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Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric yuk Fai Wan Celine Sze Ling Chui Franco Wing tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

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Colonoscopy in Hong Kong Chinese children

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World Journal of Gastroenterology 2010年第9期16卷 1119-1122页

作者： yuk Him Tam Kim Hung Lee Kin Wai Chan Jennifer Dart Yin Sihoe Sing tak Cheung Jennifer Wai Cheung Mou Division of Paediatric Surgery & Paediatric Urology Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong Kong

AIM:To investigate the safety and diagnostic yield of colonoscopy in Chinese children in whom the procedure is not often ***:We conducted a retrospective review of all colonoscopies in consecutive children who underwent their fi rst diagnostic colonoscopy from Jan 2003 to ***:Seventy-nine children (48 boys,31 girls;mean age 9.2 ± 4.2 years) were identified and reviewed with a total of 82 colonoscopies *** caecal and ileal intubation rates were 97.6% and 75.6% *** patients (50.6%) had a positive diagnosis made in colonoscopy and that included colonic polyps (23),Crohn's disease (12),ulcerative colitis (1),and miscellaneous causes (4).80% of polyps were in the rectosigmoid *** but one were juvenile hamartomatous *** exceptionwas an adenomatous *** mean ages for children with inflammatory bowel disease (IBD) and polyps were 11.3 and 4.3 years *** was no procedure-related ***:Colonoscopy is a safe procedure in our Chinese *** increasing diagnosis of IBD in recent decades may reflect a rising incidence of the disease in our children.

关键词： Colonoscopy Children Inflammatory bowel disease Colonic polyps

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The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 715-735,I0019-I0020页

作者： Tan-To Cheung yuk Tong Lee Raymond Shing-Yan Tang Wong Hoi She Kai Chi Cheng Chin Cheung Cheung Keith Wan Hang Chiu Kenneth Siu Ho Chok Wing Sun Chow tak Wing Lai Wai-Kay Seto Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Gastroenterologist in private practice Hong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery Kwong Wah HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Radiology&Imaging Queen Elizabeth HospitalHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Medicine School of Clinical MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly *** studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with *** with PCL are at risk of developing pancreatic cancer,a disease with a poor *** publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local ***:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March *** expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and ***:Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these *** should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the *** indicated,patients should undergo pancreatectomy to excise *** pancreatectomy,patients are at risk of PEI,leading to gastrointestinal dysfunction and ***,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic *** are also at risk of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if ***:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape.

关键词： Pancreatic cystic lesions pancreatic endocrine insufficiency pancreatic enzyme replacement therapy

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复合聚合物CTNI/PMMA薄膜的制备及传输特性的研究

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人工晶体学报 2007年第4期36卷 776-779,769页

作者：张福军任诠张健孙香冰王彦玲杨旭东高怡杨洪亮冯林张光辉 Chow yuk-tak 许东山东大学信息科学与工程学院济南250100 山东大学晶体材料国家重点实验室济南250100 香港城市大学电子工程系

合成了一种新型有机金属配合物:[C16H33(CH3)3N]Ni(dmit)2(简称为CTNI),通过旋涂法制备了不同质量比的复合聚合物CTNI/PMMA薄膜,用视频摄像技术测量了其光传输损耗。结果表明,对8%质量分数掺杂浓度的CTNI/PMMA聚合物复合薄膜的光传输损... 详细信息

合成了一种新型有机金属配合物:[C16H33(CH3)3N]Ni(dmit)2(简称为CTNI),通过旋涂法制备了不同质量比的复合聚合物CTNI/PMMA薄膜,用视频摄像技术测量了其光传输损耗。结果表明,对8%质量分数掺杂浓度的CTNI/PMMA聚合物复合薄膜的光传输损耗为3.001dB/cm,随着CTNI在复合聚合物薄膜中浓度的增加,薄膜的光传输损耗线性增长。

关键词：复合聚合物薄膜传输损耗视频摄像技术

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The Transmission Modes and Losses of the Poled Nano-crystal and Polymer Composite PbTiO_3 / PEK-c Thin-film Waveguides

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Journal of Wuhan University of Technology(Materials Science) 2007年第1期22卷 66-69页

作者：任诠 The Optoelectronics Research Centre City University of Hong Kong KowloonHong Kong Department of Optics Shandong University Jinan 250100 China

Composite thin films of PbTiO3 nano-crystals and high transparency polymer polyetherketone （PEK-c） for application of non-linear optical devices were prepared by spin coating. The size of PbTiO3 nano-crystals was estimated to be 30-40 nm using a transmission electron microscope. The refractive index and the mode propagation losses at 633 nm were measured using the prism coupling technique and improved photographic technique respectively. They were found to be 1.6545 and 2.00 dB cm^-1 （fundamental mode）,respectively. Moreover, it is observed that this loss is increased at higher mode indices.

关键词： optical properties nano-crystals thin-film waveguides mode propagation losses

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复合聚合物CTNI/PMMA薄膜的制备及传输损耗的研究

复合聚合物CTNI/PMMA薄膜的制备及传输损耗的研究

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第14届全国晶体生长与材料学术会议

作者：张福军任诠张健孙香冰王彦玲杨旭东高怡杨洪亮张光辉 yuk tak Chow 许东山东大学信息科学与工程学院山东大学晶体材料研究所国家重点实验室香港城市大学光电研究中心

合成了一种新型有机金属配合物:[C16H33(CH3)3N]Ni(dmit)2(简称为CTNI),通过旋涂法制备了不同质量比的复合聚合物CTNI/PMMA薄膜,分析和讨论了多种测量聚合物薄膜光传输损耗的方法,并用视频摄像技术测量了其光传输损耗。视频摄像技术具... 详细信息

合成了一种新型有机金属配合物:[C16H33(CH3)3N]Ni(dmit)2(简称为CTNI),通过旋涂法制备了不同质量比的复合聚合物CTNI/PMMA薄膜,分析和讨论了多种测量聚合物薄膜光传输损耗的方法,并用视频摄像技术测量了其光传输损耗。视频摄像技术具有测量装置简单、准确、实时、非接触等优点,测量结果表明,对8%wt掺杂浓度的CTNI/PMMA聚合物复合薄膜的光传输损耗为3.001dB/cm,随着CTNI在复合聚合物薄膜中浓度的增加,薄膜的光传输损耗线性增长。

关键词：复合聚合物薄膜传输损耗视频摄像技术

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