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Evidence of spin density wave of CeOs_4Sb_(12)

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Rare Metals 2006年第z1期25卷 550-552页

作者： IWASA Kazuaki SUGAWARA Hitoshi sato hideyuki Department of Physics Tohoku University Sendai 980-8578 Japan Department of Physics Tokyo Metropolitan University Tokyo 192-0397 Japan

关键词： elastic neutron scattering skutterudite structure antiferromagnetic ordering spin density wave

Development of self-micellizing solid dispersion system employing amphipathic copolymer for the improvement of dissolution and oral bioavailability of cyclosporine A

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 50-51页

作者： Hiroki Suzuki hideyuki sato Yoshiki Kojo Takahiro Mizumoto Kayo Yuminoki Naohumi Hashimoto Yoshiki Seto satomi Onoue University of Shizuoka 52-1 YadaSuruga-kuShizuoka 422-8526Japan ILS Inc. 1-2-1 KubogaokaMoriyaIbaraki 302-0104Japan Setsunan University 45-1 Nagaotoge-choHirakataOsaka 573-0101Japan

The main objective of the present study is to develop a selfmicellizing solid dispersion(SMSD)system of cyclosporine A(CsA)using an amphiphilic copolymer,poly[MPC-co-BMA](pMB)to improve the biopharmaceutical properties of CsA(Fig.1A).Unlike conventional carrier compounds,pMB would perform the bifunctional ability as both polymeric carrier of solid dispersion system and solubilizer derived from a high micellizing property,which could be considered beneficial for the production of highly water soluble formulation of poorly water soluble compound[1].Improvement in the aqueous solubility has been believed to be a key consideration for acquiring potent pharmacological effects of BCS class II drug like CsA.

关键词： Cyclosporine A Amphipathic copolymer Self-micellizing solid dispersion Oral bioavailability

New aspects of a small GTPase RAB35 in brain development and function

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Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ikuko Maejima Ken sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

Obstructive and secretory complications of diverting ileostomy

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World Journal of Gastroenterology 2022年第47期28卷 6732-6742页

作者： Shingo Tsujinaka hideyuki Suzuki Tomoya Miura Yoshihiro sato Chikashi Shibata Department of Gastroenterological Surgery Tohoku Medical and Pharmaceutical UniversitySendai 983-8536MiyagiJapan

This review aimed to highlight the etiology,diagnosis,treatment,and prevention of obstructive and secretory complications associated with diverting ileostomy(DI).Obstructive complications at the stoma site are termed stoma outlet obstruction(SOO)or stoma-related obstruction(SRO).The incidence of SOO/SRO is 5.4%-27.3%,and the risk factors are multifactorial;however,the configuration of the stoma limb and the thickness of the rectus abdominis muscle(RAM)may be of particular ***-stomal tube decompression is initially attempted with a success rate of 33%-86%.A thick RAM may carry the risk of *** refinement,including a wider incision of the anterior sheath and adequate stoma limb length,avoids tension and immobility and may decrease SOO/*** complications of DI are termed high output stoma(HOS).Persistent HOS lead to water and sodium depletion,and secondary hyperaldosteronism,resulting in electrolyte imbalances,such as *** incidence of HOS is 14%-24%,with an output of 1000-2000 mL/d lasting up to three *** of HOS is commenced after excluding postoperative complications or enteritis and includes fluid intake restriction,antimotility and antisecretory drug therapies,and magnesium *** monitoring and surveillance programs have been successful in decreasing readmissions for dehydration.

关键词： Small bowel obstruction Stoma outlet obstruction Stoma-related obstruction High output stoma High output syndrome Dehydration

Chronological constraints on the Paleoproterozoic Francevillian Group in Gabon

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Geoscience Frontiers 2017年第2期8卷 397-407页

作者： Yusuke Sawaki Mathieu Moussavou Tomohiko sato Kazue Suzuki Cédric Ligna Hisashi Asanuma Shuhei Sakata hideyuki Obayashi Takafumi Hirata Amboise Edou-Minkoinko Department of Earth and Planetary Sciences Tokyo Institute of Technology2-12-1 O-okayamaMeguro-kuTokyo 152-8551Japan University of Sdences and Technology in Masuku BP:90190025 FrancevilleGabon Earth-Life Science Institute(ELSI) Tokyo Institute of Technology2-12-1 O-okayamaMeguro-kuTokyo 152-8551Japan Department of Chemistry Gakushuin UniversityMejiro 1-5-1Toshima-kuTokyo 171-8588Japan Division of Earth and Planetary Sciences Graduate School of ScienceKyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto 606-8502Japan Geochemistry Research Center The University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan

The Francevillian Group in Gabonese Republic was recently established as a typical sedimentary sequence for the ***,its age is rather poorly constrained,mainly based on Rb-Sr and Nd-Sm *** study reports new zircon data obtained from Chaillu massif and N＇goutou complex,which constrain the protolith age of the basement orthogneisses and the igneous age of an intrusive granite,*** zircons from the orthogneisses are blue and exhibit oscillatory zoning in cathode-luminescence *** with lower common lead abundances tend to be distributed close to the concordia *** age clusters around 2860 Ma and 2910 Ma are found in zircons plotted on the concordia *** on the Th/U ratios of zircons,these ages correspond to the protolith ages of the orthogneisses,and the zircons are not metamorphic in *** and granites were collected from the N＇goutou complex that intrudes into the FA and FB units of the Francevillian *** granitoids exhibit chemical composition of A-type granite *** of zircons separated from the granite are non-luminous,and the remaining half exhibit obscure internal textures under cathode-luminescence *** zircon grains contain significant amounts of common lead;the lead isotopic variability is probably attributed to the mixing of two components in the *** zircon radiogenic ^（207）Pb/^（206）Pb ratio is 0.13707 ± *** to a ^（207）Pb/^（206）Pb age of 2191 ± 13 *** constrains the minimum depositional age of the FA and FB ***,the FB unit consists of manganese-rich carbonate rocks and organic carbon-rich black shales with macroscopic *** on our age constraints,these organisms appeared in the study area just after the last Paleoproterozoic Snowball Earth event,in concert with global scale oxidation event encompassing the Snowball Earth.

关键词： Gabon Francevillian Group Paleoproterozoic N'goutou complex Zircon MC-ICP-MS

Clinical characteristics of null responders to Peg-IFNα2b/ ribavirin therapy for chronic hepatitis C

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World Journal of Hepatology 2010年第11期2卷 401-405页

作者： hideyuki Suzuki satoru Kakizaki Norio Horiguchi Takeshi Ichikawa Ken sato Hitoshi Takagi Masatomo Mori Department of Medicine and Molecular Science Gunma Univ ersity Graduate School of Medicine

AIM: To predict which chronic hepatitis C patients are likely to be late-responders, we herein investigated the clinical characteristics of null-responders at 36 wk with hepatitis C virus (HCV) genotype Ib and a high viral load during the course of pegylated interferon (Peg-IFN)/ ribavirin ther apy. METHODS: One hundred forty-two patients with genotype Ib HCV and a high viral load were included in this study. Peg-IFNα2b (1.5 μg/kg once a week) and ribavirin (600-1000 mg per day according to body weight) were administered for 48 wk. We def ined nullresponders as the cases that never cleared serum HCV RNA as determined using RT-PCR until 36 wk. Other patients were def ined as responders. We compared the clinical characteristics (age, gender, body mass index, previous treatment) and HCV RNA titer during the therapy between null-responders and ***: The HCV RNA clearance rate was 17.9% (24/134), 46.3% (62/134), 60.6% (86/142), 86.6% (123/142), and 88.0% (125/142) at 4, 8, 12, 24, and 36 wk, respectively. There were 17 patients (12.0%) who were still null-responders at 36 wk. There were no differences in the clinical characteristics between the responders and null-responders except for the titer and decline rates of HCV RNA at 1 wk and 4 wk. The HCV RNA titers at 1 wk and after 4 wk of treatment were significantly higher in the null-responders in comp arison to the responders (P <0.01). The serum HCV RNA titers of the responders decreased by 1.3 log after 1 wk of treatment, and 1.6 log after 4 wk of treatm ent, respectively. On the other hand, the titers of the null responders decreased by only 0.5 log after 1 wk, and 0.7 log after 4 wk of treatment, respectively. The decrease rates of HCV RNA after 1 and 4 wk of treatm ent were signif icantly worse for null responders than for the responders (P <0.01). CONCLUSION: The HCV RNA titer at 1 wk and 4 wk after initiating treatment may be useful for predicting null-responders to Peg-IFNα2b/ribavirin therapy. Howe

关键词： Null responder Pegylated interferon α2b Ribavirin Chronic hepatitis C

Development of Deformation-Semisolid-Casting (D-SSC) Process and Applications to Some Aluminum Alloys

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Journal of Materials Science & Technology 2008年第1期24卷 12-16页

作者： Tatsuo sato Department of Metallurgy and Ceramics Science Tokyo Institute of Technology 2-12-1O-okayamaMeguro-kuTokyoJapan

Recent advances in the semisolid casting technologies are introduced for aluminum *** advantages of the rheocast and thixocast methods to fabricate alloys with refined spheroidizedα-Al particles are described. The deformation-semisolid-casting （D-SSC） process developed by the author＇s group is *** D-SSC process is extremely effective to produce microstructures of refined intermetallic compound particles as well as the spheroidizedα-Al particles in the Al-Si based alloys containing highly concentrated *** the D-SSC processed Al-Si-Cu alloy high elongation of about 20% was achieved even contained concentrated impurity of *** D-SSC process is also useful to produce wrought aluminum alloys with microstructures of refinedα-Al particles.

关键词： Semisolid casting Rheocast Thixocast Aluminum alloys Intermetallic compound

Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor

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Bone Research 2024年第3期12卷 571-581页

作者： hideyuki Kobayashi M.Alaa Terkawi Masahiro Ota Tomoka Hasegawa Tomomaya Yamamoto Tomohiro Shimizu Dai sato Ryo Fujita Toshifumi Murakami Norio Amizuka Norimasa Iwasaki Masahiko Takahata Department of Orthopaedic Surgery Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Department of Developmental Biology of Hard Tissue Graduate School of Dental MedicineHokkaido UniversitySapporoJapan Department of Orthopaedic Surgery Dokkyo Medical UniversityMibu Shimotsuga 321-0293Japan

DNAX-associated protein 12 kD size(DAP12)is a dominant immunoreceptor tyrosine-based activation motif(ITAM)-signaling adaptor that activates costimulatory signals essential for *** several DAP12-associated receptors(DARs)have been identified in osteoclasts,including triggering receptor expressed on myeloid cells 2(TREM-2),C-type lectin member 5 A(CLEC5A),and sialic acid-binding Ig-like lectin(Siglec)-15,their precise role in the development of osteoclasts and bone remodeling remain poorly *** this study,mice deficient in Trem-2,Clec5a,Siglec-15 were generated.

关键词： remodeling osteoclast stimulating

Near Range Radar and Its Application to Near Surface Geophysics and Disaster Mitigation

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Journal of Earth Science 2015年第6期26卷 858-863页

作者： Motoyuki sato Center for Northeast Asian Studies Tohoku University

In this paper, we discuss about the near range radar applied to various environmental applications and disaster mitigation issues. Synthetic aperture radar（SAR） processing or migration is the key technology in near range radar imaging, which can be used in ground penetrating radar（GPR） and ground-based synthetic aperture radar（GB-SAR）. We demonstrate some applications which include GPR for humanitarian demining, GPR for archaeological survey, GB-SAR for landslide monitoring and nondestructive inspection of wooden buildings. We also demonstrate a new array GPR system “Yakumo”, which was used for archaeological survey for demonstration of advanced multi-static radar signal processing for better radar imaging.

关键词： near range radar GPR GB-SAR disaster mitigation SAR processing migration,multi-static radar.