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Testing Potential Effect of Environmental Endocrine Disruptors in Cow Milk on Reproductive Index in Female Rats

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Biomedical and Environmental Sciences 2005年第5期18卷 307-313页

作者： XIANG-MING LI DAVAASAMBUU GANMAA LI-QIANG QIN AKIO sato Preventive Medicine Department Medical College Yangzhou University Yangzhou 225001 Jiangsu China Department of Environmental Health of Yamanashi Medical University Yamanashi 409-3898 Japan

To study the effect of endocrine disruptor chemicals in cow milk on female reproductive system. Methods A two-generation reproduction was conducted according to U. S. FDA standard. Milk was fed in special bottle to Wistar rats of both sexes through two successive generations （F0 and F1） in the milk group while artificial milk was fed to rats in the control group. Twenty-four rats of each sex were mated in each group. Measurements were made according to this guideline. Results Reproductive parameters in the milk group such as fertility index, gestation index, weights of uterus and ovary, days of vaginal opening, estrous cycles, histological morphological changes were comparable to those in the control group. However, the means of body weight had some differences. The body weight gains increased significantly in the milk-treated group in F1 and F2 generation compared with those in the control group. The concentration of insulin-like growth factor-1 （IGF-1） in blood in the milk group was comparable to that in the control group, but the standard deviation changed greatly in the milk-treated rats. Conclusion Endocrine disruptor chemicals in milk have no severe effects on the female reproductive system.

关键词： Two-generation testing Female reproductive system Endocrine disruptor

Relationship between outcomes and relative dose intensity of lenvatinib treatment in patients with advanced hepatocellular carcinoma

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Liver Research 2020年第4期4卷 199-205页

作者： Takamasa Ohki Koki sato Mayuko Kondo Eriko Goto Takahisa sato Yuji Kondo Masatoshi Akamatsu Shinpei sato Hideo Yoshida Yukihiro Koike Shuntaro Obi Department of Gastroenterology Mitsui Memorial HospitalTokyoJapan Department of Gastroenterology Kanto Central HospitalTokyoJapan Department of Gastroenterology Teikyo University Medical CenterChiba PrefectureJapan Department of Gastroenterology and Hepatology Kyoundo HospitalTokyoJapan Department of Gastroenterology JR Tokyo General HospitalTokyoJapan Department of Gastroenterology Japanese Red Cross Medical CenterTokyoJapan

Background and aims:Lenvatinib(LEN)is a newly developed tyrosine kinase inhibitor,and is approved as a first-line treatment for advanced hepatocellular carcinoma(HCC)in *** retrospective multi-center study investigated the effect of the relative dose intensity(RDI)of LEN on response rate,progression-free survival(PFS),and overall survival(OS).Methods:This retrospective study enrolled 123 patients with advanced HCC who were treated with LEN at six hospitals in Japan between March 2018 and December *** patients were divided into two groups:RDI≥70%(RDI 70 group,N=70)or RDI<70%(control group,N=53)in the first 30 *** following data were compared between groups:patient backgrounds,adverse events,treatment out-comes,PFS,and *** and OS were analyzed using the Kaplan-Meier method,followed by the log-rank *** identify significant factors that contributed to response,PFS,and OS,multivariate analysis was performed using factors for which P-values were<0.10 in univariate ***:The proportion of patients with Child-Pugh class 5A was significantly greater in the RDI 70 group than that in the control group(64.3%vs.28.3%,P<0.01).Dose interruption due to adverse events was significantly more common in the control *** response rate was significantly higher in the RDI 70 group than that in the control group(35.7%vs.11.3%,P<0.01).Median PFS was significantly longer in the RDI 70 group(9.4 vs.4.7 months,P<0.01).Multivariate analysis showed that RDI≥70%(hazard ratio(HR)=0.55,P=0.025),hypertension grade≥2(HR=0.47,P=0.019),and response(HR=0.52,P=0.033)were independently associated with improved *** OS was also significantly longer in the RDI 70 group(20.0 vs.13.3 months,P=0.045).Multivariate analysis showed that female sex(HR=0.33,P=0.034)and disease control(HR=0.31,P<0.01)were independently associated with improved ***≥70%was not statistically significant in multivariate ***:Our study revealed the importance of achieving

关键词： Advanced hepatocellular carcinoma Lenvatinib(LEN) Relative dose intensity(RDI) Chemotherapy Tyrosine kinase inhibitor

A planetary companion orbiting the intermediate-mass G Giant HD 173416

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Chinese Journal of Astronomy and Astrophysics 2009年第1期9卷 1-4页

作者： Yu-Juan Liu Bun＇ei sato Gang Zhao Hiroyasu Ando National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Tokyo Institute of Technology 2-12-10okayama Meguro-ku Tokyo 152-8550 Japan National Astronomical Observatory of Japan National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo 181-8588 Japan Deparfment of Astronomy Graduate University for Advanced Studies Shonan Village Hayama Kanagawa 240-0193 Japan

The discovery of a planetary companion to the intermediate-mass late-type giant star HD173416 from precise Doppler surveys of G and K giants at Xinglong station and Okayama Astrophysical Observatory （OAO） is presented in this letter. The planet has a minimum mass of 2.7 MJ, an eccentricity of 0.21, a semimajor axis of 1.16 AU and an orbital period of 324 days.

关键词： planetary systems -- stars individual HD173416 - stars PlanetarySystems -- techniques: radial velocities

Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma with a false-positive result on fluorodeoxyglucose PET

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World Journal of Gastroenterology 2009年第29期15卷 3691-3693页

作者： Isamu Makino Takahiro Yamaguchi Nariatsu sato Toshiaki Yasui Ichiro Kita Department of Surgery Kanazawa Social Insurance Hospital Kanazawa Ishikawa 920-8610 Japan

Recently, several reports have demonstrated that fluorine-18 fluorodeoxyglucose positron emission tomography （FDG-PET） is useful in differentiating between benign and malignant lesions in the gallbladder. However, there is a limitation in the ability of FDG-PET to differentiate between inflammatory and malignant lesions. We herein present a case of xanthogranulomatous cholecystitis misdiagnosed as gallbladder carcinoma by ultrasonography and computed tomography. FDG-PET also showed increased activity. In this case, FDG-PET findings resulted in a false-positive for the diagnosis of gallbladder carcinoma.

关键词： Fluorodeoxyglucose F18 Positron-emissiontomography Xanthogranulomatous cholecystitis Gallbladder cancer

Interventional strategies in infected necrotizing pancreatitis:Indications,timing,and outcomes

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World Journal of Gastroenterology 2022年第27期28卷 3383-3397页

作者： Birte Purschke Louisa Bolm Max Nikolaus Meyer Hiroki sato Department of Gastrointestinal Surgery Massachusetts General HospitalBostonMA 02114United States Department of Radiation Oncology Massachusetts General HospitalBostonMA 02114United States Department of Medicine Asahikawa Medical UniversityAsahikawa 0788510HokkaidoJapan Department of Gastroenterology Asahikawa Kosei HospitalAsahikawa 0788211HokkaidoJapan

Acute pancreatitis(AP)is one of the most common gastrointestinal diseases and remains a life-threatening *** AP resolves to restitutio ad integrum in approximately 80%of patients,it can progress to necrotizing pancreatitis(NP).NP is associated with superinfection in a third of patients,leading to an increase in mortality rate of up to 40%.Accurate and early diagnosis of NP and associated complications,as well as state-of-the-art therapy are essential to improve patient *** emerging role of endoscopy and recent trials on multidisciplinary management of NP established the“step-up approach”.This approach starts with endoscopic interventions and can be escalated to other interventional and ultimately surgical procedures if *** showed that this approach decreases the incidence of new multiple-organ failure as well as the risk of interventional ***,the optimal interventional sequence and timing of interventional procedures remain *** review aims to summarize the indications,timing,and treatment outcomes for infected NP and to provide guidance on multidisciplinary decision-making.

关键词： Pancreatitis Acute necrotizing pancreatitis Necrosis Superinfection Endoscopy Surgery

Exploration of organic superionic glassy conductors by process and materials informatics with lossless graph database

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npj Computational Materials 2022年第1期8卷 1622-1629页

作者： Kan Hatakeyama-sato Momoka Umeki Hiroki Adachi Naoaki Kuwata Gen Hasegawa Kenichi Oyaizu Department of Applied Chemistry Waseda University3-4-1 OkuboShinjukuTokyo169-8555Japan National Institute for Materials Science(NIMS) 1-1 NamikiTsukuba305-0044Japan

Data-driven material exploration is a ground-breaking research style;however,daily experimental results are difficult to record,analyze,and *** report a data platform that losslessly describes the relationships of structures,properties,and processes as graphs in electronic laboratory *** a model project,organic superionic glassy conductors were explored by recording over 500 different *** data analysis revealed the essential factors for a remarkable room temperature ionic conductivity of 10^(−4)–10^(−3) S cm^(−1) and a Li^(+) transference number of around *** contrast to previous materials research,everyone can access all the experimental results,including graphs,raw measurement data,and data processing systems,at a public *** data sharing will improve scientific communication and accelerate integration of material knowledge.

关键词： ionic glassy breaking

Alphonse Mucha 1860-1939

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New iridoid glucoside from Wendlandia tinctoria roots

作者： Tomoko sato.

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Chinese Chemical Letters 2011年第10期22卷 1233-1236页

作者： Biswanath Dinda Sudhan Debnath Santanu Majumder Noriko sato Yoshihiro Harigaya Department of Chemistry Tripura UniversitySuryamaninagar 799130AgartalaIndia Department of Chemistry MBB College 799004AgartalaIndia Department of Chemistry Iswarchandra Vidyasagar CollegeBelonia 799155South TripuraIndia School of Pharmaceutical Sciences Kitasato University5-9-1 ShirokaneMinato-kuTokyo 108 8641Japan

A new iridoid glucoside,10-O-veratroyleranthemoside（1） was isolated from the roots of Wendlandia *** structure was established by spectroscopic（including 2D NMR） and chemical methods.

关键词： Wendlandia tinctoria Rubiaceae Iridoid glucoside 10-O-Veratroyleranthemoside

Solid-State Interfacial Reaction between Eutectic Au-Ge Solder and Cu/Ni(P)/Au Metalized Ceramic Substrate and Its Suppression

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Journal of Materials Science & Technology 2015年第5期31卷 445-452页

作者： F.Q.Lang H.Yamaguchi H.Nakagawa H.sato Advanced Power Electronics Research Center(ADPERC) National Institute of Advanced Industrial Science and Technology(AIST).Central 21-1-1UmezonoTsukubaIbaraki 305-8568.Japan

Eutectic Au-12 Ge solder was employed to bond the SiC power devices to a Si3N4/Cu/Ni（P）/Au multilayered *** high-temperature reliability of the bond was investigated in detail at 200,250,300 and 330 ℃,*** and Ni5Ge3intermetallic compounds（IMCs） were identified at the Au-12Ge/Ni（P） interface by micro X-ray diffraction（μXRD） and scanning electron microscopy（SEM）equipped with energy dispersive X-ray analysis（EDX）.The growth of the Ni-Ge IMCs was dominated by Ni5Ge3layer,which formed at the Ni5Ge3/NiGe interface by outward diffusion of Ni from the Ni（P） *** activation energy of the total Ni-Ge IMCs growth was 66 kJ/*** shear strength of the bond was tested at both 25 ℃ and the aging temperatures,*** shear strength decreased slightly after aging at 200 and 250 ℃.The shear strength tested at 250 ℃ was 46 MPa after aging at 250 ℃ for 3000 *** shear strength aged at 300 and 330 ℃ rapidly decreased with aging time due to the rapid growth of the *** slow down the interfacial reaction between the high temperature solder and the Ni（P）layer,an approximately 200 nm-thick Ta/TaN/Ta new diffusion barrier（DB） was deposited on the *** by transmission electron microscopy（TEM） equipped with EDX,reveals that the Ta/TaN/Ta DB was bonded well to the Ni（P） layer and the *** temperature storage test at 330 ℃ for1500 h reveals that the bond of the SiC devices maintained its high shear strength of approximately56 MPa without *** new DB effectively suppressed the interfacial reaction between the Au-12 Ge solder and the Ni（P） layer of the substrate.

关键词： High-temperature solder Interfacial reaction Activ