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Multi-targeting cytotoxic drug leads from mushrooms

Asian Pacific Journal of Tropical Medicine 2019年第12期12卷 531-536页

作者： MVNL Chaitanya Asha Jose P Ramalingam sc mandal P Narendra Kumar Phytomedicine&Phytochemistry Division Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)campusAnantapuramuAPIndia Department of Pharmacology Karpagam College of PharmacyOthakkalmadapamCoimbatore 32TamilnaduIndia RERDS-CPR Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)AnantapuramuAPIndia Pharmacognosy and Phytotherapy Research Laboratory Division of PharmacognosyDepartment of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India school of Crop Production Technology Suranaree University of TechnologyThailand

Due to genetic and epigenetic mechanisms, cancer have become a resistant disease and there is a need for new molecules having multiple targeting action that promotes apoptosis. Phytomolecules having multiple targeting anticancer activity are in high demand and there is less documentation or information available on these metabolites. It is evident that mushrooms are became the store houses of new anticancer molecules and mushrooms like Agaricus blazei, Antrodia camphorate, Albatrellus confluens, Bolteus badius, Cordyceps militaris, Clitocybe maxima, Funalia trogii, Grifola frondosa, and Inocybe umbrinella, are some of the medicinal mushrooms reported for their cytotoxic activity. Cytotoxic molecules like lentinan, grifolin, illudin-S, psilocybin, ganoderic acid, theanine, and hispolon, have been isolated from various mushroom species. However, studies have been limited only to in vitro cytotoxic mechanisms and very few trials have been conducted to prove the clinical efficacy of these drug leads. Hence, the current review focuses on new anticancer metabolites isolated from various mushrooms having multiple targeting mechanisms in cancer. However, an extensive research is needed to define the biosynthesis and clinical mechanism of these multiple acting metabolites. This review provides a platform for researchers new anticancer drugs and to bring out potent multiple acting anticancer newer drugs.

关键词： Cancer Phytomolecules Multiple targeting Anticancer Drugs Leads

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Study of a crop-pest-natural enemy model with Z-type control——An approach to pest management

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International Journal of Biomathematics 2023年第4期16卷 175-207页

作者： Dibyendu Sekhar mandal Sudip Samanta Rana D.Parshad Abdennasser Chekroun Mohamed Helal Joydev Chattopadhyay Department of Mathematics AmityUniversity Maharashtra Mumbai Maharashtra 410206India Agricultural and Ecological Research Unit Indian Statistical Institute 203B.T.Road Kolkata 700108India Department of Mathematics Bankura University WestBengal722155India Department of Mathematics Iowa State University AmesIA 50011USA Laboratoire d'Analyse Nonlineaire et Mathematiques Appliquees University of Tlemcen Tlemcen 13000Algeria Biomathematics Laboratory Universite Sidi Bel-Abbes P.B.8922000Algeria

In this study,the Z-type control method is applied to an intraguild crop-pest-natural enemy model,assuming that the natural enemy can predate on both crop and pest *** this purpose,the indirect Z-type controller is considered in the natural enemy *** providing the design function for the crop-pest-natural enemy model with Z-control,we find the analytical expression of the update *** findings indicate that the uncontrolled system can produce chaos through perioddoubling bifurcation due to crop over-consumption by the pest *** draw a Poincare map to confirm the occurrence of chaos and compute the maximum Lyapunov *** the observations further indicate that the pest population can be controlled by using an indirect Z-control mechanism in the natural enemy population,we postulate that,if natural enemy abundance can be governed by the update parameter,any desired pest population abundance can be achieved through the proposed Z-type controller,thus controlling the *** verify these assertions,extensive numerical simulations are performed to explore the potential for practical application of the proposed Z-type controller.

关键词： Crop-pest-natural enemy model Z-type control numerical simulations pest control

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Nanostructured fibers as a versatile photonic platform: radiative cooling and waveguiding through transverse Anderson localization

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Light(science & Applications) 2018年第1期7卷 690-698页

作者： Norman Nan Shi Cheng-Chia Tsai Michael J.Carter Jyotirmoy mandal Adam C.Overvig Matthew Y.Sfeir Ming Lu Catherine L.Craig Gary D.Bernard Yuan Yang Nanfang Yu Department of Applied Physics and Applied Mathematics Columbia UniversityNew YorkNY 10027USA Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNY 11973USA Museum of Comparative Zoology Harvard UniversityCambridgeMA 02138USA Department of Electrical Engineering University of WashingtonSeattleWA 98195USA

Broadband high reflectance in nature is often the result of randomly,three-dimensionally structured *** study explores unique optical properties associated with one-dimensional nanostructures discovered in silk cocoon fibers of the comet moth,Argema *** fibers are populated with a high density of air voids randomly distributed across the fiber cross-section but are invariant along the *** filamentary air voids strongly scatter light in the solar spectrum.A single silk fiber measuring~50μm thick can reflect 66%of incoming solar radiation,and this,together with the fibers’high emissivity of 0.88 in the mid-infrared range,allows the cocoon to act as an efficient radiative-cooling *** inspiration from these natural radiative-cooling fibers,biomimetic nanostructured fibers based on both regenerated silk fibroin and polyvinylidene difluoride are fabricated through wet *** characterization shows that these fibers exhibit exceptional optical properties for radiative-cooling applications:nanostructured regenerated silk fibers provide a solar reflectivity of 0.73 and a thermal emissivity of 0.90,and nanostructured polyvinylidene difluoride fibers provide a solar reflectivity of 0.93 and a thermal emissivity of *** filamentary air voids lead to highly directional scattering,giving the fibers a highly reflective sheen,but more interestingly,they enable guided optical modes to propagate along the fibers through transverse Anderson *** discovery opens up the possibility of using wild silkmoth fibers as a biocompatible and bioresorbable material for optical signal and image transport.

关键词： fibers radiative transverse

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