235t Boigny d’Abidjan Abidjan C&#244te d’Ivoire LSS-UFR SSMT Université Félix Houphou&#235t Boigny d’Abidjan Abidjan C&#244te d’Ivoire Laboratoire d’Océanographie et du Climat: Expérimentations et Approches Numériques Sorbonne Université IRD CNRS MNHN Paris France Université Grenoble Alpes IRD CNRS Grenoble INP IGE Grenoble France UFHB-IRD Joint International Laboratory of Research on NEXUS Climate Water Energy and Agriculture and Development of Cli-mate Services African Centre of Excellence CCBAD (Climate Change Biodiversity and Sustainable Agriculture) Université Félix Houphou&#235t-Boigny Abidjan C&#244te D’Ivoire

The West African Monsoon (WAM) is characterized by strong decadal and multi-decadal variability and the impacts can be catastrophic for the local populations. One of the factors put forward to explain this variability involves the role of atmospheric dynamics, linked in particular to the Saharan Heat Low (SHL). This article addresses this question by comparing the sets of preindustrial control and historical simulation data from climate models carried out in the framework of the CMIP5 project and observations data over the 20th century. Through multivariate statistical analyses, it was established that decadal modes of ocean variability and decadal variability of Saharan atmospheric dynamics significantly influence decadal variability of monsoon precipitation. These results also suggest the existence of external anthropogenic forcing, which is superimposed on the decadal natural variability inducing an intensification of the signal in the historical simulations compared to preindustrial control simulations. We have also shown that decadal rainfall variability in the Sahel, once the influence of oceanic modes has been eliminated, appears to be driven mainly by the activity of the Arabian Heat Low (AHL) in the central Sahel, and by the structure of the meridional temperature gradient over the inter-tropical Atlantic in the western Sahel.

关键词： Influence of Continental Atmospheric Forcing on the Decadal Variability of the West African Monsoon

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Local Plants Potentially Suitable for Phytoremediation of Soils Polluted by Heavy Metals: The Case of Landfill Sites

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Journal of Geoscience and Environment Protection 2024年第7期12卷 72-88页

作者： Kpan Kpan Kouakou Gains Touré Mamadou Ouattara Nouffou Doudjo Kouassi Kouadio Claude Ehouman N’guetta Moïse Ouattara Djibril Tiho seydou UFR Sciences de la Nature Universit Nangui Abrogoua Abidjan Cte dIvoire UFR Agroforesterie Universit Jean Lorougnon Gud Daloa Cte dIvoire

Landfills are contaminated sites that need to be cleaned up to prevent human and environmental exposure to pollutants. This article aims to identify local plants capable of restoring soil polluted by heavy metals. To this end, plant species at the Bonoua landfill were inventoried. X-ray fluorescence spectrometry was used to determine the heavy metal content of soil and plants from the landfill. The bioconcentration factor (BCF) of metals in plants was evaluated. The Bonoua landfill is covered with 62 plant species, comprising 28 botanical families and 50 genera. The BCF varied from 0.08 (titanium) to 2.27 (strontium) for Phyllanthus amarus;from 0.06 (titanium) to 1.83 (copper) for Alternanthera sessilis and from 0.03 (arsenic) to 2.10 (strontium) for Amaranthus spinosus. Phyllanthus amarus, Alternanthera sessilis, and Amaranthus spinosus are strontium-accumulating species (BCF > 1). Similarly, copper BCF values were above 1 for Phyllanthus amarus, and Alternanthera sessilis. These two plant species are therefore copper accumulators. In short, Phyllanthus amarus, Alternanthera sessilis, and Amaranthus spinosus are candidate species for phytoremediation of heavy metal-polluted soils, given their BCF > 1.

关键词： Heavy Metals Phytoremediation Phyllanthus amarus Alternanthera sessilis Amaranthus spinosus

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Modeling the Kinetics of Moisture Desorption from Safou Pulp [Dacryodes edulis (G. Don) ***] before the Oil Extraction Step

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Open Journal of Applied Sciences 2024年第8期14卷 2050-2064页

作者： Anicet Frédéric Binaki Feueltgaldah Christian Bopoundza Bob Wilfrid Loumouamou Gueko Séraphin Nguié Eliane Thérèse Biassala Thomas Silou Multidisciplinary Food and Nutrition Research Team Regional Center of Excellence in Food and Nutrition Faculty of Science and Technology Marien Ngouabi University Brazzaville Congo Process Engineering Laboratory UNESCO-ENSP Chair Marien Ngouabi University Brazzaville Congo CR2IE Chemistry and Technology Platform Higher School of Cataract Technology (EPrES) Brazzaville Congo

The aim of this work is to model the drying kinetics of Safou pulp with or without endocarp using a phenomenological approach. Oven-drying kinetics at 70˚C, 90˚C and 105˚C were monitored using the curves given by the reduced mass as a function of time, which are modeled according to the Avrami/page, Fick and Peleg models using OringinPro 2018 software. The results showed that parameters k and n of the Avrami/Page model vary very little with fruit size and drying temperature (0.0018 ± 0.0002 k n k (Avrami model/page) were virtually identical, while b (Fick model) and n (Avrami model/page) were virtually identical for the same sample. For the Peleg model, the parameter a, varies from 0.0018 ± 0.0002 to 0.03328 ± 0.0079, with a ratio of 18.6 for all experimental conditions studied. However, with 0.977 R2 χ2 se three models can be used to describe and predict the progress of oven-drying of safou pulp.

关键词： Drying Modeling Empirical Models Dacryodes edulis Congo Basin

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