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Anti-inflammatory and antinociceptive activities of Rhipicephalus microplus saliva

Asian Pacific Journal of Tropical Biomedicine 2018年第4期8卷 194-200页

作者： DF.Buccini AA.Nunes GGO.Silva ON.Silva OL.Franco se.moreno Programa de Pos-Graduacao em Biotecnologia e Biodiversidade Universidade Federal do Mato Grosso do Sul S-Inova Biotech Programa de Pos-Graduacao em Biotecnologia Universidade Catolica Dom Bosco Programa de Pos-Graduacao em Patologia Molecular Universidade de Brasilia Centro de Analises Proteomicas e Bioquimicas Programa de Pos-Graduacao em Ciencias Genomicas e Biotecnologia Universidade Catolica de Brasilia

To evaluate the antinociceptive and anti-inflammatory activities and the toxic effects of Rlhipicephalus microplus saliva for elucidating the modulation mechanism between arthropod saliva and ***:For saliva collection,engorged ticks were obtained from a controlled bovine infestation and collected by natural *** ticks were fixed and injected pilocarpine 0.2%for induction of *** was collected,lyophilized and stored at-80℃.Cytotoxic activity was assessed by the hemolysis method(25,50,100,200 and 300μg/mL)and MTT cell viability assay(2.5,5,10,20 and 40μg/mL)for 24,48 and 72 ***-inflammatory activity was evaluated using the method of neutrophil migration to the peritoneal cavity of mice at doses of l0,15 and 20 mg/kg;antinociceptive activity was assessed using the acetic acid-induced writhing test,and formalin-induced paw-licking in mice at dose of 15 mg/***:Saliva did not cause erythrocytes hemolysis at any concentration tested,as well as did not decrease cell viability in the MTT *** inhibited neutrophil migration by 87%and 73%at doses of l5 and 20 mg/kg,*** the nociceptive tests,saliva presented analgesic activity of69.96%in the abdominal writhing test,and of 84.41%in the formalin *** study proves that Rlhipiceplhalus microplus saliva has significant in vivo anti-inflammatory and antinociceptive *** data presented herein support the development of further studies to elucidate the active principles of Rhipicephalus microplus saliva and its mechanism of action and,in future,to develop novel anti-inflammatory and analgesic drugs.

关键词： Rhipicephalus microplus Saliva Tick Antinociceptive Anti-inflammatory

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Theoretical insights of the pharmaceutical compound fluoxetine in water:Role in direct photolysis and indirect photolysis by free radicals

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Journal of Environmental Sciences 2024年第8期142卷 269-278页

作者： Ying Lu se Wang Yifan Shen School of Environmental Science and Engineering Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologyJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlNanjing University of Information Science and TechnologyNanjing 210044China

The frequent detection of pharmaceutical compounds in the environment has led to a growing awareness,which may pose a major threat to the aquatic *** this study,photodegradation(direct and indirect photolysis)of two different dissociation states of fluoxetine(FLU)was investigated in water,mainly including the determination of photolytic transition states and products,and the mechanisms of indirect photodegradation with·OH,CO_(3)^(*-)and NO_(3)^(*).The main direct photolysis pathways are defluorination and C–C bond *** addition,the indirect photodegradation of FLU in water is mainly through the reactions with·OH and NO_(3)^(*),and the photodegradation reaction with CO_(3)^(*-)is relatively difficult to occur in the water *** results provide a theoretical basis for understanding the phototransformation process of FLU in the water environment and assessing its potential risk.

关键词： Fluoxetine Photochemical mechanism Direct photolysis Free radical reaction DFT

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Presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

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Neural Regeneration Research 2024年第3期19卷 485-486页

作者： Juan JoséPérez-moreno Instituto de Biomedicina de sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSP)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower *** ients can also experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes have been implicated in HSP,encompassing various cellular components,although mutations in genes encoding endoplasmic reticulum(ER)-shaping proteins are the most prevalent(Parodi et al.,2017).ER-shaping proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSP.

关键词： reticulum endoplasmic

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Experimental implementation of phase triplicator gratings in a spatial light modulator

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Chinese Optics Letters 2024年第2期22卷 64-69页

作者：高尚 María del Mar Sánchez-López Ignacio moreno Instituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Física Aplicada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Materiales Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this work,we compare different methods for implementing a triplicator,a phase grating that generates three equiintense diffraction *** design with optimal efficiency features a continuous phase profile,which cannot be easily reproduced,and is typically affected by *** compare its performance with binary and sinusoidal phase *** also analyze the effect of quantizing the phase ***,a random approach is adopted to eliminate the additional harmonic *** all cases,a liquid-crystal-on-silicon spatial light modulator is employed to experimentally verify and compare the different approaches.

关键词： diffraction gratings phase modulation triplicator spatial light modulators

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Pathological and therapeutic effects of extracellular vesicles in neurological and neurodegenerative diseases

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Neural Regeneration Research 2024年第1期19卷 55-61页

作者： Paula lzquierdo-Altarejos Victoria moreno-Manzano Vicente Felipo Laboratory of Neurobiology Centro Investigación Príncipe FelipeValenciaSpain Neuronal and Tissue Regeneration Laboratory Centro Investigación Príncipe FelipeValenciaSpain

Extracellular vesicles are released by all cell types and contain proteins,microRNAs,mRNAs,and other bioactive *** vesicles play an important role in intercellular communication and in the modulation of the immune system and *** cargo of extra cellular vesicles(e.g.,proteins and microRNAs)is altered in pathological *** vesicles contribute to the pathogenesis of many pathologies associated with sustained inflammation and neuroinflammation,including cance r,diabetes,hype rammonemia and hepatic encephalopathy,and other neurological and neurodegenerative *** vesicles may cross the blood-brain barrier and transfer pathological signals from the periphery to the *** contributes to inducing neuroinflammation and cognitive and motor impairment in hyperammonemia and hepatic encephalopathy and in neurodegenerative *** mechanisms involved are beginning to be unde *** example,increased tumor necrosis factor a in extracellular vesicles from plasma of hype rammonemic rats induces neuroinflammation and motor impairment when injected into normal *** the mechanisms by which extracellular vesicles contribute to the pathogenesis of these diseases will help to develop new treatments and diagnostic tools for their easy and early *** contrast,extra cellular vesicles from mesenchymal stem cells have therapeutic utility in many of the above pathologies,by reducing inflammation and neuroinflammation and improving cognitive and motor *** extra cellular vesicles recapitulate the beneficial effects of mesenchymal stem cells and have advantages as therapeutic tools:they are less immunoge nic,may not diffe rentiate to malignant cells,cross the blood-brain barrier,and may reach more easily target *** vesicles from mesenchymal stem cells have beneficial effects in models of ischemic brain injury,Alzheimer's and Parkinson's diseases,hyperammonemia,and

关键词： extracellular vesicles inflammation cognitive function mesenchymal stem cells neurodegenerative diseases neuroinflammation therapy transforming growth factor-β

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Boosted Lithium-Ion Transport Kinetics in n-Type Siloxene Anodes Enabled by selective Nucleophilic Substitution of Phosphorus

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Nano-Micro Letters 2024年第10期16卷 618-637页

作者： se In Kim Woong-Ju Kim Jin Gu Kang Dong-Wan Kim School of Civil Environmental and Architectural EngineeringKorea University02841 SeoulSouth Korea Nanophotonics Research Center Korea Institute of Science and Technology02792 SeoulSouth Korea

Doped two-dimensional(2D)materials hold significant promise for advancing many technologies,such as microelectronics,optoelectronics,and energy ***,n-type 2D oxidized Si nanosheets,namely n-type siloxene(n-SX),are employed as Li-ion battery *** thermal evaporation of sodium hypophosphite at 275℃,P atoms are effectively incorporated into siloxene(SX)without compromising its 2D layered morphology and unique Kautsky-type crystal ***,selective nucleophilic substitution occurs,with only Si atoms being replaced by P atoms in the O_(3)≡Si-H *** resulting n-SX possesses two delocalized electrons arising from the presence of two electron donor types:(i)P atoms residing in Si sites and(ii)H *** doping concentrations are varied by controlling the amount of precursors or their mean free *** at 2000 mA g^(-1),the n-SX electrode with the optimized doping concentration(6.7×10^(19) atoms cm^(-3))delivers a capacity of 594 mAh g^(-1) with a 73%capacity retention after 500 *** improvements originate from the enhanced kinetics of charge transport processes,including electronic conduction,charge transfer,and solid-state *** approach proposed herein offers an unprecedented route for engineering SX anodes to boost Li-ion storage.

关键词： Li-ion battery Two-dimensional N-type siloxene Doping mechanism Kinetics

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Modeling Geometrically Nonlinear FG Plates: A Fast and Accurate Alternative to IGA Method Based on Deep Learning

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2793-2808页

作者： se Li Tiantang Yu Tinh Quoc Bui College of Mechanics and Materials Hohai UniversityNanjing211100China Duy Tan Research Institute for Computational Engineering(DTRICE) Duy Tan UniversityHo Chi Minh CityVietnam

Isogeometric analysis (IGA) is known to showadvanced features compared to traditional finite element *** IGA one may accurately obtain the geometrically nonlinear bending behavior of plates with functionalgrading (FG). However, the procedure is usually complex and often is time-consuming. We thus put forward adeep learning method to model the geometrically nonlinear bending behavior of FG plates, bypassing the complexIGA simulation process. A long bidirectional short-term memory (BLSTM) recurrent neural network is trainedusing the load and gradient index as inputs and the displacement responses as outputs. The nonlinear relationshipbetween the outputs and the inputs is constructed usingmachine learning so that the displacements can be directlyestimated by the deep learning network. To provide enough training data, we use S-FSDT Von-Karman IGA andobtain the displacement responses for different loads and gradient indexes. Results show that the recognition erroris low, and demonstrate the feasibility of deep learning technique as a fast and accurate alternative to IGA formodeling the geometrically nonlinear bending behavior of FG plates.

关键词： FG plates geometric nonlinearity deep learning BLSTM IGA S-FSDT

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Novel umami peptides from two Termitomyces mushrooms and molecular docking to the taste receptor T1R1/T1R3

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Food Science and Human Wellness 2024年第2期13卷 1055-1064页

作者： Lanyun Zhang Li Zhang Jesus Pérez-moreno Lu Bin Fengming Zhang Fuqiang Yu The Germplasm Bank of Wild Species Yunnan Key Laboratory for Fungal Diversity and Green DevelopmentKunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Chemical Science and Technology Yunnan UniversityKunming 650091China College of Food Science and Technology Yunnan Agricultural UniversityKunming 650201China Colegio Postgraduados Campus MontecilloEdafologíaTexcoco 56230México Key Laboratory for Forest Resources Conservation and Use in the Southwest Mountains of China Southwest Forestry UniversityKunming 650224China

Wild edible Termitomyces mushrooms are popular in Southwest China and umami is important flavor qualities of edible *** study aimed to understand the umami taste of Termitomyces intermedius and Termitomyces *** umami peptides from aqueous extracts were separated using a sephadex G-15 gel filtration *** intense umami fraction was evaluated by both sensory evaluation and electronic *** were identified as KLNDAQAPK,DSTDEKFLR,VGKGAHLSGEH,MLKKKKLA,SLGFGGPPGY,TVATFSSSTKPDD,AMDDDEADLLLLAM,VEDEDEKPKEK,SPEEKKEEET and *** peptides,except VEDEDEKPKEK,SPEEKKEEET and PEGADKPNK were selectively synthesized to verify their taste *** these 10 peptides had umami or salt *** 10 peptides were conducted by molecular docking to study their interaction with identified peptides and the umami taste receptor T1R1/*** these 10 peptides perfectly docked the active residues in the T1R3 *** results provide theoretical basis for the umami taste and address the umami mechanism of two wild edible Termitomyces mushrooms.

关键词： Termitomyces Non-volatile flavor compounds Umami peptides Taste characteristics Molecular docking

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Adsorption of pharmaceutical pollutants on ZnCl_(2)-activated biochar from corn cob:Efficiency,selectivity and mechanism

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Journal of Bioresources and Bioproducts 2024年第1期9卷 58-73页

作者： Christian F.Varela L.C.moreno-Aldana Yazmin Yaneth Agámez-Pertuz Department of Chemistry National University of ColombiaAv.Carrera 30 No.45-03BogotáD.C.Colombia Department of Biology and Chemistry University of the Llanoskm 12 road to Puerto LópezVillavicencioColombia

The occurrence of pharmaceuticals in water bodies and drinking water poses risks for the envi-ronment and human health,thus it is necessary to study methodologies that allow the efficient removal of these *** this work,corn cob-derived biochar was obtained by ZnCl_(2)-activation,and subsequent carbonization at 700℃.The effect of contact time,temperature,pH,and initial concentration on the adsorption capacity of acetaminophen(ACE)and amoxicillin(AMX)was determined through batch *** addition,the kinetics,isotherms,and ther-modynamics parameters were *** activated biochar exhibited a maximum adsorp-tion capacity of 332.08 mg/g for ACE and 175.86 mg/g for *** adsorption kinetics and adsorption isotherm of ACE corresponded to the pseudo-second order and Langmuir model,***,pseudo-first-order kinetics and the Freundlich isotherm model were well-fitted to AMX *** ACE and AMX co-adsorption had a synergistic effect on AMX but an antagonistic effect on ACE removal,achieving a maximum adsorption capacity of 193.51 and 184.58 mg/g,*** the other hand,fixed-bed column experiments showed that the adsorption capacity depends on the influent concentration,and the breakthrough curve fits the Thomas and Yoon-Nelson *** mechanism adsorption studies showed that surface inter-actions(hydrogen bonding formation and n-𝜋interactions)are the main driving forces for the adsorption process,and pore filling is the rate-limiting *** this way,the prepared biochar exhibits a high potential for the adsorption of pharmaceutical compounds from water.

关键词： Biochar Adsorption Acetaminophen Amoxicillin Wastewater treatment

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Ca-based materials derived from calcined cigarette butts for CO_(2)capture and thermochemical energy storage

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Journal of Environmental Sciences 2024年第6期140卷 230-241页

作者： Nabil Amghar Virginia moreno Pedro E.Sánchez-Jiménez Antonio Perejón Luis A.Pérez-Maqueda Instituto de Ciencia de Materiales de sevilla C.S.I.C.-Universidad de SevillaC.Américo Vespucio4941092 SevillaSpain Instituto de Tecnología de Materiales(ITM) Universitat Politècnica de València(UPV)Plaza Ferrándiz y Carbonell 1AlcoyAlicante 03801Spain Departamento de Química Inorgánica Facultad de QuímicaUniversidad de Sevilla41012 SevillaSpain

Cigarette butts(CBs)are one of the most common types of litter in the *** to the toxic substances they contain,the waste generated poses a harmful risk to the environment,and therefore there is an urgent need for alternative solutions to landfill ***,this work presents a possible revalorization of this waste material,which implies interesting environmental *** were used as sacrificial templates for the preparation of CaO-based materials by impregnation with calcium and magnesium nitrates followed by flaming *** materials presented enhanced porosity for their use in the Calcium Looping process applied either to thermochemical energy storage or CO_(2)capture *** influence of the concentration of Ca and Mg in the impregnating solutions on the multicycle reactivity of the samples was *** improved multicycle performance was obtained in terms of conversion for both applications.

关键词： Cigarette butts Calcium-Looping CO_(2)Capture Thermochemical energy storage

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