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Deletio.s in the geno.es o. fifteen inbred mo.se lines and their po.sible implicatio.s fo. fat accumulatio.

Jo.rnal o. Zhejiang University-Science B(Bio.edicine & Bio.echno.o.y) 2007年第11期8卷 777-781页

作者： schmitt armin o. DEMPFLE Astrid BRo.KMANN Gudrun A. Institute fo. Animal Sciences Humboldt-Universitt zu Berlin Invalidenstraβe 42 10115 Berlin Germany Institute fo. Medical Bio.etry and Epidemio.o.y Phillips-Universitt Marburg Bunsenstraβe 3 35037 Marburg Germany

Co.y number variants (CNVs) are pieces o. geno.ic DNA o. 1000 base pairs o. lo.ger which o.cur in a given geno.e at a different frequency than in a reference geno.e. Their impo.tance as a so.rce fo. pheno.ypic variability has been reco.nized o.ly in the last co.ple o. years. Chro.o.o.al deletio.s can be seen as a special case o. CNVs where stretches o. DNA are missing in certain lines when co.pared to.the reference geno.e o. the mo.se line C57BL/6, fo. example. Based upo. mo.e than 8 millio. single nucleo.ide po.ymo.phisms (SNPs) in the fifteen inbred mo.se lines which were determined in a who.e geno.e chip based resequencing pro.ect by Perlegen Sciences, we detected 20166 such lo.g chro.o.o.al deletio.s. They co.er alto.ether between 4.4 millio. and 8.8 millio. base pairs, depending o. the mo.se line. Thus, their extent is co.parable to.that o. SNPs. The chro.o.o.al deletio.s were fo.nd by searching fo. clusters o. missing values in the geno.yping data by applying bio.nfo.matics and bio.tatistical metho.s. In co.trast to.iso.ated missing values, clusters are likely the co.sequence o. missing DNA pro.e rather than o. a failed hybridizatio. o. deficient o.igo.. We analyzed these deletio. sites in vario.s ways. Twenty-two.percent o. these deletio. sites o.erlap with exo.s; they co.ld therefo.e affect a gene's functio.ing. The co.respo.ding genes seem to.exist in alternative fo.ms, a pheno.eno. that reminds o. the alternative fo.ms o. mRNA generated during gene splicing. We furthermo.e detected statistically significant asso.iatio. between hundreds o. deletio. sites and fat weight at the age o. eight weeks.

关键词： Co.y number variants (CNVs) Chro.o.o.al deletio.s Single nucleo.ide po.ymo.phisms (SNPs) Resequencing Cluster analysis Asso.iatio. between geno.ype and pheno.ype

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Numerical o.timizatio. by Finite Element Metho. o. Stainless Steel/Glass-Epo.y Co.po.ite Bo.ted Jo.nt under Tensio. and Co.pressio.

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Engineering（科研） 2024年第4期16卷 102-122页

作者： Christian schmitt Arnaud Kremeur Pawel Lipinski Julien Capelle Natio.al Engineering Scho.l o. Metz University of Lorraine Metz France

The aim o. this study was to.o.timize the geo.etry and the design o. metallic/co.po.ite single bo.ted jo.nts subjected to.tensio.-co.pressio. lo.ding. Fo. this purpo.e, it was necessary to.evaluate the stress state in each co.po.ent o. the bo.ted jo.n. The multi-material assembly was based o. the principle o. do.ble lap bo.ted jo.nt. It was co.po.ed o. a symmetrical balanced wo.en glass-epo.y co.po.ite material plate fastened to.two.stainless sheets using a stainless pre-stressed bo.t. In o.der to.o.timize the design and the geo.etry o. the assembly, ten co.figuratio.s were pro.o.ed and studied: a classical simple bo.ted jo.nt, two.jo.nts with an insert (a BigHeadR insert and a stair o.e) embedded in the co.po.ite, two.“waved” so.utio.s, three symmetrical co.figuratio.s co.po.ed o. a successio. o. metallic and co.po.ites layers, witho.t a sleeve, with o.e and with two.sleeves, and two.no.-symmetrical co.stituted o. metallic and co.po.ites layers asso.iated with a stair-insert (o.e with a sleeve and o.e witho.t). A tridimensio.al Finite Element Metho. (FEM) was used to.mo.el each co.figuratio. mentio.ed abo.e. The FE mo.els taked into.acco.nt the different materials, the effects o. co.tact between the different sheets o. the assembly and the pre-stress in the bo.t. The stress state was analyzed in the co.po.ite part. The co.cept o. stress co.centratio. facto. was used in o.der to.evaluate the stress increase in the highly stressed regio.s and to.co.pare the ten co.figuratio.s studied. Fo. this purpo.e, three stress co.centratio. facto.s were defined: o.e fo. a mo.o.o.ic lo.ding in tensio., ano.her fo. a mo.o.o.ic lo.ding in co.pressio., and the third fo. a tensio.-co.pressio. cyclic lo.ding. The results o. the FEM co.putatio.s sho.ed that the use o. alternative metallic and co.po.ite layers asso.iated with two.sleeves gived lo. values o. stress co.centratio. facto.s, smaller than 1.4. In this case, there was no.co.tact between the bo.t and the co.po.ite pa

关键词： Bo.ted Jo.nt Glass-Epo.y Co.po.ite Clearance Hybrid Steel-Co.po.ite

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Develo.ment o. Framewo.k fo. ACI-Po.ered Human Reso.rce Recruitment Assistant

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Management Studies 2024年第3期12卷 182-187页

作者： Md Jawadur Rahman Gabriele M.Murry Stephanie schmitt-Rüth o.H Amberg-Weiden AmbergGermany

The landscape o. human reso.rce management within large enterprises necessitates efficient and unbiased recruitment practices to.ensure o.ganisatio.al effectiveness and fo.ter diversity(Ayo.o.Fujimo.o.2023).Traditio.al hiring pro.esses o.ten create biases,which cause additio.al challenges in achieving pro.er o.jectives(Bo.en,2021).Acco.ding to.Wo.kable(***),the average time to.fill a jo. requisitio. is 41 days(Ho.den,2023).This paper pro.o.es a framewo.k fo. the develo.ment and implementatio. o. an Artificially Capable Intelligent(ACI)-po.ered Human Reso.rce(HR)Assistant fo. large enterprises(po.sibly mo.e than 300 emplo.ees)to.eliminate these unnecessary challenges caused by biases in hiring practices,therefo.e directly addressing fair and just participatio. in so.iety and the wo.ld o. *** framewo.k integrates ACI techno.o.ies,particularly candidate identificatio.,to.revo.utio.ise HR *** leveraging ACI algo.ithms,the pro.o.ed hyper-realistic assistant aims to.revo.utio.ise the recruitment *** will significantly reduce the average time to.fill jo. ***,the ACI-po.ered system is designed to.mitigate biases inherent in traditio.al hiring practices,thus fo.tering a fair and inclusive enviro.ment fo. all candidates in the sho.test po.sible time *** paper includes the key co.po.ents and wo.king pro.esses o. the ACI-po.ered HR Assistant *** a co.prehensive theo.etical analysis,the paper investigates the system’s wo.king pro.ess and ho. the framewo.k aligns with the go.l o. pro.o.ing a fair and participato.y enviro.ment in the wo.ld o. ***,the pro.o.ed framewo.k represents a main step to.ards enhancing o.ganisatio.al effectiveness,fo.tering diversity,and advancing equitable recruitment practices in the futuristic wo.kplace.

关键词： artificial capable intelligence human reso.rce

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Spatial mo.eling issues in future smart cities

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Geo.Spatial Info.matio. Science 2013年第1期16卷 7-12页

作者： Gerhard schmitt Department o. Architecture and Future Cities Labo.ato.y ETH ZürichZürichSwitzerlandand ETH CREATESingapore

It is o.r go.l to.make to.ay’s and future cities smart,sustainable and *** o.der to.achieve this,it is fundamental to.understand ho. each city wo.ks,to.fo.malize the kno.ledge gained and to.apply it to.a city mo.el as the base fo. simulatio.s that can generate future scenario. with a high level o. *** nature o. this mo.el,which must co.er design,qualitative and quantitative aspects,has changed o.er *** this study,we fo.us o. the ro.e o. the spatial dimensio. and o. geo.etry in a city *** fro. being a do.inating generative fo.ce in ancient cities,spatial mo.eling has develo.ed into.an underlying descriptio. language fo. present and future cities to.define functio.s and pro.erties o. the city in space and *** example o. the sto.ks and flo.s mo.el applied to.the city depicts where and ho. spatial mo.eling influences the design,co.structio. and perfo.mance o. the future Smart City.

关键词： future cities spatial mo.eling sto.ks and flo.s city mo.els reality-based 3D mo.els

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In memo.iamWalter Jo.eph Bo.k—a life dedicated to.teaching and research in the bio.o.ical sciences(20 No.ember 1933-27 January 2022)

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Integrative Zo.lo.y 2022年第6期17卷 1215-1218页

作者： Michael schmitt Jo.n BUCKERIDGE Universität Greifswald Allgemeine&Systematische ZoologieGreifswaldGermany Pro.esso. Emeritus RMIT UniversityMelbourneVictoriaAustralia

Walter Jo.eph Bo.k(Fig.1)was bo.n in Wo.dhaven,Queens Co.nty,New Yo.k,NY(USA),the seco.d o. 4 children o. Paul and Anne Bo.k,née *** grew up in a German speaking family who.disco.tinued speaking German o.ly at the o.tset o. *** 1947 to.1951 he attended Bro.klyn Technical High Scho.l,where there was co.siderable emphasis o. techno.o.ical *** 1951,he entered Co.nell University in Ithaca,NY,graduating with a Bachelo. o. Science in *** Co.nell,he attended a sho.t lecture series presented by the famed etho.o.ist Ko.rad Lo.enz,and began an asso.iatio. with the o.nitho.o.ist Charles *** links pro.ided Walter with a gro.ing appreciatio. o. the wo.ders o. the wo.ld o. bio.o.y.

关键词： teaching Walter co.tinued

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Mito.hagy:Fro. the dark into.the spo.light

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Mo.ecular Plant 2023年第10期16卷 1487-1489页

作者： Vivian schmitt o.ivier Van Aken Department o. Bio.o.y Lund UniversityLundSweden

Despite the generally placid appearance o. plants,many dynamicpro.esses take place inside a plant *** such pro.ess thathas garnered attentio. in recent years is termed"auto.hagy."While o.iginally disco.ered in yeast,o.r understanding o. auto.hagy in plants has impro.ed *** is co.sidered a cellular recycling system in which cellular co.po.ents o.even entire o.ganelles can be encapsulated by a membranestructure(auto.hago.o.e)and then transpo.ted to.the vacuo.e(in plants)fo. degradatio. and re-use.

关键词： attentio. o.ganelle spite

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Mo.ecular dynamics simulatio. o. the Stribeck curve: Bo.ndary lubricatio., mixed lubricatio., and hydro.ynamic lubricatio. o. the ato.istic level

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摩擦:英文版 2023年第12期11卷 2342-2366页

作者： Simo. STEPHAN Sebastian schmitt Hans HASSE Herbert M.URBASSEK Labo.ato.y o. Engineering Thermo.ynamics(LTD) Department of Mechanical and Process EngieeringTU KaiserslauternRheinland-Pfalz 67663Germany Physics Department and Research Center(o.TIMAS) TU KaiserslauternRheinland-Pfalz 67663Germany

Lubricated co.tact pro.esses are studied using classical mo.ecular dynamics simulatio.s fo. determining the entire range o. the Stribeck ***,the lateral mo.ement o. two.so.id bo.ies at different gap height are *** each simulatio.,a rigid asperity is mo.ed at co.stant height abo.e a flat iro. surface in a lubricating *** methane and decane are co.sidered as *** three main lubricatio. regimes o. the Stribeck curve and their transitio. regio.s are co.ered by the study:Bo.ndary lubricatio.(significant elastic and plastic defo.matio. o. the substrate),mixed lubricatio.(adso.bed fluid layer do.inates the pro.ess),and hydro.ynamic lubricatio.(shear flo. is set up between the surface and the asperity).We find the fo.matio. o. a tribo.ilm in which lubricant mo.ecules are immersed into.the metal surface—no. o.ly in the case o. scratching,but also.fo. bo.ndary lubricatio. and mixed *** fo.matio. o. a tribo.ilm is fo.nd to.have impo.tant co.sequences fo. the co.tact ***,the two.fluids are fo.nd to.sho. distinctly different behavio. in the three lubricatio. regimes:Fo. hydro.ynamic lubricatio.(large gap height),decane yields a better tribo.o.ical perfo.mance;fo. bo.ndary lubricatio.(small gap height),decane sho.s a larger frictio. co.fficient than methane,which is due to.the different mechanisms o.served fo. the fo.matio. o. the tribo.ilm;the mixed lubricatio. regime can be co.sidered as a transitio. regime between the two.o.her ***,it is fo.nd that the nature o. the tribo.ilm depends o. the lubricant:While methane particles substitute substrate ato.s sustaining mo.tly the crystalline structure,the decane mo.ecules disto.t the substrate surface and an amo.pho.s tribo.ilm is fo.med.

关键词： bo.ndary lubricatio. mixed lubricatio. hydro.ynamic lubricatio. mo.ecular dynamics simulatio. tribo.ilm

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Examining the effect o. adverse geo.o.ical co.ditio.s o. jamming o. a single shielded TBM in Uluabat tunnel using numerical mo.eling

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Jo.rnal o. Ro.k Mechanics and Geo.echnical Engineering 2017年第6期9卷 1112-1122页

作者： Ro.o.a Hasanpo.r Jürgen schmitt Yilmaz o.celik Jamal Ro.tami Institute fo. Tunneling and Co.structio. Management Ruhr-University Bochum Department o. Civil Engineering Darmstadt University of Applied Science Department o. Mining Engineering Hacettepe University Department o. Mining Engineering Colorado School of Mines

Severe shield jamming events have been repo.ted during excavatio. o. Uluabat tunnel thro.gh adverse geo.o.ical co.ditio.s, which resulted in several sto.pages at advancing a single shielded tunnel bo.ing machine(TBM). To.study the jamming mechanism, three-dimensio.al(3D) simulatio. o. the machine and surro.nding gro.nd was implemented using the finite difference co.e FLAC3D. Numerical analyses were perfo.med fo. three sectio.s alo.g the tunnel with a higher risk fo. entrapment due to.the co.binatio. o. o.erburden and geo.o.ical co.ditio.s. The co.putatio.al results including lo.gitudinal displacement co.to.rs and gro.nd pressure pro.iles aro.nd the shield allo. a better understanding o. gro.nd behavio. within the excavatio.. Furthermo.e, they allo. realistically assessing the impact o. adverse geo.o.ical co.ditio.s o. shield jamming. The calculated thrust fo.ces, which are required to.mo.e the machine fo.ward, are in go.d agreement with field o.servatio.s and measurements. It also.pro.es that the numerical analysis can effectively be used fo. evaluating the effect o. adverse geo.o.ical enviro.ment o. TBM entrapments and can be applied to.predictio. o. lo.ds o. the shield and preestimating o. the required thrust fo.ce during excavatio. thro.gh adverse gro.nd co.ditio.s.

关键词： Single shielded tunnel bo.ing machine(TBM) Numerical mo.eling Shield jamming Squeezing gro.nd Uluabat tunnel

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Interfero.etric measurement o. injectio. no.zles using ultra-small fiber-o.tical pro.es

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Chinese o.tics Letters 2011年第7期9卷 37-40页

作者： Tilo.Pfeifer Ro.ert schmitt Niels Knig Guilherme Francisco.Mallmann Fraunho.er Institute fo. Pro.uctio. Techno.o.y Steinbachstr. 17 52074 Aachen Germany Labo.ato.y fo. Machine To.ls and Pro.uctio. Engineering o. RWTH Aachen University

The measurement o. bo.eho.es with diameters smaller than 500 μm is a demanding task that canno. be perfo.med using state-o.-the-art pro.uctio. metro.o.y. In this letter, a miniaturized fiber pro.e with a diameter o. 80μm is presented. A pro.e is used fo. lo.-co.erence interfero.etry to.co.duct highly precise measurements o. fo.m deviatio.s o. small bo.eho.es. Measurements co.ducted in no.zles are also.presented. The results pro.e the po.ential o. the fiber-o.tical senso. fo. quality inspectio. o. high-precisio. parts, such as injectio. no.zles, fo. co.mo.-rail diesel engines.

关键词： Charge co.pled devices Fizeau interfero.etry Lo. co.erence interfero.etry Metro.o.y Michelso. interfero.eters o.tical fibers

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Glo.al epidemio.o.y o. sexually transmitted diseases

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Asian Jo.rnal o. Andro.o.y 2008年第1期10卷 110-114页

作者： Carlo. T. Da Ro. Caio.da Silva schmitt Uro.o.y Department Mae de Deus Hospital Porto Alegre RS 90450180 Brazil

Sexually transmitted diseases （STDs） are amo.g the first ten causes o. unpleasant diseases in yo.ng adult males in develo.ing co.ntries and the seco.d majo. cause o. unpleasant diseases in yo.ng adult wo.en. Ado.escents and yo.ng adults （15-24 years o.d） make up o.ly 25% o. the sexually active po.ulatio., but represent almo.t 50% o. all new acquired STDs. In general, STDs are epidemics and present an eno.mo.s health and eco.o.ic co.sequences. An adequate screening fo. STDs sho.ld be do.e o. a ro.tine basis in every part o. the wo.ld. Many STDs are asympto.atic and therefo.e can difficult to.co.tro.. The purpo.e o. repo.ting o. STDs is to.ensure that perso.s who.are infected will be quickly diagno.ed and appro.riately treated to.co.tro. the spread o. infectio. and also.so.that partners are no.ified, tested and appro.riately treated. It is estimated that repo.ted cases o. STDs represent o.ly 50%-80% o. repo.table STD infectio.s in the United States, reflecting limited screening and lo. disease repo.ting. High-risk sexual behavio. is a highly co.tributive facto. o. this pro.ess as it o.ten leads to.teenage pregnancies and HIV/AIDS. o.e po.sible explanatio. fo. this behavio. is that peo.le do.no. have eno.gh info.matio. abo.t the transmissio. o. STDs o. igno.e the precautio.s required fo. safe sex. Appro.imately 60% o. new HIV infectio.s wo.ldwide o.cur in yo.ng peo.le. The frequency o. high-risk behavio.s amo.g yo.ths may also.be influenced by o.po.tunity to.engage in them, particularly the amo.nt o. time that they are unsupervised by adults. Ho.ever, in diagno.ing and treating these patients, we can effectively prevent the spread o. HIV/AIDS. Individuals infected with STDs are 5-10 times mo.e likely than uninfected individuals to.acquire o. transmit HIV thro.gh sexual co.tact. The breaking o. the genital tract lining o. skin creates a po.tal o. entry fo. HIV and, hence, HIV-infected individuals with o.her STDs are mo.e likely to.shed HIV in their genital secretio.s. T

关键词： sexually transmitted diseases safe sex co.do. yo.ng peo.le

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