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Trends in insulin resistance:insights into mechanisms and therapeutic strategy

Signal Transduction and Targeted Therapy 2022年第8期7卷 2762-2786页

作者： Mengwei Li Xiaowei Chi Ying Wang sarra setrerrahmane Wenwei Xie Hanmei Xu The Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation of Jiangsu Province China Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines Ministry of EducationChina Pharmaceutical UniversityNanjing 210009China Development Center for Medical Science&Technology National Health Commission of the People’s Republic of China 100044 BeijingChina NANJING ANJI BIOTECHNOLOGY CO.LTD Nanjing 210033China

The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic *** is a key peptide hormone and mediates the systemic glucose metabolism in different *** resistance(IR)is a disordered biological response for insulin stimulation through the disruption of different molecular pathways in target *** conditions and genetic factors have been implicated in *** genetic and biochemical studies suggest that the dysregulated metabolic mediators released by adipose tissue including adipokines,cytokines,chemokines,excess lipids and toxic lipid metabolites promote IR in other *** is associated with several groups of abnormal syndromes that include obesity,diabetes,metabolic dysfunction-associated fatty liver disease(MAFLD),cardiovascular disease,polycystic ovary syndrome(PCOS),and other *** no medication is specifically approved to treat IR,we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin ***,the systematic discussion of complex mechanism will help to identify potential new targets and treat the closely associated metabolic syndrome of IR.

关键词： metabolism stimulation diagnosis

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Centranthera grandiflore alleviates alcohol-induced oxidative stress and cell apoptosis

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Chinese Journal of Natural Medicines 2022年第8期20卷 572-579页

作者： GAO Xin-Mei DONG Wen-Han XIA Chun-Lei MA Zhuo-Yi WANG Ying sarra setrerrahmane XU Han-Mei QI Wei-Yan The Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation Jiangsu ProvinceState Key Laboratory of Natural MedicinesMinistry of EducationDepartment of Marine PharmacyChina Pharmaceutical UniversityNanjing 211198China Science and Technology Administration Department of Yunnan Agricultural University Yunnan 650205China Nanjing Anji Biotechnology Co. Ltd.Nanjing 210033China

Alcohol liver disease(ALD)has become a global threat to human *** is associated with a wide range of liver diseases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cancer and even *** grandiflora is a traditional Chinese medicinal herb commonly used to treat ALD,but no research about its mechanism is *** study evaluated the hepatoprotective effect and mechanism of *** against alcohol-induced liver injury in *** found that the ethanol extracts of ***(CgW)alleviated the alcohol-induced liver injury,enhanced the levels of antioxidant enzymes,and reduced the amount of lipid *** also affected cell apoptosis by inhibiting the activity of Bax,cleaved-caspase 3 and cleaved-caspase 9,and increasing the activity of *** conclusion,the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first *** study suggested that *** is a promising herbal medicine for ALD treatment.

关键词： Centranthera grandiflora Alcohol liver diseases Oxidative stress Apoptosis Hepatoprotective effect

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Integrins as attractive targets for cancer therapeutics

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2726-2737页

作者： Meng Li Ying Wang Mengwei Li Xuezhen Wu sarra setrerrahmane Hanmei Xu National Institutes for Food and Drug Control Beijing 102629China State Key Laboratory of Natural Medicines Ministry of Educationthe Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu ProvinceDepartment of Marine PharmacyChina Pharmaceutical University Nanjing 211198ChinaAffiliated Hospital of Chifeng CollegeInner Mongolia Autonomous Region 024005China

Integrins are transmembrane receptors that have been implicated in the biology of various human physiological and pathological *** molecules facilitate cell-extracellular matrix and cell-cell interactions,and they have been implicated in fibrosis,inflammation,thrombosis,and tumor *** role of integrins in tumor progression makes them promising targets for cancer treatment,and certain integrin antagonists,such as antibodies and synthetic peptides,have been effectively utilized in the clinic for cancer ***,we discuss the evidence and knowledge on the contribution of integrins to cancer ***,we summarize the clinical attempts targeting this family in anti-cancer therapy development.

关键词： Integrins Extracellular matrix Tumor progression Targeted drug Antagonists Clinical trial

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连接肽在融合蛋白设计中的选择及应用

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药物生物技术 2016年第3期23卷 260-263页

作者：于健 sarra setrerrahmane 徐寒梅中国药科大学多肽药物创制工程研究中心江苏南京210009

融合蛋白的设计中，经常需要用链接肽将不同功能的蛋白进行连接融合。连接肽的设计和选择对融合蛋白的表达、稳定性及功能活性至关重要。文章将常见的两种连接肽分为柔性（Flexibility）和刚性（Rigidity）进行比较说明。其中柔性连接... 详细信息

融合蛋白的设计中，经常需要用链接肽将不同功能的蛋白进行连接融合。连接肽的设计和选择对融合蛋白的表达、稳定性及功能活性至关重要。文章将常见的两种连接肽分为柔性（Flexibility）和刚性（Rigidity）进行比较说明。其中柔性连接肽即成柔软线性的一类易弯折的氨基酸序列，常见为（GGGGS）。重复序列（n=3—4）；刚性连接肽即成稳固螺旋结构的一类长度固定的氨基酸序列，常见为（EAAAK）。重复序列（n=2～5）。设计连接肽时应考虑长度、氨基酸成分、亲水性、构象、柔韧性及电荷等因素。连接肽中的氨基酸组成对柔性连接肽影响较大，而氨基酸排列影响着刚性连接肽的结构。文章结合近年来融合蛋白设计中两种最常用连接肽的相关报道进行阐述，为连接肽的研究提供参考。

关键词：融合蛋白重组蛋白连接肽接头序列柔性连接肽刚性连接肽

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